Article
Multidisciplinary Sciences
Adam Wisnewski, Julian Campillo Luna, Carrie A. Redlich
Summary: Study on 4 subjects showed that COVID-19 mRNA vaccines effectively induce spike antigen-specific IgG and IgA, but there are marked differences in their persistence in serum.
Review
Immunology
Marissa L. Matsumoto
Summary: As central effectors of the adaptive immune response, immunoglobulins, or antibodies, provide essential protection from pathogens. IgA and IgM, the only antibody isotypes capable of multimerization, have unique biological functions and play critical roles in mucosal immunity.
ANNUAL REVIEW OF IMMUNOLOGY
(2022)
Article
Immunology
Corinne J. J. Smith, Nikki Ross, Ali Kamal, Kevin Y. Kim, Elizabeth Kropf, Pascal Deschatelets, Cedric Francois, William J. Quinn, Inderpal Singh, Anna Majowicz, Federico Mingozzi, Klaudia Kuranda
Summary: AAV gene transfer shows promise in treating genetic diseases, but the host immune response poses challenges. This study characterizes the innate immune response to AAV in human whole blood, finding that high levels of neutralizing antibodies can increase inflammation and vector uptake. Inhibiting the complement pathway may be a strategy for reducing immunogenicity in AAV-based therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Andrea Knies, Dennis Ladage, Ralf J. Braun, Janine Kimpel, Miriam Schneider
Summary: This study summarizes findings on the persistence of humoral response post SARS-CoV-2 infection, with IgG antibodies showing the longest duration of six to eight months, while IgM and IgA studies yielded mixed results. Most studies observed neutralizing antibodies lasting up to eight months, which have been associated with protection from re-infection.
REVIEWS IN MEDICAL VIROLOGY
(2022)
Article
Immunology
Ana Marcos-Jimenez, Santiago Sanchez-Alonso, Ana Alcaraz-Serna, Laura Esparcia, Celia Lopez-Sanz, Miguel Sampedro-Nunez, Tamara Mateu-Albero, Ildefonso Sanchez-Cerrillo, Pedro Martinez-Fleta, Ligia Gabrie, Luciana del Campo Guerola, Jose Miguel Rodriguez-Frade, Jose M. Casasnovas, Hugh T. Reyburn, Mar Vales-Gomez, Margarita Lopez-Trascasa, Enrique Martin-Gayo, Maria Jose Calzada, Santos Castaneda, Hortensia de la Fuente, Isidoro Gonzalez-Alvaro, Francisco Sanchez-Madrid, Cecilia Munoz-Calleja, Arantzazu Alfranca
Summary: The immune response in peripheral blood of COVID-19 patients is associated with disease severity, with an imbalanced humoral response potentially being a characteristic of severe cases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Carson L. Smith, Beth Bednarchik, Htin Aung, Dennis J. Wilk, Rebecca S. Boxer, Andrea E. Daddato, Brigid M. Wilson, Stefan Gravenstein, David H. Canaday
Summary: This study conducted a randomized clinical trial to analyze the immune response of nursing home residents who received adjuvanted influenza vaccine. The findings show that the adjuvanted vaccine induced a stronger immune response, particularly in the production of antibodies against A/H3N2 neuraminidase, compared to the nonadjuvanted vaccine.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Mengmeng Jia, Xinming Wang, Wensheng Gong, Jingchuan Zhong, Zhiwei Leng, Lili Ren, Luzhao Feng, Li Guo, Lidong Gao, Xian Liang, Enfu Chen, Wenge Tang, Qiangru Huang, Qiao Zhang, Guangjiong Jiang, Shanlu Zhao, Zhu Liu, Yan Feng, Li Qi, Libing Ma, Tingxuan Huang, Yong Yue, Ju Wang, Binshan Jiang, Liuhui Xu, Jianwei Wang, Weizhong Yang, Chen Wang
Summary: This study evaluated the immune responses to inactivated COVID-19 vaccination in different groups (naive individuals, asymptomatically infected individuals, and recovered patients), and found that a single dose of vaccine is sufficient for recovered patients, and the second dose does not substantially increase antibody levels.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Geriatrics & Gerontology
Ran Duan, Tong Feng, Jixin Hou, Yu Wei, Lin Lin
Summary: This study aimed to investigate the relationship between vitamin D and sleep duration in older adults. The study found a positive correlation between serum 25(OH)D levels and sleep duration in the fully adjusted model. The analysis also revealed a non-linear relationship, with a saturation point observed at a serum 25(OH)D level of 40.6 ng/mL.
