Article
Multidisciplinary Sciences
Paola S. Apaolaza, Diana Balcacean, Jose Zapardiel-Gonzalo, Grace Nelson, Nataliya Lenchik, Pouria Akhbari, Ivan Gerling, Sarah J. Richardson, Teresa Rodriguez-Calvo
Summary: The study reveals the presence of IFN response markers in the islets of T1D patients, which may lead to inflammation and impair beta cell function. Therapeutic interventions targeting the elimination of persistent infections and reduction of inflammation are crucial for individuals with T1D.
Article
Clinical Neurology
Lois Bolko, Wei Jiang, Nozomu Tawara, Oceane Landon-Cardinal, Celine Anquetil, Olivier Benveniste, Yves Allenbach
Summary: The classification of idiopathic inflammatory myopathies is based on clinical, serological, and histological criteria. The identification of myositis-specific antibodies has helped to define more homogeneous groups of myositis into four dominant subsets, each with distinct pathophysiological mechanisms. Additionally, interferon pathways have been identified as key players in the pathophysiology of myositis, with different types of interferons playing specific roles in each subset.
Article
Biochemistry & Molecular Biology
Julian Roos, Meike Dahlhaus, Jan-Bernd Funcke, Monika Kustermann, Gudrun Strauss, Daniel Halbgebauer, Elena Boldrin, Karlheinz Holzmann, Peter Moeller, Bernadette M. Trojanowski, Bernd Baumann, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky
Summary: The study revealed that miR-146a regulates adipose tissue inflammation by suppressing the NPR3 gene, thereby impacting the development of obesity and insulin resistance.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sowmya Gunasekaran, Ramakrishnapillai Vyomakesannair Omkumar
Summary: MicroRNAs, specifically miR-146a and miR-200b, play important physiological roles in neurological disorders such as Alzheimer's disease and schizophrenia. They are involved in regulating learning and memory mechanisms and interact with NMDAR subunits. Overexpression of these miRNAs leads to downregulation of related proteins, resulting in cognitive deficits. In rat models, upregulated levels of these miRNAs indicate their involvement in downregulating NMDAR subunits.
Article
Biochemistry & Molecular Biology
Sima Kazemi, Saeid Afshar, Fariba Keramat, Massoud Saidijam, Manoochehr Karami, Seyed Hamid Hashemi, Mohammad Yousef Alikhani
Summary: This study aimed to investigate the relationship between miR-146a gene polymorphism and gene expression and cytokine levels in patients with brucellosis. The results showed that TRAF-6 gene expression levels were significantly different in patients in the rs2910164 genotype, while no significant differences were observed in the rs57095329 genotype.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Fabiola Olivieri, Francesco Prattichizzo, Angelica Giuliani, Giulia Matacchione, Maria Rita Rippo, Jacopo Sabbatinelli, Massimiliano Bonafe
Summary: Inflammaging is a key concept in understanding how aging contributes to the development of age-related diseases, with a focus on the role of miRNAs in regulating inflammatory pathways. The assessment of individual genetic make-up alone is insufficient to depict the trajectories of age-related inflammation, and studies have shown that circulating inflammamiRs could be used to measure the degree of inflammaging.
