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Biochemistry & Molecular Biology
Yefei Shi, Bo Li, Xinru Huang, Wenxin Kou, Ming Zhai, Yanxi Zeng, Shuangjie You, Qing Yu, Yifan Zhao, Jianhui Zhuang, Wenhui Peng, Weixia Jian
Summary: This study found that TET2 was significantly downregulated under hypoxia and led to a global decrease of 5-hmC level. Knockdown of TET2 aggravated the hypoxia-induced dysfunction of endothelial cells, while overexpression of TET2 alleviated the dysfunction. The deficiency of TET2 in endothelial cells impaired blood flow recovery and capillary density. These findings provide solid evidence for TET2 as a therapeutic alternative for ischemic diseases.
CELL AND BIOSCIENCE
(2023)
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Immunology
Geethani Bandara, Guido H. Falduto, Andrea Luker, Yun Bai, Annika Pfeiffer, Justin Lack, Dean D. Metcalfe, Ana Olivera
Summary: The HMC-1.2 cell line expresses two oncogenic mutations, while the HMC-1.3 cell line expresses only one oncogenic mutation. The HMC-1.3 cells are more sensitive to interventional drugs and have increased tumorigenicity, suggesting they may serve as an improved preclinical model for mastocytosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Carsten Carlberg
Summary: The vitamin D metabolite 1 alpha,25-dihydroxyvitamin D-3 acts as a ligand for the transcription factor vitamin D receptor (VDR), and regulates the expression of target genes through chromatin changes. VDR binds to genomic DNA and interacts with partner proteins.
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Plant Sciences
Rowan Herridge, Samarth, Lynette Brownfield, Richard Macknight
Summary: The flowering of perennial ryegrass is crucial for both farmers and seed producers, as it affects metabolizable energy content and seed yield. Gene studies on flowering time regulation can provide insights into the growth and flowering processes of ryegrass.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Genetics & Heredity
Xiangfu Kong, Xuangang Wang, Moli Li, Weihao Song, Kejia Huang, Fengyan Zhang, Quanqi Zhang, Jie Qi, Yan He
Summary: A continuous skeletal muscle cell line from juvenile rockfish was established, showing predominant composition of myoblasts and key genes involved in proliferation and differentiation. The study provides a cell platform for future research on marine fish myoblast differentiation and myogenesis, opening a window into the understanding of indeterminate muscle growth in large teleosts.
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Plant Sciences
Dongna Ma, Zhengfeng Lai, Qiansu Ding, Kun Zhang, Kaizhen Chang, Shuhao Li, Zhizhu Zhao, Fenglin Zhong
Summary: We systematically identified orphan genes (OGs) in eight Cucurbitaceae species and found that the content and characteristics of OGs vary among species. Gene expression analysis and functional prediction revealed the importance of OGs in Cucurbitaceae species and domesticated crops.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Huanyu Du, Runting Ge, Ling Zhang, Jiangyan Zhang, Keping Chen, Chengjun Li
Summary: In this study, we used RNA-seq and qRT-PCR analysis to identify differentially expressed transcripts in Tribolium castaneum during different developmental stages. Functional enrichment analysis revealed that genes related to DNA replication, cell cycle, and insect hormone biosynthesis were significantly enriched. The transcription of DNA replication and cell cycle genes decreased after hatching but increased after pupation. The study also showed that silencing the ecdysteroid degradation gene CYP18A1 resulted in developmental arrest at the late larval stage. Overall, this research contributes to our understanding of insect growth and development.