Article
Virology
Andrei Ivanov, Elena Semenova
Summary: This study aimed to monitor the immune response to SARS-CoV-2 infection for 9 months, involving 180 volunteers. All COVID-19 patients developed a stable humoral immune response, but with individual differences. Some patients showed unusual changes in plasma anti-SARS-CoV-2 IgA levels after recovery.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Microbiology
Jennifer M. Sasson, Joseph J. Campo, Rebecca M. Carpenter, Mary K. Young, Arlo Z. Randall, Krista Trappl-Kimmons, Amit Oberai, Christopher Hung, Joshua Edgar, Andy A. Teng, Jozelyn Pablo, Xiaowu Liang, Angela Yee, William A. Petri, David Camerini
Summary: The study revealed stronger antibody responses to specific SARS-CoV-2 epitopes in older patients, correlated with systemic cytokine responses. Additionally, some patients showed minimal antibody reactivity to SARS-CoV-2 antigens and experienced severe clinical outcomes.
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Immunology
Sarah Delliere, Magalie Duchateau, Sarah Sze Wah Wong, Quentin Giai Gianetto, Helene Guegan, Mariette Matondo, Jean-Pierre Gangneux, Vishukumar Aimanianda
Summary: The study identified several humoral immune components in bronchoalveolar lavage fluid affected by Aspergillus fumigatus infection or colonization, indicating their potential as diagnostic markers for such conditions. These findings provide new insights into the complex interaction between host and Aspergillus, highlighting the importance of crosstalk between these humoral components in understanding the pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ryan M. Pace, Janet E. Williams, Kirsi M. Jarvinen, Courtney L. Meehan, Melanie A. Martin, Sylvia H. Ley, Celestina Barbosa-Leiker, Aline Andres, Laxmi Yeruva, Mandy B. Belfort, Beatrice Caffe, Alexandra D. Navarrete, Kimberly A. Lackey, Christina D. W. Pace, Alexandra C. Gogel, Bethaney D. Fehrenkamp, Miranda Klein, Bridget E. Young, Casey Rosen-Carole, Nichole Diaz, Stephanie L. Gaw, Valerie Flaherman, Mark A. McGuire, Michelle K. McGuire, Antti E. Seppo
Summary: The study found that milk produced by women with COVID-19 does not contain SARS-CoV-2 and contains anti-RBD IgA, providing lasting passive immunity. Therefore, it is recommended for lactating women to continue breastfeeding during and after COVID-19 infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Rami Abu Fanne, Ghalib Lidawi, Emad Maraga, Mahmud Moed, Ariel Roguin, Simcha-Ron Meisel
Summary: The study found that the efficacy of COVID-19 vaccines is related to baseline vitamin D levels, with low vitamin D levels associated with an increased risk of breakthrough infection.