AGEING RESEARCH REVIEWS
(2021)
Article
Hematology
Kentaro Mizuhara, Yuji Shimura, Taku Tsukamoto, Akinori Kanai, Saeko Kuwahara-Ota, Junko Yamaguchi, Ayako Muramatsu, Haruya Okamoto, Yoko Taminishi-Katsuragawa, Yuka Kawaji-Kanayama, Reiko Isa, Shinsuke Mizutani, Toshiya Inaba, Junya Kuroda
Summary: In multiple myeloma, the shift of the tumour immune microenvironment to a suppressive state promotes disease development and resistance to immunotherapy. This study demonstrates that miR-106a-5p and miR-146a-5p delivered by tumour-derived exosomes play essential roles in inducing monocyte-derived suppressor cells in multiple myeloma. These miRNAs collaborate with CCL5 and MIF to promote the induction of suppressor cells. This finding may contribute to the development of novel therapeutic approaches to improve the efficacy of immunotherapy.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Jakub Benko, Miroslava Sarlinova, Veronika Mikusova, Tomas Bolek, Martin Jozef Pec, Erika Halasova, Peter Galajda, Matej Samos, Marian Mokan
Summary: This study aimed to assess the utility of miR-126, miR-146a, and miR-375 as novel diagnostic markers for type 2 diabetes mellitus (T2D). The results showed a significant reduction of miR-126 and miR-146a in patients with T2D. MiR-126 was particularly promising as a diagnostic test with high sensitivity and specificity.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2023)
Article
Immunology
Bo Yang, Ruicheng Yang, Bojie Xu, Jiyang Fu, Xinyi Qu, Liang Li, Menghong Dai, Chen Tan, Huanchun Chen, Xiangru Wang
Summary: E. coli infection induced upregulation of miR-155 and miR-146a in astrocytes, which modulated bacteria-triggered neuroinflammatory responses through negative feedback regulation involving the TLR-mediated NF-kappa B and EGFR-NF-kappa B signaling pathways, thus protecting the central nervous system from further neuroinflammatory damage.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Sujung Jun Kim, Ashley E. Russell, Wei Wang, Darren E. Gemoets, Saumyendra N. Sarkar, James W. Simpkins, Candice M. Brown
Summary: AD and other neurodegenerative diseases are characterized by chronic neuroinflammation and reduced brain energy metabolism. miRNAs such as miR-146a are elevated in AD patients and play a role in immune activation and cellular energy metabolism. Extracellular vesicles (EVs) also play a role in AD progression by transferring active proteins and RNA between diseased and healthy cells.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Wei-Wei Chang, Li-Ying Wen, Liu Zhang, Xin Tong, Yue-Long Jin, Gui-Mei Chen
Summary: This study investigated the relationship between the miR-146a rs2910164 polymorphism and the genetic susceptibility of T2DM in the Chinese Han population and conducted a meta-analysis. The results showed that the miR-146a rs2910164 polymorphism was associated with the risk of T2DM in certain age and BMI subgroups, but no significant association was found in the overall meta-analysis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haocheng Qin, Cuicui Wang, Yonghua He, Aiwu Lu, Tiandao Li, Bo Zhang, Jie Shen
Summary: Osteoarthritis (OA) is a prevalent joint disease and a leading cause of disability, but its underlying pathogenesis is poorly understood. Inflammation is known to disturb joint homeostasis in OA, and microRNA-146a-5p (miR-146a-5p) has been identified as a key regulator of inflammation in this study. Increased expression of miR-146a-5p was found in human OA cartilage, and experimental results showed that miR-146a-5p can regulate inflammatory responses and catabolism in chondrocytes. Silencing miR-146a-5p alleviated cartilage destruction and reduced OA-induced pain in a mouse model.
Article
Cell Biology
Prasad Tongaonkar, Katie K. Trinh, Andre J. Ouellette, Michael E. Selsted
Summary: Theta- (theta-) defensins are host defense peptides with antimicrobial and immune-modulating activities. Rhesus theta-defensin-1 (RTD-1) inhibits proinflammatory gene expression and cytokine secretion by suppressing the NF-kappa B and MAP kinase pathways in immune-stimulated cells. RTD-1 also suppresses endotoxin tolerance and enhances TNF-alpha secretion and NF-kappa B activity upon secondary LPS stimulation by downregulating miR-146a expression and stabilizing IRAK1 protein. These findings reveal a novel role for RTD-1 in the innate immune response and its potential as an anti-inflammatory agent.
MEDIATORS OF INFLAMMATION
(2023)
Article
Endocrinology & Metabolism
Xinfeng Zhou, Yijian Zhang, Mingzhuang Hou, Hao Liu, Huilin Yang, Xi Chen, Tao Liu, Fan He, Xuesong Zhu
