Article
Nutrition & Dietetics
Daniel Merenstein, Claire M. Fraser, Robert F. Roberts, Tian Liu, Silvia Grant-Beurmann, Tina P. Tan, Keisha Herbin Smith, Tom Cronin, Olivia A. Martin, Mary Ellen Sanders, Sean C. Lucan, Maureen A. Kane
Summary: Probiotic Bifidobacterium animalis subsp. lactis BB-12 demonstrates protection against antibiotic-induced disruptions in gut microbiota and short-chain fatty acids, enhancing microbial recovery. Compared to the control group, the BB-12 group showed smaller changes in fecal acetate levels and less loss in gut microbiota diversity after antibiotic treatment.
Article
Pharmacology & Pharmacy
Yadong Li, Li Zhang, Ping Zhang, Zhiying Hao
Summary: The study demonstrated that dehydrocorydaline (Deh) alleviates sepsis-induced cardiomyocyte injury by inhibiting the TRAF6/NF-kappa B pathway, showing anti-inflammatory and anti-oxidative stress properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Xiaokang Niu, Nana Zhang, Shusen Li, Ning Li, Ran Wang, Qi Zhang, Jingjing He, Erna Sun, Xiaohong Kang, Jing Zhan
Summary: This study aimed to investigate the preventive effects of Bifidobacterium animalis subsp. lactis MN-Gup and fermented milk containing MN-Gup against high fat diet-induced obesity and endotoxemia in mice. The results showed that MN-Gup could significantly protect mice against body weight gain, increased fat percentage, dyslipidemia, and increased lipopolysaccharides. Fermented milk containing MN-Gup had better preventive effects on fat percentage and dyslipidemia than fermented milk without MN-Gup.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Hyun-Su Lee, Gil-Saeng Jeong
Summary: This study found that 6,7,4'-trihydroxyflavanone (THF) can alleviate DSS-induced colitis by regulating the activity of T cells and colon cells through the NF kappa B and MAPK pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Yingxue Yue, Yuqi Wang, Qinggang Xie, Xiuli Lv, Linyi Zhou, Etareri Evivie Smith, Ting Cao, Yifan Zhang, Bailiang Li, Guicheng Huo, Weiwei Ma
Summary: Changes in intestinal barrier functions during sepsis were evaluated by injecting lipopolysaccharide (LPS) into mice. The probiotic effect of Bifidobacterium strains (BB, BL, BB12, and BLBB) was studied. The BLBB group showed improved ileal villus length, increased immune cells, reduced serum levels of DAO and D-lactic acid, increased expression of tight junction proteins and mucin, decreased inflammatory cytokines, and altered gut microbiota composition. Bifidobacterium bifidum E3 combined with Bifidobacterium longum subsp. infantis E4 showed promise in protecting against LPS-induced intestinal injury.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zuoxing Wu, Chen Li, Yu Chen, Qian Liu, Na Li, Xuemei He, Weibin Li, Rong Shen, Li Li, Chenming Wei, Siyuan Shao, Fangsheng Fu, Jiaxin Ding, Xiaochen Sun, Dairong Wang, Guixin Yuan, Yiji Su, Jinmin Zhao, Jiake Xu, Ren Xu, Xin Xu, Feng Xu
Summary: Bone homeostasis relies on the balance between osteoblasts and osteoclasts. Excessive activation of osteoclasts leads to bone resorption diseases. Chrysin (CHR) has inhibitory effects on osteoclasts and may serve as a potential therapeutic agent for osteolytic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Xin Dong, Jialin Jiang, Zhijun Lin, Ruijia Wen, Ling Zou, Tong Luo, Zhuoji Guan, Xuan Li, Linhai Wang, Lu Lu, Huan Li, Yusheng Huang, Zhongqi Yang, Junyan Wang, Xiaohan Ye, Xiaohua Hong, Lingjun Wang, Shaoxiang Xian, Zixin Chen
Summary: This study demonstrated that Nuanxinkang (NXK) has a protective effect on ischemia/reperfusion (IR)-induced heart failure (HF). NXK modulates the ratio of proinflammatory and anti-inflammatory macrophages, reducing inflammation and improving cardiac function. The results suggest that NXK could be a natural strategy for the anti-inflammatory treatment of HF.
