期刊
BMC IMMUNOLOGY
卷 15, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1471-2172-15-9
关键词
Allergic rhinitis; Interleukin-10; Eosinophils; Mast cells; T-cell subsets; Regulatory T cells
类别
资金
- National Nature Science Foundation of China (NSFC) [81070766]
- NSFC [81020108018, 81325006, 81300813]
- Young Foundation of Hubei University of Science and Technology [KY10058]
- Ministry of Health of China [201202005]
Background: Interleukin-10 (IL-10) has an important anti-inflammatory and immunoregulatory function, and its expression is negatively correlated with the development and severity of allergic rhinitis (AR). However, the in vivo effects of exogenous IL-10 on AR have not been studied and the mechanisms underlying the effects of IL-10 have not been fully understood. Here, we investigated the effects of intranasal administration of recombinant mouse (rm) IL-10 on the expression of Th responses and local IL-10 in a mouse model of AR induced by ovalbumin. Results: Administration of rmIL-10 during challenge significantly reduced the number of eosinophils and mast cells, as well as Type 2 helper T (Th2) and Th17 cell related cytokine and transcription factor levels in the nasal mucosa and nasal lavage fluid in AR mice. The rmIL-10 treatment significantly inhibited the number of IL-10-positive cells and IL-10 mRNA expression in the nasal mucosa in AR mice. Conclusion: Our results show that exogenous IL-10 administrated in challenge phase alleviates nasal allergic inflammation in AR mice, most likely by inhibiting Th2 and Th17 responses. It can also inhibit local IL-10 levels in the nasal mucosa. Our findings indicate that IL-10 may have the potential as an inhibitor of AR.
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