Article
Immunology
Chun-Mei Feng, Jia-Yi Cheng, Zheng Xu, Hong-Yan Liu, De-Xiang Xu, Lin Fu, Hui Zhao
Summary: Serum resistin levels on admission in patients with Community-Acquired Pneumonia (CAP) are positively correlated with the severity and length of hospital stay, suggesting a potential role of resistin in the physiological process of CAP. Resistin may serve as a potential biomarker for diagnosis and prognosis of CAP.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zheng Xu, Xue-Feng Hou, Chun-Mei Feng, Ling Zheng, De-Xiang Xu, Hui Zhao, Lin Fu
Summary: This study analyzed the association between serum complement C3a and severity scores of community-acquired pneumonia (CAP). The results showed that serum C3a levels were elevated in CAP patients and positively correlated with the severity scores. Inhibiting the complement system can attenuate the secretion of inflammatory cytokines in pulmonary epithelial cells, indicating the involvement of C3a in the pathophysiology of CAP. Serum complement C3a may serve as an earlier diagnostic biomarker for CAP.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Medicine, General & Internal
Jan O. Friedrich, Elisa Gouvea Bogossian
Summary: In a trial evaluating the efficacy of hydrocortisone in treating community-acquired pneumonia, researchers found a nearly 50% lower 28-day mortality rate in the hydrocortisone group compared to the placebo group. They also observed a higher incidence of septic shock in the placebo group. The trial did not allow the use of open-label glucocorticoids, which may have contributed to the higher mortality rate in the placebo group.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Immunology
Xiao Jiang, Chun-Mei Huang, Chun-Mei Feng, Zheng Xu, Lin Fu, Xin-Ming Wang
Summary: Elevated serum S100A12 levels in patients with community-acquired pneumonia (CAP) were positively associated with disease severity and adverse prognosis, suggesting its potential role in the pathophysiological process of CAP. Serum S100A12 levels may serve as a diagnostic and prognostic biomarker for patients with CAP.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jia-Le Wang, Xue Chen, Yi Xu, Yue-Xin Chen, Jing Wang, Yu-Lu Liu, Hal-Tao Song, Jun Fei, Hui Zhao, Lin Fu
Summary: The study revealed a significant negative correlation between serum IL-37 levels and the severity and prognosis of CAP patients. Lower levels of serum IL-37 upon admission were associated with prolonged hospital stay, indicating a potential role of IL-37 in the development of CAP. Serum IL-37 may serve as a biomarker for diagnosis and prognosis in CAP patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Lucia Boix-Palop, Andrea Vergara, Emma Padilla, Diego Martinez, Ana Blanco, Josefa Perez, Esther Calbo, Jordi Vila, Climent Casals-Pascual
Summary: The aim of this study was to evaluate the diagnostic performance of plasma Lipocalin-2 (LCN2) concentration in adult patients with community-acquired pneumonia (CAP) and its association with etiology, severity, and prognosis. The study found that LCN2 concentration was higher in bacterial CAP compared to non-bacterial CAP and had a limited ability to distinguish between the two. It also found that LCN2 concentration was associated with disease severity in adult patients with CAP. However, its utility as a biomarker to discriminate between viral and bacterial etiology in CAP is limited.
Article
Immunology
Todd A. Florin, Lilliam Ambroggio, Samir S. Shah, Richard M. Ruddy, Eric S. Nylen, Lauren Balmert
Summary: The study found that the urinary proADM/Cr ratio is associated with disease severity in pediatric community-acquired pneumonia (CAP), serving as a potential predictor for severe outcomes, with stronger discriminatory performance in radiographic CAP.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Infectious Diseases
Li Chen, Lili Zhao, Ying Shang, Yu Xu, Zhancheng Gao
Summary: This study investigated the role of lysophosphatidylethanolamine acyltransferase (LPEAT) in community-acquired pneumonia (CAP) and found that serum LPEAT levels in patients can predict disease severity and risk of death, serving as a predictive marker in CAP patients.
Article
Medicine, General & Internal
Minghao Gu, Xiudi Han, Xuedong Liu, Fengxiang Sui, Quansan Zhang, Shengqi Pan
Summary: This study assessed the clinical utility of AnxA1 level as a biomarker for determining the severity of illness and predicting the risk of death in hospitalized patients with CAP. The results showed that AnxA1 level at admission was significantly higher in severe CAP patients and correlated with disease severity scores. AnxA1 level decreased after treatment and was associated with 30-day mortality. These findings suggest that AnxA1 is a useful biomarker for early diagnosis and prognostic assessment of CAP.
