Article
Immunology
Josephine Diony Nanda, Chiau-Jing Jung, Rahmat Dani Satria, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Tzong-Shiann Ho, Chiou-Feng Lin
Summary: This study developed a multiplex panel of cytokine/chemokine assays to monitor dengue cytokine release syndrome (CRS). The results showed significant alterations in cytokine levels between patients with mild dengue fever and severe dengue diseases, with IL-8 and IL-18 levels markedly increased in severe cases. Additionally, IL-18 was found to be elevated in severe dengue with comorbidities compared to severe dengue without comorbidities and mild dengue, which has not been previously reported.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ariadna Montero-Blay, Javier Delgado Blanco, Irene Rodriguez-Arce, Claire Lastrucci, Carlos Pinero-Lambea, Maria Lluch-Senar, Luis Serrano
Summary: Researchers have developed a non-pathogenic bacterium, Mycoplasma pneumoniae (MPN), for the treatment of lung diseases. By designing a single-chain interleukin-10 (SC-IL10), they were able to significantly increase the expression level of IL-10 in the MPN bacteria, resulting in a powerful anti-inflammatory effect on lung infections.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Article
Infectious Diseases
Cynthia Bernal, Sara A. Ping, Alejandra Rojas, Oliver Caballero, Victoria Stittleburg, Yvalena de Guillen, Patricia Langjahr, Benjamin A. Pinsky, Marta J. Von-Horoch, Patricia Luraschi, Sandra M. Cabral, Maria Cecilia Sanchez, Aurelia M. Torres, Fatima Cardozo, Jesse J. M. Waggoner
Summary: This study analyzed the associations between disease severity and demographic factors, clinical laboratory data, lipopolysaccharide binding protein, and chymase in the Paraguayan population. The study found that patient age, male gender, presence of comorbid illnesses, low platelet count, low lymphocyte percentage, and elevated chymase level were associated with severe disease.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Adriana Hernandez-Pliego, Dayana Nicte Vergara-Ortega, Antonia Herrera-Ortiz, Cairo Toledano-Jaimes, Fernando R. Esquivel-Guadarrama, Miguel Angel Sanchez-Aleman
Summary: There is limited knowledge about the immune response against syphilis, particularly in people living with HIV (PLWH). This systematic review summarizes the available data on immune response against infection and suggests a potential role for CD4(+)T cells, such as Th17 and T rex cells, in worsening the progression of the disease in PLWH through the cytokines IL-10 and IL-17.
Article
Infectious Diseases
Chansuda Bongsebandhu-phubhakdi, Vichit Supornsilchai, Suphab Aroonparkmongkol, Umaporn Limothai, Sasipha Tachaboon, Janejira Dinhuzen, Watchadaporn Chaisuriyong, Supachoke Trongkamolchai, Mananya Wanpaisitkul, Chatchai Chulapornsiri, Anongrat Tiawilai, Thawat Tiawilai, Terapong Tantawichien, Usa Thisyakorn, Nattachai Srisawat
Summary: This prospective study aimed to investigate the pattern of cortisol response after dengue infection and evaluate the possibility of using serum cortisol as a biomarker to predict the severity of dengue infection. The study found that serum cortisol levels were highest on the day of admission and day 3, and a serum cortisol level above 18.2 mcg/dL could predict severe dengue infection. Combining serum cortisol with persistent vomiting and day of fever increased the accuracy of predicting dengue severity.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Sumatha Channapatna Suresh, Rajeev Hanumanthaiha, Chethana Ramakrishna, Ramishetty Sandeep, Padmini Saligrama Narasimhasetty, Vedavathy Ramakrihna, K. P. Balraj, Bharath Raju
Summary: Currently, there is no method to predict the course of dengue illness, but serum ferritin levels on day 1 and day 4 of admission can predict the severity of the disease. Serum ferritin is an inexpensive and easily accessible biomarker that can assist in monitoring and prognosticating dengue-positive patients.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Pediatrics
Dhirendra Singh, Veena Raghunathan, Maninder Dhaliwal, Neha Rastogi, Ritu Chadha, Satya Prakash Yadav
Summary: Children with dengue-induced HLH have high levels of IL2R, serving as a useful diagnostic marker. Early recognition of dengue HLH and prompt treatment can lead to improved outcomes for patients.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Migle Palivonaite, Greta Gedvilaite, Brigita Glebauskiene, Loresa Kriauciuniene, Vita Rovite, Rasa Liutkeviciene
Summary: The aim of this study was to determine the association between gene IL-10 polymorphisms and serum IL-10 levels in patients with pituitary adenoma. The results indicated that IL-10 rs1800871 and IL-10 rs1800872 may be associated with the development of inactive pituitary adenoma. However, no statistically significant association was found between IL-10 polymorphisms and invasiveness or recurrence of pituitary adenoma.
