Article
Clinical Neurology
Bastian Tugemann, Joseph R. Berger
Summary: The study reevaluated algorithms for stratifying PML risk in natalizumab-treated multiple sclerosis patients and identified issues, including the separate assessment of PML incidence in the U.S. and Europe and the potential higher risk in JCV antibody-negative patients. The study also suggested introducing a low-risk JCV index threshold for individuals with prior immunosuppressant exposure and adjusting the low-risk threshold based on pretherapy history. Additionally, the study observed a plateau and decrease in PML risk after approximately 5 years of natalizumab treatment.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Clinical Neurology
Kevin Bigaut, Laurent Kremer, Thibaut Fabacher, Guido Ahle, Mathilde Goudot, Marie Fleury, Claude Gaultier, Sylvie Courtois, Nicolas Collongues, Jerome de Seze
Summary: This study compared the effectiveness of ocrelizumab and fingolimod after natalizumab cessation. The results showed that ocrelizumab had a significantly lower relapse rate at 1 year compared to fingolimod.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Tobias Monschein, Sarinah Dekany, Tobias Zrzavy, Markus Ponleitner, Patrick Altmann, Gabriel Bsteh, Barbara Kornek, Paulus Rommer, Christian Enzinger, Franziska Di Pauli, Jorg Kraus, Thomas Berger, Fritz Leutmezer, Michael Guger
Summary: With data from the Austrian Multiple Sclerosis Therapy Registry, the effectiveness and safety of natalizumab in multiple sclerosis patients were assessed for up to 14 years. The results showed that natalizumab was effective in treating relapsing-remitting multiple sclerosis and had a favorable safety profile during long-term use.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Markus Kinner, Christian Prehn, Ruth Schneider, Christoph Schroeder, Eva Kolb, Ralf Gold, Robert Hoepner, Andew Chan
Summary: This study evaluated the neuropsychological disease course of NTZ-PML patients and found that working memory and visuospatial abilities are core deficits. NTZ-PML patients performed worse in neuropsychological examinations compared to controls, especially affecting visuospatial ability and working memory during different disease stages.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
S. Grahl, M. Bussas, B. Wiestler, P. Eichinger, C. Gaser, J. Kirschke, C. Zimmer, A. Berthele, B. Hemmer, M. Muehlau
Summary: This study compared the effects of Fingolimod and Natalizumab in treating relapsing-remitting multiple sclerosis, finding that Fingolimod treatment led to more new white matter lesions but lower overall brain atrophy. The results support the notion that Fingolimod has stronger neuroprotective properties compared to Natalizumab.
Article
Clinical Neurology
Cavit Boz, Serkan Ozakbas, Murat Terzi, Rana Karabudak, Serhan Sevim, Recai Turkoglu, Aysun Soysal, Belgin Petek Balci, Husnu Efendi, Omer Faruk Turan, Nur Yuceyar, Mehmet Fatih Yetkin, Serap Zengin Karahan, Meltem Demirkiran, Sibel Guler, Kadriye Agan, Nefati Kiylioglu, Cavid Baba, Asli Tuncer, Mesrure Koseoglu
Summary: This study compared the efficacy of three drugs (fingolimod, natalizumab, and ocrelizumab) in reducing disease activity in RRMS. The results showed that natalizumab and ocrelizumab had similar effects on relapse control, and both were better than fingolimod. The three therapies had similar effects on disability outcomes.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Jose M. Serra Lopez-Matencio, Yaiza Perez Garcia, Virginia Meca-Lallana, Raquel Juarez-Sanchez, Angeles Ursa, Lorena Vega-Piris, Dora Pascual-Salcedo, Annick de Vries, Theo Rispens, Cecilia Munoz-Calleja
Summary: The main variables influencing the pharmacology of natalizumab are body mass index and dosing interval. The concentrations of natalizumab and/or RO vary widely among patients, emphasizing the importance of routinely measuring them for personalized treatment and avoiding over or underdosing.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
M. Gaughan, M. Gilligan, I. Patterson, I. McGurgan, S. M. Yap, N. Tubridy, C. McGuigan
Summary: This study evaluated the evolution of the JCV index over time in individuals with multiple sclerosis treated with natalizumab. The findings showed that individuals who were seronegative at baseline had a long duration of treatment before seroconversion, while those with positive JCV antibody index at treatment initiation experienced an increase in antibody index over time.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
M. C. Kowarik, D. Astling, G. Lepennetier, A. Ritchie, B. Hemmer, G. P. Owens, Jeffrey L. Bennett
Summary: Natalizumab and fingolimod have differential effects on B cell populations in multiple sclerosis, with fingolimod treatment contracting peripheral blood B cells while natalizumab treatment expands them. The clonal overlap between CSF and PB B cells is reduced with natalizumab but remains stable with fingolimod therapy. These findings suggest that the two therapies have distinct impacts on the exchange and clonal expansion of B cells in MS patients.
