Article
Immunology
Eishika Dissanayake, Rebecca A. A. Brockman-Schneider, Reed M. M. Stubbendieck, Britney A. A. Helling, Zhumin Zhang, Yury A. A. Bochkov, Charmaine Kirkham, Timothy F. F. Murphy, Carole Ober, Cameron R. R. Currie, James E. E. Gern
Summary: Rhinovirus infection promotes the adhesion and survival of Moraxella catarrhalis on the respiratory epithelium, potentially leading to more severe illness. Rhinovirus-A and rhinovirus-C, but not rhinovirus-B, increased cell-associated M. catarrhalis. This co-infection could promote epithelial damage and leukocyte inflammatory responses at the epithelial surface.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Medea Padra, John Benktander, Janos T. Padra, Anders Andersson, Bettina Brundin, Sara Tengvall, Karin Christenson, Ingemar Qvarfordt, Robert Gad, Magnus Paulsson, Nikolaos Pournaras, Anders Linden, Sara K. Linden
Summary: Inflammation-induced Neu5Ac is associated with the adhesion of Moraxella catarrhalis to airway mucins in smokers with and without COPD, suggesting a key role of inflammation in pathogen binding. The binding of Moraxella catarrhalis correlated with inflammatory parameters and Neu5Ac content, indicating a potential host defense mechanism. This study highlights the importance of Neu5Ac in modulating interactions between mucins and pathogens, particularly in the context of COPD.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Immunology
Alex Kayongo, Nicole M. Robertson, Trishul Siddharthan, Moses Levi Ntayi, Josephine Caren Ndawula, Obondo J. Sande, Bernard S. Bagaya, Bruce Kirenga, Harriet Mayanja-Kizza, Moses L. Joloba, Sofia K. Forslund
Summary: Chronic Obstructive Pulmonary Disease (COPD) is a major contributor to global mortality, with three million deaths reported annually. The impact is expected to increase, with approximately five million people predicted to die from COPD-related causes each year in the next 40 years. The immune mechanisms driving disease progression, as well as the relationship between airway microbiome changes and immune activation, remain unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Respiratory System
Lucio Malvisi, Laura Taddei, Aparna Yarraguntla, Tom M. A. Wilkinson, Ashwani Kumar Arora
Summary: The study found that the presence of Hi or Mcat at a stable timepoint was associated with a higher risk of subsequent Hi- or Mcat-related exacerbation. However, not all exacerbations associated with Hi or Mcat could be detected at an earlier timepoint, suggesting interventions to reduce exacerbations should not solely rely on bacterial presence at baseline.
RESPIRATORY RESEARCH
(2021)
Article
Microbiology
Xinzhu Yi, Yanjun Li, Haiyue Liu, Xiaomin Liu, Junhao Yang, Jingyuan Gao, Yuqiong Yang, Zhenyu Liang, Fengyan Wang, Dandan Chen, Lingwei Wang, Weijuan Shi, David C. L. Lam, Martin R. Stampfli, Paul W. Jones, Rongchang Chen, Zhang Wang
Summary: The airway resistome in COPD patients is associated with the inflammatory endotype, and there are distinct resistome profiles based on neutrophilic or eosinophilic inflammation. Different bacterial species, host pathways, and inflammatory markers are associated with these resistome profiles.
MICROBIOLOGY SPECTRUM
(2022)
Article
Respiratory System
Yoshihiko Raita, Marcos Perez-Losada, Robert J. Freishtat, Andrea Hahn, Eduardo Castro-Nallar, Ignacio Ramos-Tapia, Nathaniel Stearrett, Yury A. Bochkov, James E. Gern, Jonathan M. Mansbach, Zhaozhong Zhu, Carlos A. Camargo, Kohei Hasegawa
Summary: Through transcriptome and clustering analysis, we identified biologically distinct metatranscriptome profiles with differential risks of asthma in infant bronchiolitis.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Medicine, General & Internal
Klara Szalontai, Nikolett Gemes, Jozsef Furak, Tunde Varga, Patricia Neuperger, Jozsef A. Balog, Laszlo G. Puskas, Gabor J. Szebeni
Summary: COPD is a frequently fatal pathology of the respiratory tract, often caused by chronic inflammatory response to irritants such as tobacco smoke. Early diagnosis, smoking cessation, and global abandonment of biomass fuels are crucial in alleviating the major health problems associated with COPD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Malgorzata Proboszcz, Krzysztof Goryca, Patrycja Nejman-Gryz, Tadeusz Przybylowski, Katarzyna Gorska, Rafal Krenke, Magdalena Paplinska-Goryca
Summary: The study investigated distinct disease profiles based on clinical, cellular, and molecular data from patients with mild-to-moderate obstructive pulmonary diseases. Five key variables were identified to differentiate between asthma and COPD, and cluster analysis revealed two main clusters within the combined samples of asthma and COPD patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Infectious Diseases
Lucio Malvisi, Aparna Yarraguntla, Marie-Cecile Mortier, Karen Osman, David W. Cleary, Beatrice Sente, Thierry G. Pascal, Vincent Weynants, Stuart C. Clarke, Laura Taddei, Tom M. A. Wilkinson, Jeanne-Marie Devaster, Nathalie Devos
Summary: This study observed bacterial infections in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and found that non-typeable Haemophilus influenzae and Moraxella catarrhalis infections are associated with AECOPD, but may have different mechanisms in triggering exacerbations.