Article
Multidisciplinary Sciences
Camila Mareti Bonin-Jacob, Larissa Zatorre Almeida-Lugo, Marco Antonio Moreira Puga, Ana Paula Machado, Cacilda Tezelli Junqueira Padovani, Mariana Calarge Noceti, Alda Maria Teixeira Ferreira, Carlos Eurico dos Santos Fernandes, Julio Cesar Possati Resende, Adriane Cristina Bovo, Ines Aparecida Tozetti
Summary: Persistent infection by high-risk human papillomavirus (HR-HPV) is the main cause of cervical cancer, with IL-6 and IL-10 levels potentially affecting the persistence of infection and multiple HPV infections being associated with higher IL-6 levels.
Article
Oncology
Wei Shen, Luyan Bian, Ying Ma, Xiuyan Yin
Summary: Serum IL-6 shows great potential as an important marker for disease progression in interstitial nephritis, and it is correlated with other indicators such as serum creatinine and erythrocyte sedimentation rate.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Immunology
Qianting Yang, Yanling Wen, Furong Qi, Xiang Gao, Weixin Chen, Gang Xu, Cailing Wei, Haiyan Wang, Xian Tang, Jingyan Lin, Juanjuan Zhao, Mingxia Zhang, Shuye Zhang, Zheng Zhang
Summary: In patients with severe COVID-19, there is an increase in HLA-DRlow/- monocytes and a decrease in MAIT cells, along with impaired functional response. The unique pattern of immune dysregulation in severe COVID-19 is characterized by enrichment of suppressive HLA-DRlow/- monocytes associated with functional impairment of MAIT cells through the IFN/IL-10 pathway.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Ye Miao, Zhen-xing Zhang, Xu Feng, Wei-ming Sun
Summary: The study revealed that serum IL-33 levels upon admission were significantly associated with the prognosis of patients with ICH, with higher IL-33 levels correlating with better outcomes. Further studies on the underlying mechanisms are needed to confirm this relationship.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Immunology
Elisa Toppi, Laura Sireno, Micaela Lembo, Nerisa Banaj, Beatrice Messina, Sedigheh Golesorkhtafti, Gianfranco Spalletta, Paola Bossu
Summary: Homotaurine is a potential therapeutic compound for Alzheimer's disease (AD) and has anti-inflammatory properties. This study suggests that supplementation of homotaurine in patients with mild cognitive impairment (MCI) increases the levels of anti-inflammatory cytokines IL-10 and IL-33, while decreasing the levels of pro-inflammatory cytokine IL-18. The elevation of IL-10 and IL-33 is associated with improved episodic memory in treated patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Mahima T. Rasquinha, Meghna Sur, Ninaad Lasrado, Jay Reddy
Summary: The discovery of IL-10 over 30 years ago marked the beginning of our understanding of how cytokines regulate immune responses. IL-10 has anti-inflammatory action by suppressing APCs, which indirectly inhibits Th1 cells. Regulatory T cells also play a role in IL-10-mediated suppression.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Infectious Diseases
Kah Wai Looi, Yukari Matsui, Mari Kono, Chandramathi Samudi, Nozomi Kojima, Jin Xu Ong, Chin Aun Tan, Chong Siang Ang, Peter Hao Yuan Tan, Hemalatha Shamnugam, Shamala Devi Sekaran, Sharifah Faridah Syed Omar, Lucy Chai See Lum
Summary: This study evaluated the trend of Immature Platelet Fraction (IPF) as an early recovery indicator of platelets in dengue patients with thrombocytopenia, and its relationship with severe dengue in conjunction with reticulocyte count. The results showed that IPF% increased significantly in severe dengue patients on days 3-5 after the onset of fever, and reticulocyte count also increased significantly on day 5. IPF can be utilized as an early recovery indicator of platelets in patients with dengue and thrombocytopenia.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Allergy
Ioana Agache, Cezmi Akdis, Mubeccel Akdis, Knut Brockow, Tomas Chivato, Stefano del Giacco, Thomas Eiwegger, Kilian Eyerich, Ana Gimenez-Arnau, Jan Gutermuth, Emma Guttman-Yassky, Marcus Maurer, Graham Ogg, Peck Y. Ong, Liam O'Mahony, Juergen Schwarze, Amena Warner, Thomas Werfel, Oscar Palomares, Marek Jutel
Summary: Chronic spontaneous urticaria (CSU) poses a significant burden on patients, families and healthcare systems, but a stratified approach to management supported by better understanding of mechanisms allows for targeted treatment with omalizumab.