Article
Oncology
Peng Li, Xinhai Zhu, Guangchao Cao, Ruan Wu, Ke Li, Wenhui Yuan, Biyun Chen, Guodong Sun, Xichun Xia, Hua Zhang, Xiao Wang, Zhinan Yin, Ligong Lu, Yunfei Gao
Summary: This study demonstrates that serum vitamin D level is negatively correlated with the expression of PD-1, TIGIT, and Tim-3, while positively correlated with the expression of CD28 on CD8(+) and V gamma 9V delta 2(+) T cells in patients with NSCLC. The active form of vitamin D, 1 alpha,25(OH)(2)D-3, promotes the nuclear translocation of VDR and inhibits the expression of ICRs by binding to their promoter regions. In addition, VDR-mediated Ca2+ influx enhances Th1 cytokine production and increases antitumor immunity in T cells. Overall, this research highlights the pleiotropic effects of 1 alpha,25(OH)(2)D-3 in rescuing exhausted cytotoxic T cells and promoting antitumor immunity in patients with tumor.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Carol Strahm, Marco Seneghini, Sabine Gusewell, Thomas Egger, Onicio Leal-Neto, Angela Brucher, Eva Lemmenmeier, Dorette Meier Kleeb, J. Carsten Moeller, Philip Rieder, Markus Ruetti, Remus Rutz, Hans-Ruedi Schmid, Reto Stocker, Danielle Vuichard-Gysin, Benedikt Wiggli, Ulrike Besold, Stefan P. Kuster, Allison McGeer, Lorenz Risch, Andree Friedl, Matthias Schlegel, Dagmar Schmid, Pietro Vernazza, Christian R. Kahlert, Philipp Kohler
Summary: In a study among healthcare workers, participants with a positive nasopharyngeal swab for SARS-CoV-2 were more likely to experience long COVID symptoms, while seropositive participants without a positive swab had only mild effects. Additionally, baseline physical activity was negatively associated with neurocognitive impairment and fatigue symptoms.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Critical Care Medicine
Tobias Sinnberg, Christa Lichtensteiger, Omar Hasan Ali, Oltin T. Pop, Ann-Kristin Jochum, Lorenz Risch, Silvio D. Brugger, Ana Velic, David Bomze, Philipp Kohler, Pietro Vernazza, Werner C. Albrich, Christian R. Kahlert, Marie-Therese Abdou, Nina Wyss, Kathrin Hofmeister, Heike Niessner, Carl Zinner, Mara Gilardi, Alexandar Tzankov, Martin Rocken, Alex Dulovic, Srikanth Mairpady Shambat, Natalia Ruetalo, Philipp K. Buehler, Thomas C. Scheier, Wolfram Jochum, Lukas Kern, Samuel Henz, Tino Schneider, Gabriela M. Kuster, Maurin Lampart, Martin Siegemund, Roland Bingisser, Michael Schindler, Nicole Schneiderhan-Marra, Hubert Kalbacher, Kathy D. McCoy, Werner Spengler, Martin H. Brutsche, Boris Macek, Raphael Twerenbold, Josef M. Penninger, Matthias S. Matter, Lukas Flatz
Summary: COVID-19 can cause severe respiratory distress syndrome, and dysregulated immune responses, including autoimmunity, play a key role. This study investigated the presence of IgA autoantibodies targeting lung-specific proteins and their effects on pulmonary surfactant in severe COVID-19 cases.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Medical Laboratory Technology
Linda Salzmann, Janik Wild, Neeraj Singh, Tobias Schierscher, Franziska Liesch, Friederike Bauland, Andrea Geistanger, Lorenz Risch, Christian Geletneky, Christoph Seger, Judith Taibon
Summary: This study developed a reference measurement procedure for gabapentin, using quantitative nuclear magnetic resonance (qNMR) spectroscopy to determine the absolute content of standard materials and isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) to accurately measure the concentration of gabapentin in serum and plasma. The analytical protocol showed good selectivity, precision, and accuracy, allowing for standardization of routine tests and reliable evaluation of clinical samples.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Medicine, General & Internal
Linnea Malmgren, Carl Oberg, Emil den Bakker, Felicia Leion, Joanna Siodmiak, Anna Akesson, Veronica Lindstrom, Erik Herou, Alain Dardashti, Liana Xhakollari, Gabriel Grubb, Helena Strevens, Magnus Abrahamson, Johanna Helmersson-Karlqvist, Martin Magnusson, Jonas Bjork, Ulf Nyman, Johan Arnlov, Peter Ridefelt, Torbjorn Akerfeldt, Magnus Hansson, Anna Sjostrom, Johan Martensson, Yoshihisa Itoh, David Grubb, Olav Tenstad, Lars-Olov Hansson, Isleifur Olafsson, Araceli Jarquin Campos, Martin Risch, Lorenz Risch, Anders Larsson, Gunnar Nordin, Hans Pottel, Anders Christensson, Henrik Bjursten, Arend Bokenkamp, Anders Grubb
