Article
Biochemistry & Molecular Biology
Shi-Le Wang, Man-Man Zhang, Han Zhou, Guo-Qiang Su, Yi Ding, Guang-Hui Xu, Xu Wang, Cheng-Fu Li, Wei-Feng Huang, Li-Tao Yi
Summary: This study suggests that inhibition of NLRP3 inflammasome regulates gut microbiota and attenuates IBD-like symptoms, providing a basis for the clinical application of NLRP3 as a target for the treatment of IBD.
BIOMEDICAL JOURNAL
(2023)
Article
Nutrition & Dietetics
Tao Wang, Junquan Tian, Wenxuan Su, Fan Yang, Jie Yin, Qian Jiang, Yuying Li, Kang Yao, Tiejun Li, Yulong Yin
Summary: This study evaluated the optimal dosage of ornithine a-ketoglutarate (OKG) and explored its preventive effect on DSS-induced colitis in mice. Results showed that 1% OKG supplementation increased body weight, serum growth hormone (GH), insulin (INS), alkaline phosphatase (ALP), and certain amino acids, while decreasing urea nitrogen (BUN), NH3L, and Ile. Moreover, 1% OKG supplementation prevented DSS-induced colitis in mice by altering microbial compositions and reducing the secretion of inflammatory cytokines in serum.
Article
Veterinary Sciences
Yitong Zhang, Lanmei Yin, Xianglin Zeng, Jun Li, Yuebang Yin, Qiye Wang, Jianzhong Li, Huansheng Yang
Summary: The study investigated the effects of high-dose iron on intestinal damage and regeneration in mice with colitis. The results showed that high-dose iron exacerbated intestinal injury but promoted intestinal repair by regulating intestinal epithelial cell renewal and intestinal stem cell activity.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Neeracha Sangpreecha, Saoraya Chanmuang, Kyung-Hee Park, Madhuri Sangar, Divya Sharma, Doyoung Song, Yun-Ja Park, Hea-Mi Sung, Kitipong Promyo, Kyung-Sik Ham
Summary: This study compared the effects of fresh and fermented onions on gut health in rats for the first time. The findings have potential implications for the development of healthy food products using onions. Fresh onion is high in FODMAPs, which may be problematic for inflammatory bowel disease (IBD). Fermentation of onion could help reduce FODMAP issues and increase the availability of beneficial compounds like quercetin. The study demonstrated that high doses of fermented onion improved IBD symptoms, while fresh onion consumption appeared to worsen the condition.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Ming-Luen Hu, Wei-Shiung Lian, Feng-Sheng Wang, Chao-Hui Yang, Wan-Ting Huang, Jing-Wen Yang, I-Ya Chen, Ming-Yu Yang
Summary: Recent studies have shown that dysbiosis is associated with inflammatory bowel disease (IBD). Trying to restore microbial diversity via fecal microbiota transplantation (FMT) or probiotic intervention fails to achieve clinical benefit in IBD patients. This study performed a probiotic intervention on a simulated IBD murine model and found that the intervention changed microbial composition but did not improve colitis and colitis-associated neoplasms, and even caused dysbiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Meng Xu, Hui Xue, Gaoxiang Qiao, Mingfu Liao, Li Kong, Qingfeng Zhang, Lezhen Lin, Licong Yang, Guodong Zheng
Summary: This study found that Smilax china L. polyphenols (SCP) have therapeutic effects on inflammatory bowel diseases (IBD). SCP can improve the symptoms of IBD by regulating inflammatory factors, inhibiting oxidative stress, reducing intestinal tissue damage, and regulating the ecological imbalance of intestinal microbiota.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Chemistry, Medicinal
Ahmed M. Kabel, Aliaa Atef, Hany M. Borg, Azza A. K. El-Sheikh, Hana J. Al Khabbaz, Hany H. Arab, Remon S. Estfanous
Summary: This study investigated the effects of perindopril and ambrosin, alone or in combination, on DSS-induced colitis in mice. The results showed that both perindopril and ambrosin were able to alleviate oxidative stress, suppress proinflammatory pathways, inhibit apoptosis, and enhance autophagy in colonic tissues. The combination of perindopril and ambrosin had the most remarkable effects compared to either agent alone.
