Article
Public, Environmental & Occupational Health
Njekwa Mukamba, Anjali Sharma, Chanda Mwamba, Herbert Nyirenda, Marksman Foloko, Kasapo Lumbo, Katerina Christopoulos, Sandra Simbeza, Kombatende Sikombe, Charles B. Holmes, Elvin H. Geng, Izukanji Sikazwe, Carolyn Bolton-Moore, Laura K. Beres
Summary: This study examined the HIV care experiences and health priorities of PLHIV during the first wave of COVID-19 outbreak in Lusaka, Zambia. The findings indicated that changes in health system policies and economic hardships had both positive and negative impacts on HIV care.
Article
Public, Environmental & Occupational Health
Javies Ngui Joel, Patrick Awuor, Natalia Blanco, Marie-Claude C. Lavoie, Taylor Lascko, Carol Ngunu, Jonathan Mwangi, Immaculate Mutisya, Caroline Ng'eno, Rebecca Wangusi, Emily Koech
Summary: This study describes the implementation strategies and outcomes of the index testing program in Nairobi County, Kenya. The index testing services were well-accepted and effective in identifying individuals living with HIV, both in the general population and key populations.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Dorothy C. Nyemba, Emma Kalk, Michael J. Vinikoor, Hlengiwe P. Madlala, Mwangelwa Mubiana-Mbewe, Maureen Mzumara, Carolyn Bolton Moore, Amy L. Slogrove, Andrew Boulle, Mary-Ann Davies, Landon Myer, Kathleen Powis
Summary: Infants born HIV-exposed yet remain uninfected (HEU) are at increased risk of poorer growth and health compared to infants born HIV-unexposed (HU). The effects of maternal antiretroviral treatment (ART) on the growth of HEU infants are not well understood. Differences in risks between high burden HIV settings have not been extensively explored.
Article
Public, Environmental & Occupational Health
Anais Mennecier, Beauty Matoka, Maria Melany Wilfred-Tonga, Catherine Chunda-Liyoka, Mwiya Mwiya, Nicolas Nagot, Jean-Pierre Moles, Philippe van de Perre, Chipepo Kankasa, Rachel King, PROMISE EPI Social Sci Sub Study Grp
Summary: This study found that using lamivudine as post-natal prophylaxis for preventing HIV transmission through breastfeeding is more advantageous than using a triple drug prophylaxis. The formulation and taste of the triple drug prophylaxis posed barriers to adherence. The extended use of lamivudine proposed in the PROMISE-EPI study was well accepted and strategies to improve adherence were identified.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Health Policy & Services
Ana C. Villegas, Deanna Saylor, Michelle Kvalsund, Masharip Atadzhanov, Clarence Chiluba, Lorraine Chishimba, Stanley Zimba, Mashina Chomba, Omar K. Siddiqi
Summary: The study investigated opportunities for task shifting in an outpatient neurology clinic in Zambia to address overcrowding and long wait times. By analyzing patient flow and conducting interviews, it was found that shifting stable patients to less specialized healthcare workers for follow-ups and medication refills could substantially reduce wait times.
HUMAN RESOURCES FOR HEALTH
(2021)
Article
Obstetrics & Gynecology
Mario Jesus Trejo, Amr S. Soliman, Yuli Chen, Mulele Kalima, Alick Chuba, Eslone Chama, Catherine K. Mwaba, Lewis Banda, Kennedy Lishimpi
Summary: This study examined the association between the duration of HIV infection and the stage of cervical cancer in Lusaka, Zambia. Results showed that HIV-positive women were more likely to be diagnosed with early-onset cervical cancer, and a longer duration of HIV infection was associated with lower odds of initial metastatic cancer diagnosis among HIV-positive patients. Further examination of the cervical screening program's impact on the relationship between cervical screening, age, duration of HIV infection, and stage of cervical cancer diagnosis in this population is recommended.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Medicine, General & Internal
Chanda Mwamba, Laura K. Beres, Stephanie M. Topp, Njekwa Mukamba, Sandra Simbeza, Kombatende Sikombe, Aaloke Mody, Elvin Geng, Charles B. Holmes, Caitlin E. Kennedy, Izukanji Sikazwe, Julie A. Denison, Carolyn Bolton Moore
Summary: The fear of side effects and the need to mentally prepare for lifelong treatment were cited as reasons for delaying ART initiation among HIV patients in Zambia. Healthcare systems should address patient-specific concerns and fears to support rapid acceptance of treatment, rather than relying on fear-based messaging about the consequences of missing doses or changing treatment times. Social stigma surrounding HIV remains a significant barrier to treatment initiation.
