Preclinical Alzheimer disease: identification of cases at risk among cognitively intact older individuals

Systematic Analysis of Candidate Genes for Alzheimer's Disease in a French, Genome-Wide Association Study

(2017) Geoffroy Laumet et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

Shapes of the Trajectories of 5 Major Biomarkers of Alzheimer Disease

(2012) Clifford R. Jack et al.   ARCHIVES OF NEUROLOGY

Proteomic Changes in Cerebrospinal Fluid of Presymptomatic and Affected Persons Carrying Familial Alzheimer Disease Mutations

(2012) John M. Ringman   ARCHIVES OF NEUROLOGY

Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience

(2012) Orwa Aboud et al.   BMC Medicine

Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's disease

(2012) Ina Caesar et al.   BMC Medicine

SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population

(2012) Hui-Fu Wang et al.   BRAIN RESEARCH

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

(2012) T. T. Seppala et al.   NEUROLOGY

Accelerated cortical atrophy in cognitively normal elderly with high  -amyloid deposition

(2012) G. Chetelat et al.   NEUROLOGY

Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease

(2012) D. S. Knopman et al.   NEUROLOGY

White Matter Differences between Healthy Young ApoE4 Carriers and Non-Carriers Identified with Tractography and Support Vector Machines

(2012) Laurence O'Dwyer et al.   PLoS One

CSF T-Tau/Aβ42 Predicts White Matter Microstructure in Healthy Adults at Risk for Alzheimer’s Disease

(2012) Barbara B. Bendlin et al.   PLoS One

Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies

(2011) Peter T. Nelson et al.   ACTA NEUROPATHOLOGICA

Amyloid imaging in members of a family harbouring the Arctic APP mutation

(2011) Michael Schöll et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Amyloid-beta plaque growth in cognitively normal adults: Longitudinal [11C]Pittsburgh compound B data

(2011) Andrei G. Vlassenko et al.   ANNALS OF NEUROLOGY

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

(2011) Victor L. Villemagne et al.   ANNALS OF NEUROLOGY

An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease

(2011) Clifford R. Jack et al.   ANNALS OF NEUROLOGY

Longitudinal Patterns of β-Amyloid Deposition in Nondemented Older Adults

(2011) Jitka Sojkova et al.   ARCHIVES OF NEUROLOGY

The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease

(2011) Mert R. Sabuncu   ARCHIVES OF NEUROLOGY

Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden

(2011) Alexander Drzezga et al.   BRAIN

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort

(2011) N. S. M. Schoonenboom et al.   NEUROLOGY

Early detection of Alzheimer disease: 11C-PiB PET in twins discordant for cognitive impairment

(2011) N. M. Scheinin et al.   NEUROLOGY

MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults

(2011) B. C. Dickerson et al.   NEUROLOGY

Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults

(2011) B. C. Dickerson et al.   NEUROLOGY

Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease

(2011) J. Karlawish   NEUROLOGY

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Functional Disconnection and Compensation in Mild Cognitive Impairment: Evidence from DLPFC Connectivity Using Resting-State fMRI

(2011) Peipeng Liang et al.   PLoS One

The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older

(2011) Gerbrand J. Izaks et al.   PLoS One

Altered Connectivity Pattern of Hubs in Default-Mode Network with Alzheimer's Disease: An Granger Causality Modeling Approach

(2011) Xiaoyan Miao et al.   PLoS One

Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE

(2011) Ellen M. Wijsman et al.   PLoS Genetics

Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42

(2010) Jonathan M. Schott et al.   ANNALS OF NEUROLOGY

SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk

(2010) Christiane Reitz et al.   ANNALS OF NEUROLOGY

Amyloid-β associated cortical thinning in clinically normal elderly

(2010) J. Alex Becker et al.   ANNALS OF NEUROLOGY

Hypometabolism in Alzheimer-Affected Brain Regions in Cognitively Healthy Latino Individuals Carrying the Apolipoprotein E ε4 Allele

(2010) Jessica B. S. Langbaum et al.   ARCHIVES OF NEUROLOGY

Malignant Astrocytomas

(2010) Hassan M. Fathallah-Shaykh   ARCHIVES OF NEUROLOGY

Replication of CLU, CR1, and PICALM Associations With Alzheimer Disease

(2010) Minerva M. Carrasquillo et al.   ARCHIVES OF NEUROLOGY

Identification of Novel Loci for Alzheimer Disease and Replication of CLU, PICALM, and BIN1 in Caribbean Hispanic Individuals

