Article
Public, Environmental & Occupational Health
Owen R. Albin, Keith S. Kaye
Summary: A novel strategy of keyword abstraction from chest radiography transcripts effectively identified patients with misdiagnosed pneumonia, providing opportunities for antibiotic discontinuation and/or de-escalation.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Multidisciplinary Sciences
My V. T. Phan, Charles N. Agoti, Patrick K. Munywoki, Grieven P. Otieno, Mwanajuma Ngama, Paul Kellam, Matthew Cotten, D. James Nokes
Summary: This study investigated the performance of routine virus diagnostics in Kilifi, Kenya, and found that viral next generation sequencing (viral NGS) can identify additional viruses and reveal failures in the diagnostic methods used. This method can provide actionable information to improve local pneumonia diagnostics.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Nishadi Maduwanthi Neluwa Liyanage, Bandusekara Supun Bandusekara, Rajapakshaa Walimuni Mudiyanselage Kumudumali Kanchanamala, Hathurusinghe Arachchilage Bhagya Madhushani Hathurusinghe, Adasooriya Mudiyanselage Ranhami Wedaralage Shanaka Dilhan Rathnayaka, D. K. N. Gamini Pushpakumara, Sembakutti Samita, Kitulgala Gamaethige Gamini Wijesinghe, Godakanda Gamage Jayasinghe, Wasantha Kumara Liyanage, Pradeepa Chandani Gunathilake Bandaranayake
Summary: The study focused on the morphological, yield, and biochemical characterization of the largest Ceylon cinnamon germplasm in the world, revealing that most samples had above-average chemical composition and almost no coumarin content. This research identified 16 superior genotype accessions for immediate breeding or release to farmers after mass propagation.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Immunology
Annika Eklundh, Samuel Rhedin, Malin Ryd-Rinder, Maria Andersson, Jesper Gantelius, Giulia Gaudenzi, Magnus Lindh, Ville Peltola, Matti Waris, Pontus Naucler, Andreas Martensson, Tobias Alfven
Summary: Immunization with pneumococcal conjugate vaccines has reduced the burden of community-acquired pneumonia in children and potentially changed the etiology of CAP. The majority of clinical CAP episodes in children were classified as viral etiology, with bacterial etiology being uncommon.
Article
Infectious Diseases
Naoyuki Miyashita, Yasushi Nakamori, Makoto Ogata, Naoki Fukuda, Akihisa Yamura, Yoshihisa Ishiura, Shosaku Nomura
Summary: The combination of the JRS scoring system and chest CT findings is useful for the rapid presumptive diagnosis of COVID-19 pneumonia in patients aged <60 years. Mycoplasma pneumoniae pneumonia shows higher manifestations of bronchial wall thickening and nodules in chest CT results compared to COVID-19 pneumonia.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Antonio L. Cunha Jr, Ana P. S. Champs, Carla M. Mello, Monica M. M. Navarro, Frederico J. C. Godinho, Cassia M. B. Carvalho, Teresa C. A. Ferrari
Summary: The study found that over 25% of GSD patients had central nervous system (CNS) injuries, with spinal cord injury present in 21.7% of patients and brain injury in 5.9% of patients. Back pain, os odontoideum, and abnormal neuropsychomotor development (NPMD) were independently associated with CNS injury. Early identification of these abnormalities may help prevent compressive CNS injury in GSD patients.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Helmia Farida, Rina Triasih, Dewi Lokida, Yan Mardian, Gustiani Salim, Wahyu Nawang Wulan, Deni P. Butar-butar, Rizki Amalia Sari, Arif Budiman, Chakrawati Hayuningsih, Moh Syarofil Anam, Setya Dipayana, Mujahidah Mujahidah, Amalia Setyati, Abu Tholib Aman, Adhella Menur Naysilla, Nurhayati Lukman, Aly Diana, Muhammad Karyana, Ahnika Kline, Aaron Neal, H. Clifford Lane, Herman Kosasih, Chuen-Yen Lau
Summary: This study aimed to develop a prediction model to differentiate between bacterial and viral etiologies of childhood community-acquired pneumonia (CAP) using epidemiological, clinical, and laboratory data. Diarrhea was more common in bacterial and mixed CAP, while viral infections occurred more frequently during the rainy season in Indonesia. White blood cell counts, absolute neutrophil counts, neutrophil-lymphocyte ratio, C-reactive protein, and procalcitonin were significantly higher in bacterial and mixed cases. Conclusion: Combining clinical and laboratory profiles can help discriminate between bacterial and mixed from viral pediatric CAP and guide antibiotic use.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Meiling Jin, Tianye Jia, Xiong Liu, Meitao Yang, Na Zhang, Jiali Chen, Xiaojing Yang, Shiyu Qin, Fangni Liu, Yue Tang, Yong Wang, Jinpeng Guo, Yong Chen, Boan Li, Changjun Wang
