Article
Evolutionary Biology
Laura Martinez-Gomez, Daniel Cerdan-Velez, Federico Abascal, Michael L. Tress
Summary: Tandem duplicated exon substitution events are rare but highly important alternative splicing events. The isoforms produced from these events are often highly expressed and have more pathogenic mutations compared to other splice events. The important structural and functional residues in the homologous regions are conserved, with most changes being conservative. The isoforms produced from these events are tissue-specific, particularly in nervous and cardiac tissues, and are enriched in functional terms related to structures in the brain and skeletal muscle. Additionally, there is evidence of convergent evolution of these events in vertebrates, arthropods, and nematodes.
GENOME BIOLOGY AND EVOLUTION
(2022)
Review
Endocrinology & Metabolism
Panyisha Wu, Moya Zhang, Nicholas J. G. Webster
Summary: Alternative RNA splicing is an important biological process that has been linked to various clinical syndromes, but its applicability to common diseases is still uncertain. This review focuses on the changes in alternative RNA splicing in fatty liver disease and the role of splicing regulation in disease progression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
A. Gallo, D. Dolfini, A. Bernardini, N. Gnesutta, R. Mantovani
Summary: NF-YA, the regulatory subunit of the trimeric CCAAT-binding transcription factor NF-Y, has multiple alternative spliced isoforms, and NF-YAx and NF-YAg are enriched in Aves and play a major role in early chicken embryo development. In addition, the absence of exon-5 in NF-YAg leads to a global reduction of beta-stranded elements, while removal of the disordered exon-3 sequence has limited effects on TAD architecture.
Article
Biotechnology & Applied Microbiology
Ang Qu, Yulin Bai, Xinyi Zhang, Junjia Zeng, Fei Pu, Linni Wu, Peng Xu, Tao Zhou
Summary: In this study, the molecular mechanisms and regulation processes for the large yellow croaker's resistance to Cryptocryon irritans infection were investigated. The results showed that alternative splicing and differentially expressed isoforms play important roles in the immune response, providing insights into the immune-related roles of DAS and DEIs in the infection process of L. crocea.
MARINE BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francisco Carranza, Hossein Shenasa, Klemens J. Hertel
Summary: Alternative splicing is a highly combinatorial mechanism that allows higher eukaryotes to increase mRNA diversity. The selection of alternative splice sites is influenced by sequence, cis-regulatory elements, exon and intron length, and RNA secondary structures. The study showed that the mode of splice site recognition, either intron or exon definition, plays a role in alternative splicing decisions.
Review
Immunology
Jianli Zhou, Qiao Zhang, Yuzhen Zhao, Yuchen Song, Yanan Leng, Moxian Chen, Shaoming Zhou, Zhaoxia Wang
Summary: Inflammatory bowel disease (IBD) is a group of chronic diseases including Crohn's disease and ulcerative colitis, which have a global impact on both children and adults. The burden of IBD is increasing worldwide, and the costs associated with it are high. The pathogenesis of IBD is still unclear, but is believed to be related to environmental factors, gut microbiota, immune imbalance, and genetic susceptibility. This article reviews the research progress on alternative splicing events, splicing factors, and splicing mutations associated with IBD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Entomology
Jie Jiang, Li-Xin Huang, Feng Chen, Cheng-Wang Sheng, Qiu-Tang Huang, Zhao-Jun Han, Chun-Qing Zhao
Summary: The study on the resistance to dieldrin gene (RDL) of the small brown planthopper revealed that the four splice variants of exon 9 have a significant impact on the sensitivity of LsRDL. The alternative splicing of exon 9 broadens the functional capabilities of the GABAR in L. striatellus by influencing the action of GABA.
Review
Biochemistry & Molecular Biology
Yunqi Chao, Yonghui Jiang, Mianling Zhong, Kaiyan Wei, Chenxi Hu, Yifang Qin, Yiming Zuo, Lili Yang, Zheng Shen, Chaochun Zou
Summary: Alternative splicing plays a crucial role in regulating gene expression patterns post-transcriptionally, particularly in adipogenesis. Aberrant expression and alterations in splicing regulators are linked to mutations in obesity-related genes, indicating their potential role in diet-induced obesity and metabolic dysregulation. Research on the splicing machinery's interaction with obesity and metabolic disorders provides insights for potential therapeutic strategies in clinical settings.