Article
Clinical Neurology
Fabien Rollot, Justine Couturier, Romain Casey, Sandrine Wiertlewski, Marc Debouverie, Jean Pelletier, Jerome De Seze, Pierre Labauge, Aurelie Ruet, Eric Thouvenot, Jonathan Ciron, Eric Berger, Olivier Gout, Pierre Clavelou, Bruno Stankoff, Olivier Casez, Bertrand Bourre, Helene Zephir, Thibault Moreau, Christine Lebrun-Frenay, Elisabeth Maillart, Gilles Edan, Jean-Philippe Neau, Alexis Montcuquet, Philippe Cabre, Jean-Philippe Camdessanche, Gilles Defer, Haifa Ben Nasr, Aude Maurousset, Karolina Hankiewicz, Corinne Pottier, Emmanuelle Leray, Sandra Vukusic, David-Axel Laplaud
Summary: This study compared the effectiveness of NTZ and anti-CD20 as a switch for FNG in highly active RRMS patients in France. The results showed no difference between the two treatments regarding the first occurrence of relapse, EDSS worsening, and MRI activity. However, there was a higher risk of treatment discontinuation with NTZ compared to anti-CD20.
Article
Clinical Neurology
Darius Hausler, Katja Akgun, Lidia Stork, Hans Lassmann, Tjalf Ziemssen, Wolfgang Bruck, Imke Metz
Summary: Natalizumab is an effective drug for treating multiple sclerosis, but there are still inflammatory infiltrates and immune cell accumulation in the central nervous system during treatment; although the number of some immune cells increases, there is no significant correlation with clinical disability, and the pathogenic mechanism and clinical significance of these immune cells remain unclear.
Article
Neurosciences
Helmut Butzkueven, Paul S. Giacomini, Stanley Cohan, Tjalf Ziemssen, Daniel Sienkiewicz, Ying Zhang, Yvonne Geissbuehler, Diego Silva, Davorka Tomic, Harald Kropshofer, Maria Trojano
Summary: The TRANSITION study evaluated the safety and effectiveness of fingolimod as a treatment for multiple sclerosis patients who switched from natalizumab. The results showed that fingolimod was safe and effective in this patient population.
Article
Medical Laboratory Technology
Lesley J. Page, Jacqueline Lagunas-Acosta, Raphaela Heussen, Edward T. Castellana, Bradley T. Messmer
Summary: A novel assay was developed to quantify unexchanged and exchanged natalizumab variants in clinical samples. This assay will enable investigations into the clinical significance of the relationship between PK/PD and the monovalent-to-bivalent ratio, as it relates to the efficacy of the drug and risk of PML.
THERAPEUTIC DRUG MONITORING
(2023)
Article
Clinical Neurology
Xue Gong, Rong Luo, Jie Liu, Kundian Guo, Aiqing Li, Xu Liu, Yue Liu, Dong Zhou, Zhen Hong
Summary: This study compared the effectiveness and safety of different treatment strategies as initial therapy for anti-NMDAR encephalitis. The results showed that combined treatment with IVIg and IVMP had a higher response rate, improved Rankin Scale scores, and lower recurrence rate compared to either IVIg or IVMP monotherapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Ryutaro Nakamura, Akihiro Kitamura, Takahito Tsukamoto, Ryota Tamura, Nobuhiro Ogawa, Isamu Yamakawa, Hyoh Kim, Michihiro Kawai, Mitsuru Sanada, Makoto Urushitani
Summary: A 65-year-old man with PML after remission from acute myeloid leukemia experienced left hemiparesis episodes, responding well to steroid pulse therapy which suggests exacerbations are excessive immune responses to the JC virus, not IRIS. Neuroimaging cannot differentiate between excessive and controlled inflammation, cautioning against steroid use in the latter.
