Article
Immunology
Nancy Evelyn Aguilar-Gomez, Jocelin Merida-Vieyra, Oscar Daniel Isunza-Alonso, Maria Gabriela Morales-Pirela, Oscar Colin-Martinez, Enrique Josue Juarez-Benitez, Silvestre Garcia de la Puente, Alejandra Aquino-Andrade
Summary: This study describes the phenotypic and genotypic characteristics of Staphylococcus aureus isolates from osteoarticular infections in paediatric patients. The majority of isolates were methicillin-sensitive S. aureus, and the pvl gene was only observed in these isolates. The study highlights the importance of a multidisciplinary team for the diagnosis and treatment of osteoarticular infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Iona M. Munjal, Jill Dreyfus, Holly Yu, Elizabeth Begier, Alejandra Gurtman, Julie A. Gayle, Margaret A. Olsen
Summary: The objective of this study was to determine the incidence of Staphylococcus aureus infections in pediatric patients after elective surgeries. The study found that the overall incidence of S. aureus infection was 1.79% for inpatient surgeries and 0.36% for outpatient surgeries. The findings highlight the importance of continued infection prevention efforts and long-term surveillance after surgery.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Letter
Microbiology
Lisiane da Luz Rocha Balzan, Adriana Medianeira Rossato, Cezar Vinicius Wurdig Riche, Vlademir Vicente Cantarelli, Pedro Alves D'Azevedo, Aline Valerio de Lima, Beatriz Rodrigues, Ivan Leonardo Avelino Franca e Silva, Cicero Armidio Gomes Dias, Jorge Luiz Mello Sampaio
Summary: In 2015, two new species related to Staphylococcus aureus were proposed. We report the isolation of five strains of the newly identified species, Staphylococcus argenteus, from human cases of bacteremia and skin and soft tissue infections. This is the first documentation of S. argenteus causing community-acquired and hospital-acquired infections in South America.
MICROBIOLOGY SPECTRUM
(2023)
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Emil L. Fosbol, Thomas A. Gerds, Kasper Iversen, Henning Bundgaard, Niels Eske Bruun, Anders R. Larsen, Andreas Petersen, Paal S. Andersen, Robert L. Skov, Lauge Ostergaard, Eva Havers-Borgersen, Gunnar H. Gislason, Christian Torp-Pedersen, Lars Kober, Jonas B. Olesen
Summary: This study investigated the 1-year risks of Staphylococcus aureus bacteraemia, sepsis, and pneumonia in patients undergoing percutaneous coronary intervention and treated with ticagrelor or clopidogrel. The results showed that treatment with ticagrelor was associated with significantly lower risks of Staphylococcus aureus bacteraemia, sepsis, and pneumonia compared to treatment with clopidogrel.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Immunology
Wei Su, Ying Liu, Qing Wang, Lin Yuan, Wei Gao, Kai H. Yao, Yong H. Yang, Lin Ma
Summary: The surveillance network for skin and soft tissue infections (SSTIs) caused by Staphylococcus aureus (S. aureus) in pediatric patients was established in China in 2009 to monitor epidemiological changes. The study aimed to assess the present antibiotic sensitivity and molecular characteristics of S. aureus and MRSA from SSTIs in children nationwide, and track changes over the past decade.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Jill Dreyfus, Holly Yu, Elizabeth Begier, Julie Gayle, Margaret A. Olsen
Summary: This study assessed the 180-day postsurgical Staphylococcus aureus incidence in real-world hospital settings, revealing a high burden of S. aureus infections after both inpatient and outpatient elective surgeries, emphasizing the continued need for surveillance and novel infection prevention efforts.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Opeyemi U. Lawal, Maria J. Fraqueza, Ons Bouchami, Peder Worning, Mette D. Bartels, Maria L. Goncalves, Paulo Paixao, Elsa Goncalves, Cristina Toscano, Joanna Empel, Malgorzata Urbas, M. Angeles Dominguez, Henrik Westh, Herminia de Lencastre, Maria Miragaia
Summary: Staphylococcus saprophyticus is a major cause of community-acquired UTIs in young women, with evidence suggesting the meat-production chain as a major source of the bacteria causing human UTIs. The pathogenic S. saprophyticus belongs to lineages with distinctive features that are globally and locally disseminated.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Microbiology
Veronica Folliero, Federica Dell'Annunziata, Biagio Santella, Emanuela Roscetto, Carla Zannella, Nicoletta Capuano, Alessandro Perrella, Anna De Filippis, Giovanni Boccia, Maria Rosaria Catania, Massimiliano Galdiero, Gianluigi Franci
Summary: The emergence of multidrug-resistant strains requires the urgent discovery of new antibacterial drugs. In this study, the anthelmintic avermectins were screened for antibacterial activity against gram-positive and gram-negative strains. Selamectin, a subset of avermectins, showed potent antibacterial activity against gram-positive strains, particularly Staphylococcus aureus. Further studies demonstrated its ability to inhibit bacterial growth, alter cell surface, and reduce biofilm biomass. Synergistic effects were also observed with other antibiotics. These findings suggest that selamectin may be a promising candidate for the treatment of S. aureus infections.