Article
Immunology
Deshni Jayathilaka, Chandima Jeewandara, Laksiri Gomes, Tibutius Thanesh Pramanayagam Jayadas, Achala Kamaladasa, Gayasha Somathilake, Dinuka Guruge, Pradeep Darshana Pushpakumara, Thushali Ranasinghe, Inoka Sepali Aberathna, Saubhagya Danasekara, Buddini Gunathilaka, Heshan Kuruppu, Ananda Wijewickrama, Ruwan Wijayamuni, Lisa Schimanski, T. K. Tan, Graham S. Ogg, Alain Townsend, Gathsaurie Neelika Malavige
Summary: The study investigated the antibody responses to SARS-CoV-2 in Sri Lankan individuals following natural infection and vaccination with AZD1222. The findings showed that vaccinated individuals had lower IgA antibody levels to SARS-CoV-2 proteins compared to those with natural infection, indicating a need to reduce the gap between vaccine doses in countries experiencing VOC outbreaks.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Laksiri Gomes, Chandima Jeewandara, Tibutius Pramanayagam Jayadas, Osanda Dissanayake, Michael Harvie, Dinuka Guruge, Vigeetha Withanage, Pasyodun Koralage Buddhika Mahesh, Wajira Rajapakse, Rajanthi Ramachandran, Venoden Dharmarajan, Indika Pathiraja, Anusha Sanjeewani, Priyantha Bandara, Geetha Nanayakkara, Vaithehi Rajeevan Francis, Ananda Kithsiri, Dilini Anushika Edirisinghe, Kaushalya De Silva, Ruwan Wijayamuni, Graham S. Ogg, Jesse Waggoner, Gathsaurie Neelika Malavige
Summary: The study in Sri Lanka utilized a multiplex real-time PCR assay to detect different SARS-CoV-2 variants, with the delta variant being the most prevalent. This method appears to be a fast and cost-effective alternative to genomic sequencing for tracking variant spread in lower income countries.
JOURNAL OF VIROLOGICAL METHODS
(2022)
Article
Multidisciplinary Sciences
Chandima Jeewandara, Suranga Fernando, Pradeep Darshana Pushpakumara, Shyrar Tanussiya Ramu, Achala Kamaladasa, Banuri Gunasekara, Inoka Sepali Aberathna, Heshan Kuruppu, Thushali Ranasinghe, Shashika Dayarathne, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jewantha Jayamali, Ayesha Wijesinghe, Madushika Dissanayake, Gayasha Somathilake, Michael Harvie, Saubhagya Danasekara, Deshni Jayathilaka, Helanka Dinesh Kumara Wijayatilake, Nihal Weerasooriya, Chinthaka Kekulandara, Lisa Schimanski, Pramila Rijal, Tiong K. Tan, Tao Dong, Alain Townsend, Graham S. Ogg, Gathsaurie Neelika Malavige
Summary: The immunogenicity of Gam-COVID-Vac as a single dose vaccine was investigated, with 88.7% of individuals seroconverting. Seroconversion rates were significantly lower in individuals over 60 years and lower than with AZD1222. 82.6% of individuals developed ACE2 receptor blocking antibodies, but at significantly lower levels compared to natural infection and a single dose of AZD1222. Antibody titres against different variants were similar to AZD1222, except for B.1.351 which had significantly higher levels. Some individuals developed immune cell responses. Administration of a second dose of the vaccine is likely to be beneficial.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Tehani Silva, Laksiri Gomes, Chandima Jeewandara, Graham S. Ogg, Gathsaurie Neelika Malavige
Summary: This study found that the NS1 protein of the dengue virus can induce the production of PLA2 enzymes, leading to the release of prostaglandins and inflammatory cytokines, which may contribute to the pathogenesis of dengue.
