Article
Pharmacology & Pharmacy
Bihao Liu, Yiwen Cao, Dejuan Wang, Yuan Zhou, Peichun Zhang, Junbiao Wu, Junqi Chen, Jianguang Qiu, Jiuyao Zhou
Summary: In this study, Zhen-wu-tang (ZWT) was found to improve the condition of chronic glomerulonephritis (CGN) model rats by reducing serum creatinine and blood urea nitrogen levels, inhibiting mesangial matrix proliferation, and protecting against foot processes fusion and basement membrane thickening. ZWT also enhanced mitochondrial function by increasing the expressions of antioxidases, ATP content, and mitochondrial membrane potential, while decreasing excessive mitochondrial ROS. Moreover, ZWT induced mitophagy and inhibited the PI3K/AKT/mTOR pathway to ameliorate renal mitochondrial dysfunction in CGN.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Juan Irure-Ventura, Lara Belmar-Vega, Gema Fernandez-Fresnedo, Elena Gonzalez-Lopez, Carolina Castro-Hernandez, Emilio Rodrigo-Calabia, Milagros Heras-Vicario, Juan Carlos Ruiz San Millan, Marcos Lopez-Hoyost
Summary: An increase in the development of ANCA-associated vasculitis (AAV) has been observed in 2021, with most cases occurring after SARS-CoV-2 vaccination, particularly the second dose. The kidneys and respiratory tracts are the main organs affected.
Editorial Material
Urology & Nephrology
Dominick Santoriello, Glen S. Markowitz
Summary: A novel diagnostic tool introduced in this issue of Kidney International utilizes immunofluorescence staining for conformational epitopes at the junction of Ig heavy chains and light chains, potentially enhancing the evaluation of apparent monoclonal forms of renal disease.
KIDNEY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
A. Marques-Ramos, R. Cervantes
Summary: mTOR, a protein discovered in 1991, plays a key role in maintaining cellular homeostasis by integrating intra- and extracellular signals. Dysregulation of mTOR pathway is implicated in various human diseases. Research on mTOR gene expression regulation and its potential as a biomarker for diagnosis, prognosis and therapeutics response is emerging.
Article
Neurosciences
Beatrice Paola Festa, Farah H. Siddiqi, Maria Jimenez-Sanchez, Hyeran Won, Matea Rob, Alvin Djajadikerta, Eleanna Stamatakou, David C. Rubinsztein
Summary: In neurodegenerative diseases, activated microglia secrete pro-inflammatory factors, disrupting neuronal autophagy and protein clearance. The microglia-derived CCL-3/-4/-5 activate neuronal CCR5, leading to mTORC1 activation and autophagy dysfunction. Upregulation of CCR5 and its chemokines in mouse models suggests their role in the early phases of Huntington's disease (HD) and tauopathy. Inhibiting CCR5 can rescue autophagy dysfunction and improve HD and tau pathologies in mouse models.
Editorial Material
Oncology
Sergei Kusmartsev
Summary: The study demonstrates a positive association between AKI induced by ischemia-reperfusion injury and the formation of clear-cell renal cell carcinoma in genetically modified mice, with blockade of CXCL1 signaling inhibiting kidney tumor emergence. This provides a new experimental approach to prevent and reduce kidney cancer incidence through modulation of the AKI-induced inflammatory response.
