From hype to reality: data science enabling personalized medicine

Electronic Health Record Phenotypes for Precision Medicine: Perspectives and Caveats From Treatment of Breast Cancer at a Single Institution

(2018) Matthew K. Breitenstein et al.   CTS-Clinical and Translational Science

Causal Structure Learning

(2018) Christina Heinze-Deml et al.   Annual Review of Statistics and Its Application

Integrative Personal Omics Profiles during Periods of Weight Gain and Loss

(2018) Brian D. Piening et al.   Cell Systems

Deep Learning in Medical Imaging: General Overview

(2017) June-Goo Lee et al.   KOREAN JOURNAL OF RADIOLOGY

Real-world first-line treatment and overall survival in non-small cell lung cancer without known EGFR mutations or ALK rearrangements in US community oncology setting

(2017) Amy P. Abernethy et al.   PLoS One

Reconstructing blood stem cell regulatory network models from single-cell molecular profiles

(2017) Fiona K. Hamey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The P4 Health Spectrum – A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan

(2017) Michael Sagner et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Semantics derived automatically from language corpora contain human-like biases

(2017) Aylin Caliskan et al.   SCIENCE

Quantifying critical states of complex diseases using single-sample dynamic network biomarkers

(2017) Xiaoping Liu et al.   PLoS Computational Biology

Using recurrent neural network models for early detection of heart failure onset

(2016) Edward Choi et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

(2016) Fatima Cardoso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toward a Shared Vision for Cancer Genomic Data

(2016) Robert L. Grossman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features

(2016) Kun-Hsing Yu et al.   Nature Communications

Reconciling evidence-based medicine and precision medicine in the era of big data: challenges and opportunities

(2016) Jacques S. Beckmann et al.   Genome Medicine

Deep Patient: An Unsupervised Representation to Predict the Future of Patients from the Electronic Health Records

(2016) Riccardo Miotto et al.   Scientific Reports

MediBoost: a Patient Stratification Tool for Interpretable Decision Making in the Era of Precision Medicine

(2016) Gilmer Valdes et al.   Scientific Reports

Comparative study on gene set and pathway topology-based enrichment methods

(2015) Michaela Bayerlová et al.   BMC BIOINFORMATICS

Could Big Data be the end of theory in science?: A few remarks on the epistemology of data-driven science

(2015) F. Mazzocchi   EMBO REPORTS

Survival Prediction of Clear Cell Renal Cell Carcinoma Based on Gene Expression Similarity to the Proximal Tubule of the Nephron

(2015) Florian Büttner et al.   EUROPEAN UROLOGY

PathVisio 3: An Extendable Pathway Analysis Toolbox

(2015) Martina Kutmon et al.   PLoS Computational Biology

Variable selection in regression with compositional covariates

(2014) W. Lin et al.   BIOMETRIKA

Challenges of Big Data analysis

(2014) Jianqing Fan et al.   National Science Review

NaviCell: a web-based environment for navigation, curation and maintenance of large molecular interaction maps

(2013) Inna Kuperstein et al.   BMC Systems Biology

Hybrid semi-parametric modeling in process systems engineering: Past, present and future

(2013) Moritz von Stosch et al.   COMPUTERS & CHEMICAL ENGINEERING

Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map

(2013) Kazuhiro A. Fujita et al.   MOLECULAR NEUROBIOLOGY

Combination of a Proteomics Approach and Reengineering of Meso Scale Network Models for Prediction of Mode-of-Action for Tyrosine Kinase Inhibitors

(2013) Stefan Balabanov et al.   PLoS One

Prognostic gene signatures for patient stratification in breast cancer - accuracy, stability and interpretability of gene selection approaches using prior knowledge on protein-protein interactions

(2012) Yupeng Cun et al.   BMC BIOINFORMATICS

Mining electronic health records: towards better research applications and clinical care

(2012) Peter B. Jensen et al.   NATURE REVIEWS GENETICS

Multi-Target Drugs: The Trend of Drug Research and Development

(2012) Jin-Jian Lu et al.   PLoS One

Evolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases

(2012) Solip Park et al.   Scientific Reports

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

How evolutionary principles improve the understanding of human health and disease

(2011) Peter D. Gluckman et al.   Evolutionary Applications

Electronic medical records and personalized medicine

(2011) Mark A. Hoffman et al.   HUMAN GENETICS

Medicina P4: el futuro a la vuelta de la esquina

(2010) Patricia Sobradillo et al.   ARCHIVOS DE BRONCONEUMOLOGIA

Predicting causal effects in large-scale systems from observational data

(2010) Marloes H Maathuis et al.   NATURE METHODS

Local identification of scalar hybrid models with tree structure

(2008) B. Fiedler et al.   IMA JOURNAL OF APPLIED MATHEMATICS