Article
Infectious Diseases
Luis A. Ruiz, Leyre Serrano, Silvia Perez, Sonia Castro, Amaia Urrutia, Ane Uranga, Amaia Artaraz, Ainhoa Gomez, Pedro P. Espana, Rafael Zalacain
Summary: This study aimed to evaluate the impact of using a predefined cutoff value for lymphopenia as an early predictor of in-hospital mortality and other outcomes in patients with pneumococcal pneumonia. The study found that lymphopenia could be used as a reproducible predictor of complicated clinical course in these patients.
Article
Infectious Diseases
Felippe Lazar Neto, Lucas Oliveira Marino, Antoni Torres, Catia Cilloniz, Julio Flavio Meirelles Marchini, Julio Cesar Garcia de Alencar, Andrea Palomeque, Nuria Albacar, Rodrigo Antonio Brandao Neto, Heraldo Possolo Souza, Otavio T. Ranzani
Summary: The study externally validated pneumonia risk assessment tools on COVID-19 patients from two distinct countries, comparing their performance with recently developed COVID-19 mortality risk stratification tools. The results show that recent clinical COVID-19 assessment scores had comparable performance to standard pneumonia prognostic tools, providing important clinical reference value.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Leigh M. Howard, Kathryn M. Edwards, Yuwei Zhu, Carlos G. Grijalva, Wesley H. Self, Seema Jain, Krow Ampofo, Andrew T. Pavia, Sandra R. Arnold, Jonathan A. McCullers, Evan J. Anderson, Richard G. Wunderink, Derek J. Williams
Summary: Clinical features did not reliably distinguish HMPV-associated pneumonia from other pathogens. HMPV-associated pneumonia was less severe than bacterial and adult RSV pneumonia, but was otherwise as or more severe than other common pathogens.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Leigh M. Howard, Kathryn M. Edwards, Yuwei Zhu, Derek J. Williams, Wesley H. Self, Seema Jain, Krow Ampofo, Andrew T. Pavia, Sandra R. Arnold, Jonathan A. McCullers, Evan J. Anderson, Richard G. Wunderink, Carlos G. Grijalva
Summary: The study found that PIV was more commonly detected in children, but often co-detected with other pathogens. Clinical features of PIV-1, PIV-2, and PIV-3 infections were similar in children and adult pneumonia patients. In children, PIV pneumonia was less severe than bacterial pneumonia.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Li Chen, Yali Zheng, Lili Zhao, Ying Zhang, Lu Yin, Yukun He, Xinqian Ma, Yu Xu, Zhancheng Gao
Summary: This study utilized lipidomic analysis to investigate the responses to community-acquired pneumonia (CAP), identifying specific lipid species associated with disease severity, survival rates, and length of hospitalization. The findings suggest that certain lipid profiles may serve as potential biomarkers for diagnosing and monitoring CAP.
Article
Critical Care Medicine
James Bradley, Nadine Sbaih, Thomas R. Chandler, Stephen Furmanek, Julio A. Ramirez, Rodrigo Cavallazzi
Summary: The CURB-65 score and PSI are effective in predicting in-hospital mortality for both SARS-CoV-2-associated CAP and non-SARS-CoV-2-associated CAP. The addition of procalcitonin and D-dimer does not significantly improve the prognostic performance of these clinical prediction rules in SARS-CoV-2-associated CAP.
Article
Critical Care Medicine
Sharina Kort, Marjolein Brusse-Keizer, Hugo Schouwink, Emanuel Citgez, Frans H. de Jongh, Jan W. G. van Putten, Ben van den Borne, Elisabeth A. Kastelijn, Daiana Stolz, Milou Schuurbiers, Michel M. van den Heuvel, Wouter H. van Geffen, Job van der Palen
Summary: This study developed and validated a prediction model to distinguish patients with non-small cell lung cancer from non-lung cancer subjects using exhaled breath analysis. It also investigated the impact of adding clinical variables to improve the diagnosis. The results showed that combining exhaled breath data and clinical variables can effectively differentiate lung cancer patients from non-lung cancer subjects in a noninvasive manner, paving the way for the implementation of exhaled breath analysis in lung cancer diagnosis.
Review
Nutrition & Dietetics
Carla Gressies, Pascal Tribolet, Philipp Schuetz
Summary: Disease-related malnutrition in patients in the general medical ward is a complex syndrome that affects recovery and increases morbidity and mortality. Recent advances in research have led to better understanding of diagnostic criteria and evidence-based treatment for malnutrition. More specific clinical parameters and blood biomarkers are needed to personalize treatments. There is also a need for improved education and screening for nutrition risk in hospitals.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Leonie Mueller, Nicole Mentil, Nathalie Staub, Stephanie Griot, Tobias Olpe, Felice Burn, Sebastian Schindera, Beat Mueller, Philipp Schuetz, Zeno Stanga, Annic Baumgartner
Summary: This study examined the association of skeletal muscle index (SMI) at the thoracic level with nutritional and clinical outcomes and response to nutritional intervention. The results showed that SMI at the thoracic vertebra provided limited prognostic information regarding clinical outcomes and nutritional treatment response.