Article
Biochemistry & Molecular Biology
Chunxiu Lin, Yugui Lin, Shunhe Wang, Jialiang Wang, Xuhua Mao, Yonghua Zhou, Hao Zhang, Wei Chen, Gang Wang
Summary: The study demonstrates that pretreatment with B. animalis subsp. lactis can reshape the gut microbiota and influence the systemic immune responses of neonatal rats against Salmonella infection by modifying the composition and metabolism of the gut microbiota.
Article
Dermatology
Hafeez Rahman, Dileep Kumar, Tong Liu, Nwanneka Okwundu, David Lum, Scott R. Florell, Christin E. Burd, Kenneth M. Boucher, Matthew W. VanBrocklin, Douglas Grossman
Summary: Aspirin can reduce UVB-induced DNA damage and skin cancer, decrease inflammation and DNA damage lesions, and delay the onset of non-melanoma and squamous cell carcinoma while translating into greater chemopreventive efficacy than melanoma in mouse models.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
So-Ra Kim, Kyung-Joo Seong, Won-Jae Kim, Ji-Yeon Jung
Summary: EGCG protects microglia from hypoxia-induced inflammation and oxidative stress through inhibition of the NF-κB pathway and activation of the Nrf-2/HO-1 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Dalia Kamal Mostafa, Maha M. Eissa, Doaa A. Ghareeb, Shaymaa Abdulmalek, Wafaa A. Hewedy
Summary: The study found that resveratrol has an anti-fibrotic effect and can halt the progression of hepatic schistosomiasis by targeting the SIRT1/NF-kappa B signaling pathway.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Yan-yan Yu, Xiang-qian Li, Wen-peng Hu, Shi-chao Cu, Jia-jia Dai, Ya-nan Gao, Yi-ting Zhang, Xiao-yi Bai, Da-yong Shi
Summary: The NF-kappa B inhibitor 270 showed anti-inflammatory effects in LPS-induced AKI and ALI, improving pathological changes, reducing pro-inflammation gene expression, blocking NF-kappa B and JNK pathway activation, attenuating oxidative stress and autophagy inhibition, and reducing inflammation markers in plasma.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yi Cheng, Feng Li, Wen-Sheng Zhang, Guo-You Zou, Yi-Xin Shen
Summary: The study reveals that silencing BLNK can delay the progression of OA and IL-1 beta-induced chondrocyte injury by regulating the NF Kappa B pathway.
Article
Pharmacology & Pharmacy
Xiu-lian Lin, Ya-ning Shi, Yu-ling Cao, Xi Tan, Ya-ling Zeng, Shi-teng Luo, Ya-mei Li, Li Qin, Bo-hou Xia, Rong-geng Fu, Li-mei Lin, Kai Li, Deliang Cao, Jian-guo Zeng, Duan-fang Liao
Summary: This study found that Sanguinarine (SA) significantly prevented small intestinal inflammatory lesions induced by NSAIDs through the regulation of the Nrf2 pathway and NF-kappa Bp65 pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Jun Tang, Bo Yang, Yinkun Yan, Wenfeng Tong, Renke Zhou, Junhui Zhang, Jie Mi, Duo Li
Summary: This study found an inverse association between circulating POA and primary hypertension in humans, and demonstrated that exogenous POA supplementation can decrease systolic blood pressure and improve aortic remodeling by inhibiting NF-kappa B-mediated inflammation in spontaneously hypertensive rats.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Pediatrics
Susan Byrne, Hailey Sledge, Ruth Franklin, Fiona Boland, Deirdre M. Murray, Jonathan Hourihane
Summary: Babies born during the COVID-19 pandemic and lockdown period have shown deficits in social communication skills compared to a historical cohort, possibly due to limited exposure to social interaction.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Multidisciplinary Sciences