Article
Biochemistry & Molecular Biology
Yoon-Young Kim, Kwang-Soo Kim, Yong-Jin Kim, Sung-Woo Kim, Hoon Kim, Seung-Yup Ku
Summary: The study extensively investigated premature ovarian insufficiency in females, identifying differentially expressed genes through RNA sequencing and highlighting the crucial role of miRNAs in regulation, especially in different stages of ovarian development impacting key genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Shuai Ye, Dinara Sharipova, Marya Kozinova, Lilli Klug, Jimson D'Souza, Martin G. Belinsky, Katherine J. Johnson, Margret B. Einarson, Karthik Devarajan, Yan Zhou, Samuel Litwin, Michael C. Heinrich, Ronald DeMatteo, Margaret von Mehren, James S. Duncan, Lori Rink
Summary: The management of Gastrointestinal Stromal Tumors (GISTs) has been greatly influenced by the identification of activating mutations in KIT and PDGFRA and the clinical application of RTK inhibitors. Despite the effectiveness of these inhibitors in most cases, resistance remains a clinical challenge, necessitating the identification of novel targets for refractory GISTs. Global kinome profiling shows promise in uncovering critical signaling networks and essential protein kinases in GISTs.
Article
Entomology
Zhijun Dai, Bangyong Sun, Yun Wang, Ze Zhang, Wei Sun
Summary: 20-hydroxyecdysone (20E) is an active insect ecdysteroid and a major phytoecdysteroid in some plants. Plants produce phytoecdysteroids as a defensive weapon against phytophagous insects, while insects have evolved resistance mechanisms. This study investigates how Spodoptera litura resists high dosage of 20E and compares the transcriptomics of two noctuid insects. The results show that different species of insects evolved different strategies to tolerate ingested 20E.
Article
Biotechnology & Applied Microbiology
Chen Sisi, Deng Jieru, Cheng Peidong, Zhang Zhaolong, Wang Yihang, Chen Shuwen, Tang Yan, Wang Tianyu, Yang Guiyan
Summary: This study investigated the stress response mechanism of walnut trees by analyzing the PP2C genes in walnut trees. The results showed that JrPP2C genes exhibited diversity in response to stress and ABA treatment, indicating their potential roles in plant response to multiple stimuli and involvement in ABA-dependent signaling pathway.
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Biotechnology & Applied Microbiology
Zhe-Ran Wu, Jian-Ting Fan, Na Tong, Jin-Meng Guo, Yang Li, Min Lu, Xiao-Long Liu
Summary: A total of 74 putative chemosensory genes were identified through transcriptome analysis of larvae heads in Plagiodera versicolora, providing new insights for functional studies on the chemoreception mechanism in this species.
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Plant Sciences
Guoan Shen, Ranran Wu, Yaying Xia, Yongzhen Pang
Summary: In studying the isoflavonoid biosynthetic pathway in kudzu, potential regulatory genes, including MYB, bHLH, and WD40 transcription factors, were identified. The expression of certain genes was closely correlated with the accumulation of isoflavonoids in different tissues and cell cultures of kudzu. Over-expression of a MYB gene in Arabidopsis thaliana resulted in increased accumulation of specific compounds, suggesting potential applications in bioengineering of bioactive isoflavonoids.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Huairen Zhang, Jie Zang, Yanqing Huo, Zhaogui Zhang, Huabang Chen, Xunji Chen, Juan Liu
Summary: This study identified the critical stage and major locus regulating maize seed germination speed through transcriptome analysis. It also proposed candidate genes that may regulate germination speed in maize.
Article
Entomology
Xiaoyan Zhu, Qiling Yu, Xingyu Gan, Liwen Song, Kaipeng Zhang, Tongtong Zuo, Junjie Zhang, Ying Hu, Qi Chen, Bingzhong Ren
Summary: This study identified and analyzed seven chemosensory gene families in B. dioryctriae and validated the expression bias of candidate genes in female antennae and ovipositors. These findings provide a molecular foundation for further research on the olfactory system of this parasitic wasp.