Article
Infectious Diseases
H. L. Aung, M. Bloch, T. Vincent, D. Quan, A. Jayewardene, Z. Liu, T. M. Gates, B. Brew, L. Mao, L. A. Cysique
Summary: The study investigated premature cognitive ageing among people living with HIV (PLHIV) and found a medium-sized premature ageing effect on cognition in a community sample with optimal HIV care. The results support routine screening of cognitive and mental health among PLHIV aged >= 50 years.
Article
Clinical Neurology
Christopher Blair, Leon Edwards, Cecilia Cappelen-Smith, Dennis Cordato, Andrew Cheung, Jason Wenderoth, Alex McQuinn, Nathan W. Manning
Summary: The study showed that patients who achieved reperfusion with a single pass during endovascular thrombectomy had better outcomes at 90 days compared to those who required multiple passes. Bridging intravenous thrombolysis did not provide additional benefit in first-pass patients but reduced the risk of disability and mortality in multiple-pass patients.
CEREBROVASCULAR DISEASES
(2021)
Meeting Abstract
Clinical Neurology
Amrou Sarraj, Marc Ribo, Jordi Blasco, Natalia Perez de la Ossa, Michael Chen, Ameer E. Hassan, Teddy Y. Wu, Dennis Cordato, Timothy J. Kleinig, Joanna D. Schaafsma, Spiros Blackburn, Michael G. Abraham, Daniel Gibson, Adam Wallace, Deep Pujara, Faris Shaker, Javier Moreno Negrete, James Beharry, Cecilia Cappelen-Smith, Luis Rodriguez-Esparragoza, Marta Olive Gadea, Manuel Requena, Vitor Pereira, Arthur L. Day, Clark Sitton, Sheryl B. Martin-schild, Sarah Song, Peter J. Mitchell, Mark Parsons, James C. Grotta, Greg Albers
Article
Clinical Neurology
Leah N. Kim, Dennis Cordato, Alan McDougall, Clare Fraser
Summary: The pilot study found that the Queen Square Screening Test for Visual Deficits may have limited applicability in individuals with dementia, and the test score is correlated with cognitive impairment.
NEURO-OPHTHALMOLOGY
(2021)
Editorial Material
Clinical Neurology
Bruce J. Brew
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Amrou Sarraj, Gregory W. Albers, Jordi Blasco, Juan F. Arenillas, Marc Ribo, Ameer E. Hassan, Natalia Perez de la Ossa, Teddy Yuan-Hao Wu, Pere Cardona Portela, Michael G. Abraham, Michael Chen, Laith Maali, Timothy J. Kleinig, Dennis Cordato, Adam Nathan Wallace, Joanna D. Schaafsma, Navdeep Sangha, Daniel P. Gibson, Spiros L. Blackburn, Mercedes De Lera Alfonso, Deep Pujara, Faris Shaker, Margy E. McCullough-Hicks, Javier Luis Moreno Negrete, Arturo Renu, James Beharry, Cecilia Cappelen-Smith, Luis Rodriguez-Esparragoza, Marta Olive-Gadea, Manuel Requena, Tareq Almaghrabi, Vitor Mendes Pereira, Clark Sitton, Sheryl Martin-Schild, Sarah Song, Henry Ma, Leonid Churilov, Peter J. Mitchell, Mark W. Parsons, Anthony Furlan, James C. Grotta, Geoffrey A. Donnan, Stephen M. Davis, Bruce C. V. Campbell
Summary: In patients with large vessel occlusion (LVO) and mild neurological deficits, stratified by perfusion imaging mismatch, endovascular thrombectomy (EVT) did not show improved clinical outcomes compared to medical management (MM). However, EVT was associated with increased functional independence in patients with target mismatch profile.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Dennis Cordato, Christopher Blair, Peter Thomas, Angela Firtko, Megan Miller, Leon Stephen Edwards, James Thomas, Anna H. Balabanski, Angela Dos Santos, Longting Lin, Suzanne Hodgkinson, Cecilia Cappelen-Smith, Roy G. Beran, Alan McDougall, Mark Parsons
Summary: This study compared the rates of cerebrovascular disease and stroke risk factors between Australian-born and overseas-born individuals in South Western Sydney. The results showed higher rates of cerebrovascular disease and risk factors in specific CALD communities, highlighting the need for culturally specific interventions to address health disparities in this population.