Katherine M. Kennedy, Marcus C. de Goffau, Maria Elisa Perez-Munoz, Marie-Claire Arrieta, Fredrik Backhed, Peer Bork, Thorsten Braun, Frederic D. Bushman, Joel Dore, Willem M. de Vos, Ashlee M. Earl, Jonathan A. Eisen, Michal A. Elovitz, Stephanie C. Ganal-Vonarburg, Michael G. Ganzle, Wendy S. Garrett, Lindsay J. Hall, Mathias W. Hornef, Curtis Huttenhower, Liza Konnikova, Sarah Lebeer, Andrew J. Macpherson, Ruth C. Massey, Alice Carolyn McHardy, Omry Koren, Trevor D. Lawley, Ruth E. Ley, Liam O'Mahony, Paul W. O'Toole, Eric G. Pamer, Julian Parkhill, Jeroen Raes, Thomas Rattei, Anne Salonen, Eran Segal, Nicola Segata, Fergus Shanahan, Deborah M. Sloboda, Gordon C. S. Smith, Harry Sokol, Tim D. Spector, Michael G. Surette, Gerald W. Tannock, Alan W. Walker, Moran Yassour, Jens Walter
Summary: The colonization of microbial communities in the human fetus and the prenatal intrauterine environment is still controversial. Recent studies analyzing microbial populations in human fetuses indicate that the detected signals might be due to contamination during sample collection or DNA sequencing processes. The presence of live and replicating microbial populations in healthy fetal tissues contradicts fundamental concepts in immunology and clinical microbiology. This has significant implications for our understanding of human immune development and highlights the challenges in studying microbial communities in low-biomass environments.
Article
Multidisciplinary Sciences
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan, Nino Stocker, Anja Heider, Patrick Westermann, Silvio Steiner, Anita Dreher, Paulina Wawrzyniak, Beate Ruckert, Juan Rodriguez-Coira, Damir Zhakparov, Mengting Huang, Bogdan Jakiela, Marek Sanak, Marcin Moniuszko, Liam O'Mahony, Marek Jutel, Tatiana Kebadze, J. David Jackson, R. Michael Edwards, Volker Thiel, L. Sebastian Johnston, A. Cezmi Akdis, Milena Sokolowska
Summary: Viral infections and exposure to inhaled allergens, such as rhinovirus and house dust mite, are associated with asthma exacerbations. In this study, the authors found that rhinovirus-induced activation of the RIG-I inflammasome suppresses antiviral immunity, promotes inflammation, and aggravates subsequent infection with SARS-CoV-2, particularly after exposure to house dust mite. Understanding these mechanisms could lead to more effective treatment strategies for asthma and respiratory virus infections.
NATURE COMMUNICATIONS
(2023)
Correction
Multidisciplinary Sciences
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan, Nino Stocker, Anja Heider, Patrick Westermann, Silvio Steiner, Anita Dreher, Paulina Wawrzyniak, Beate Ruckert, Juan Rodriguez-Coira, Damir Zhakparov, Mengting Huang, Bogdan Jakiela, Marek Sanak, Marcin Moniuszko, Liam O'Mahony, Marek Jutel, Tatiana Kebadze, David J. Jackson, Michael R. Edwards, Volker Thiel, Sebastian L. Johnston, Cezmi A. Akdis, Milena Sokolowska
NATURE COMMUNICATIONS
(2023)
Article
Allergy
Duygu Yazici, Eren Cagan, Ge Tan, Manru Li, Evan Do, Ozan C. Kucukkase, Abdurrahman Simsek, Muhammed Ali Kizmaz, Tugce Bozkurt, Tamer Aydin, Anja Heider, Beate Ruckert, Marie-Charlotte Bruggen, Raja Dhir, Liam O'Mahony, Mubeccel Akdis, Kari C. Nadeau, Ferah Budak, Cezmi A. Akdis, Ismail Ogulur
Summary: This study assessed the potential of biomarkers of epithelial barrier dysfunction in predicting severe COVID-19. The results showed significantly elevated levels of circulating bacterial DNA in severe COVID-19 cases, while serum bacterial DNA levels in mild cases were significantly lower than in healthy controls, suggesting tightness of the epithelial barrier as a predictor of a mild disease course. The study also identified potential early biomarkers and proteins associated with disease progression and mortality in COVID-19 patients.
