Article
Hematology
Sarah Weber, Aaron Magh, Michael Hogardt, Volkhard A. J. Kempf, Maria J. G. T. Vehreschild, Hubert Serve, Sebastian Scheich, Bjorn Steffen
Summary: The study found that polymicrobial and sequential bloodstream infections were associated with a worse 30-day overall survival in hematological and oncological patients. Different bacterial groups were classified into three outcome clusters – favorable, intermediate, and adverse. The presence of polymicrobial BSI and assignment into specific outcome clusters were identified as independent risk factors for 30-day mortality.
ANNALS OF HEMATOLOGY
(2021)
Article
Pediatrics
Jose Antonio Villegas Rubio, Pilar Palomo Moraleda, Ana De Lucio Delgado, Gonzalo Solis Sanchez, Belen Prieto Garcia, Corsino Rey Galan
Summary: The usefulness of CRP, PCT, and IL6 as biomarkers in predicting high-risk episodes in pediatric cancer patients with fever was evaluated. The results showed that IL6-1, PCT-2, and CRP-2vs1 had a strong and independent correlation with high-risk episodes.
Article
Virology
PengFei Cheng, Hao Wu, JunZhe Yang, XiaoYang Song, MengDa Xu, BiXi Li, JunJun Zhang, MingZhe Qin, Cheng Zhou, Xiang Zhou
Summary: The study found that for patients with severe novel coronavirus pneumonia, the APACHE II score can effectively predict disease severity and mortality risk, while the MuLBSTA score is a good predictor only in terms of mortality risk.
Review
Dentistry, Oral Surgery & Medicine
Fred K. L. Spijkervet, Jennifer M. Schuurhuis, Monique A. Stokman, Max J. H. Witjes, Arjan Vissink
Summary: Pretreatment dental screening aims to locate and eliminate oral foci of infection in order to prevent complications during and after oncologic treatment. The effects of chemotherapy on healthy oral tissues are temporary and reversible, while patients undergoing head and neck radiotherapy bear a lifelong risk of oral sequelae. Removal of acute foci of infection is necessary before or early during oncologic treatment, while chronic foci of infection can be treated during a remission phase.
Article
Infectious Diseases
Marios Karvouniaris, Garyphallia Poulakou, Konstantinos Tsiakos, Maria Chatzimichail, Panagiotis Papamichalis, Anna Katsiaflaka, Katerina Oikonomou, Antonios Katsioulis, Eleni Palli, Apostolos Komnos
Summary: Intensive care unit patients may be infected by difficult-to-treat-resistant Gram-negative microorganisms. Colistin, as a last resort antibiotic, may not improve survival after the emergence of colistin-resistant isolates. The severity of infection is the independent predictor of mortality.
Article
Microbiology
Burcu Isler, David L. Paterson, Patrick N. A. Harris, Weiping Ling, Felicity Edwards, Claire M. Rickard, Timothy J. Kidd, Ian Gassiep, Kevin B. Laupland
Summary: This study investigated the incidence, risk factors, and outcomes of Achromobacter species bloodstream infection in an Australian population. The results showed that patients with chronic lung disease were at highest risk of infection. Community-onset cases were more common, and a significant proportion of cases occurred in patients without significant underlying chronic co-morbidities.
Article
Oncology
Julia Pohl, Raluca-Ileana Mincu, Simone M. Mrotzek, Reza Wakili, Amir A. Mahabadi, Sophia K. Potthoff, Jens T. Siveke, Ulrich Keller, Ulf Landmesser, Tienush Rassaf, Markus S. Anker, Matthias Totzeck
Summary: This study evaluated a new electrocardiographic (ECG) score in therapy-naive cancer patients to predict cardiotoxicity, showing that an ECG score of >= 2 points was associated with a higher risk of developing cardiotoxicity. High-risk patients did not differ in age, LV ejection fraction, cardiovascular risk factors, or cardiac biomarkers compared to those with a low-risk ECG score.