Summary: This study investigates the clinical and genomic characteristics of Hypermucoviscous Klebsiella pneumoniae (HmKp) to better understand its virulence mechanisms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Catherine S. O'Neal, Diana Hamer, Mandi W. Musso, Terrell S. Caffery, Morgan K. Walker, Katherine W. Lavie, Matthew S. Berlinger, Christopher B. Thomas, Shannon M. Alwood, Tonya Jagneaux, Michael A. Sanchez, Hollis R. O'Neal
Summary: This study compared three methods for retrospectively identifying infection in emergency department patients and found that using modified definitions of infection had similar agreement with physician adjudication, while emergency department treating physician behavior was less accurate.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Review
Oncology
Cynthia Aristei, Yasemin Bolukbasi, Orit Kaidar-Person, Raphael Pfeffer, Meritxell Arenas, Liesbeth J. Boersma, Antonella Ciabattoni, Charlotte E. Coles, Pierfrancesco Franco, Marco Krengli, Maria Cristina Leonardi, Fabio Marazzi, Valeria Masiello, Icro Meattini, Angel Montero, Birgitte Offersen, Maria Lurdes Trigo, Celine Bourgier, Domenico Genovesi, Vassilis Kouloulias, Alessio G. Morganti, Bruno Meduri, Nadia Pasinetti, Sara Pedretti, Elisabetta Perrucci, Sofia Rivera, Vincenzo Tombolini, Cristiana Vidali, Vincenzo Valentini, Philip Poortmans
Summary: This paper reports on the third Assisi Think Tank Meeting (ATTM) on breast cancer, which aimed to identify key clinical questions and areas requiring research to improve management and outcomes. The meeting discussed three main topics and proposed research protocols to address clinical challenges in these areas.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Health Care Sciences & Services
Bryan D. Steitz, Gen Li, Adam Wright, Brent Dunworth, Robert E. Freundlich, Jonathan P. Wanderer
Summary: Positive patient identification is crucial for ensuring correct patient identity before healthcare delivery. A study found that using a clinical decision support tool can significantly improve the success rate of patient identification, thereby enhancing patient safety workflows.
JOURNAL OF MEDICAL SYSTEMS
(2022)
Article
Infectious Diseases
Fei Xie, Zhimei Duan, Weiqi Zeng, Shumei Xie, Mingzhou Xie, Han Fu, Qing Ye, Teng Xu, Lixin Xie
Summary: The study found that clinical metagenomics has significant advantages in the diagnosis and treatment of community-acquired pneumonia, being able to detect more pathogens and identify polymicrobial infections, and it helps improve patient outcomes.
BMC INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Stanislaw Boguslawski, Agnieszka Strzelak, Kacper Gajko, Joanna Peradzynska, Jolanta Popielska, Magdalena Marczynska, Marek Kulus, Katarzyna Krenke
Summary: The objective of this study was to assess the pulmonary sequelae of COVID-19 pneumonia in children. Children diagnosed with COVID-19 pneumonia were followed up 3 months postdischarge, and if abnormalities were found, a second visit after 3 months was scheduled. The study showed that children may experience mild long-term sequelae, which generally resolve over time.
PEDIATRIC PULMONOLOGY
(2023)
Article
Immunology
Gongxun Xie, Qing Hu, Xuefang Cao, Wenjie Wu, Penghui Dai, Wei Guo, Ouxi Wang, Liang Wei, Ruotong Ren, Yanchun Li
Summary: Recently, there has been an increase in chlamydial pneumonia caused by rare pathogens such as C. psittaci or C. abortus. Traditional methods for identifying pathogens are limited, leading to potential misdiagnosis or delayed treatment. mNGS provides a more sensitive detection method for rare pathogens and can help identify co-infection and its impact on lung microbiota diversity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Rheumatology
Stefan Kleinert, Florian Schuch, Praxedis Rapp, Monika Ronneberger, Joerg Wendler, Patrizia Sternad, Florian Popp, Peter Bartz-Bazzanella, Cay von der Decken, Kirsten Karberg, Georg Gauler, Patrick Wurth, Susanna Spaethling-Mestekemper, Christoph Kuhn, Wolfgang Vorbrueggen, Martin Welcker
Summary: The categorization of axSpA into r-axSpA and nr-axSpA subtypes may have less value in clinical practice. A study in German clinical rheumatology sites found that slightly more than half of axSpA patients underwent radiographic imaging, and follow-up imaging confirmed r-axSpA in a significant portion of originally classified nr-axSpA patients.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Infectious Diseases
Beatriz Quiambao, Lijoy Varghese, Nadia Demarteau, Ruth Faye Sengson, Jenaline Javier, Piyali Mukherjee, Leah Cheryl Manio, Scott Preiss
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Health Care Sciences & Services
Mark Donald C. Renosa, Kate Baernighausen, Sarah L. Dalglish, Veronica L. Tallo, Jhoys Landicho-Guevarra, Maria Paz Demonteverde, Carol Malacad, Thea Andrea Bravo, Mary Lorraine Mationg, Socorro Lupisan, Shannon A. McMahon