Article
Allergy
Alexandra F. Santos, Carmen Riggioni, Ioana Agache, Cezmi A. Akdis, Mubeccel Akdis, Alberto Alvarez-Perea, Montserrat Alvaro-Lozano, Barbara Ballmer-Weber, Simona Barni, Kirsten Beyer, Carsten Bindslev-Jensen, Helen A. Brough, Betul Buyuktiryaki, Derek Chu, Stefano Del Giacco, Audrey Dunn-Galvin, Bernadette Eberlein, Motohiro Ebisawa, Philippe Eigenmann, Thomas Eiwegger, Mary Feeney, Montserrat Fernandez-Rivas, Helen R. Fisher, David M. Fleischer, Mattia Giovannini, Claudia Gray, Karin Hoffmann-Sommergruber, Susanne Halken, Jonathan O'B. Hourihane, Christina J. Jones, Marek Jutel, Edward Knol, George N. Konstantinou, Gideon Lack, Susanne Lau, Andreina Marques Mejias, Mary Jane Marchisotto, Rosan Meyer, Charlotte G. Mortz, Beatriz Moya, Antonella Muraro, Caroline Nilsson, Lucila Camargo Lopes de Oliveira, Liam O'Mahony, Nikolaos G. Papadopoulos, Kirsten Perrett, Rachel L. Peters, Marcia Podesta, Lars K. Poulsen, Graham Roberts, Hugh A. Sampson, Juergen Schwarze, Peter Smith, Elizabeth Huiwen Tham, Eva Untersmayr, Ronald Van Ree, Carina Venter, Brian P. Vickery, Berber Vlieg-Boerstra, Thomas Werfel, Margitta Worm, George Du Toit, Isabel Skypala
Summary: This guideline from the European Academy of Allergy and Clinical Immunology provides recommendations for diagnosing IgE-mediated food allergy, including clinical history, tests for determining IgE sensitization, and the use of oral food challenges for confirmation.
Article
Allergy
Nonhlanhla Lunjani, Anoop T. Ambikan, Carol Hlela, Michael Levin, Avumile Mankahla, Jeannette I. Heldstab-Kast, Tadech Boonpiyathad, Ge Tan, Can Altunbulakli, Clive Gray, Kari C. Nadeau, Ujjwal Neogi, Cezmi A. Akdis, Liam O'Mahony
Summary: The study found that children with atopic dermatitis have a distinct gene expression pattern in their peripheral blood mononuclear cells. Early life exposures, including animals, time outdoors, and types of cooking and heating fuels, have the most significant effects on the immune cell transcriptome. Differences in gene expression patterns were also observed between rural and urban areas.
Article
Allergy
Marek Jutel, Ioana Agache, Magdalena Zemelka-Wiacek, Mubeccel Akdis, Tomas Chivato, Stefano del Giacco, Pawel Gajdanowicz, Ibon Eguiluz Gracia, Ludger Klimek, Antti Lauerma, Markus Ollert, Liam O'Mahony, Jurgen Schwarze, Mohamed H. Shamji, Isabel Skypala, Oscar Palomares, Oliver Pfaar, Maria Jose Torres, Jonathan A. Bernstein, Alvaro A. Cruz, Stephen R. Durham, Stephen J. Galli, R. Maximiliano Gomez, Emma Guttman-Yassky, Tari Haahtela, Stephen T. Holgate, Kenji Izuhara, Kenji Kabashima, Desiree E. Larenas-Linnemann, Erica von Mutius, Kari C. Nadeau, Ruby Pawankar, Tomas A. E. Platts-Mills, Scott H. Sicherer, Hae-Sim Park, Stefan Vieths, Gary Wong, Luo Zhang, M. Beatrice Bilo, Cezmi A. Akdis
Summary: The exponential growth of precision diagnostic tools has led to vast amounts of data enabling in-depth disease characterization. New disease endotypes have been identified, moving from symptom-focused descriptions to identifying biomarkers and intricate pathways. The current disease taxonomy must be revised for better categorization.
Article
Gastroenterology & Hepatology
Jonathan M. Keane, Vanessa Las Heras, Jorge Pinheiro, Jamie A. FitzGerald, Maria A. Nunez-Sanchez, Cara M. Hueston, Liam O'Mahony, Paul D. Cotter, Colin Hill, Silvia Melgar, Cormac G. M. Gahan
Summary: A high-fat diet reduces resistance to Listeria monocytogenes, but short-term administration of Akkermansia muciniphila increases resistance to oral and systemic infection of L. monocytogenes in mice fed a high-fat diet. A. muciniphila reduces inflammation in the gut and liver, and normalizes the inflammatory cell infiltration in the ileum. It does not significantly affect the microbiota composition or microbial metabolites.