INFECTIOUS DISEASES
(2022)
Article
Microbiology
Sonia Schoonbroodt, Jean-Laurent Ichante, Sophie Boffe, Nathalie Devos, Jeanne-Marie Devaster, Laura Taddei, Simona Rondini, Ashwani Kumar Arora, Thierry Pascal, Ludovic Malvaux
Summary: Comparison of real-time PCR with culture-based methods for identifying bacteria in sputum samples from COPD patients showed that real-time PCR has higher sensitivity and specificity compared to culture-based methods. Real-time PCR on frozen samples can be used for the identification of common respiratory bacterial species in patients with COPD.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kyle Stearns, Monica Goldklang, Rui Xiao, Tina Zelonina, Keith Blomenkamp, Jeffery Teckman, Jeanine M. D'Armiento
Summary: Research findings suggest that although ASO treatment reduces AAT levels, it does not significantly worsen lung injury. This could be due to off-target effects or compensatory mechanisms. Compared to liver injury, AAT ASO treatment may have no negative impact on the lungs.
Article
Biochemistry & Molecular Biology
Jessica Anastacia Silva Barbosa, Luana Laura Sales da Silva, Juliana Morelli Lopes Goncalves Joao, Elaine Cristina de Campos, Silvia Fukuzaki, Leandro do Nascimento Camargo, Tabata Maruyama dos Santos, Henrique Tibucheski dos Santos, Suellen Karoline Moreira Bezerra, Beatriz Mangueira Saraiva-Romanholo, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Camila Ramalho Bonturi, Maria Luiza Vilela Oliva, Edna Aparecida Leick, Renato Fraga Righetti, Iolanda de Fatima Lopes Calvo Tiberio
Summary: The synthesized peptide (pep3-EcTI) derived from Enterolobium contortisiliquum exhibits potent anti-inflammatory and antioxidant effects, and shows potential as a treatment for experimental asthma-COPD overlap (ACO).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Lei Han, Yuning Huang, Qiang Fu, Yishu Xue, Fengming Ding, Min Zhang
Summary: Pseudomonas aeruginosa infection contributes to the progression of COPD, as an early Th1-related inflammation gradually shifts to a later Th2-related inflammation, and small-airway function decline occurs earlier than that of large-airway function.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Critical Care Medicine
Imran Sulaiman, Benjamin G. Wu, Matthew Chung, Bradley Isaacs, Jun-Chieh J. Tsay, Meredith Holub, Clea R. Barnett, Benjamin Kwok, Matthias C. Kugler, Jake G. Natalini, Shivani Singh, Yonghua Li, Rosemary Schluger, Joseph Carpenito, Destiny Collazo, Luisanny Perez, Yaa Kyeremateng, Miao Chang, Christina D. Campbell, Philip M. Hansbro, Beno W. Oppenheimer, Kenneth I. Berger, Roberta M. Goldring, Sergei B. Koralov, Michael D. Weiden, Rui Xiao, Jeanine D'Armiento, Jose C. Clemente, Elodie Ghedin, Leopoldo N. Segal
Summary: This study investigated whether there is lower airway dysbiosis in mild-to-moderate COPD patients and its possible contributions to COPD pathogenesis. The results showed that the lower airways of COPD patients were enriched with common oral commensals. Additionally, in a preclinical mouse model exposed to cigarette smoke, lower airway dysbiosis with common oral commensals augmented the inflammatory injury, showing similar gene expression characteristics to COPD patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Medicine, Research & Experimental
Peter J. Barnes, Jonathan Baker, Louise E. Donnelly
Summary: Autophagy is a cellular process that removes damaged molecules and organelles, and abnormalities in autophagy may contribute to the pathogenesis of chronic diseases like asthma and COPD. Autophagy can be either increased or decreased depending on the cell type and environment, making it challenging to target therapeutically. Some existing drugs can activate or inhibit autophagy, but more selective drugs are being developed.