ANNALS OF MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Helene J. Smith, Michael E. Herce, Chilambwe Mwila, Peter Chisenga, Chisenga Yenga, Besa Chibwe, Vivien Mai, Lillian Kashela, Mirriam Nanyagwe, Sisa Hatwiinda, Clement N. Moonga, Maurice Musheke, Yotam Lungu, Izukanji Sikazwe, Stephanie M. Topp
Summary: In sub-Saharan Africa, incarcerated people have a higher HIV burden than the general population. Little is known about their transition to and post-release experience with care in the community. To address this gap, a qualitative study was conducted in Zambia to describe factors that may influence post-release HIV care continuity.
GLOBAL HEALTH-SCIENCE AND PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Jake M. Pry, Kombatende Sikombe, Aaloke Mody, Shilpa Iyer, Jacob Mutale, Natalie Vlahakis, Theodora Savory, Mwanza Wa Mwanza, Keith Mweebo, Annie Mwila, Consity Mwale, Mpande Mukumbwa-Mwenechanya, Andrew D. Kerkhoff, Izukanji Sikazwe, Carolyn Bolton Moore, Daniel Mwamba, Elvin H. Geng, Michael E. Herce
Summary: The Zambian Ministry of Health issued COVID-19 mitigation guidance for HIV care, which successfully increased the proportion of early clinic return and reduced the proportion of late visits. The implementation of these measures had a positive impact on HIV care in Zambia.
Article
Ethics
Kasoka Kasoka, Matthew Weait
Summary: This study explores the views of participants from Zambia on personal autonomy in HIV testing. The results show that participants view interdependence, rather than autonomy, as an essential characteristic of being human. Their views have the potential to provide a contextual and appropriate ethical foundation for HIV testing policies.
JOURNAL OF BIOETHICAL INQUIRY
(2022)
Article
Economics
Simon Manda, Nyambe Mukanda
Summary: This study examines whether REDD+ Projects in private tenure arrangements can provide livelihood benefits and development in rural communities. Through a case study in Zambia, it explores the convergence of private capital in rural areas and the impact of this coordination arrangement on local communities. Findings indicate that private tenure arrangements result in resource restrictions, unequal benefit sharing, and a loss of community agency. While some infrastructure developments have been funded through carbon payments, REDD+ activities have been limited and have contributed to inequalities and gender differentiation. Continued deforestation and traditional charcoal production in project areas demonstrate community disempowerment. Therefore, REDD+ schemes in private tenure arrangements are likely to be precarious and hinder political reactions and alternative livelihood possibilities.
FOREST POLICY AND ECONOMICS
(2023)
Article
Medicine, General & Internal
Jake M. Pry, Chilambwe Mwila, Herbert Kapesa, Musunge Mulabe, Christiana Frimpong, Misinzo Moono, Theodora Savory, Carolyn Bolton-Moore, Michael E. Herce, Shilpa Iyer
Summary: This study aimed to estimate potential silent transfer among individuals new to HIV care in Lusaka, Zambia. The results showed that participants aged 40+ years and those with no formal education had a significantly higher prevalence of potential silent transfer. The high proportion of potential silent transfers indicates an opportunity to improve care continuity at the time of HIV care entry.
Article
Medicine, General & Internal
Cassidy W. Claassen, Daliso Mumba, Mwansa Njelesani, Derrick Nyimbili, Linah K. Mwango, Mundia Mwitumwa, Ellen Mubanga, Lloyd B. Mulenga, Tina Chisenga, Brooke E. Nichols, Cheryl Hendrickson, Lastone Chitembo, Jackson Okuku, Heidi O'Bra
Summary: Zambia successfully implemented national PrEP service delivery, with 3626 individuals starting PrEP in the first year and 23,327 individuals by the second year. Key lessons include the use of risk-based criteria for PrEP service, the importance of training healthcare workers, and the need for expansion into community education for full potential.
Article
Public, Environmental & Occupational Health
Eileen A. Yam, Edith Namukonda, Tracy McClair, Samir Souidi, Nachela Chelwa, Nelly Muntalima, Michael Mbizvo, Ben Bellows
Summary: By providing a chatbot service in the waiting areas of family planning clinics, HIV information can be delivered to FP clients before their consultations, preparing them to discuss their dual HIV and pregnancy prevention needs with their providers. FP clients expressed particular interest in learning more about PrEP, underscoring the importance of integrating HIV into FP services.