Article
Pediatrics
Derrick Alexandre Fassbind, Raissa Queiroz Rezende, Cicero Armidio Gomes Dias, Fabrizio Motta
Summary: This study evaluated the impact of healthcare-associated and community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections in a pediatric hospital in southern Brazil. The prevalence of community-acquired MRSA infections was 46.1% and healthcare-associated MRSA infections was 8.1%, with no significant change over the study period. The study highlights the need to review initial protocols for severe staphylococcal infections based on local epidemiology.
FRONTIERS IN PEDIATRICS
(2023)
Article
Infectious Diseases
Virginia Nunez-Samudio, Ivan Landires
Summary: ARIs are a global public health issue caused by viruses in up to 80% cases. Limited epidemiological studies on ARI-related viruses in hospitalized children in Central America. This study in central Panama analyzed the clinical records of pediatric patients with ARIs in 2016, showing RSV, influenza A, and rhinovirus as the most common viruses, varying with age and season. No human metapneumovirus associated with ARI reported. Local epidemiology of respiratory viruses in tropical areas can aid in forecasting hospitalization peaks and improving prevention efforts.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Rosanna Leuzzi, Margherita Bodini, Isaac P. Thomsen, Elisabetta Soldaini, Erika Bartolini, Alessandro Muzzi, Bruna Clemente, Bruno Galletti, Andrea Guido Oreste Manetti, Cinzia Giovani, Stefano Censini, Sonia Budroni, Fabiana Spensieri, Erica Borgogni, Silvia Rossi Paccani, Immaculada Margarit, Fabio Bagnoli, Giuseppe Del Giudice, Clarence B. Creech
Summary: The study identified specific cytokine and functional antibody signatures in patients with different primary invasive diseases caused by Staphylococcus aureus. These data provide insights into human responses to invasive staphylococcal infections and are important for guiding the identification of novel preventive and therapeutic interventions against S. aureus. Our findings showed distinct differences in inflammatory responses and antibody levels between patients with invasive S. aureus disease and healthy donors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Mingbiao Ma, Minjun Chu, Lvyan Tao, Jue Li, Xiaojuan Li, Hailin Huang, Kexuan Qu, Haiping Wang, Li Li, Tingyi Du
Summary: The study revealed a high detection rate of OS-MRSA in children's hospital, with the dominant molecular typing being ST59-SCCmec IV. The automated antimicrobial susceptibility test system has limited ability to identify OS-MRSA, therefore a combination of phenotypic analysis and molecular detection is recommended for better identification.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Jawad H. Butt, Emil L. Fosbol, Peter Verhamme, Thomas A. Gerds, Kasper Iversen, Henning Bundgaard, Niels Eske Bruun, Anders R. Larsen, Andreas Petersen, Paal S. Andersen, Robert L. Skov, Gunnar H. Gislason, Christian Torp-Pedersen, Lars Kober, Jonas B. Olesen
Summary: In this observational cohort study, dabigatran was associated with a significantly lower incidence rate of Staphylococcus aureus bacteremia compared with factor Xa-inhibitors in patients with atrial fibrillation. This suggests that dabigatran may help reduce the risk of S. aureus infections.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Daniela Talapan, Andreea-Mihaela Sandu, Alexandru Rafila
Summary: This study aimed to evaluate the frequency of isolation of Staphylococcus aureus strains and their antibiotic resistance pattern from pathological samples in Romania. The results showed a high percentage of methicillin-resistant Staphylococcus aureus (MRSA) strains, with a higher proportion isolated from the blood compared to other clinical specimens. The study also observed a decrease in the percentage of MRSA strains over time, except for a sharp increase in 2021 during the COVID-19 pandemic.
Review
Infectious Diseases
Matthew S. Linz, Arun Mattappallil, Diana Finkel, Dane Parker
Summary: The most common pathogen in skin-and-soft-tissue infections (SSTIs) in the United States is the pathogenic bacterium Staphylococcus aureus. The epidemic clone USA300 is responsible for the majority of S. aureus SSTIs in the USA. These infections can be serious, with a global age-standardized mortality rate of 0.5 in 2019. S. aureus SSTIs can present as superficial infections with local symptoms or as monomicrobial necrotizing fasciitis, which can cause systemic manifestations and potentially lead to complications or death. Treatment for S. aureus SSTIs usually involves oral therapy, with severe cases requiring parenteral therapy. Treatment options range from cephalosporins and penicillin agents such as oxacillin for methicillin-sensitive S. aureus (MSSA), to vancomycin for methicillin-resistant S. aureus (MRSA). Treatment challenges include adverse effects, risk for Clostridioides difficile infection, and antibiotic resistance.