Article
Microbiology
Sara M. Karaba, Katherine E. Goodman, Joe Amoah, Sara E. Cosgrove, Pranita D. Tamma
Summary: A risk score was developed to predict hematologic malignancy patients at increased risk for Stenotrophomonas maltophilia bloodstream infections, with the knowledge-driven risk score outperforming the automatically selected variable risk score. Further validation with a larger cohort is needed before broad clinical application.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Environmental Sciences
Ghada N. El-Sarnagawy, Amira A. Abdelnoor, Arwa A. Abuelfadl, Inas H. El-Mehallawi
Summary: This study compared the efficacy of APACHE II, MEWS, and PSS scores in predicting ICU admission and mortality of acute pesticide-poisoned patients. The results showed that PSS had the best discriminatory power in predicting ICU admission and mortality. APACHE II and MEWS scores had similar performance in predicting ICU admission, and PSS and APACHE II scores had similar performance in predicting mortality of ALP-poisoned patients. The study concluded that these scores are good discriminators for outcome prediction of acute pesticide poisoning on admission.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Oncology
Senmin Chen, Sixi Liu, Xiuli Yuan, Huihui Wang, Feiqiu Wen
Summary: The study investigated the clinical significance of CRP, PCT, albumin, fibrinogen, and D-dimer as potential biomarkers for classifying BSIs in pediatric hematology-oncology patients, revealing that PCT levels were significantly lower in neutropenic and Gram-positive BSI episodes. PCT may potentially serve as a biomarker for differentiating between Gram-positive and Gram-negative BSIs in pediatric hematology-oncology patients.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2021)
Article
Oncology
Daniel N. Willis, Mary Claire McGlynn, Patrick J. Reich, Robert J. Hayashi
Summary: This study evaluated the risk of bloodstream infections (BSI) and death in pediatric oncology patients, finding that BSI is a significant cause of mortality in this population. Younger age, specific diagnoses, ethnicity, and history of hematopoietic stem cell transplant (HSCT) were identified as risk factors for BSI. The mortality rate for patients with BSI was 6.5%. Patients with febrile neutropenia had a lower mortality rate compared to those without. These findings highlight the importance of BSI prevention to reduce the risk of death in pediatric oncology patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Critical Care Medicine
Spyridon Fortis, Amy M. J. O'Shea, Brice F. Beck, Rajeshwari Nair, Michihiko Goto, Gregory A. Schmidt, Peter J. Kaboli, Eli N. Perencevich, Heather Schacht Reisinger, Mary Vaughan Sarrazin
Summary: The study aimed to develop a simplified critical illness severity scoring system with high prediction accuracy for 30-day mortality using commonly available variables. The newly created system showed excellent performance in predicting 30-day mortality internally and required easily extracted commonly used variables from electronic health records.
JOURNAL OF CRITICAL CARE
(2021)
Article
Clinical Neurology
Sara Lener, Christoph Wipplinger, Anna Lang, Sebastian Hartmann, Anto Abramovic, Claudius Thome
Summary: This study aimed to establish an assessment score to predict mortality in spinal infection and facilitate decision-making. Through a retrospective analysis of 252 patients, eight parameters associated with mortality were identified and included in the novel assessment score. The results suggest that patients with an MSI-20 score of 11 or higher may not be suitable for surgery, while early surgery can be considered for patients with an MSI-20 score of 10 or lower. These findings need to be confirmed in prospective studies.
Article
Pediatrics
Ashraf Kharrat, Faith Zhu, Michelle Baczynski, Xiang Y. Y. Ye, Dany Weisz, Amish Jain
Summary: This study aimed to establish an outcome-based definition for organ dysfunction (ODF) in preterm infants and evaluate factors associated with mortality. Significant metabolic acidosis, use of vasopressors/inotropes, and hypoxic respiratory failure can identify high-risk infants.
PEDIATRIC RESEARCH
(2023)
Article
Infectious Diseases
Kevin B. Laupland, David L. Paterson, Adam G. Stewart, Felicity Edwards, Patrick N. A. Harris
Summary: This study describes the epidemiology and outcome of Sphingomonas species bloodstream infections (BSI) in an Australian population. The findings suggest that this infection primarily occurs in the community and is associated with a significant risk of death.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)