GLOBAL HEALTH-SCIENCE AND PRACTICE
(2022)
Review
Health Care Sciences & Services
Sunny C. Okoroafor, Christmal Dela Christmals
Summary: A scoping review was conducted to synthesize evidence on task shifting and task sharing in Africa. The review identified 61 studies, with 53 providing insights on the rationale and scope of task shifting and task sharing. The rationales included health worker shortages, optimal utilization of existing health workers, and expanding access to health services. The scope of services shifted or shared in 23 countries included HIV/AIDS, tuberculosis, hypertension, diabetes, mental health, eyecare, maternal and child health, sexual and reproductive health, surgical care, medicines' management, and emergency care.
Article
Immunology
Austin Tucker, Tannia Tembo, Radhika P. Tampi, Jacob Mutale, Mpande Mukumba-Mwenechanya, Anjali Sharma, David W. Dowdy, Carolyn B. Moore, Elvin Geng, Charles B. Holmes, Izukanji Sikazwe, Hojoon Sohn
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2020)
Article
Immunology
Charles S. Morrison, G. Justus Hofmeyr, Katherine K. Thomas, Helen Rees, Neena Philip, Thesla Palanee-Phillips, Kavita Nanda, Gonasagrie Nair, Maricianah Onono, Timothy D. Mastro, Maggie Lind, Renee Heffron, Vinodh Edward, Jen Deese, Mags E. Beksinska, Ivana Beesham, Jeffrey S. A. Stringer, Jared M. Baeten, Khatija Ahmed
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2020)
Article
Obstetrics & Gynecology
Kartik K. Venkatesh, Catherine J. Vladutiu, Angelica Glover, Robert A. Strauss, Jeffrey S. A. Stringer, David M. Stamilio, Brenna Hughes, Sarah Dotters-Katz
Summary: In an era of routine GBS screening and prophylaxis, maternal colonization with GBS was associated with slightly lower odds of chorioamnionitis, while the risk of postpartum infectious outcomes did not increase.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Immunology
Aaloke Mody, David Glidden, Ingrid Eshun-Wilson, Kombatende Sikombe, Sandra Simbeza, Njekwa Mukamba, Paul Somwe, Laura K. Beres, Jake Pry, Carolyn Bolton-Moore, Nancy Padian, Charles B. Holmes, Izukanji Sikazwe, Elvin H. Geng
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Medicine, General & Internal
Andrew D. Kerkhoff, Kombatende Sikombe, Ingrid Eshun-Wilson, Izukanji Sikazwe, David V. Glidden, Jake M. Pry, Paul Somwe, Laura K. Beres, Sandra Simbeza, Chanda Mwamba, Chama Bukankala, Cardinal Hantuba, Carolyn Bolton Moore, Charles B. Holmes, Nancy Padian, Elvin H. Geng
Article
Immunology
Jake Pry, Jenala Chipungu, Helene J. Smith, Carolyn Bolton Moore, Jacob Mutale, Miquel Duran-Frigola, Theodora Savory, Michael E. Herce
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2020)
Article
Immunology
Laura K. Beres, Sheree Schwartz, Sandra Simbeza, John McGready, Ingrid Eshun-Wilson, Chanda Mwamba, Kombatende Sikombe, Stephanie M. Topp, Paul Somwe, Aaloke Mody, Njekwa Mukamba, Peter D. Ehrenkranz, Nancy Padian, Jake Pry, Carolyn Bolton Moore, Charles B. Holmes, Izukanji Sikazwe, Julie A. Denison, Elvin Geng
Summary: This study tracked disengaged HIV patients and found that 73.0% of patients returned to HIV care, with decreasing return rates over time. Interventions are needed to improve patient trust in treatment, and differential interventions based on individual circumstances may be more effective in promoting re-engagement.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Article
Acoustics
Qianqian Cai, Chang Peng, Jian-Yu Lu, Juan C. Prieto, Alan J. Rosenbaum, Jeffrey S. A. Stringer, Xiaoning Jiang
Summary: The study proposed a hemispherical marker rigid body to improve the tracking performance of ultrasound probes, reducing self-occlusion issues and providing a larger rotational range. The system equipped with this design showed high tracking accuracy and superior data capturing ability in experiments.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Obstetrics & Gynecology
Chileshe M. Mabula-Bwalya, Megan E. Smithmyer, Humphrey Mwape, Gabriel Chipili, Madelyn Conner, Bellington Vwalika, Kristina De Paris, Jeffrey S. A. Stringer, Joan T. Price