Summary: Estimation of kidney function is commonly done using endogenous GFR-markers creatinine or cystatin C. The recommendation in 2010 to use both markers in parallel led to the identification of selective glomerular hypofiltration syndromes, which are associated with increased mortality and morbidity. These syndromes, characterized by a selective reduction in the glomerular filtration of certain molecules, such as cystatin C, have proteomic changes that promote the development of atherosclerosis and may require new treatment modalities.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Hossein Gorji, Ivan Lunati, Fabian Rudolf, Beatriz Vidondo, Wolf-Dietrich Hardt, Patrick Jenny, Doortje Engel, Jorg Schneider, Marina Jamnicki, Rudolf Leuthold, Lorenz Risch, Martin Risch, Martin Buhler, Adrian Sommer, Alexa Caduff
Summary: This study evaluates the effects of a unique RNA mass testing program implemented in Canton Grisons, which targeted the local labor force. The analysis of test results from over 27,000 participants shows a significant decrease in test positivity rate and a reduction in associated incidence rate. These findings provide empirical evidence that long-term repetitive mass testing can effectively prevent the spread of COVID-19.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Baharak Babouee Flury, Sabine Gusewell, Thomas Egger, Onicio Leal, Angela Brucher, Eva Lemmenmeier, Dorette Meier Kleeb, J. Carsten Moller, Philip Rieder, Markus Rutti, Hans-Ruedi Schmid, Reto Stocker, Danielle Vuichard-Gysin, Benedikt Wiggli, Ulrike Besold, Allison McGeer, Lorenz Risch, Andree Friedl, Matthias Schlegel, Stefan P. Kuster, Christian R. Kahlert, Philipp Kohler
Summary: Background knowledge about protection conferred by previous SARS-CoV-2 infection and/or vaccination against emerging viral variants allows for prediction and reduction of future COVID-19 burden. This study investigated the risk and symptoms of SARS-CoV-2 (re)infection and vaccine breakthrough infection during the Delta and Omicron waves, depending on baseline immune status and subsequent vaccinations.
Article
Medical Laboratory Technology
Linda Salzmann, Tino Spescha, Neeraj Singh, Tobias Schierscher, Martina Bachmann, Friederike Bauland, Andrea Geistanger, Lorenz Risch, Christian Geletneky, Christoph Seger, Judith Taibon
Summary: In this study, an isotope dilution (ID)-liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based candidate reference measurement procedure (RMP) was developed for the measurement of lamotrigine in human serum and plasma. The method provides traceability and reliability for standardization of routine assays and evaluation of clinical samples.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Anja Kobel, Tobias Schierscher, Neeraj Singh, Linda Salzmann, Franziska Liesch, Friederike Bauland, Andrea Geistanger, Lorenz Risch, Christian Geletneky, Christoph Seger, Judith Taibon
Summary: Developed an isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure (RMP) for levetiracetam quantification in human serum and plasma. The RMP was highly selective and specific, with no evidence of a matrix effect. Its expanded measurement uncertainty of <= 4.0% meets the clinical needs in levetiracetam monitoring. Utilized quantitative nuclear magnetic resonance spectroscopy (qNMR) to ensure metrological traceability to SI units for levetiracetam reference materials.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Immunology
Christian R. Kahlert, Carol Strahm, Sabine Gusewell, Alexia Cusini, Angela Brucher, Stephan Goppel, Elisabeth Moller, J. Carsten Moller, Manuela Ortner, Markus Ruetti, Reto Stocker, Danielle Vuichard-Gysin, Ulrike Besold, Allison McGeer, Lorenz Risch, Andree Friedl, Matthias Schlegel, Pietro Vernazza, Stefan P. Kuster, Philipp Kohler