ANTIVIRAL RESEARCH
(2022)
Article
Infectious Diseases
Chandima Jeewandara, Dinuka Guruge, Pradeep Darshana Pushpakumara, Deshan Madhusanka, Tibutius Thanesh Jayadas, Indika Prasad Chaturanga, Inoka Sepali Aberathna, Saubhagya Danasekara, Thilagaraj Pathmanathan, Deshni Jayathilaka, Gayasha Somathilaka, Heshan Kuruppu, Laksiri Gomes, Vitjith Gunasekara, Ruwan Wijayamuni, Graham S. Ogg, Gathsaurie Neelika Malavige
Summary: In a community setting in Sri Lanka, both rapid antigen tests showed high sensitivity in detecting individuals with lower Ct values. However, further research on the relationship to infectivity is important.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Gathsaurie Neelika Malavige, Chandima Jeewandara, Ananda Wijewickrama, Dumni Gunasinghe, Sameera Mahapatuna, Chathurika Gangani, Vimalahan Vimalachandran, Geethal S. Jayarathna, Yashoda Perera, Chandanie Wanigatunga, Harsha Dissanayake, Shamini Prathapan, Eranga Narangoda, Damayanthi Idampitiya, Laksiri Gomes, Samurdhi Wickramanayake, Pramodth Sahabandu, Graham Ogg
Summary: Rupatadine has shown potential in reducing the incidence of dengue haemorrhagic fever (DHF), improving platelet counts, and alleviating symptoms such as vomiting, headache, and hepatic tenderness in patients with acute dengue. However, it does not significantly affect the hospital admission rate or the duration of illness. The efficacy of Rupatadine in combination with other treatment modalities should be further explored.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Chandima Jeewandara, Inoka Sepali Aberathna, Laksiri Gomes, Pradeep Darshana Pushpakumara, Saubhagya Danasekara, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Anushika Mudunkotuwa, Michael Harvie, Thashmi Nimasha, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K. Tan, Tao Dong, Alain Townsend, Graham S. Ogg, Gathsaurie Neelika Malavige
Summary: This study compared the antibody and T cell responses of two cohorts with different dosing gaps of the AZD1222 vaccine. The results showed that there was no difference in antibody titers or positivity rates in different age groups, but cohort 2 with a longer dosing gap had significantly higher levels of ACE2-blocking antibodies and antibodies to the RBD of the VOCs compared to cohort 1.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Immunology
Chandima Jeewandara, Inoka Sepali Aberathna, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Dinuka Guruge, Ayesha Wijesinghe, Banuri Gunasekera, Shyrar Tanussiya Ramu, Heshan Kuruppu, Thushali Ranasinghe, Shashika Dayarathna, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Madushika Dissanayake, Tibutius Thanesh Jayadas, Anushika Mudunkotuwa, Gayasha Somathilake, Michael Harvie, Thashmi Nimasha, Saubhagya Danasekara, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K. Tan, Tao Dong, Alain Townsend, Graham S. Ogg, Gathsaurie Neelika Malavige
Summary: This study investigated the immune responses in a cohort of Sri Lankan individuals following Sinopharm/BBIBP-CorV vaccination. The results showed a decline in antibody levels in all age groups, especially in those aged 60 and above. However, T cell responses remained persistent. Long-term efficacy studies are needed to assess the impact of waning immunity on hospitalization and severe disease.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Immunology
Chandima Jeewandara, Inoka Sepali Aberathna, Saubhagya Danasekara, Laksiri Gomes, Suranga Fernando, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Jeewantha Jayamali, Deshni Jayathilaka, Helanka Dinesh Kumara Wijayatilake, Pradeep Darshana Pushpakumara, Michael Harvie, Thashmi Nimasha, Shiromi Devika Grace de Silva, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Jack Tan, Alain Townsend, Graham S. Ogg, Gathsaurie Neelika Malavige
Summary: In order to determine the immune response to different vaccines against SARS-CoV-2, researchers compared antibody responses in individuals who had received different vaccines in Sri Lanka. The results showed that the Moderna vaccine elicited the highest levels of ACE2 blocking antibodies, while the Sinopharm vaccine had the lowest levels. Further studies are needed to understand the impact on clinical outcomes.
