Article
Oncology
Jian Zhou, Xianxiu Ge, Xikang Fan, Jiayu Wang, Lin Miao, Dong Hang
Summary: Research from UK Biobank showed that higher concentrations of serum 25(OH)D are associated with decreased incidence and improved survival of colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Veronika Holubekova, Dusan Loderer, Marian Grendar, Peter Mikolajcik, Zuzana Kolkova, Eva Turyova, Eva Kudelova, Michal Kalman, Juraj Marcinek, Juraj Miklusica, Ludovit Laca, Zora Lasabova
Summary: This study focused on analyzing the expression profiles of inflammatory and immune-related genes in colorectal cancer (CRC) to identify aberrant signaling pathways associated with carcinogenesis and tumor metastasis. The findings contribute to a better understanding of the role of the immune system in the tumor microenvironment (TME) and may provide insights for personalized pharmacological treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Meizhi Du, Yu Wang, Jillian Vallis, Matin Shariati, Patrick S. Parfrey, John R. Mclaughlin, Peizhong Peter Wang, Yun Zhu
Summary: This study investigated the association between genetic variants of LEP and LEPR and colorectal cancer (CRC) survival. The results showed that variations in the LEP and LEPR genes were associated with disease-free survival and CRC-specific survival in patients with CRC. It was also found that the association between LEPR single-nucleotide polymorphisms and survival was modified by red meat intake and BMI status.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Cell Biology
Wei Feng, Yongxin Zhang, Wenwei Liu, Xiaofeng Wang, Tianxiang Lei, Yujie Yuan, Zehong Chen, Wu Song
Summary: By analyzing the gene data of colorectal cancer (CRC) patients, we constructed a prognosis model based on immune genes and studied the immune mechanisms and therapeutic sensitivity of CRC. This is of great significance for the diagnosis and treatment of CRC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Junyong Weng, Shanbao Li, Zhonglin Zhu, Qi Liu, Ruoxin Zhang, Yufei Yang, Xinxiang Li
Summary: Immunotherapy with immune checkpoint blockade has shown progress in the treatment of metastatic colorectal cancer (mCRC), although its effectiveness is limited. This review summarizes treatment strategies, discusses the mechanism and application of immune checkpoint blockade in mCRC treatment, and provides the latest research and clinical trial results.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Genetics & Heredity
Yucheng Qian, Jingsun Wei, Wei Lu, Fangfang Sun, Maxwell Hwang, Kai Jiang, Dongliang Fu, Xinyi Zhou, Xiangxing Kong, Yingshuang Zhu, Qian Xiao, Yeting Hu, Kefeng Ding
Summary: This study focused on immune-related genes (IRGs) to establish a prognostic model for colorectal cancer patients, providing recommendations for clinical treatment. The 18-IRG signature was identified as an independent prognostic factor for overall survival in CRC patients, reflecting the state of tumor immune microenvironment (TIME) to a certain extent.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Enkui Zhang, Xueliang Zhou, Xiaodong Fan, Shuchun Li, Chengsheng Ding, Hiju Hong, Batuer Aikemu, Guang Yang, Galiya Yesseyeva, Xiao Yang, Junjun Ma, Minhua Zheng
Summary: In this study, we identified three key genes (MPC1, COQ2, and ADAMTS13) relevant to colorectal cancer metabolism. These genes were able to stratify the cohort into three patterns with distinct prognoses and were associated with different molecular pathways and immune infiltration. The findings suggest that these genes could serve as effective prognostic biomarkers and highlight the link between lactate metabolism and the immune microenvironment in colorectal cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Wenqiang Li, Tong Liu, Liang Qian, Yiming Wang, Xiangming Ma, Liying Cao, Qingsong Zhang, Jun Qu
Summary: This study found that the association between abdominal obesity and colorectal cancer risk may be mediated by factors such as insulin resistance and inflammation. General and abdominal obesity were associated with an increased risk of colorectal cancer in males, while only abdominal obesity was associated with an increased risk in females. Additionally, the mediation effects of fasting triglyceride-glucose index and C-reactive protein were observed for the association between abdominal obesity and colorectal cancer risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Tianxiang Lei, Yongxin Zhang, Xiaofeng Wang, Wenwei Liu, Wei Feng, Wu Song