Article
Immunology
Mary C. Gallo, Charmaine Kirkham, Samantha Eng, Remon S. Bebawee, Yong Kong, Melinda M. Pettigrew, Herve Tettelin, Timothy F. Murphy
INFECTION AND IMMUNITY
(2018)
Article
Multidisciplinary Sciences
Melinda M. Pettigrew, Christian P. Ahearn, Janneane F. Gent, Yong Kong, Mary C. Gallo, James B. Munro, Adonis D'Mello, Sanjay Sethi, Herve Tettelin, Timothy F. Murphy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Microbiology
David M. Jacobs, Heather M. Ochs-Balcom, Jiwei Zhao, Timothy F. Murphy, Sanjay Sethi
JOURNAL OF CLINICAL MICROBIOLOGY
(2018)
Article
Infectious Diseases
Fredrik Resman, Guillaume Manat, Victor Lindh, Timothy F. Murphy, Kristian Riesbeck
BMC INFECTIOUS DISEASES
(2018)
Article
Immunology
Timothy F. Murphy, Aimee L. Brauer, Melinda M. Pettigrew, Eric R. LaFontaine, Herve Tettelin
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Immunology
Yu-Ching Su, Emma Mattsson, Birendra Singh, Farshid Jalalvand, Timothy F. Murphy, Kristian Riesbeck
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Chemistry, Medicinal
Livia Shehaj, Santosh K. Choudary, Kamlesh M. Makwana, Mary C. Gallo, Timothy F. Murphy, Joshua A. Kritzer
ACS INFECTIOUS DISEASES
(2019)
Article
Microbiology
Timothy F. Murphy, Charmaine Kirkham, Adonis D'Mello, Sanjay Sethi, Melinda M. Pettigrew, Herve Tettelin
Summary: Chronic obstructive pulmonary disease (COPD) is a common and debilitating disorder that is the third leading cause of death worldwide. This study analyzed the persistence of nontypeable Haemophilus influenzae (NTHi) in COPD airways and found that the NTHi genome undergoes inversion during persistence, resulting in changes in expression of key virulence factors. It was also discovered that the adhesins HMW1 and HMW2 play a critical role in NTHi adherence and invasion of respiratory epithelial cells. These findings provide important insights into the mechanisms of NTHi persistence in COPD airways and may inform the development of novel interventions.
Article
Medicine, Research & Experimental
E. Bengert, L. Towle-Miller, J. Boccardo, G. Mercene, P. J. Ohtake, P. Balkundi, P. L. Elkin, J. Balthasar, T. F. Murphy, K. Noyes
Summary: This study proposes a practical method to track institutional changes in research teamwork and productivity using commonly available electronic databases. The study shows that the extent of interdisciplinary collaboration varies significantly depending on academic unit, faculty appointment, and seniority. Interdisciplinary grants constitute a significant proportion of all grants and have been on the rise in recent years. Departments with more interdisciplinary grants receive more research funding. Further research is needed to improve the efficiency of interdisciplinary collaborations.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Timothy F. Murphy, Rita Hubbard Robinson, Kelly M. Wofford, Alan J. Lesse, Susan Grinslade, Henry L. Taylor, Kinzer M. Pointer, George F. Nicholas, Heather Orom
Summary: The African American population in Buffalo, New York faces significant health disparities due to social determinants of health. A community-university partnership organized the annual Igniting Hope conference series to address these disparities. The series has become the premier conference on health disparities in the region, attracting community members, leaders, university faculty, and trainees. It has led to initiatives such as a new state law, mitigation of COVID-19 fatalities, and the establishment of a university-supported institute.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Microbiology
John M. Atack, Timothy F. Murphy, Melinda M. Pettigrew, Kate L. Seib, Michael P. Jennings
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)
Article
Immunology
Antonia C. Perez, Antoinette Johnson, Ziqiang Chen, Gregory E. Wilding, Michael G. Malkowski, Timothy F. Murphy
INFECTION AND IMMUNITY
(2018)
Article
Microbiology
Brian T. Tsuji, James Fisher, Raheal Boadi-Yeboah, Patricia N. Holden, Sanjay Sethi, Melinda M. Pettigrew, Timothy F. Murphy
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Respiratory System
David M. Jacobs, Katia Noyes, Jiwei Zhao, Walter Gibson, Timothy F. Murphy, Sanjay Sethi, Heather M. Ochs-Balcom
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2018)
Article
Microbiology
John M. Atack, Timothy F. Murphy, Lauren O. Bakaletz, Kate L. Seib, Michael P. Jennings
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2018)