Article
Oncology
Watchara Sakares, Wannaporn Wongkhattiya, Ponlawat Vichayachaipat, Chompunoot Chaiwut, Varalee Yodsurang, Pattiya Nutthachote
Summary: This study aimed to investigate the potential of chemokines as biomarkers for differential diagnosis between benign tumors and ovarian cancer. CCL20 was found to be a potential biomarker for diagnosing early-stage OC with endometriosis differentiation. Further studies are recommended to confirm the accuracy of CCL20 levels in a large patient sample.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shan Liu, Xiao-Bing Lan, Miao-Miao Tian, Chun-Hao Zhu, Lin Ma, Jia-Mei Yang, Juan Du, Ping Zheng, Jian-Qiang Yu, Ning Liu
Summary: Chronic pain poses a significant public health challenge, impacting patients' physical and psychological health as well as their quality of life. Current drug treatments for chronic pain often have limited efficacy and come with numerous side effects. The chemokine system, specifically the CCL2/CCR2 axis, plays a crucial role in the development and maintenance of chronic pain. Targeting this system through various approaches, such as siRNA, blocking antibodies, or small molecule antagonists, holds promise for managing chronic pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Nora Garam, Marcell Cserhalmi, Zoltan Prohaszka, Agnes Szilagyi, Nora Veszeli, Edina Szabo, Barbara Uzonyi, Attila Ilias, Christof Aigner, Alice Schmidt, Martina Gaggl, Gere Sunder-Plassmann, Dora Bajcsi, Jurgen Brunner, Alexandra Dumfarth, Daniel Cejka, Stefan Flaschberger, Hana Floegelova, Agnes Haris, Agnes Hartmann, Andreas Heilos, Thomas Mueller, Krisztina Rusai, Klaus Arbeiter, Johannes Hofer, Daniel Jakab, Maria Sinko, Erika Szigeti, Csaba Bereczki, Viktor Janko, Kata Kelen, Gyoergy S. Reusz, Attila J. Szabo, Nora Klenk, Krisztina Kobor, Nika Kojc, Maarten Knechtelsdorfer, Mario Laganovic, Adrian Catalin Lungu, Anamarija Meglic, Rina Rus, Tanja Kersnik Levart, Ernesta Macioniene, Marius Miglinas, Anna Pawlowska, Tomasz Stompor, Ludmila Podracka, Michael Rudnicki, Gert Mayer, Romana Rysava, Jana Reiterova, Marijan Saraga, Tomas Seeman, Jakub Zieg, Eva Sladkova, Natasa Stajic, Tamas Szabo, Andrei Capitanescu, Simona Stancu, Miroslav Tisljar, Kresimir Galesic, Andras Tisler, Inga Vainumae, Martin Windpessl, Tomas Zaoral, Galia Zlatanova, Mihaly Jozsi, Dorottya Csuka
Summary: This study investigated CFHR5 variations and serum FHR-5 levels in patients with IC-MPGN and C3G for the first time, finding that some patients had CFHR5 variations and lower serum FHR-5 levels compared to controls. Low serum FHR-5 concentration at presentation was associated with better renal survival during the follow-up period.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Satoru Kudose, Pietro Canetta, Nicole K. Andeen, M. Barry Stokes, Ibrahim Batal, Glen S. Markowitz, Vivette D. D'Agati, Dominick Santoriello
Summary: This study successfully reclassified glomerulonephritis with fibrillar IgG deposits into different subtypes using various immunofluorescence and ancillary techniques, providing important information for diagnosis and treatment.
KIDNEY INTERNATIONAL REPORTS
(2021)
Editorial Material
Pharmacology & Pharmacy
Parishmita Sarma, Ramanuj Banerjee, Arun K. Shukla
Summary: In this study, the researchers used cryo-EM to determine the structures of agonist-bound ACKR3. They identified a distinct chemokine-binding mechanism and provided a structural template for investigating the transducer-coupling bias in this receptor.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Immunology
Yu-ting Lin, Hao-dong Chen, Qi-di Ai, Yan-tao Yang, Zhao Zhang, Shi-feng Chu, Nai-hong Chen
Summary: Chemokines, small molecular proteins, have a crucial role in immune and inflammatory responses after stroke. They are recognized as potential targets for stroke treatment, involved in neovascularization, neurogenesis, and neural network reconstruction. In this review, we summarized chemokine alterations during the post-stroke nerve repair phase to understand their pathological mechanisms and find effective therapeutic targets for stroke.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cheuk-Chun Szeto, Ho So, Peter Yam-Kau Poon, Cathy Choi-Wan Luk, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Fernand Mac-Moune Lai, Lai-Shan Tam
Summary: Through the study of three cohorts of lupus nephritis patients and controls, we identified specific lncRNA targets in urine that are associated with the severity and histological classification of lupus nephritis. These urinary lncRNA levels may serve as biomarkers for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Aleksandra Derwich, Monika Sykutera, Barbara Brominska, Miroslaw Andrusiewicz, Marek Ruchala, Nadia Sawicka-Gutaj
Summary: This review investigates the expression of mTOR gene and protein in papillary thyroid cancer (PTC) and their relationship with PTC risk and clinical outcome. It also reviews the use of mTOR inhibitors and potential targeted therapies in PTC. The results of previous studies are summarized, and future research directions are suggested.