CELL AND BIOSCIENCE
(2021)
Article
Oncology
Peng Han, Peng Cao, Jiaqi Yue, Kangle Kong, Shan Hu, Yu Deng, Lequn Li, Fan Li, Bo Zhao
Summary: This study found that hnRNPA1 affects the migration, invasion, and EMT transition of lung cancer cells by regulating the splicing of LAS1L gene. The expression of hnRNPA1 in lung cancer tissues showed heterogeneity and may provide new directions for research and potential therapeutic targets in lung cancer metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Plant Sciences
Xiao-Xiao Liu, Qian-Huan Guo, Wei-Bo Xu, Peng Liu, Kang Yan
Summary: Plants use diverse strategies and complex regulations to adapt to changing environmental conditions. In addition to direct gene transcription regulation, alternative splicing plays a crucial role in coping with various stresses.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Miaomiao Liu, Jihua Guo, Rong Jia
Summary: Alternative RNA splicing is an important cellular process that, when dysregulated, contributes to cancer development. Dysregulated expression of splicing factors is involved in oral squamous cell carcinoma. Therapeutic approaches targeting RNA splicing are being developed.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jia Liu, Dekang Lv, Xiaobin Wang, Ruicong Wang, Xiaodong Li
Summary: This study systematically analyzed the survival-related AS signal in ovarian serous cystadenocarcinoma and established a new comprehensive prognostic model based on seven AS events. The models were highly efficient in distinguishing patient survival and showed higher prediction ability than mRNA signature, which could be used as potential predictor and therapeutic target for patients with OV.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eun Ji Lee, Seung-Jae Noh, Huiseon Choi, Min Woo Kim, Su Jin Kim, Yeon Ah Seo, Ji Eun Jeong, Inkyung Shin, Jong-Seok Kim, Jong-Kwon Choi, Dae-Yeon Cho, Suhwan Chang
Summary: This study used RNA-seq analysis to investigate the changes in splicing patterns and correlations of tissue-specific genes during primary-patient derived xenograft (PDX) tumor formation. The results revealed significant changes in splicing patterns and overall strong positive correlations between primary and PDX tumors, except for gastric cancer cases. These findings suggest that tissue specificity and splicing events may play a role in primary-PDX integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ping Ye, Yan Yang, Liqiang Zhang, Guixi Zheng
Summary: This study identified 2,212 AS events significantly associated with overall survival in esophageal carcinoma patients from TCGA database. Prognostic signatures based on these AS events were established through multivariate analysis, with risk score proving to be an independent survival factor. The interaction network between AS events and splicing factors revealed hub genes and AS events warranting further investigation, providing novel insights into tumorigenesis and progression mechanisms of esophageal carcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yuka Ikeda-Iwabu, Yoshiaki Taniyama, Naruto Katsuragi, Fumihiro Sanada, Nobutaka Koibuchi, Kana Shibata, Kenzo Shimazu, Hiromi Rakugi, Ryuichi Morishita
Summary: The study found that POSTN in cancer cells can be detected using an Ex17 antibody but not an Ex12 antibody. A short fragment of POSTN with exon 17 was identified in the fraction secreted from fibroblasts. POSTN with exon 17 specifically bound to wnt3a, and this binding was inhibited by the Ex17 antibody.
Article
Endocrinology & Metabolism
Anne M. A. Tryggestad, Karol Axcrona, Ulrika Axcrona, Iris Bigalke, Bjorn Brennhovd, Else M. Inderberg, Turid K. Honnashagen, Lisbeth J. Skoge, Guri Solum, Stein Saeboe-Larssen, Dag Josefsen, Richard W. Olaussen, Steinar Aamdal, Rolf I. Skotheim, Tor A. Myklebust, Dolores J. Schendel, Wolfgang Lilleby, Svein Dueland, Gunnar Kvalheim
Summary: This study aimed to reduce the risk of biochemical relapse in high-risk prostate cancer patients after robot-assisted laparoscopic prostatectomy by administering personalized dendritic cell vaccines as adjuvant therapy. The results showed promising efficacy of the vaccine in reducing biochemical relapse incidence, as well as associations between baseline immune response and vaccine response during the vaccination period. Further investigation in larger cohorts is warranted to validate these findings and explore the potential of dendritic cell vaccines in post-surgical treatment of high-risk prostate cancer.