Summary: This study constructed a diagnostic model for CRC involving 6 exosomal genes, validated internally and externally, and identified 10 key hub genes through protein-protein interaction and competing endogenous RNA network analysis.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Lipeng Niu, Ce Gao, Yang Li
Summary: By analyzing the gene expression profiles of colorectal cancer patients with liver metastasis, this study identified ITIH2 as a potential core gene for colon cancer liver metastasis, while highlighting COL1A2 as a key gene in colorectal carcinoma.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Wenjing Lv, Junqi Jiang, Yi Xu, Zhiyuan Chen, Zixuan Wang, Ang Xing, Xueping Zheng, Tingting Qu, Qi Wan
Summary: By using a comprehensive analysis approach, including DEG analysis, WGCNA, and pathway analysis, the genetic transcription profile of brain ischemic and reperfusion injury was studied. It was found that there were 58 upregulated DEGs and some validated core genes associated with stroke in mouse and rat models. Factors such as ischemic treatment and reperfusion time were important confounding factors in gene profile changes. Additionally, modules related to reperfusion time, inflammation, and thrombo-inflammation were identified, and core hub genes within these modules were identified as well. Overall, these findings expand our understanding of the genetic profile involved in brain ischemia and reperfusion, emphasizing the crucial role of inflammatory disequilibrium.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Sanaz Keshavarz Shahbaz, Khadijeh Koushki, Seyed Hassan Ayati, Abigail R. Bland, Evgeny E. Bersonov, Amirhossein Sahebkar
Summary: Inflammasomes play contradictory roles in inflammation-induced cancer development, as they can both promote carcinogenesis and exhibit anticancer effects through triggering pyroptosis and immunoregulatory functions.
Article
Oncology
Md. Ariful Islam, Md. Bayazid Hossen, Md. Abu Horaira, Md. Alim Hossen, Md. Kaderi Kibria, Md. Selim Reza, Khanis Farhana Tuly, Md. Omar Faruqe, Firoz Kabir, Rashidul Alam Mahumud, Md. Nurul Haque Mollah
Summary: This study identified core genes related to colorectal cancer (CRC) and investigated their functions, pathways, and regulatory factors. The prognostic power of these genes was assessed in different stages of CRC, and candidate drugs were suggested for CRC treatment. The findings of this study provide valuable resources for early diagnosis, prognosis, and therapies of CRC.
Article
Chemistry, Multidisciplinary
Alessia Vignoli, Elena Mori, Samantha Di Donato, Luca Malorni, Chiara Biagioni, Matteo Benelli, Vanessa Calamai, Stefano Cantafio, Annamaria Parnofiello, Maddalena Baraghini, Alessia Garzi, Francesca Del Monte, Dario Romagnoli, Ilenia Migliaccio, Claudio Luchinat, Leonardo Tenori, Laura Biganzoli
Summary: The study investigated the changes in preoperative and postoperative serum metabolomic fingerprints of CRC patients and found that some metabolic changes may be associated with cancer relapse. Certain metabolites such as pyruvate and HDL-related parameters appear to play important roles in discriminating between preoperative and postoperative serum samples of CRC patients.
APPLIED SCIENCES-BASEL
(2021)
Article
Urology & Nephrology
Temitope Rude, Odinachi Moghalu, John Stoffel, Sara Lenherr, Jeremy B. Myers, Sean Elliott, Blayne Welk, Jennifer S. Herrick, Angela P. Presson, David A. Ginsberg
Summary: The study found an association between insurance coverage and the type of bladder management following spinal cord injury, with publicly insured patients more likely to use indwelling catheters. However, insurance status did not impact bladder symptoms or quality of life when controlling for bladder management.
JOURNAL OF UROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander R. Zheutlin, Catherine G. Derington, Jordan B. King, Ransmond O. Berchie, Jennifer S. Herrick, Dave L. Dixon, Jordana B. Cohen, Daichi Shimbo, Ian M. Kronish, Joseph J. Saseen, Paul Muntner, Andrew E. Moran, Adam P. Bress
Summary: Combination antihypertensive therapy is underused, especially in certain race/ethnic groups, in the treatment of hypertension in the United States. Factors associated with monotherapy use despite uncontrolled blood pressure include higher systolic blood pressure, younger age, recent healthcare visits, higher body mass index, and the presence of heart failure.
AMERICAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Zachary A. Marcum, Jordana B. Cohen, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress
Summary: The use of antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors is associated with a lower risk of dementia. This study examines the impact of exclusively stimulating vs inhibiting antihypertensive medication regimens on mild cognitive impairment (MCI) or dementia. The findings suggest that prevalent users of stimulating medications had lower rates of cognitive impairment.
Article
Cardiac & Cardiovascular Systems
Aubrey E. Jones, Madeleine M. McCarty, Juan P. Brito, Peter A. Noseworthy, Kerri L. Cavanaugh, Kenzie A. Cameron, Geoffrey D. Barnes, Benjamin A. Steinberg, Daniel M. Witt, George H. Crossley, Rod Passman, Preeti Kansal, Ian Hargraves, Monika Schmidt, Elizabeth Jackson, Adriana Guzman, Anthony Ariotti, Mandy L. Pershing, Jennifer Herrick, Victor M. Montori, Angela Fagerlin, Elissa M. Ozanne
Summary: This study aims to compare the effectiveness of patient decision aid (PDA) and encounter decision aid (EDA) in shared decision making. The study will recruit atrial fibrillation (AF) patients and their managing clinicians for stroke prevention strategies in a randomized controlled trial. The results will contribute to improving AF outcomes and patient experiences with stroke prevention strategies.
AMERICAN HEART JOURNAL
(2022)
Article
Clinical Neurology
Sudipto Dolui, John A. Detre, Sarah A. Gaussoin, Jennifer S. Herrick, Danny J. J. Wang, Manjula Kurella Tamura, Monique E. Cho, William E. Haley, Lenore J. Launer, Henry A. Punzi, Anjay Rastogi, Carolyn H. Still, Daniel E. Weiner, Jackson T. Wright, Jeff D. Williamson, Clinton B. Wright, R. Nick Bryan, Adam P. Bress, Nicholas M. Pajewski, Ilya M. Nasrallah
Summary: Intensive antihypertensive treatment is associated with increased cerebral perfusion, particularly in patients with a history of cardiovascular disease.
Review
Medicine, General & Internal
Chase Paulson, Samuel C. Thomas, Orlando Gonzalez, Samuel Taylor, Cole Swiston, Jennifer S. Herrick, Lori McCoy, Karen Curtin, Craig J. Chaya, Brian C. Stagg, Barbara M. Wirostko
Summary: This study is the largest epidemiological study of exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in the Baja Verapaz region of Guatemala among individuals seeking eye exams and interventions. The study found a high prevalence of XFS/XFG, particularly among individuals in rural areas and those who speak the Mayan language.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jordana B. Cohen, Zachary A. Marcum, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Daniel Scharfstein, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress
Summary: This observational cohort study aimed to evaluate the cognitive outcomes of individuals at risk for mild cognitive impairment and probable dementia after initiating an ARB- vs ACEI-based antihypertensive regimen. The study found no significant difference in the rate of amnestic MCI or PD among new users of ARB compared with ACEI.
Article
Cardiac & Cardiovascular Systems
Alexander R. Zheutlin, Catherine G. Derington, Jennifer S. Herrick, Robert S. Rosenson, Bharat Poudel, Monika M. Safford, Todd M. Brown, Elizabeth A. Jackson, Mark Woodward, Stephanie Reading, Kate Orroth, Jason Exter, Salim S. Virani, Paul Muntner, Adam P. Bress
Summary: This study investigated lipid-lowering therapy (LLT) among US veterans after myocardial infarction or elective coronary revascularization. The results showed that less than half of the patients received LLT intensification within one year, indicating a missed opportunity to reduce cardiovascular disease risk.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Peripheral Vascular Disease
Catherine G. Derington, Adam P. Bress, Andrew E. Moran, William S. Weintraub, Jennifer S. Herrick, William C. Cushman, Ian M. Kronish, Barry Stults, Daichi Shimbo, Paul Muntner, Tom Greene, Jeffrey T. Bates, Tara I. Chang, Lois Anne Katz, Shakaib U. Rehman, Christianne L. Roumie, Leonardo Tamariz, Jordan B. King
Summary: In the SPRINT study, the use of ACE inhibitors or ARBs, thiazide diuretics, and calcium channel blockers in combination is favored to target systolic blood pressure (SBP) < 120 mm Hg, instead of using ACE/ARB monotherapy to target SBP < 140 mm Hg.