Article
Biochemistry & Molecular Biology
Andreas Nerlich, Nanthapon Ruangkiattikul, Kristin Laarmann, Nina Janze, Oliver Dittrich-Breiholz, Michael Kracht, Ralph Goethe
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2015)
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Cell Biology
Liane Jurida, Johanna Soelch, Marek Bartkuhn, Katja Handschick, Helmut Mueller, Doris Newel, Axel Weber, Oliver Dittrich-Breiholz, Heike Schneider, Sabin Bhuju, Vera V. Saul, M. Lienhard Schmitz, Michael Kracht
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Biochemistry & Molecular Biology
Christoph Lipps, Muhammad Badar, Milada Butueva, Tatyana Dubich, Vivek Vikram Singh, Sophie Rau, Axel Weber, Michael Kracht, Mario Koester, Tobias May, Thomas F. Schulz, Hansjoerg Hauser, Dagmar Wirth
CELLULAR AND MOLECULAR LIFE SCIENCES
(2017)
Correction
Biochemistry & Molecular Biology
Sonam Dhamija, Anneke Doerrie, Reinhard Winzen, Oliver Dittrich-Breiholz, Azadeh Taghipour, Nancy Kuehne, Michael Kracht, Helmut Holtmann
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Virology
Sharmistha Dam, Michael Kracht, Stephan Pleschka, M. Lienhard Schmitz
JOURNAL OF VIROLOGY
(2016)
Article
Cell Biology
Alfonso Rodriguez-Gil, Olesja Ritter, Juliane Hornung, Hilda Stekman, Marcus Krueger, Thomas Braun, Elisabeth Kremmer, Michael Kracht, M. Lienhard Schmitz
MOLECULAR BIOLOGY OF THE CELL
(2016)
Correction
Biochemistry & Molecular Biology
Ulas Tenekeci, Michael Poppe, Knut Beuerlein, Christin Buro, Helmut Mueller, Hendrik Weiser, Daniela Kettner-Buhrow, Katharina Porada, Doris Newel, Ming Xu, Zhijian J. Chen, Julia Busch, M. Lienhard Schmitz, Michael Kracht
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Biochemistry & Molecular Biology
Ulas Tenekeci, Michael Poppe, Knut Beuerlein, Christin Buro, Helmut Mueller, Hendrik Weiser, Daniela Kettner-Buhrow, Katharina Porada, Doris Newel, Ming Xu, Zhijian J. Chen, Julia Busch, M. Lienhard Schmitz, Michael Kracht
Review
Pharmacology & Pharmacy
M. Lienhard Schmitz, Michael Kracht
TRENDS IN PHARMACOLOGICAL SCIENCES
(2016)
Article
Multidisciplinary Sciences
Alfonso Rodriguez-Gil, Olesja Ritter, Vera V. Saul, Jochen Wilhelm, Chen-Yuan Yang, Rudolf Grosschedl, Yumiko Imai, Keiji Kuba, Michael Kracht, M. Lienhard Schmitz
SCIENTIFIC REPORTS
(2017)
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Microbiology
Michael Poppe, Sascha Wittig, Liane Jurida, Marek Bartkuhn, Jochen Wilhelm, Helmut Mueller, Knut Beuerlein, Nadja Karl, Sabin Bhuju, John Ziebuhr, M. Lienhard Schmitz, Michael Kracht
Article
Biochemistry & Molecular Biology
Maja Milanovic, Michael Kracht, M. Lienhard Schmitz
BIOCHEMICAL JOURNAL
(2014)
Review
Biochemistry & Molecular Biology
M. Lienhard Schmitz, Michael Kracht, Vera V. Saul
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2014)
Article
Gastroenterology & Hepatology
Haiying Li, Lillienne Chan, Paulina Bartuzi, Shelby D. Melton, Axel Weber, Shani Ben-Shlomo, Chen Varol, Megan Raetz, Xicheng Mao, Petro Starokadomskyy, Suzanne van Sommeren, Mohamad Mokadem, Heike Schneider, Reid Weisberg, Harm-Jan Westra, Tonu Esko, Andres Metspalu, Vinod Kumar, William A. Faubion, Felix Yarovinsky, Marten Hofker, Cisca Wijmenga, Michael Kracht, Lude Franke, Vincent Aguirre, Rinse K. Weersma, Nathan Gluck, Bart van de Sluis, Ezra Burstein
Article
Developmental Biology
Michael Stauber, Marina Weidemann, Oliver Dittrich-Breiholz, Katharina Lobschat, Leonie Alten, Michaela Mai, Anja Beckers, Michael Kracht, Achim Gossler
DEVELOPMENTAL BIOLOGY
(2017)