Letter
Gastroenterology & Hepatology
Marjolijn C. J. Jongmans, Junxiao Zhang, Roland P. Kuiper, Nicoline Hoogerbrugge, Marjolijn J. L. Ligtenberg, Richarda M. de Voer
Article
Oncology
Kristina T. Carm, Bjarne Johannessen, Mari Bogaard, Anne Cathrine Bakken, Aase Maltau, Andreas M. Hoff, Ulrika Axcrona, Karol Axcrona, Ragnhild A. Lothe, Rolf Skotheim
Summary: Our study highlights the spatio-temporal heterogeneity of multifocal prostate cancer and emphasizes the importance of testing a recent sample in genomics-based precision medicine for metastatic prostate cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Marta Cardoso, Sofia Maia, Andreia Brandao, Ruta Sahasrabudhe, Paul Lott, Natalia Belter, Luis G. Carvajal-Carmona, Paula Paulo, Manuel R. Teixeira
Summary: The study identified PRUNE2 as a novel prostate cancer predisposition gene, with pathogenic/likely pathogenic germline variants found in 2.8% of the patients. This is the first report of such variants in PRUNE2 in patients with early-onset/familial prostate cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Jose Garcia-Pelaez, Rita Barbosa-Matos, Silvana Lobo, Alexandre Dias, Luzia Garrido, Sergio Castedo, Sonia Sousa, Hugo Pinheiro, Liliana Sousa, Rita Monteiro, Joaquin J. Maqueda, Susana Fernandes, Fatima Carneiro, Nadia Pinto, Carolina Lemos, Carla Pinto, Manuel R. Teixeira, Stefan Aretz, Svetlana Bajalica-Lagercrantz, Judith Balmana, Ana Blatnik, Patrick R. Benusiglio, Maud Blanluet, Vincent Bours, Hilde Brems, Joan Brunet, Daniele Calistri, Gabriel Capella, Sergio Carrera, Chrystelle Colas, Karin Dahan, Robin de Putter, Camille Desseignes, Elena Dominguez-Garrido, Conceicao Egas, D. Gareth Evans, Damien Feret, Eleanor Fewings, Rebecca C. Fitzgerald, Florence Coulet, Maria Garcia-Barcina, Maurizio Genuardi, Lisa Golmard, Karl Hackmann, Helen Hanson, Elke Holinski-Feder, Robert Huneburg, Mateja Krajc, Kristina Lagerstedt-Robinson, Conxi Lazaro, Marjolijn J. L. Ligtenberg, Cristina Martinez-Bouzas, Sonia Merino, Genevieve Michils, Srdjan Novakovic, Ana Patino-Garcia, Guglielmina Nadia Ranzani, Evelin Schrock, Ines Silva, Catarina Silveira, Jose L. Soto, Isabel Spier, Verena Steinke-Lange, Gianluca Tedaldi, Maria-Isabel Tejada, Emma R. Woodward, Marc Tischkowitz, Nicoline Hoogerbrugge, Carla Oliveira
Summary: This study analyzed families carrying rare CDH1 variants, comparing the cancer spectrum in carriers of pathogenic or likely pathogenic variants (PV/LPV) or missense variants of unknown significance, and evaluated the performance of expanded criteria for CDH1 testing. The results showed that PV/LPV carriers were positively associated with lobular breast cancer, diffuse gastric cancer, and gastric cancer, while missense variants of unknown significance did not show this positive association.