Article
Peripheral Vascular Disease
Jordan B. King, Catherine G. Derington, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Molly B. Conroy, William C. Cushman, Adam P. Bress
Summary: This study aimed to assess the availability of commercially available single-pill combination (SPC) antihypertensive products for achieving an intensive systolic blood pressure goal of <120 mm Hg. The results showed that most participants in the intensive treatment arm were using antihypertensive regimens that are not available as class-equivalent SPC products. Therefore, improvements in the product landscape are needed to achieve the desired results in real-world settings and reduce medication burden.
Article
Peripheral Vascular Disease
Byron C. Jaeger, Ligong Chen, Kathryn Foti, Shakia T. Hardy, Adam P. Bress, Sean P. Kane, Lei Huang, Jennifer S. Herrick, Catherine G. Derington, Bharat Poudel, Ashley Christenson, Lisandro D. Colantonio, Paul Muntner
Summary: A web-based application was developed to provide hypertension statistics for US adults using data from the US National Health and Nutrition Examination Survey. The study found that the mean systolic blood pressure decreased from 123 mm Hg in 1999-2000 to 120 mm Hg in 2009-2010 and then increased to 123 mm Hg in 2017-2020. The age-adjusted prevalence of hypertension was 47.9% in 1999-2000, 43.0% in 2009-2010, and 44.7% in 2017-2020. The study also estimated that 115.3 million US adults had hypertension in 2017-2020.
Article
Cardiac & Cardiovascular Systems
Catherine G. G. Derington, Adam P. P. Bress, Jennifer S. S. Herrick, Joshua A. A. Jacobs, Alexander R. R. Zheutlin, Ransmond O. O. Berchie, Molly B. B. Conroy, William C. C. Cushman, Jordan B. B. King
Summary: It is found that only one-third of hypertensive patients in the US market can be satisfied with the currently available fixed-dose combination antihypertensive products, indicating the need for further improvement in the pharmaceutical product landscape.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Peripheral Vascular Disease
Alexander R. Zheutlin, Daniel K. Addo, Joshua A. Jacobs, Catherine G. Derington, Jennifer S. Herrick, Tom Greene, Eric L. Stulberg, Dan R. Berlowitz, Jeff D. Williamson, Nicholas M. Pajewski, Mark A. Supiano, Adam P. Bress
Summary: Despite evidence supporting the benefits of intensive blood pressure management, older adults have the lowest rates of blood pressure control. The association between age and therapeutic inertia was determined in the SPRINT study, with older age found to be associated with greater therapeutic inertia independent of physical or cognitive function. This suggests age bias in hypertension management.
Article
Cardiac & Cardiovascular Systems
Jordan B. King, Ransmond O. Berchie, Catherine G. Derington, Zachary A. Marcum, Daniel O. Scharfstein, Tom H. Greene, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Adam P. Bress, Jordana B. Cohen
Summary: This study compared the effects of new users of ARBs versus ACEIs on cardiovascular disease events and death. The results showed similar rates of cardiovascular disease events between the two groups, with lower death rates associated with ARBs. There were subgroup differences in the effects of ARBs versus ACEIs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Catherine G. Derington, Adam P. Bress, Jennifer S. Herrick, Wenjun Fan, Nathan D. Wong, Katherine E. Andrade, Jonathan Johnson, Sephy Philip, David Abrahamson, Lixia Jiao, Deepak L. Bhatt, William S. Weintraub
Summary: Treating all eligible adults with icosapent ethyl as part of the REDUCE-IT trial can prevent a substantial number of ASCVD events, although there are significant medication costs involved. The indirect cost savings from event prevention may outweigh the incurred direct costs.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)