Article
Agriculture, Dairy & Animal Science
Qing Gu, Ziqi Chen, Nana Liu, Chenlan Xia, Qingqing Zhou, Ping Li
Summary: This study found that ingestion of L. plantarum ZJ316-fermented milk effectively alleviates chronic colitis by suppressing the inflammatory response and regulating intestinal microbiota.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Guitao Huang, Zhineng Wang, Guangxu Wu, Ruifen Zhang, Lihong Dong, Fei Huang, Mingwei Zhang, Dongxiao Su
Summary: The study found that supplementation with lychee pulp phenolics (LPP) could alleviate DSS-induced gut barrier damage, activate the microbiota-SCFA-FFAR signaling cascade, and suppress the TLR4/NLRP3-NF-κB pathway, showing promise in protecting the intestinal tract.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Jia-Li Wang, Xiao Han, Jun-Xiang Li, Rui Shi, Lei-Lei Liu, Kai Wang, Yu-Ting Liao, Hui Jiang, Yang Zhang, Jun-Cong Hu, Li-Ming Zhang, Lei Shi
Summary: The study reveals the differential intestinal microbiota and metabolites in the pathogenesis of ulcerative colitis (UC), suggesting that different microbiota and metabolites may cause varying degrees of colitis. Some microbiota and metabolites may have protective roles against colitis, influencing the composition and function of intestinal mucus barrier under colitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Integrative & Complementary Medicine
Wenbin Dai, Longhai Long, Xiaoqiang Wang, Sen Li, Houping Xu
Summary: This review surveyed the in vivo effects of phytochemicals targeting TLR4 in different models of IBD and highlighted the significance of TLR4 as a therapeutic target for IBD.
Article
Food Science & Technology
Hye-Jung Moon, Suk-Heung Oh, Ki-Bum Park, Youn-Soo Cha
Summary: This study investigated the alleviating effects of kimchi and Leuconostoc mesenteroides DRC 1506 on ulcerative colitis (UC). Mice were orally given a dose of 1 x 10(9) CFU/day of freeze-dried kimchi suspension and DRC for 3 weeks, and UC was induced with dextran sulfate sodium (DSS). The results showed that the kimchi and DRC groups reduced colitis symptoms and improved the inflammatory response and mucosal barrier function in the colon.
Article
Nutrition & Dietetics
Minhao Xie, Xianzhu Zhang, Xiaoxiao Wang, Guijie Chen, Jianhui Liu, Xiaoxiong Zeng, Wenjian Yang
Summary: Dietary non-starch polysaccharides and phenolics are both considered prebiotics and regulate the intestinal microbiota through different mechanisms. In this study, the effects of arabinoxylan (AX) and chlorogenic acid (CA) on the intestinal microbiota of dextran sulfate sodium (DSS)-treated mice were investigated. The data showed that CA attenuated the negative effects of DSS, while AX seemed to weaken the beneficial effects of CA.
FRONTIERS IN NUTRITION
(2022)
Review
Cell Biology
Elise E. Bruning, Janet K. Coller, Hannah R. Wardill, Joanne M. Bowen
Summary: TLR4 is a highly conserved protein involved in innate immunity with distinct roles in epithelial and immune cells throughout the gastrointestinal tract. While epithelial cell expression of TLR4 contributes to maintaining homeostasis, promoting immunoglobulin A production, and regulating permeability, immune cell expression is centered on maturation of dendritic cells and priming the adaptive immune system. However, further research is needed to fully understand the impact of site-specific TLR4 expression on inflammation and disease progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Ping-Yun Fan-Jiang, Pei-Sheng Lee, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: The study showed that PTS significantly reduced the accumulation of plasma interleukin6 induced by HFD and DSS, inhibited the formation of aberrant crypt foci, and decreased the colon weight-to-length ratio in HFD/DSS-induced colitis mice. PTS also suppressed the expressions of IL-1 beta, CHOP, COX-2, and TGF-beta 1/Smad2, while maintaining Muc2 and E-cadherin expressions. Post-treatment with PTS further reduced the colon weight-to-length ratio and loss of Muc2 in HFD/DSS-induced colitis mice, indicating its potential in preventing colitis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Veterinary Sciences
R. L. Pfeifle, E. M. Beasley, N. E. Crabtree, C. Fraser, J. A. Elbert, E. Ducker, K. Nagata, B. C. Garner, K. Sakamoto
Summary: A 27-year-old Arabian pony presented with weight loss, neutropenia, thrombocytopenia, and a bony lesion of the proximal left femur. Despite medical management and palliative radiation, the patient developed acute neurological signs and required euthanasia.