Review
Gastroenterology & Hepatology
Marisa Linhares, Claudia Marques Pinto, Diogo Libanio, Manuel R. Teixeira, Mario Dinis-Ribeiro, Catarina Brandao
Summary: Gastric adenocarcinoma is a common and deadly cancer worldwide. Screening the general population is recommended in eastern countries, but may not be cost-effective in low to intermediate-risk countries. Therefore, it is important to identify high-risk populations for adequate screening and surveillance. This review summarizes the data required to identify individuals at risk and highlights the importance of hereditary syndromes and screening protocols.
GE PORTUGUESE JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Genetics & Heredity
Burcu F. Darst, Jiayi Shen, Ravi K. Madduri, Alexis A. Rodriguez, Yukai Xiao, Xin Sheng, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Thomas J. Hoffmann, Kenneth Muir, Peggy Wan, Loic Le Marchand, Lynne Wilkens, Ying Wang, Johanna Schleutker, Robert J. MacInnis, Cezary Cybulski, David E. Neal, Borge G. Nordestgaard, Sune F. Nielsen, Jyotsna Batra, Judith A. Clements, Henrik Gronberg, Nora Pashayan, Ruth C. Travis, Jong Y. Park, Demetrius Albanes, Stephanie Weinstein, Lorelei A. Mucci, David J. Hunter, Kathryn L. Penney, Catherine M. Tangen, Robert J. Hamilton, Marie-Elise Parent, Janet L. Stanford, Stella Koutros, Alicja Wolk, Karina D. Sorensen, William J. Blot, Edward D. Yeboah, James E. Mensah, Yong-Jie Lu, Daniel J. Schaid, Stephen N. Thibodeau, Catharine M. West, Christiane Maier, Adam S. Kibel, Geraldine Cancel-Tassin, Florence Menegaux, Esther M. John, Eli Marie Grindedal, Kay-Tee Khaw, Sue A. Ingles, Ana Vega, Barry S. Rosenstein, Manuel R. Teixeira, Manoli Kogevinas, Lisa Cannon-Albright, Chad Huff, Luc Multigner, Radka Kaneva, Robin J. Leach, Hermann Brenner, Ann W. Hsing, Rick A. Kittles, Adam B. Murphy, Christopher J. Logothetis, Susan L. Neuhausen, William B. Isaacs, Barbara Nemesure, Anselm J. Hennis, John Carpten, Hardev Pandha, Kim De Ruyck, Jianfeng Xu, Azad Razack, Soo-Hwang Teo, Lisa F. Newcomb, Jay H. Fowke, Christine Neslund-Dudas, Benjamin A. Rybicki, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Jose Esteban Castelao, Paul A. Townsend, Dana C. Crawford, Gyorgy Petrovics, Graham Casey, Monique J. Roobol, Jennifer F. Hu, Sonja I. Berndt, Stephen K. van den Eeden, Douglas F. Easton, Stephen J. Chanock, Michael B. Cook, Fredrik Wiklund, John S. Witte, Rosalind A. Eeles, Zsofia Kote-Jarai, Stephen Watya, John M. Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman
Summary: In this study, the predictive ability of several genome-wide polygenic risk score (GW-PRS) approaches was compared to a recently developed PRS of established prostate cancer-risk variants. The findings suggest that the PRS269 developed from multi-ancestry GWASs and fine-mapping has better predictive ability for prostate cancer risk compared to current GW-PRS approaches.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Oncology
Denise G. O'Mahony, Susan J. Ramus, Melissa C. Southey, Nicola S. Meagher, Andreas Hadjisavvas, Esther M. John, Ute Hamann, Evgeny N. Imyanitov, Irene L. Andrulis, Priyanka Sharma, Mary B. Daly, Christopher R. Hake, Jeffrey N. Weitzel, Anna Jakubowska, Andrew K. Godwin, Adalgeir Arason, Anita Bane, Jacques Simard, Penny Soucy, Maria A. Caligo, Phuong L. Mai, Kathleen B. M. Claes, Manuel R. Teixeira, Wendy K. Chung, Conxi Lazaro, Peter J. Hulick, Amanda E. Toland, Inge Sokilde Pedersen, Susan L. Neuhausen, Ana Vega, Miguel de la Hoya, Heli Nevanlinna, Mallika Dhawan, Valentina Zampiga, Rita Danesi, Liliana Varesco, Viviana Gismondi, Valerio Gaetano Vellone, Paul A. James, Ramunas Janavicius, Liene Nikitina-Zake, Finn Cilius Nielsen, Thomas