Summary: This study aimed to investigate the relationship between vaccination, viral variants, and PASC. The results showed that previous infection with wild-type and Alpha/Delta variants was the strongest risk factor for PASC symptoms among healthcare workers. Vaccination before Omicron BA.1 infection did not show a clear protective effect against PASC symptoms in this population.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Philipp Kohler, Baharak Babouee Flury, Sabine Guesewell, Thomas Egger, Onicio Leal, Angela Brucher, Eva Lemmenmeier, Dorette Meier Kleeb, J. Carsten Moller, Manuela Ortner, Philip Rieder, Markus Ruetti, Hans-Ruedi Schmid, Reto Stocker, Danielle Vuichard-Gysin, Oliver Speer, Benedikt Wiggli, Ulrike Besold, Allison McGeer, Lorenz Risch, Andree Friedl, Matthias Schlegel, Pietro R. Vernazza, Christian P. Kahlert, Stefan Kuster
Summary: This study prospectively assessed the effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the Omicron variant breakthrough infection. The results showed that hybrid immunity, compared to vaccination alone, was associated with a reduction of symptoms such as dizziness, muscle or limb pain, and headache. Furthermore, individuals who received a booster dose of the vaccine had lower frequencies of dizziness, cough, and muscle or limb pain. Thus, hybrid immunity and booster vaccine doses can provide additional protection against specific symptoms during breakthrough infections.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Geriatrics & Gerontology
Jean-Pierre Gutzwiller, Krisztina Mueller-Bolla, Carlo Ferrari, Zeno Stanga, Urs. E. E. Nydegger, Lorenz Risch, Martin Risch
Summary: This study conducted a long-term follow-up on Swiss pensioners and identified potential risk factors associated with increased mortality in healthy older adults. This has important implications for understanding healthy ageing populations and reducing their global economic burden.
Article
Medical Laboratory Technology
Linda Salzmann, Tino Spescha, Neeraj Singh, Anja Kobel, Vanessa Fischer, Tobias Schierscher, Friederike Bauland, Andrea Geistanger, Lorenz Risch, Christian Geletneky, Christoph Seger, Judith Taibon
Summary: A novel reference measurement procedure (RMP) was developed and validated for the quantification of topiramate in human serum and plasma. The method showed high analytical performance, fulfilling the requirements on measurement uncertainty, and is suitable for routine assay standardization and clinical sample evaluation.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Niklas Fabio Wohlwend, Kirsten Grossmann, Stefanie Aeschbacher, Ornella C. Weideli, Julia Telser, Martin Risch, David Conen, Lorenz Risch
Summary: The soluble urokinase plasminogen activator receptor (suPAR) is a marker of chronic low-grade inflammation that can be used to predict cardiovascular risk. This study found that suPAR plasma levels were associated with cardiovascular risk factors, with differences between males and females.
Article
Medicine, General & Internal
Martin Risch, Kirsten Grossmann, Stefanie Aeschbacher, Ornella C. Weideli, Marc Kovac, Fiona Pereira, Nadia Wohlwend, Corina Risch, Dorothea Hillmann, Thomas Lung, Harald Renz, Raphael Twerenbold, Martina Rothenbuehler, Daniel Leibovitz, Vladimir Kovacevic, Andjela Markovic, Paul Klaver, Timo B. Brakenhoff, Billy Franks, Marianna Mitratza, George S. Downward, Ariel Dowling, Santiago Montes, Diederick E. Grobbee, Maureen Cronin, David Conen, Brianna M. Goodale, Lorenz Risch
Summary: This study investigated the use of machine learning to identify presymptomatic COVID-19 and detect infection-related changes in physiology using a wearable device. The results showed that wearable sensor technology can enable COVID-19 detection during the presymptomatic period. The developed algorithm had a high recall rate in detecting COVID-19 up to 2 days prior to symptom onset.
Article
Public, Environmental & Occupational Health
Johannes Sumer, Domenica Flury, Christian R. Kahlert, Nicolas J. Mueller, Lorenz Risch, Susanne Nigg, Marco Seneghini, Pietro Vernazza, Matthias Schlegel, Philipp Kohler
Summary: This study prospectively evaluated the safety concept of the congress of the Swiss Societies of Infectious Diseases and Hospital Hygiene. The results indicate that congresses with a rigorous safety concept may take place, even in areas with moderately-high COVID-19 activity.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2022)