Article
Microbiology
David Shapiro, Fatemeh Ramezani Kapourchali, Anthony Santilli, Yingchun Han, Gail A. M. Cresci
Summary: Antibiotic therapy can disrupt gut microbes and negatively affect the host. This study tested the efficacy of a Bacillus-based probiotic during antibiotic therapy in mice. The probiotic protected against bacterial overgrowth and inflammation in the intestine, suggesting it can regulate host immune responses.
Article
Microbiology
Adam J. Berlinberg, Ana Brar, Andrew Stahly, Mark E. Gerich, Blair P. Fennimore, Frank Scott, Kristine A. Kuhn
Summary: This study compares two methods of intestinal tissue collection for evaluating metabolites and microbiomes, finding that using a brush to sample the microbiome provides valuable data. However, for metabolomics assessment, biopsy samples may still be required.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Qiuyue He, Min Niu, Jiandie Bi, Na Du, Shumin Liu, Kai Yang, Huanqin Li, Jing Yao, Yan Du, Yong Duan
Summary: This study demonstrates the anti-inflammatory effects of B. fragilis ATCC25285 both in vivo and in vitro. It attenuates inflammation by inhibiting the TLR/NF-kappa B pathway and inflammatory cytokines. The metabolic supernatant of B. fragilis also shows anti-inflammatory properties. Animal experiments show that live B. fragilis ameliorates DSS-induced colitis.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Binita Poudel, Naama Shterzer, Yara Sbehat, Nir Ben-Porat, Michal Rakover, Ron Tovy-Sharon, Dvora Wolicki, Stav Rahamim, Enav Bar-Shira, Erez Mills
Summary: The development of probiotics for chickens is a rapidly growing field. The current main approach is to administer probiotics through the bird's life, usually through feed incorporation. This study reports two colonization experiments using 14 different bacterial strains, and finds that some strains are able to colonize chicks after a single exposure. Fecal samples are shown to be useful for identifying and understanding colonization dynamics.
Review
Medicine, Research & Experimental
Periyanaina Kesika, Natarajan Suganthy, Bhagavathi Sundaram Sivamaruthi, Chaiyavat Chaiyasut
Summary: Gut microbiota plays a crucial role in the development of Alzheimer's disease (AD) through dysbiosis, leading to inflammatory signaling pathway disturbances that promote neuroinflammation and neuronal death. Understanding the relationship between gut microbiota and CNS can help identify probiotic-based supplementation as a potential therapeutic option for AD.
Review
Gastroenterology & Hepatology
Anais B. Larabi, Hugo L. P. Masson, Andreas J. Baumler
Summary: Changes in gut microbiota composition are associated with human illnesses, and bile acids play a key role in shaping the microbiota. Bile acids exert antimicrobial activity and activate host signaling pathways to maintain gut homeostasis. Manipulating the composition or size of the bile acid pool could be a promising strategy to address dysbiosis and its associated diseases.
Review
Gastroenterology & Hepatology
Vivienne Woo, Theresa Alenghat
Summary: The complex relationship between the gastrointestinal tract and microbiota is regulated by epigenetic modifications, including modifications to DNA or histones and regulation of non-coding RNAs. Further research is needed to fully understand the mechanisms of epigenetic regulation.
Article
Immunology
Meghan A. Berryman, Patricia L. Milletich, Joseph R. Petrone, Luiz F. W. Roesch, Jorma Ilonen, Eric W. Triplett, Johnny Ludvigsson
Summary: This study demonstrates the significant influence of autoimmune-associated genetic factors on the colonization of common Bifidobacterium strains in the gut. HLA DR1-DQ5 is proposed as a protective haplotype associated with increased Bifidobacterium abundance. These findings suggest that HLA genetics should be considered when designing probiotics for individuals at high genetic risk for autoimmune diseases.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Agriculture, Dairy & Animal Science
Yufeng Du, Ya Gao, Mingyang Hu, Jinxiu Hou, Linhai Yang, Xianghuang Wang, Wenjuan Du, Jianxin Liu, Qingbiao Xu
Summary: Colonization and development of the gut microbiome are essential for the growth and health of calves. This review summarized the colonization, beneficial nutrition, immune function, gut barrier function, and evolution of core microbiota in the gut of calves of different ages. Homeostasis of the gut microbiome is beneficial for the nutritional and immune system development of calves. Disruption of the gut microbiome leads to digestive diseases in calves, such as diarrhea and intestinal inflammation. Colonization of microbiota in the gut of calves is influenced by various factors, including probiotics, diet, age, and genotype. The interaction between gut microbiota and the immune system of calves is crucial for colonization. The abundance and diversity of commensal microbiota play a critical role in the health of calves.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Review
Immunology
Zhipeng Yang, Xiangchen Liu, Yanting Wu, Jian Peng, Hongkui Wei
Summary: This review explores the significance of early-life microbial colonization and the development of intestinal innate immunity, as well as discusses two main methods of early-life intervention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zidong Donna Fu, Felcy Pavithra Selwyn, Julia Yue Cui, Curtis D. Klaassen
Summary: This study compared the transcriptomes of four sections of the intestine between germ-free (GF) mice and conventional (CV) controls using RNA-Seq, revealing differential gene expressions related to the absence of commensal microbiota. The results showed specific alterations in metabolic pathways in GF mice, highlighting the importance of intestinal microbiota in host intestinal physiology and drug responses.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jun Bao, Lili Li, Yangheng Zhang, Min Wang, Faming Chen, Shaohua Ge, Bin Chen, Fuhua Yan
Summary: This study aimed to investigate whether periodontitis induces dysbiosis of gut microbiota through invasion by salivary microbes. The results showed significant differences in both the faecal and salivary microbiota between periodontally healthy participants and patients with severe periodontitis. Furthermore, transplantation of salivary microbes into mice revealed significant differences in the composition of the gut microbiota and alterations in intestinal health-related markers. In addition, salivary microbes were found to persist in the gut for at least 24 hours.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Review
Chemistry, Medicinal
Yang Su, Fan Zhang, Wen Qin, Lun Wu, Qiuhong Wang, Genhong Cheng, Haixue Kuang
Summary: This paper explores the pathogenesis of psoriasis from the intestines based on the gut-skin axis concept. Treatment of psoriasis through the gut-skin axis in traditional Chinese medicine has shown high effectiveness, but more research on the mechanisms is needed.