Summary: Biomarker concentrations were similar between cases and controls. Participants with concomitant low sEng and high sFLT-1 had the highest odds of SGA, suggesting that a combination of biomarkers may be better for predicting SGA than single biomarkers.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Medicine, General & Internal
Chanda Mwamba, Laura K. Beres, Stephanie M. Topp, Njekwa Mukamba, Sandra Simbeza, Kombatende Sikombe, Aaloke Mody, Elvin Geng, Charles B. Holmes, Caitlin E. Kennedy, Izukanji Sikazwe, Julie A. Denison, Carolyn Bolton Moore
Summary: The fear of side effects and the need to mentally prepare for lifelong treatment were cited as reasons for delaying ART initiation among HIV patients in Zambia. Healthcare systems should address patient-specific concerns and fears to support rapid acceptance of treatment, rather than relying on fear-based messaging about the consequences of missing doses or changing treatment times. Social stigma surrounding HIV remains a significant barrier to treatment initiation.
ANNALS OF MEDICINE
(2022)
Review
Immunology
Izukanji Sikazwe, Carolyn Bolton-Moore, Michael B. Herce
Summary: This paper provides a case study of how NGOs like CIDRZ can play a pivotal role in the health system by identifying, integrating, and scaling up evidence-based practices for HIV prevention, care, and treatment. It emphasizes the importance of local NGOs in bringing their deep understanding of the context and knowledge of local health problems to the HIV response.
CURRENT OPINION IN HIV AND AIDS
(2023)
Article
Acoustics
Qianqian Cai, Jiale Hu, Mengyue Chen, Juan Prieto, Alan J. Rosenbaum, Jeffrey S. A. Stringer, Xiaoning Jiang
Summary: This study developed an IMU-assisted ultrasonic tracking system that achieved high accuracy positional and orientational localization. The system was designed using acoustic pressure field simulation, receiver configuration, position-variant error simulation, and sensor fusion. The prototype was tested within the typical operation speed ranges and compared with a commercial optical tracking device, showing centimeter-level positional tracking accuracy and sub-degree orientational tracking accuracy. These results indicate the potential of implementing the IMU-assisted ultrasonic tracking system in US probe localization.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Medicine, General & Internal
Herbert Chabwera Nyirenda, Marksman Foloko, Carolyn Bolton-Moore, Jaime Vera, Anjali Sharma
Summary: Research conducted on adolescent boys and young men in urban Lusaka highlighted the impact of gender and rural-urban disparities on their HIV testing behaviors. The study emphasizes the importance of creating targeted interventions that address the specific needs and barriers faced by this population in accessing HIV prevention and treatment services.
Article
Public, Environmental & Occupational Health
Jake M. Pry, Albert Manasyan, Sharon Kapambwe, Katayoun Taghavi, Miquel Duran-Frigola, Mulindi Mwanahamuntu, Izukanji Sikazwe, Jane Matambo, Jack Mubita, Kennedy Lishimpi, Kennedy Malama, Carolyn Bolton Moore
Summary: The study examined cervical cancer screening among different age groups in Zambia and found that HIV-positive women were more likely to test positive. Younger women (<= 29 years) with HIV had the highest predictive probability of screening positive. Customized sensitization strategies could improve uptake and adherence to screening.
LANCET GLOBAL HEALTH
(2021)
Article
Immunology
Aaloke Mody, Kombatende Sikombe, Laura K. Beres, Sandra Simbeza, Njekwa Mukamba, Ingrid Eshun-Wilson, Sheree Schwartz, Jake Pry, Nancy Padian, Charles B. Holmes, Carolyn Bolton-Moore, Izukanji Sikazwe, Elvin H. Geng
Summary: This study identified 5 profiles of HIV care disruptions in 547 patients from 64 clinics in Zambia, including Livelihood and Mobility, Clinic Accessibility, Mobility and Family, Doubting Need for HIV care, and Multidimensional Barriers to Care. These profiles were significantly associated with patients' care status, providing insights for more effective interventions targeting specific barriers.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)