(2010) Joseph H. Lee et al.   ARCHIVES OF NEUROLOGY

High PIB Retention in Alzheimers Disease is an Early Event with Complex Relationship with CSF Biomarkers and Functional Parameters

(2010) A. Forsberg et al.   Current Alzheimer Research

Subjective cognitive impairment: Functional MRI during a divided attention task

(2010) J. Rodda et al.   EUROPEAN PSYCHIATRY

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

(2010) Jason J. Corneveaux et al.   HUMAN MOLECULAR GENETICS

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Can Alzheimer disease be prevented by amyloid-β immunotherapy?

(2010) Cynthia A. Lemere et al.   Nature Reviews Neurology

Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease

(2010) Rahul S. Desikan et al.   PLoS One

Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity

(2010) Ernesto J. Sanz-Arigita et al.   PLoS One

Decreased cerebrospinal fluid Aβ42correlates with brain atrophy in cognitively normal elderly

(2009) Anne M. Fagan et al.   ANNALS OF NEUROLOGY

High Striatal Amyloid β-Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types

(2009) Victor L. Villemagne et al.   ARCHIVES OF NEUROLOGY

Preclinical Evidence of Alzheimer Changes

(2009) Eric C. Petrie et al.   ARCHIVES OF NEUROLOGY

Pittsburgh Compound B Imaging and Prediction of Progression From Cognitive Normality to Symptomatic Alzheimer Disease

(2009) John C. Morris et al.   ARCHIVES OF NEUROLOGY

Mild Cognitive Impairment

(2009) Ronald C. Petersen et al.   ARCHIVES OF NEUROLOGY

Treatment of Mild Cognitive Impairment (MCI)

(2009) M. Farlow   Current Alzheimer Research

Cerebrospinal fluid tau and ptau181increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease

(2009) Anne M. Fagan et al.   EMBO Molecular Medicine

FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease

(2009) Lisa Mosconi et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment

(2009) Niklas Mattsson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation

(2009) Michael Schöll et al.   NEUROBIOLOGY OF AGING

Reduced hippocampal CA2, CA3, and dentate gyrus activity in asymptomatic people at genetic risk for Alzheimer's disease

(2009) Nanthia A. Suthana et al.   NEUROIMAGE

Semantic memory activation in individuals at risk for developing Alzheimer disease

(2009) M. Seidenberg et al.   NEUROLOGY

Basal forebrain atrophy is a presymptomatic marker for Alzheimer's disease

(2008) Andrew M. Hall et al.   Alzheimers & Dementia

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

Episodic memory loss is related to hippocampal-mediated  -amyloid deposition in elderly subjects

(2008) E. C. Mormino et al.   BRAIN

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

(2008) Milos D. Ikonomovic et al.   BRAIN

The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals

(2008) Bradford C. Dickerson et al.   CEREBRAL CORTEX

PET Amyloid Ligand [11C]PIB Uptake and Cerebrospinal Fluid β-Amyloid in Mild Cognitive Impairment

(2008) J. Koivunen et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease

(2008) J J Virta et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Prefrontal cortex atrophy predicts dementia over a six-year period

(2008) S. Burgmans et al.   NEUROBIOLOGY OF AGING

Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment

(2008) Sarah B. Martin et al.   NEUROBIOLOGY OF AGING

Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal

(2008) Liana G. Apostolova et al.   NEUROBIOLOGY OF AGING

Improved predictive model for pre-symptomatic mild cognitive impairment and Alzheimer's disease

(2008) C. D. Smith et al.   NEUROLOGICAL RESEARCH

Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer disease

(2008) M. A. Yassa et al.   NEUROLOGY

Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease

(2008) L. Mosconi et al.   NEUROLOGY

Biochemical markers in persons with preclinical familial Alzheimer disease

(2008) J. M. Ringman et al.   NEUROLOGY

Aβ deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease

(2008) V.L. Villemagne et al.   NEUROPSYCHOLOGIA

Hypometabolism and Altered Cerebrospinal Fluid Markers in Normal Apolipoprotein E E4 Carriers with Subjective Memory Complaints

(2007) Lisa Mosconi et al.   BIOLOGICAL PSYCHIATRY

PET imaging of amyloid deposition in patients with mild cognitive impairment

(2007) Anton Forsberg et al.   NEUROBIOLOGY OF AGING