Article
Immunology
Chandima Jeewandara, Inoka Sepali Aberathna, Pradeep Darshana Pushpakumara, Achala Kamaladasa, Dinuka Guruge, Ayesha Wijesinghe, Banuri Gunasekera, Shyrar Tanussiya, Heshan Kuruppu, Thushali Ranasinghe, Shashika Dayarathne, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Madushika Dissanayake, Deshan Madusanka, Tibutius Thanesh Jayadas, Anushika Mudunkotuwa, Gayasha Somathilake, Michael Harvie, Thashmi Nimasha, Saubhagya Danasekara, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K. Tan, Tao Dong, Alain Townsend, Graham S. Ogg, Gathsaurie Neelika Malavige
Summary: The immunogenicity of the Sinopharm/BBIBP-CorV vaccine in individuals in Sri Lanka was investigated, showing a 95% seroconversion rate, lower in individuals over 60 years compared to those aged 20-39. The vaccine induced ACE2 receptor blocking antibodies in 81.25% of individuals at 6 weeks, with significantly lower levels of antibodies to the RBD of the wild-type and alpha variants, but similar levels for beta and delta as compared to convalescent sera.
Article
Public, Environmental & Occupational Health
Diyanath Ranasinghe, Deshni Jayathilaka, Chandima Jeewandara, Dumni Gunasinghe, Dinuka Ariyaratne, Tibutius Thanesh Pramanayagam Jayadas, Heshan Kuruppu, Ayesha Wijesinghe, Fathima Farha Bary, Deshan Madhusanka, Pradeep Darshana Pushpakumara, Dinuka Guruge, Ruwan Wijayamuni, Graham S. Ogg, Gathsaurie Neelika Malavige
Summary: The SARS-CoV-2 outbreak in Sri Lanka was primarily caused by the AY.28 and AY.104 sub-lineages, which exhibited differences in mutations and disease severity. AY.28 and AY.104 showed a fitness advantage over the B.1.617.2 variant and AY.28 had higher expression of sg-RNA. Further investigation is needed to understand the clinical implications of these findings.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Shyrar Tanussiya Ramu, Madushika Dissanayake, Chandima Jeewandara, Farha Bary, Michael Harvie, Laksiri Gomes, Ayesha Wijesinghe, Dinuka Ariyaratne, Graham S. Ogg, Gathsaurie Neelika Malavige
Summary: To understand the role of NS1-specific antibodies in disease pathogenesis, the levels of neutralizing antibodies, NS1-antibodies, IgG antibody subclasses, and NS1-specific memory B-cell responses were compared in individuals with different severities of dengue. The results showed that individuals with past severe dengue had higher levels of neutralizing antibodies and NS1-antibodies, as well as stronger antibody responses to DENV1, 2, and 4. The study also found that individuals with past dengue had broadly cross-reactive B-cell responses to multiple DENV serotypes. These findings are important for further understanding the functionality of NS1-specific antibodies and the antibody repertoire associated with protection against severe disease.
Meeting Abstract
Immunology
J. M. K. Chandima Jeewandara, Inoka Sepali Aberathna, Saubhagya Danasekara, Laksiri Gomes, Suranga Fernando, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Jeewantha Jayamali, Deshni Jayathilaka, Helanka Dinesh Kumara Wijayatilake, Pradeep Darshana Pushpakumara, Michael Harvie, Thashmi Nimasha, Shiromi Devika Grace De Silva, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Jack Tan, Alain Townsend, Graham S. Ogg, Gathsaurie Neelika Malavige
JOURNAL OF IMMUNOLOGY
(2022)
Review
Cell Biology
Gathsaurie Neelika Malavige, Chandima Jeewandara, Graham S. Ogg
Summary: There are similarities between dengue and COVID-19 infections in terms of clinical presentations and immunopathogenesis, including shared symptoms and common risk factors for severe illness. Studying the similarities between these two infections is crucial for the development of more effective therapeutic interventions.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