Article
Gastroenterology & Hepatology
Yan Hui, Birgitte Smith, Martin Steen Mortensen, Lukasz Krych, Soren J. Sorensen, Gorm Greisen, Karen Angeliki Krogfelt, Dennis Sandris Nielsen
Summary: The study found that probiotic supplementation in preterm neonates affected gut colonization by certain bacteria, but did not change the overall longitudinal bacterial progression during the neonatal period.
Review
Pediatrics
Nitin Sajankila, Samantha Jane Wala, Mecklin Victoria Ragan, Samuel Grant Volpe, Zachary Dumbauld, Nanditha Purayil, Belgacem Mihi, Gail E. Besner
Summary: Necrotizing enterocolitis (NEC) is a complex intestinal disease that primarily affects premature neonates. The use of probiotics is a potential preventative strategy for NEC, but clear guidelines and FDA-approved products are currently lacking. There is ongoing debate about the benefits, safety, and efficacy of probiotics, and further research and product development is needed to support their use in the preterm population.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biology
Melissa Kelley, John Yochem, Michael Krieg, Andrea Calixto, Maxwell G. Heiman, Aleksandra Kuzmanov, Vijaykumar Meli, Martin Chalfie, Miriam B. Goodman, Shai Shaham, Alison Frand, David S. Fay
Article
Biochemistry & Molecular Biology
Gabriela C. Monsalve, Cheryl Van Buskirk, Alison R. Frand
Article
Developmental Biology
Sascha Russel, Alison R. Frand, Gary Ruvkun
DEVELOPMENTAL BIOLOGY
(2011)
Article
Cell Biology
Vijaykumar S. Meli, Beatriz Osuna, Gary Ruvkun, Alison R. Frand
MOLECULAR BIOLOGY OF THE CELL
(2010)
Article
Multidisciplinary Sciences
Randall M. Chin, Xudong Fu, Melody Y. Pai, Laurent Vergnes, Heejun Hwang, Gang Deng, Simon Diep, Brett Lomenick, Vijaykumar S. Meli, Gabriela C. Monsalve, Eileen Hu, Stephen A. Whelan, Jennifer X. Wang, Gwanghyun Jung, Gregory M. Solis, Farbod Fazlollahi, Chitrada Kaweeteerawat, Austin Quach, Mahta Nili, Abby S. Krall, Hilary A. Godwin, Helena R. Chang, Kym F. Faull, Feng Guo, Meisheng Jiang, Sunia A. Trauger, Alan Saghatelian, Daniel Braas, Heather R. Christofk, Catherine F. Clarke, Michael A. Teitell, Michael Petrascheck, Karen Reue, Michael E. Jung, Alison R. Frand, Jing Huang
Article
Multidisciplinary Sciences
Guillaume Moissiard, Shawn J. Cokus, Joshua Cary, Suhua Feng, Allison C. Billi, Hume Stroud, Dylan Husmann, Ye Zhan, Bryan R. Lajoie, Rachel Patton McCord, Christopher J. Hale, Wei Feng, Scott D. Michaels, Alison R. Frand, Matteo Pellegrini, Job Dekker, John K. Kim, Steven E. Jacobsen
Article
Developmental Biology
Gabriel D. Hayes, Alison R. Frand, Gary Ruvkun
Article
Biochemistry & Molecular Biology
AR Frand, S Russel, G Ruvkun
Article
Cell Biology
AR Frand, CA Kaiser
MOLECULAR BIOLOGY OF THE CELL
(2000)
Review
Cell Biology
AR Frand, JW Cuozzo, CA Kaiser
TRENDS IN CELL BIOLOGY
(2000)