Article
Gastroenterology & Hepatology
Junhui Li, Tarini Shankar Ghosh, Rachel McCann, Patrick Mallon, Colin Hill, Lorraine Draper, David Schult, Liam J. Fanning, Robert Shannon, Corinna Sadlier, Mary Horgan, Liam O'Mahony, Paul W. O'Toole
Summary: In this meta-analysis, the association between the gut microbiome and COVID-19 disease severity was investigated. It was found that disease severity was associated with taxonomic and functional microbiome differences, which peaked between 7-30 days after diagnosis and gradually returned to a configuration similar to that of healthy individuals. A core set of species consistently associated with disease severity was identified, and Actinomyces oris abundance was found to predict the mortality rate of COVID-19. Additionally, the composition of intestinal archaeal, fungal, viral, and parasitic communities was associated with disease severity.
Article
Biochemistry & Molecular Biology
Tim Hensen, Daniel Faessler, Liam O'Mahony, Werner C. Albrich, Beatrice Barda, Christian Garzoni, Gian-Reto Kleger, Urs Pietsch, Noemie Suh, Johannes Hertel, Ines Thiele
Summary: This study characterized the serum metabolomic changes in hospitalized COVID-19 patients and identified potential biomarkers for disease severity. The findings showed significant alterations in metabolite concentrations related to hospitalization, physiological functioning, and disease progression. These results provide insights into monitoring the course of COVID-19 and offer a wide range of potential biomarkers for further study.
Review
Allergy
P. K. Smith, C. Venter, L. O'Mahony, R. Berni Canani, O. J. L. Lesslar
Summary: Sugars can form compounds called AGEs when they bind to proteins, nucleic acids or lipids. Factors in the Western diet such as high sugar levels, protein dehydration, high temperature sterilization, frying, and microwaving can lead to excessive dietary AGEs. The increased consumption of dietary AGEs may be correlated with the rise in food allergy.
FRONTIERS IN ALLERGY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Damir Zhakparov, Kathleen Moriarty, Nonhlanhla Lunjani, Marco Schmid, Carol Hlela, Michael Levin, Avumile Mankahla, Cezmi Akdis, Liam O'Mahony, Katja Baerenfaller, Damian Roqueiro
Summary: High throughput RNA sequencing (RNA-Seq) allows for profiling of transcripts in multiple samples. Standard methods are limited by high dimensionality and imbalanced sample-to-feature ratio. Machine learning-based feature selection methods can address these limitations.
MACHINE LEARNING AND PRINCIPLES AND PRACTICE OF KNOWLEDGE DISCOVERY IN DATABASES, ECML PKDD 2022, PT II
(2023)
Article
Biochemistry & Molecular Biology
Romain Bagnol, Claudia Siverino, Vincent Barnier, Liam O'Mahony, Dirk W. Grijpma, David Eglin, T. Fintan Moriarty
Summary: In this study, a negatively charged exopolysaccharide from Bifidobacterium longum (EPS624) was used in multilayered polyelectrolyte coatings with positively charged chitosan, and its immunoregulatory and cytocompatible properties were investigated. The results showed that the polyelectrolyte coatings exhibited excellent cytocompatibility and stable immunoregulatory effects, making them suitable for biomedical engineering applications.
Review
Allergy
Franziska Roth-Walter, Roberto Berni Canani, Liam O'Mahony, Diego Peroni, Milena Sokolowska, Emilia Vassilopoulou, Carina Venter
Summary: Nutritional Immunity is an important innate immune response that restricts pathogens' access to nutrients and their uptake by the gut mucosa. However, this response can also contribute to non-communicable diseases and hinder nutrient uptake and distribution in the body. Research suggests that while certain micronutrients may be hindered during inflammation, the lymphatic system remains available. Clinical trials have shown that increasing the intake of antioxidants, vitamins, and minerals can reduce inflammation and improve disease outcomes.