Summary: Limited studies have been conducted on the Integrated Management of Childhood Illness (IMCI) program in the Philippines, with a focus on the perspectives of frontline health care workers. Challenges faced by HCWs implementing IMCI in the Philippines include inadequate financial resources, training, leadership, access to relevant documents, and professional hierarchies, despite the perceived holistic benefits of the program to the community. More effective implementation processes are needed to improve acceptance in primary health care facilities.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Hirono Otomaru, Johanna Beulah T. Sornillo, Taro Kamigaki, Samantha Louise P. Bado, Michiko Okamoto, Mariko Saito-Obata, Marianette T. Inobaya, Edelwisa Segubre-Mercado, Portia P. Alday, Mayuko Saito, Veronica L. Tallo, Beatriz P. Quiambao, Hitoshi Oshitani, Alex R. Cook
Summary: This study found that the risk of RSV transmission is associated with viral load trajectory, and the first week after household exposure is a critical period for preventing virus spread, especially potential presymptomatic transmissions.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Immunology
Kentaro Yamada, Koji Kuribayashi, Naotaka Inomata, Kazuko Noguchi, Kazunori Kimitsuki, Catalino S. Demetria, Nobuo Saito, Satoshi Inoue, Chun-Ho Park, Ryo Kaimori, Motoi Suzuki, Mariko Saito-Obata, Yasuhiko Kamiya, Daria L. Manalo, Beatriz P. Quiambao, Akira Nishizono
Summary: Rabies is an acute fetal encephalitis caused by the rabies virus, which is incurable after symptom onset but can be prevented by post-exposure prophylaxis during the long incubation period. Apolipoprotein A1 (ApoA1) was identified as a serum biomarker for preclinical diagnosis, with its levels increasing during the incubation period and on the day of symptom onset. Additional biomarker candidates are needed for effective preclinical diagnosis of rabies.
MICROBIOLOGY AND IMMUNOLOGY
(2021)
Article
Infectious Diseases
Milagros R. Mananggit, Daria L. Manalo, Nobuo Saito, Kazunori Kimitsuki, Alyssa Marie G. Garcia, Patricia Mae T. Lacanilao, Joely T. Ongtangco, Cornhlo R. Velasco, Maria Victoria A. del Rosario, Maria Glofezita O. Lagayan, Kentaro Yamada, Chun-Ho Park, Satoshi Inoue, Motoi Suzuki, Mariko Saito-Obata, Yasuhiko Kamiya, Catalino S. Demetria, Beatriz P. Quiambao, Akira Nishizono
Summary: The study evaluated the diagnostic accuracy of lateral flow devices (LFD) with the straw sampling method compared to the direct fluorescent antibody test (dFAT) in animal rabies diagnosis, showing that LFD with straw sampling method had relatively high sensitivity and 100% specificity. This method can be a strong tool to overcome limited animal surveillance in remote areas.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Timothy John R. Dizon, Nobuo Saito, Marianette Inobaya, Alvin Tan, Mark Donald C. Renosa, Thea Andrea Bravo, Vivienne Endoma, Catherine Silvestre, Micah Angela O. Salunga, Patricia Mae T. Lacanilao, Jerric Rhazel Guevarra, Yasuhiko Kamiya, Maria Glofezita O. Lagayan, Kazunori Kimitsuki, Akira Nishizono, Beatriz P. Quiambao
Summary: In the Philippines, human rabies cases have not decreased, posing the highest risk for rabies in the country. Conducting a survey on the owned dog population and community knowledge about rabies can improve vaccine coverage and awareness campaigns.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
Daisetsu Fujita, Clyde Dapat, Emmanuel Kagning Tsinda, Mayuko Saito, Michiko Okamoto, Mariko Saito-Obata, Beatriz P. Quiambao, Socorro P. Lupisan, Hitoshi Oshitani
Summary: This study reports 19 nearly complete genome sequences of influenza C virus isolated from clinical samples recovered from children in the Philippines between 2014 and 2019.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Article
Microbiology
Michiko Okamoto, Masahiro Sakamoto, Clyde Dapat, Mayuko Saito, Mariko Saito-Obata, Raita Tamaki, Socorro P. Lupisan, Beatriz P. Quiambao, Hitoshi Oshitani
Summary: Complete genome sequences of 4 Glade A and 12 Glade D enterovirus D68 strains detected in nasopharyngeal swabs from children with acute respiratory illness in the Philippines have been determined. These sequence data will be valuable for future epidemiological monitoring, including observation of viral evolution.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Review
Virology
Stephen J. Scholand, Beatriz P. Quiambao, Charles E. Rupprecht
Summary: Rabies is a devastating disease that needs appropriate and timely prevention and treatment. The current categorization for rabies exposure needs revision to include a special Category IV for severe bites. Multiple factors that contribute to the severity of the disease have not been considered in current recommendations. The introduction of Category IV will optimize patient management and improve care for high-risk patients, highlighting the urgency of this neglected disease at a global level.