Summary: Melatonin enhances NRF2 protein levels by inhibiting miR-146a, improving early-stage osteoarthritis cartilage degradation, and holds therapeutic potential.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Oncology
Suzanne I. S. Mosely, John E. Prime, Richard C. A. Sainson, Jens-Oliver Koopmann, Dennis Y. Q. Wang, Danielle M. Greenawalt, Miika J. Ahdesmaki, Rebecca Leyland, Stefanie Mullins, Luciano Pacelli, Danielle Marcus, Judith Anderton, Amanda Watkins, Jane Coates Ulrichsen, Philip Brohawn, Brandon W. Higgs, Matthew McCourt, Hazel Jones, James A. Harper, Michelle Morrow, Viia Valge-Archer, Ross Stewart, Simon J. Dovedi, Robert W. Wilkinson
CANCER IMMUNOLOGY RESEARCH
(2017)
Article
Rheumatology
Xiang Guo, Brandon W. Higgs, Anne-Christine Bay-Jensen, Yuling Wu, Morten A. Karsdal, Michael Kuziora, Alex Godwood, David Close, Patricia C. Ryan, Lorin K. Roskos, Wendy I. White
Article
Oncology
Brandon W. Higgs, Christopher A. Morehouse, Katie Streicher, Philip Z. Brohawn, Fernanda Pilataxi, Ashok Gupta, Koustubh Ranade
CLINICAL CANCER RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Yanan Zheng, Rajesh Narwal, ChaoYu Jin, Paul G. Baverel, Xiaoping Jin, Ashok Gupta, Yong Ben, Bing Wang, Pralay Mukhopadhyay, Brandon W. Higgs, Lorin Roskos
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2018)
Article
Rheumatology
Katie Streicher, Sriram Sridhar, Mike Kuziora, Christopher A. Morehouse, Brandon W. Higgs, Yinong Sebastian, Christopher J. Groves, Fernanda Pilataxi, Philip Z. Brohawn, Ronald Herbst, Koustubh Ranade
ARTHRITIS & RHEUMATOLOGY
(2018)
Article
Dermatology
Paige W. Wolstencroft, Kerri E. Rieger, Hayley W. Leatham, David F. Fiorentino
JOURNAL OF CUTANEOUS PATHOLOGY
(2019)
Article
Cell Biology
Yonggang Zhou, Binqing Fu, Xiuxiu Xu, Jinghe Zhang, Xianhong Tong, Yanshi Wang, Zhongjun Dong, Xiaoren Zhang, Nan Shen, Yiwen Zhai, Xiangdong Kong, Rui Sun, Zhigang Tian, Haiming Wei
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Rheumatology
Jun Li, Huihua Ding, Yao Meng, Guanhua Li, Qiong Fu, Qiang Guo, Zhihua Yin, Zhizhong Ye, Haibo Zhou, Nan Shen
ARTHRITIS & RHEUMATOLOGY
(2020)
Biographical-Item
Rheumatology
Nan Shen, Peter E. Lipsky
Article
Rheumatology
Yan Ye, Xueliang Zhang, Teng Li, Jiaqiang Ma, Ran Wang, Chunmei Wu, Runci Wang, Chunde Bao, Shuang Ye, Nan Shen, Qiang Guo, Qiong Fu, Xiaoming Zhang
Summary: The aim of this study was to identify immunologic features and biomarkers predicting prognosis in patients with ADM-ILD. The results showed that patients with ADM-ILD can be stratified based on immune cell subsets, which can predict disease activity and clinical outcomes, and immunophenotype is an independent risk factor associated with prognosis.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Engineering, Biomedical
Jiali Zhang, Qianqian Guo, Dai Dai, Jian Yu, Liting Wang, Zhihua Wu, Huihua Ding, Nan Shen, Yourong Duan
Summary: Excessive CD4(+ )T helper (Th)-B-cell interactions and loss of Treg homeostasis are crucial to the pathogenesis of systemic lupus erythematosus (SLE). In this study, RAP-encapsulated ICOS/CD40L bispecific nanoparticles were designed to selectively target SLE Th cells and inhibit Th-B-cell reciprocal activation, with the sustained release of RAP further promoting the expansion of Treg cells and alleviating SLE progression without obvious toxicity.
Article
Immunology
Zhaorui Cheng, Guojun Hou, Nan Shen
Summary: Autoimmune diseases (ADs) are characterized by autoreactive immune cells and inflammation. Non-coding RNAs (ncRNAs) have been found to play a significant role in ADs and immune responses. Dysregulation of ncRNAs in immune cells disrupts immune homeostasis and is implicated in various ADs. ncRNAs could be potential biomarkers for AD diagnosis and therapeutic targets. This review focuses on recent studies on the involvement of ncRNAs in autoimmunity and ADs.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Danting Zhang, Fangfang Sun, Jie Chen, Huihua Ding, Xiaodong Wang, Nan Shen, Ting Li, Shuang Ye
Summary: Four trajectories of 24-hour urine protein in lupus nephritis were identified and user-friendly nomograms were developed to predict treatment response. These findings have important implications for guiding the management of lupus nephritis and designing clinical trials.
Article
Rheumatology
Huihua Ding, Cheng Lin, Jingyi Cai, Qiang Guo, Min Dai, Chandra Mohan, Nan Shen
ARTHRITIS RESEARCH & THERAPY
(2020)
Article
Oncology
Rajiv Raja, Michael Kuziora, Philip Z. Brohawn, Brandon W. Higgs, Ashok Gupta, Phillip A. Dennis, Koustubh Ranade
CLINICAL CANCER RESEARCH
(2018)