EQUINE VETERINARY EDUCATION
(2021)
Article
Parasitology
Christopher C. Evans, Katherine M. Day, Yi Chu, Bridget Garner, Kaori Sakamoto, Andrew R. Moorhead
Summary: The Mongolian jird has been found to be permissive to Brugia malayi but nonpermissive to Dirofilaria immitis. In vitro experiments showed that there is high cell attachment to live D. immitis and low attachment to B. malayi, indicating a species-dependent response. Heat-killing and pre-incubation of parasites affected cell attachment, suggesting a role for excretory/secretory products in host immune evasion and/or antigenicity.
PARASITES & VECTORS
(2021)
Article
Multidisciplinary Sciences
Vanessa O. Ezenwa, Sarah A. Budischak, Peter Buss, Mauricio Seguel, Gordon Luikart, Anna E. Jolles, Kaori Sakamoto
Summary: Pathogen interactions during coinfection may worsen disease severity, as host immune responses shaped by historical evolutionary interactions can affect defenses against different pathogens. In a study on wild mammals, natural resistance to worms independently influenced bovine tuberculosis (BTB) severity, with resistant individuals more likely to die from BTB and experiencing quicker disease progression. Anthelmintic treatment moderated, but did not eliminate, this effect, suggesting different mechanisms at play for resistance and active worm infection in impacting BTB progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Veterinary Sciences
Kara D. Wyatt, Kaori Sakamoto, Wendy T. Watford
Summary: The study reveals significant changes in cellular infiltration in mice treated with tamoxifen, causing lung inflammation, without observable clinical symptoms.
LABORATORY ANIMALS
(2022)
Article
Multidisciplinary Sciences
Kara D. Wyatt, Demba Sarr, Kaori Sakamoto, Wendy T. Watford
Summary: Tpl2 plays a basal regulatory role in the antiviral response in lung epithelial cells during influenza A virus infection, but does not have a significant impact on host cytokine production or lung pathology.
Article
Biochemistry & Molecular Biology
Oliver Shey-Njila, Ahmed F. Hikal, Tuhina Gupta, Kaori Sakamoto, Hind Yahyaoui Azami, Wendy T. Watford, Frederick D. Quinn, Russell K. Karls
Summary: This study examines the role of the P-type ATPase CtpB in the response to host nutritional immunity in Mycobacterium tuberculosis(M.tb). It was found that CtpB plays a crucial role in acquiring or transporting copper to the copper-dependent respiration supercomplex. The findings highlight the importance of elucidating copper-uptake mechanisms in pathogenic mycobacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Carolin M. Lieber, Robert M. Cox, Julien Sourimant, Josef D. Wolf, Kate Juergens, Quynh Phung, Manohar T. Saindane, Meghan K. Smith, Zachary M. Sticher, Alexander A. Kalykhalov, Michael G. Natchus, George R. Painter, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper
Summary: Molnupiravir shows equal inhibition against SARS-CoV-2 variants of concern and reduces pathogenicity in a dwarf hamster model. However, treatment efficacy varies in individuals infected with omicron and is not significant in females.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Tuhina Gupta, Naveen Somanna, Thomas Rowe, Monica LaGatta, Shelly Helms, Simon Odera Owino, Tomislav Jelesijevic, Stephen Harvey, Wayne Jacobs, Thomas Voss, Kaori Sakamoto, Cheryl Day, Christopher Whalen, Russell Karls, Biao He, S. Mark Tompkins, Abhijeet Bakre, Ted Ross, Frederick D. Quinn
Summary: Despite the COVID-19 pandemic, tuberculosis remains a leading cause of human death. Ferrets have been successfully used as a model to study the transmission of Mycobacterium tuberculosis, with their infection leading to clinical signs and pathological features similar to acute disease in larger animals. Infected ferrets can transmit the bacteria to other ferrets, and the efficiency of transmission is higher when the transmitting animal has a well-established acute infection. This study supports further assessment of the ferret model for tuberculosis transmission and testing prevention measures and vaccine efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Julien Sourimant, Carolin M. Lieber, Jeong-Joong Yoon, Mart Toots, Mugunthan Govindarajan, Venkata Udumula, Kaori Sakamoto, Michael G. Natchus, Joseph Patti, John Vernachio, Richard K. Plemper
Summary: Respiratory syncytial virus (RSV) is a major cause of lower respiratory infections in infants and the immuno-compromised. A study has identified a compound called AVG that can inhibit RSV RNA synthesis, potentially providing a therapeutic solution for RSV disease.