Article
Cardiac & Cardiovascular Systems
Martin Segeroth, David Jean Winkel, Ivo Strebel, Shan Yang, Jan Gerrit van der Stouwe, Jude Formambuh, Patrick Badertscher, Joshy Cyriac, Jakob Wasserthal, Federico Caobelli, Antonio Madaffari, Pedro Lopez-Ayala, Michael Zellweger, Alexander Sauter, Christian Mueller, Jens Bremerich, Philip Haaf
Summary: The aim of the study was to quantify pulmonary transit time (PTT) in routine cardiovascular magnetic resonance imaging perfusion sequences. PTT was found to be significantly associated with left and right ventricular ejection fraction. The study suggests that PTT can be used as a non-invasive biomarker to evaluate patients with dyspnea and heart failure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Sigrun Halvorsen, Julinda Mehilli, Christian Mueller
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Anissa Pelouto, Julie C. Refardt, Mirjam Christ-Crain, Adrienne A. M. Zandbergen, Ewout J. Hoorn
Summary: Current guidelines recommend treating symptomatic hyponatremia with fixed volumes of hypertonic saline regardless of body weight. Our study found that this approach is associated with overcorrection in patients with low body weight and undercorrection in patients with high body weight. Prospective studies are needed to develop individualized dosing models.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Clara Odilia Sailer, Odile Gaisl, Svetlana Beglinger, Martina Frech-Dorfler, Vivienne Sommer, Maya Horst Luthy, Mirjam Christ-Crain
Summary: This study found that plasma copeptin ratio can predict the treatment response to desmopressin in children with monosymptomatic nocturnal enuresis. A lower copeptin ratio indicates a better treatment response to desmopressin.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Eleni Michou, Desiree Wussler, Christian Mueller
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Nutrition & Dietetics
Roxana Wimmer, Andrea Audetat, Julia Binggeli, Philipp Schuetz, Nina Kaegi-Braun
Summary: A study conducted in the Swiss population found that a significant proportion of individuals have low energy and protein intake. Factors such as high income, obesity, and living in households with children were associated with a reduced risk of low energy intake, while being in the age group of 65-75 years and being female were associated with a higher risk of low protein intake. Regular meat consumption was found to reduce the risk of low protein intake.
Review
Nutrition & Dietetics
Franziska Stumpf, Bettina Keller, Carla Gressies, Philipp Schuetz
Summary: The interplay between inflammation and nutrition has attracted significant attention recently. Inflammation has been identified as a critical factor in disease-related malnutrition, leading to anorexia, reduced food intake, muscle catabolism, and insulin resistance. Inflammation also affects the response to nutritional treatment, with patients with high inflammation showing no response and patients with lower inflammation levels showing a response. This may explain the conflicting results of nutritional trials.
Editorial Material
Cardiac & Cardiovascular Systems
Christian Puelacher, Nicholas L. Mills, Christian Mueller
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Letter
Cardiac & Cardiovascular Systems
Desiree Wussler, Maria Belkin, Christian Mueller
Article
Medicine, General & Internal
Giorgia Luethi-Corridori, Maria Boesing, Nicola Ottensarendt, Anne Barbara Leuppi-Taegtmeyer, Philipp Schuetz, Joerg Daniel Leuppi
Summary: This study aimed to identify predictors of length of hospital stay, mortality, and rehospitalization in patients admitted for acute exacerbation of COPD. The results showed that the need for oxygen supplementation was the only significant predictor of hospital stay, while older age, COPD severity, active cancer, and arrhythmias were associated with higher mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Evangelos Giannitsis, Nicholas L. Mills, Christian Mueller
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Urology & Nephrology
Biruh T. Workeneh, Priti Meena, Mirjam Christ-Crain, Helbert Rondon-Berrios
Summary: Hyponatremia is a common and poorly understood problem in clinical practice. Its prevalence varies depending on the population and criteria used for diagnosis. Hyponatremia is associated with negative outcomes and its pathogenesis involves the accumulation of electrolyte-free water. Differentiating between etiologies can be done using plasma and urine measurements. The management of hyponatremia depends on symptoms and causes and is discussed in this review.
ADVANCES IN KIDNEY DISEASE AND HEALTH
(2023)