Article
Immunology
Qi Yu, Jisong Yan, Shan Tian, Wujin Weng, Hong Luo, Gang Wei, Gangyu Long, Jun Ma, Fengyun Gong, Xiaorong Wang
Summary: This study developed and validated a scoring system based on common clinical metrics to discriminate between active pulmonary tuberculosis (APTB) and inactive pulmonary tuberculosis (IPTB). The scoring system showed excellent diagnostic performance in distinguishing APTB from IPTB.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Clinical Neurology
A. Stein, E. Sody, N. Bruns, U. Felderhoff-Muser
Summary: This study aimed to develop a simple and objective ultrasound scoring system to assess cortical development in preterm infants. The results showed that clinical landmarks identified through ultrasound were significantly correlated with gestational age. This scoring system has the potential to serve as an objective indicator of brain maturation, reducing the reliance on individual growth trajectories and percentiles.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ying Hou, Xin Zhang, Xia Sun, Qiaohong Qin, Di Chen, Min Jia, Yulong Chen
Summary: Genetically modified (GM) rabbits expressing human genes have been widely used as animal models for studying cardiovascular diseases. Current methods for gene modification in rabbits include prokaryotic microinjection and RNA interference, but stable ES cell lines are lacking. However, with the emergence of new genetic technologies such as ZFNs, TALENs, CRISPR, and CRISPR/Cas9, significant progress has been made in rabbit gene targeting.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Microbiology
Firat Kaya, Jacqueline P. Ernest, Katherine LoMauro, Martin Gengenbacher, Abdeldjalil Madani, Wassihun Wedajo Aragaw, Matthew D. Zimmerman, Jansy P. Sarathy, Nadine Alvarez, Isaac Daudelin, Han Wang, Faye Lanni, Danielle M. Weiner, Laura E. Via, Clifton E. Barry, Kenneth N. Olivier, Thomas Dick, Brendan K. Podell, Radojka M. Savic, Veronique Dartois
Summary: This study found that the rabbit model of active tuberculosis reproduces key features of human NTM-PD and provides an acceptable surrogate model for studying antibiotic penetration and efficacy. The research also revealed that the clinical activity of clarithromycin is limited by pharmacodynamic factors.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biology
Vorada Sakulsaengprapha, Paul Wasuwanich, Gayathri Naraparaju, Yelena Korotkaya, Supharerk Thawillarp, Kiyoko Oshima, Christine Karwowski, Ann O. Scheimann, Wikrom Karnsakul
Summary: Autoimmune hepatitis (AIH) is a challenging liver disease to diagnose, and the International Autoimmune Hepatitis Group (IAIHG) scoring system was developed to assist in AIH diagnosis. The scoring system was originally designed for adults, so its performance in children needed evaluation. Liver biopsies were found to be an important component of the IAIHG scoring system, with specific biopsy features significantly associated with AIH. Incorporating liver biopsy data improved the performance of the scoring system, but there are differences between children and adults. Overall, the IAIHG score is effective but can be further improved for diagnosing AIH in children.
Article
Urology & Nephrology
Fei-Fei Chen, Xiao-Juan Yu, Hui Wang, Xu Zhang, Ying Tan, Zhen Qu, Su-Xia Wang, Feng Yu, Min Chen, Ming-Hui Zhao
Summary: This study aimed to establish a renal thrombotic microangiopathy (TMA) scoring system based on clinical needs and investigate its predictive value for patients' long-term outcomes. The scoring system showed good reproducibility and correlated well with clinical parameters, indicating its potential prognostic value.
Article
Engineering, Environmental
Jianying Song, Jianlong Wang, Wenhai Wang, Liuwei Peng, Hongxin Li, Changhe Zhang, Xing Fang
Summary: The study compared different infiltration models and found that the Horton model performed well, with parameters easily obtainable through monitoring. Therefore, it can be used to describe the infiltration performance of PBPs effectively.