Article
Immunology
Heba R. Gouda, Iman M. Talaat, Amal Bouzid, Hoda El-Assi, Amira Nabil, Thenmozhi Venkatachalam, Poorna Manasa Bhamidimarri, Inken Wohlers, Amena Mahdami, Saba El-Gendi, Ahmed ElKoraie, Hauke Busch, Maha Saber-Ayad, Rifat Hamoudi, Nahed Baddour
Summary: The study identified potential mutations in complement regulating genes in patients with glomerulonephritis, suggesting their possible role in disease pathogenesis. A novel variant was found in the Egyptian population for the first time. Further research is needed to understand the impact of these gene variants on protein function, disease progression, and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Hugo You-Hsien Lin, Chan-Jung Liang, Meng-Chieh Liu, Mei-Fang Huang, Jung-San Chang, Shih-Shin Liang
JOURNAL OF CHROMATOGRAPHY A
(2018)
Article
Medicine, General & Internal
Hugo You-Hsien Lin, Tun-Chieh Chen, Yen-Hsu Chen, Po-Liang Lu, Wei-Ru Lin, Yuan-Chieh Yang
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2008)
Article
Medicine, Research & Experimental
Hugo You-Hsien Lin, Su-Chu Lee, Sheng-Fung Lin, Hui-Hua Hsiao, Yi-Chang Liu, Wen-Chi Yang, Daw-Yang Hwang, Chi-Chih Hung, Hung-Chun Chen, Jinn-Yuh Guh
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2013)
Article
Urology & Nephrology
Hugo Y-H Lin, Yumay Chen, Yu-Han Chen, Albert P. Ta, Hsiao-Chen Lee, Grant R. MacGregor, Nosratola D. Vaziri, Ping H. Wang
Summary: Tubular mitochondrial AKT1 signaling plays a crucial role in the development of acute kidney injury and chronic kidney disease. Inhibiting or enhancing mitochondrial AKT1 can significantly improve azotemia, kidney injuries, and renal function.
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Chih-Hao Liu, Hugo You-Hsien Lin
Summary: The global pandemic threat of COVID-19 has significant impacts on healthcare and also influences medical education. This brief communication discusses the measures taken by medical schools in Taiwan facing COVID-19 and the impacts on medical education.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Paul Wei-Hua Tang, Ping-Hsun Wu, Yi-Ting Lin, Chen-Hao Chiu, Tien-Li Cheng, Wen-Hui Guan, Hugo You-Hsien Lin, Kun-Tai Lee, Yau-Hung Chen, Chien-Chih Chiu, Wangta Liu
Summary: Patients with kidney disease often have associated mineral bone disorder and hypertension. In this study, we found that indoxyl sulfate negatively affects the cardiac and renal development of zebrafish embryos, leading to decreased survival rates, cardiac edema, increased mortality, and shortened body length. This is mediated through the ROS and MAPK pathways, causing inflammation in the embryos.
Article
Health Care Sciences & Services
Sheng-Wen Niu, Chi-Chih Hung, Hugo Y. -H. Lin, I-Ching Kuo, Jiun-Chi Huang, Jiun-Shiuan He, Zhi-Hong Wen, Peir-In Liang, Yi-Wen Chiu, Jer-Ming Chang, Shang-Jyh Hwang
Summary: Gout patients who use benzbromarone have a lower incidence of stroke compared to non-users. The risk of stroke is significantly reduced in male benzbromarone users. In the age groups of 40-59 years and >= 60 years, benzbromarone users have a significantly lower risk of stroke compared to non-users. This study evaluates the effects of benzbromarone on stroke incidence in gout patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hugo Y. -H. Lin, Li-Yun Chang, Sheng-Wen Niu, I-Ching Kuo, Chia-Hung Yen, Feng-Ching Shen, Phang-Lang Chen, Jer-Ming Chang, Chi-Chih Hung
Summary: This study investigated whether metabolic syndrome (MetS) could predict renal outcome in patients with established chronic kidney disease (CKD). The study found that MetS was positively associated with proteinuria, inflammation, and nutrition markers. MetS could predict renal outcome in patients with CKD stage 1-4 independent of diabetes mellitus (DM), and blood pressure was identified as the most important component of MetS for renal outcomes.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Medicine, Research & Experimental
Hugo You-Hsien Lin, Zu-Yau Lin, Paul Ming-Chen Shih, Wan-Long Chuang
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2007)