van Overeem Hansen, Tanja Pejovic, Ake Borg, Johanna Rantala, Kenneth Offit, Marco Montagna, Katherine L. Nathanson, Susan M. Domchek, Ana Osorio, Maria J. Garcia, Beth Y. Karlan, Anna De Fazio, David Bowtell, Lesley McGuffog, Goska Leslie, Michael T. Parsons, Thilo Doerk, Lisa-Marie Speith, Elizabeth Santana dos Santos, Alexandre Andre B. A. da Costa, Paolo Radice, Paolo Peterlongo, Laura Papi, Christoph Engel, Eric Hahnen, Rita K. Schmutzler, Barbara Wappenschmidt, Douglas F. Easton, Marc Tischkowitz, Christian F. Singer, Yen Yen Tan, Alice S. Whittemore, Weiva Sieh, James D. Brenton, Drakoulis Yannoukakos, Florentia Fostira, Irene Konstantopoulou, Jana Soukupova, Michal Vocka, Georgia Chenevix-Trench, Paul D. P. Pharoah, Antonis C. Antoniou, David E. Goldgar, Amanda B. Spurdle, Kyriaki Michailidou, Marian J. E. Mourits, Fabienne Lesueur
Summary: This study assessed the utility of ovarian tumour characteristics as predictors of BRCA1 and BRCA2 variant pathogenicity and provided evidence for improved classification and clinical management of carriers.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Ana Peixoto, Luis Cirnes, Ana Luisa Carvalho, Maria Joao Andrade, Maria Jose Brito, Paula Borralho, Pedro M. Borralho, Ana Sofia Carneiro, Lisandra Castro, Lurdes Correia, Maria Rita Dionisio, Carlos Faria, Paulo Figueiredo, Ana Gomes, Joana Paixao, Manuela Pinheiro, Hugo Prazeres, Joana Ribeiro, Natalia Salgueiro, Fernando C. Schmitt, Fatima Silva, Ana Rita Silvestre, Ana Carla Sousa, Joana Almeida-Tavares, Manuel R. Teixeira, Saudade Andre, Jose Carlos Machado
Summary: The U-PIK project aimed to validate and implement the PIK3CA mutation testing in multiple Portuguese centers, and the testing results showed high concordance rates between the method used by each tester center and NGS, demonstrating the importance of this test in clinical practice for ER+/HER2-BC patients eligible for PI3K alpha inhibitor treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Oncology
Taru Muranen, Anna Morra, Sofia R. Khan, Daniel K. Barnes, Manjeet Bolla, Joe Dennis, Renske Keeman, Goska T. Leslie, Michael Parsons, Qin U. Wang, Thomas Ahearn, Kristiina L. Aittomaeki, Irene K. Andrulis, Banu Arun, Sabine Behrens, Katarzyna E. Bialkowska, Stig J. Bojesen, Nicola Camp, Jenny Chang-Claude, Kamila Czene, Peter M. Devilee, Susan M. Domchek, Alison Dunning, Christoph Engel, D. Gareth Evans, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Anne-Marie Gerdes, Gord Glendon, Pascal Guenel, Eric Hahnen, Ute Hamann, Helen J. Hanson, Maartje Hooning, Reiner Hoppe, Louise Izatt, Anna A. Jakubowska, Paul N. James, Vessela Kristensen, Fiona J. Lalloo, Geoffrey Lindeman, Arto Mannermaa, Sara L. Margolin, Susan G. Neuhausen, William Newman, Paolo Peterlongo, Kelly-Anne Phillips, Miquel Angel Pujana, Johanna Rantala, Karina Ronlund, Emmanouil K. Saloustros, Rita Schmutzler, Andreas F. Schneeweiss, Christian Singer, Maija Suvanto, Yen Yen R. Tan, Manuel Teixeira, Mads Thomassen, Marc Tischkowitz, Vishakha Tripathi, Barbara Wappenschmidt, Emily F. Zhao, Douglas C. Easton, Antonis Antoniou, Georgia Chenevix-Trench, Paul D. P. K. Pharoah, Marjanka Schmidt, Carl Blomqvist, Heli Nevanlinna
Summary: This study assessed the PREDICT v 2.2 for prognosis of breast cancer patients with pathogenic germline BRCA1 and BRCA2 variants. The results showed that PREDICT had modest discrimination for BRCA1 carrier patients with ER-negative breast cancer, but clearly distinguished the high-mortality group from lower risk categories. However, for ER-positive breast cancer, the discrimination was slightly lower in BRCA2 variant carriers, and the inclusion of tumor grade distorted the prognostic estimates.
