Review
Acoustics
Poornima Palanisamy, Monzurul Alam, Shuai Li, Simon K. H. Chow, Yong-Ping Zheng
Summary: Low-intensity pulsed ultrasound (LIPUS) is a developing technology that has been shown to improve fracture healing with minimal thermal effects by accelerating bone formation through various interactions with tissues and cells. While beneficial effects of LIPUS treatment on different bone fracture locations have been observed, further studies are needed to explore its effects on deeper bones.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Bob Biewer, Felix Kleine-Borgmann, Gael P. Hammer, Eric H. Rompen, Michel Mittelbronn, Pascale Quatresooz
Summary: This study evaluated the influence of Low-Intensity Pulsed Ultrasound (LIPUS) on bone regeneration in irradiated and non-irradiated rabbit tibias with non-critical-size defects. The results showed that LIPUS treatment significantly improved bone formation in non-irradiated bones, while its effects on irradiated bones were less clear. Further studies are needed to refine the understanding of these results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Julene B. Samuels, Bruce Katz, Robert A. Weiss
Summary: This study investigated the efficacy of a novel device for abdominal toning and fat reduction. The results showed that the active treatment group, which utilized simultaneous application of radiofrequency and HIFEM therapy, had a significant increase in rectus abdominis thickness and reduction in subcutaneous fat, exceeding previously published results for separate HIFEM and radiofrequency treatments.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Engineering, Biomedical
Kunzhan Cai, Yilai Jiao, Quan Quan, Yulin Hao, Jie Liu, Lin Wu
Summary: The study utilized a barium titanate/TC4 composite material to promote osteogenesis in MC3T3-E1 cells, achieving favorable bone formation effects with low-intensity pulsed ultrasound as a mechanical stimulus. The synergistic effects of this piezoelectric material with ultrasound loading show promise as a potential treatment for early stage formation of reliable bone-implant contact.
BIOACTIVE MATERIALS
(2021)
Article
Orthopedics
Shengcan Li, Zihan Xu, Zhanwen Wang, Jie Xiang, Tao Zhang, Hongbin Lu
Summary: The study found that LIPUS treatment can accelerate bone-tendon interface healing, which is associated with macrophages. Using a murine rotator cuff repair model, it was discovered that LIPUS treatment can promote the formation of fibrocartilage and improve bone quality.
Article
Acoustics
Priscilla Machado, Jingzhi Li, Rachel Blackman, Ji-Bin Liu, Christopher K. Kepler, Taolin Fang, Robert Muratore, Jason H. Winder, Alan A. Winder, Flemming Forsberg
Summary: This study compared the effects of a novel bimodal acoustic signal device and a clinical low-intensity pulsed ultrasound system on bone fracture healing. The results showed that the novel device achieved better fracture healing response than the currently FDA-approved LIPUS system.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Multidisciplinary Sciences
Lang Jia, Dongqian Li, Xia Wei, Jinyun Chen, Deyu Zuo, Wenzhi Chen
Summary: This study compared the efficacy and safety of focused low-intensity pulsed ultrasound (FLIPUS) with pulsed shortwave diathermy (PSWD) in patients with knee osteoarthritis (OA). The results showed that FLIPUS was more effective than PSWD in alleviating pain and improving dysfunction and health status among subjects with knee OA in the short term.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Reimon Yamaguchi, Xin Guo, Jianbo Zheng, Jing Zhang, Jia Han, Akihiro Shioya, Hidetaka Uramoto, Takashi Mochizuki, Sohsuke Yamada
Summary: PRDX4 plays a crucial role in wound healing process by reducing oxidative stress, inflammation, and promoting angiogenesis. Overexpression of PRDX4 can accelerate wound healing in aged mice, making fibroblasts more resistant to oxidative damage caused by hydrogen peroxide.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Yi-Hua Liao, Wen-Shiang Chen, Shiou-Hwa Jee
Summary: The study demonstrated that LIPUS showed significant enhancement in repigmentation for truncal vitiligo, but not for facial vitiligo. Truncal vitiligo and higher intensity of LIPUS administered were statistically associated with the effectiveness of LIPUS treatment as an adjunct for repigmentation of vitiligo. The LIPUS treatment was well-tolerated without remarkable adverse effects, suggesting its potential therapeutic benefits for truncal vitiligo.
DERMATOLOGIC THERAPY
(2021)
Article
Acoustics
Xiaowei Huang, Lili Niu, Long Meng, Zhengrong Lin, Wei Zhou, Xiufang Liu, Jiqing Huang, Derek Abbott, Hairong Zheng
Summary: Autophagy, the process of cellular self-digestion, plays a crucial role in eliminating abnormal proteins in mammalian cells. Studies have shown that low-intensity pulsed ultrasound (LIPUS) stimulation can enhance neuronal autophagy, indicating its potential as a safe and effective tool for activating autophagy in neurons.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Review
Acoustics
Yujie Li, Wei Li, Xinyue Liu, Xueli Liu, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li, Zhongfa Zhang
Summary: Tendon injuries are common soft tissue injuries caused by overuse and degeneration. Tendon repair is slow and inefficient due to the lack of cellular structure and blood vessels. Low-intensity pulsed ultrasound (LIPUS) is a promising non-invasive method for promoting tendon healing. This review examines studies on LIPUS and summarizes its effects on tendon injury, with 87.5% of studies showing improvement. Further research on the application of LIPUS in tendon diseases is warranted.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Food Science & Technology
Yaru Qi, Fen Yu, Xuecheng Wang, Na Wan, Ming Yang, Zhenfeng Wu, Yuanhui Li
Summary: In this study, low-intensity pulsed ultrasound-assisted vacuum drying (LPUVD) was shown to offer quality advantages over continuous ultrasound-assisted vacuum drying (CUVD) for wolfberry fruit juice, with the optimal drying conditions being at 50 degrees C and a pulsed ultrasound ratio of 10 s: 10 s.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Orthopedics
Wilson C. Lai, Brenda C. Iglesias, Bryan J. Mark, Dean Wang
Summary: In animal studies, LIPUS treatment enhanced healing of acute tendon, ligament, and bone-soft tissue junction injuries through increased collagen content and organization, increased anti-inflammatory cellular signaling, and increased angiogenesis. However, in human trials investigating chronic tendinopathy, LIPUS did not lead to superior outcomes compared with controls.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Orthopedics
Xingwang Liu, Kai Sun, Pengzhi Xu, Zhongshen Yu, Zeming Le, Huihui Zhou, Jutao Li, Xi Li, Zhiyong Zhu, Huisheng Wang, Chen Chen, Xizhuang Bai
Summary: Low-intensity pulsed ultrasound system (LIPUS) promotes cell viability and osteogenic differentiation in vitro, and enhances graft-bone healing of artificial ligaments in vivo.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tatsuya Shimizu, Naomasa Fujita, Kiyomi Tsuji-Tamura, Yoshimasa Kitagawa, Toshiaki Fujisawa, Masato Tamura, Mari Sato
Summary: Research has shown that bone-embedded osteocytes play a crucial role in promoting fracture healing through transcriptional control of target genes, which activates neighboring cells involved in the fracture healing processes.
SCIENTIFIC REPORTS
(2021)