WATER SCIENCE AND TECHNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Yuvaraj Krishnamoorthy, Komala Ezhumalai, Sharan Murali, Sathish Rajaa, Marie Gilbert Majella, Sonali Sarkar, Subitha Lakshminarayanan, Noyal Mariya Joseph, Govindarajan Soundappan, Senbagavalli Prakash Babu, Charles Horsburgh, Natasha Hochberg, W. Evan Johnson, Selby Knudsen, Sri Ram Pentakota, Padmini Salgame, Gautam Roy, Jerrold Ellner
Summary: A prognostic-scoring model was developed to predict death among newly diagnosed drug sensitive pulmonary TB patients in South India. The model, which had a discriminative power of 0.81, could aid clinicians and policy makers in devising targeted interventions to reduce TB mortality.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Orthopedics
Melissa A. Fraser, Michael Kuo, Anne Marie Boeckmann, Leah M. Kilchrist
Summary: The study aimed to assess the differences between different versions of the Balance Error Scoring System (BESS) among healthy and concussed collegiate student-athletes. The results showed significant differences between the BESS and BESS-R versions at baseline, but these differences were not clinically meaningful. The various versions of the BESS may not accurately identify balance deficits at baseline or postinjury.
CLINICAL JOURNAL OF SPORT MEDICINE
(2022)
Article
Pathology
Khadiga M. Ali, Khaled R. Zalata, Tarik Barakat, Sherine M. Elzeiny
Summary: Liver biopsy is crucial for the diagnosis of persistent neonatal cholestasis, especially for biliary atresia. This study developed a simple scoring system based on liver biopsy and non-invasive methods to improve the diagnostic accuracy of biliary atresia. Histopathologic predictors of biliary atresia were identified, and the performance of liver biopsy in diagnosing biliary atresia was evaluated.
Article
Respiratory System
Senquan Wu, Shaomei Li, Nianxin Fang, Weiliang Mo, Huadong Wang, Ping Zhang
Summary: This study developed a scoring diagnostic model to differentiate tuberculous pleural effusion from non-tuberculous pleural effusion. By selecting six clinical features and laboratory variables, the model showed high sensitivity, specificity, and accuracy in diagnosing TBPE.
BMC PULMONARY MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Ziling Huang, Lijun Chen, Lei Lv, Chi-Cheng Fu, Yan Jin, Qiang Zheng, Boyang Wang, Qiuyi Ye, Qu Fang, Yuan Li
Summary: This study tested a new AI-assisted scoring system for evaluating PD-L1 expression in NSCLC. The results showed that the Aitrox AI model performed well in the negative and low TPS groups, comparable to experienced pathologists, but had unsatisfactory performance in the high TPS group. The study demonstrates the potential of the Aitrox AI model in assisting pathologists in routine diagnosis of NSCLC.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Veterinary Sciences
Fernanda Larenas-Munoz, Ines Ruedas-Torres, Laura Hunter, Alison Bird, Irene Agullo-Ros, Rebecca Winsbury, Simon Clark, Emma Rayner, Francisco J. Salguero
Summary: Tuberculosis remains a significant infectious disease worldwide, requiring the development of new vaccines and therapies. Guinea pigs are a valuable animal model for studying TB, as their granulomatous lesions resemble those observed in humans.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Immunology
Gonzalo G. Alvarez, Alice A. Zwerling, Carla Duncan, Christopher Pease, Deborah Van Dyk, Marcel A. Behr, Robyn S. Lee, Sunita Mulpuru, Smita Pakhale, D. William Cameron, Shawn D. Aaron, Michael Patterson, Jean Allen, Kathryn Sullivan, Anne Jolly, Meenu K. Sharma, Frances B. Jamieson
Summary: This study used whole-genome sequencing to investigate the transmission dynamics of TB among the Inuit population in the Canadian Arctic, identifying clusters related to Euro-American lineage and highlighting superspreading events associated with homeless shelters and gambling houses. The study suggests that socioeconomic factors played a significant role in explaining the rise in TB cases in this predominantly Inuit community.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Virology
Sung Woon Kang, Heedo Park, Ji Yeun Kim, Sunghee Park, So Yun Lim, Sohyun Lee, Joon-Yong Bae, Jeonghun Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang -Oh Lee, Sang -Ho Choi, Yang Soo Kim, Sung-Cheol Yun, Man-Seong Park, Sung -Han Kim
Summary: This study developed a clinical scoring system to predict viable viral shedding in patients with COVID-19. By identifying clinical predictors, the system provides objective probability of culture-negative state, which could be useful for implementing personalized de-isolation policies.
JOURNAL OF CLINICAL VIROLOGY
(2022)