Article
Immunology
Beatriz P. Quiambao, Jonathan G. Lim, Valerie Bosch Castells, Christele Augard, Celine Petit, Catherine Bravo, Valentine Delore, Guy Houillon
Summary: Shorter rabies pre-exposure prophylaxis (PrEP) regimens offer improved convenience and feasibility over classic 3-week regimens, especially for regions with limited access to vaccines or travelers to rabies-endemic areas. In this multicenter trial, a 1-week PrEP regimen was found to be effective in generating robust immune responses across age groups, with no safety concerns.
Article
Immunology
Beatriz Quiambao, Cecilia Montalban, Ada -Maria Minutello, Francoise Guinet-Morlot, Annick Moureau, Celine Petit, Sylvie Pichon
Summary: This study demonstrates the non-inferior immune profile of PVRV-NG compared with HDCV in a pediatric population and shows good tolerability.
Article
Pharmacology & Pharmacy
Kazunori Kimitsuki, Sakirul Khan, Ryo Kaimori, Takaaki Yahiro, Nobuo Saito, Kentaro Yamada, Nozomi Nakajima, Takashi Komeno, Yosuke Furuta, Beatriz P. Quiambao, Phatthamon Virojanapirom, Thiravat Hemachudha, Akira Nishizono
Summary: This study assessed the potential of the antiviral drug favipiravir as an alternative treatment for rabies. The results showed that using favipiravir with the rabies vaccine provided complete protection against death caused by the virus, and the virus-neutralizing antibody titer was significantly higher compared to the treatment with the vaccine and immunoglobulin. A clinical trial of this approach is needed, especially in countries with limited availability of immunoglobulin.
ANTIVIRAL RESEARCH
(2023)
Article
Microbiology
Jaira D. Mauhay, Nobuo Saito, Kazunori Kimitsuki, Milagros R. Mananggit, Jeffrey L. Cruz, Maria G. Lagayan, Alyssa M. Garcia, Patricia M. Lacanilao, Kentaro Yamada, Mariko Saito-Obata, Daria L. Manalo, Catalino S. Demetria, Beatriz P. Quiambao, Akira Nishizono
Summary: The study found that used lateral flow devices (LFDs) can be used for molecular analysis of rabies virus, regardless of the storage temperature, for accurate diagnosis. However, refrigerated storage conditions are recommended for further genetic analysis.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Tropical Medicine
Catalino Demetria, Kazunori Kimitsuki, Takaaki Yahiro, Nobuo Saito, Takehiro Hashimoto, Sakirul Khan, Maria Yna Joyce Chu, Daria Manalo, Milagros Mananggit, Beatriz Quiambao, Akira Nishizono
Summary: The study aims to develop an assay to detect the rabies virus genome in field samples using a portable real-time reverse transcription-polymerase chain reaction (RT-PCR) instrument. The developed PCR1100 assay showed high sensitivity and specificity, even detecting low copy numbers of the virus. This assay has the potential to effectively improve surveillance and confirmation of rabies in remote areas.
TROPICAL MEDICINE AND HEALTH
(2023)
Article
Tropical Medicine
Milagros R. Mananggit, Kazunori Kimitsuki, Nobuo Saito, Alyssa Marie G. Garcia, Patricia Mae T. Lacanilao, Joely T. Ongtangco, Cornelio R. Velasco, Maria Victoria D. Rosario, Maria Glofezita O. Lagayan, Kentaro Yamada, Chun-Ho Park, Satoshi Inoue, Motoi Suzuki, Mariko Saito-Obata, Yasuhiko Kamiya, Daria L. Manalo, Catalino S. Demetria, Beatriz P. Quiambao, Akira Nishizono
Summary: The study described and analyzed the characteristics of rabies suspect animals in Central Luzon, Philippines, showing that most of the confirmed rabies cases were from pet animals provided by owners, and the majority of owners did not vaccinate their animals.
TROPICAL MEDICINE AND HEALTH
(2021)