Article
Oncology
Paula Paulo, Marta Cardoso, Andreia Brandao, Pedro Pinto, Ariane Falconi, Manuela Pinheiro, Nuno Cerveira, Rui Silva, Catarina Santos, Carla Pinto, Ana Peixoto, Sofia Maia, Manuel R. Teixeira
Summary: Using targeted next-generation sequencing (T-NGS), this study examined 462 cases of early-onset/familial PrCa and identified a link between mutations in the IGF2R gene and susceptibility to PrCa.
GENES CHROMOSOMES & CANCER
(2023)
Article
Oncology
Joana Guerra, Carla Pinto, Pedro Pinto, Manuela Pinheiro, Catarina Santos, Ana Peixoto, Carla Escudeiro, Ana Barbosa, Miguel Porto, Ines Francisco, Paula Lopes, Ana Raquel Isidoro, Ana Luisa Cunha, Cristina Albuquerque, Isabel Claro, Carla Oliveira, Joao Silva, Manuel R. Teixeira
Summary: This study aimed to evaluate the contribution of CTNNA1 and CTNND1 germline variants to hereditary diffuse gastric cancer (HDGC) and compare the frequencies of CDH1 and CTNNA1 (and eventually CTNND1) germline variants between patients with diffuse and mixed gastric carcinomas. The findings revealed a high frequency of CDH1 pathogenic variants in HDGC patients, while the frequency of CTNNA1 and CTNND1 pathogenic variants was lower. No pathogenic variants were found in CDH1 and CTNNA1 in patients with mixed gastric cancer, suggesting that this tumor type may not be included in the genetic testing criteria.
Meeting Abstract
Medicine, General & Internal
Marta Cardoso, Sofia Maia, Andreia Brandao, Ruta Sahasrabudhe, Paul Lott, Natalia Belter, Luis G. Carvajal-Carmona, Paula Paulo, Manuel R. Teixeira
Meeting Abstract
Medicine, General & Internal
Maria P. Silva, Luisa T. Ferreira, Natercia F. Bras, Lurdes Torres, Andreia Brandao, Manuela Pinheiro, Marta Cardoso, Joana Vieira, Carlos M. Palmeira, Gabriela Martins, Sofia Maia, Helder Maiato, Manuel R. Teixeira, Paula Paulo
Article
Cell & Tissue Engineering
Ana Marote, Diogo Santos, Barbara Mendes-Pinheiro, Claudia Serre-Miranda, Sandra Anjo, Joana Vieira, Filipa Ferreira-Antunes, Joana Sofia Correia, Caroline Borges-Pereira, Andreia G. Pinho, Jonas Campos, Bruno Manadas, Manuel R. Teixeira, Margarida Correia-Neves, Luisa Pinto, Pedro M. Costa, Laurent Roybon, Antonio J. Salgado
Summary: This study compared the secretomes of long-term cultured BM-MSCs and iMSCs, and conducted a comprehensive characterization of both sources. The results showed that although there were significant differences in proliferation between the two sources, the secretome composition of both sources was similar in pre-senescent and senescent states. These findings suggest that shifting from BM-MSCs to a more advantageous source like iMSCs may yield similar therapeutic effects as the gold-standard MSC source.
STEM CELL REVIEWS AND REPORTS
(2023)