CEREBROVASCULAR DISEASES
(2022)
Article
Immunology
Xiaoying Yu, Judith D. D. Lobo, Erin Sundermann, Darren J. J. Baker, Russell P. P. Tracy, George A. A. Kuchel, Kathryn E. E. Stephenson, Scott L. L. Letendre, Bruce Brew, Lucette A. A. Cysique, Sannisha K. K. Dale, Chelsie Wallen, Ken M. M. Kunisaki, Giovanni Guaraldi, Jovana Milic, Alan Winston, David J. J. Moore, Joseph B. B. Margolick, Kristine M. M. Erlandson
Summary: This article summarizes the key oral presentations from the 12th Annual International Workshop on HIV and Aging, providing insights into the challenges and opportunities of HIV and aging research under the COVID-19 pandemic. The workshop enriched our understanding of HIV and aging, identified the impact of COVID-19 on HIV communities, and offered future research directions.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2023)
Review
Clinical Neurology
Monokesh K. K. Sen, Md Jakir Hossain, David A. A. Mahns, Bruce J. Brew
Summary: Multiple sclerosis (MS) is a complex and unpredictable neuroinflammatory disease. Identifying a reliable biomarker to predict disease progression and guide treatment decisions is imperative. Recent studies have suggested that the protein serum neurofilament light chain (sNfL) could be an ideal prognostic biomarker for MS. However, unresolved factors currently prevent its routine clinical use. This review critiques these findings and highlights areas for further research to facilitate the use of sNfL as a prognostic biomarker in MS management.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Leon Stephen Edwards, Cecilia Cappelen-Smith, Dennis Cordato, Andrew Bivard, Leonid Churilov, Longting Lin, Chushuang Chen, Carlos Garcia-Esperon, Kenneth Butcher, Tim Kleinig, Phillip M. C. Choi, Xin Cheng, Qiang Dong, Richard I. Aviv, Mark William Parsons, INSPIRE Study Grp
Summary: CT perfusion (CTP) plays a promising role in diagnosing posterior circulation infarction (POCI). The optimal thresholds for defining ischemic penumbra and infarct core in POCI are DT >1s and MTT >145%, and DT >1.5s, respectively.
FRONTIERS IN NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Bruce Brew, Steven G. Faux, Elizabeth Blanchard
Summary: This study aims to assess the accuracy of a novel smartwatch algorithm for fall detection and identifies factors influencing its effectiveness. The results show that the sensitivity of the smartwatch app for falls is 77% with an accuracy of 89%. Falls are more likely to be detected if they occur on the same side as the wrist with the smartwatch, but the influence of smartwatch brands and operating systems on sensitivity did not reach statistical significance.
JMIR FORMATIVE RESEARCH
(2022)
Article
Clinical Neurology
James Orton Thomas, Angelos Sharobeam, Abhay Venkat, Christopher Blair, Nese Ozalp, Zeljka Calic, Peter Wyllie, Paul M. Middleton, Miriam Welgampola, Dennis Cordato, Cecilia Cappelen-Smith
Summary: The study evaluated the use of video Head Impulse Test (v-HIT) combined with Head Impulse, Nystagmus, and Test of Skew (HINTs) as a reliable tool to differentiate between vestibular neuritis (VN) and posterior circulation stroke (PCS) in acute vestibular syndrome (AVS) cases in the emergency department (ED).
BMJ NEUROLOGY OPEN
(2022)
Letter
Respiratory System
David Ross Darley, Gregory John Dore, Anthony Luke Byrne, Marshall Lawrence Plit, Bruce James Brew, Anthony Kelleher, Gail Veronica Matthews
Meeting Abstract
Clinical Neurology
B. Parameshwaran, D. J. Cordato, M. Parsons, A. Cheung, N. Manning, J. Wenderoth, C. Cappelen-Smith
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Health Policy & Services
Josephine S. F. Chow, Andrew Hopkins, Hany Dimitri, Hui Tie, Rachael Williams, Rohan Rajaratnam, Sumana Gopinath, Suzana Lazarovska, Stanica Andrijevic, Upul Premawardhana, Veronica E. Gonzalez-Arce, Alan McDougall
Summary: This study compared conventional ward telemetry (WT) to a wearable ECG monitor (S-Patch) for detecting atrial fibrillation (AF) in stroke patients, finding that the S-Patch was preferred by patients and nursing staff and had a higher accuracy in detecting AF, despite a high false positive rate.
JOURNAL OF INTEGRATED CARE
(2021)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