Meeting Abstract
Toxicology
N. M. Filipov, R. S. Mote, K. Sakamoto, T. Gupta, O. K. Wallon, J. M. Carpenter
TOXICOLOGY LETTERS
(2022)
Article
Microbiology
Krishna Latha, Sanjana Rao, Kaori Sakamoto, Wendy T. Watford
Summary: This study demonstrates the protective role of the serine-threonine mitogen-activated protein kinase, Tpl2, in influenza virus pathogenesis and reveals that host Tpl2 deficiency is sufficient to convert a low-pathogenicity influenza A virus infection into severe influenza disease that resembles ARDS, both histopathologically and transcriptionally. The IAV-infected Tpl2(-/-) mouse thereby represents a novel murine model for studying ARDS-like disease that could improve our understanding of this aggressive disease and assist in the design of better diagnostics and treatments.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Hilary Ann Lakin, Hannah Tavalire, Kaori Sakamoto, Peter Buss, Michele Miller, Sarah A. Budischak, Kristina Raum, Vanessa O. Ezenwa, Brianna Beechler, Anna Jolles
Summary: The progression of bovine tuberculosis in African buffalo resembles that in experimental cattle models, providing insight into the disease and its interaction with the host in a natural environment.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
Carolin Lieber, Megha Aggarwal, Jeong-Joong K. Yoon, Robert A. Cox, Hae-Ji M. Kang, Julien A. Sourimant, Mart T. Toots, Scott M. Johnson, Cheryl Jones, Zachary R. Sticher, Alexander G. Kolykhalov, Manohar Saindane, Stephen K. Tompkins, Oliver Planz, George Painter, Michael Natchus, Kaori Sakamoto, Richard Plemper
Summary: The nucleoside analog 4'-fluorouridine has been shown to effectively inhibit a broad spectrum of influenza viruses in various cell culture and animal models. It acts as a chain terminator of the influenza virus polymerase and has the potential to be a therapeutic option for vulnerable patient groups and pandemic influenza.
Article
Immunology
Tuhina Gupta, Demba Sarr, Kayla Fantone, Nuha Milad Ashtiwi, Kaori Sakamoto, Frederick D. Quinn, Balazs Rada
Summary: Mtb is the primary cause of human tuberculosis, but the role of Duox1 in bacterial infections remains largely unknown. This study showed that in a mouse model, Duox1 is dispensable for the overall clinical course of Mtb lung infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Parasitology
Andrew R. Moorhead, Christopher C. Evans, Kaori Sakamoto, Michael T. Dzimianski, Abdelmoneim Mansour, Utami DiCosty, Crystal Fricks, Scott McCall, Ben Carson, C. Thomas Nelson, John W. McCall
Summary: According to the study, using doxycycline prior to adulticide administration can effectively reduce the levels of Wolbachia and its associated metabolites, which are a leading cause of pulmonary pathology. The current guidelines recommend a 30-day wait period after using doxycycline, but this wait period may not be necessary. Therefore, reducing the wait period and doxycycline dosage may bring practical benefits to animals, pet owners, and veterinarians.
PARASITES & VECTORS
(2023)