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Biochemistry & Molecular Biology
Elena Galati, Maria C. Bosio, Daniele Novarina, Matteo Chiara, Giulia M. Bernini, Alessandro M. Mozzarelli, Maria L. Garcia-Rubio, Belen Gomez-Gonzalez, Andres Aguilera, Thomas Carzaniga, Marco Todisco, Tommaso Bellini, Giulia M. Nava, Gianmaria Frige, Sarah Sertic, David S. Horner, Anastasia Baryshnikova, Caterina Manzari, Anna M. D'Erchia, Graziano Pesole, Grant W. Brown, Marco Muzi-Falconi, Federico Lazzaro
Summary: This study identifies VID22 as a novel regulator of genome integrity in yeast cells, involved in DNA double-strand break repair and protection of G4-DNA structures. Loss of VID22 leads to increased levels of endogenous DNA damage and hypersensitivity to G4-stabilizing ligands.
NUCLEIC ACIDS RESEARCH
(2021)
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Biochemistry & Molecular Biology
Malihe Mehdizadeh Allaf, Charles G. Trick
Summary: The study used a central composite design to investigate the effect of salinity, light intensity, and temperature on the toxicity, lipid, and protein production of H. akashiwo. The optimum conditions for toxicity, lipid production, and protein production were found to be 25°C temperature, 17.5 salinity, and 250 μmol photons m(-2) s(-1) light intensity. The combination of warm water and lower salinity can potentially enhance the toxicity of H. akashiwo, which is of great concern for aquaculture facilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
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Microbiology
Sylvia Kalli, Cindy Vallieres, Joseph Violet, Jan-Willem Sanders, John Chapman, Jean-Paul Vincken, Simon V. Avery, Carla Araya-Cloutier
Summary: The prenylated isoflavonoids glabridin and wighteone have been found to exhibit antifungal properties by disrupting the plasma membrane and inducing endoplasmic reticulum membrane stress. Understanding their mode of action is crucial for their application in food preservation.
MICROBIOLOGY SPECTRUM
(2023)
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Multidisciplinary Sciences
Zhen Zhou, Yuting Liu, Yushen Feng, Stephen Klepin, Lev S. Tsimring, Lorraine Pillus, Jeff Hasty, Nan Hao
Summary: Synthetic biology allows the design of gene networks for specific biological functions, but it is challenging to engineer the complex trait of longevity. By rewiring a naturally occurring toggle switch, we created a genetic clock that generates oscillations between nucleolar and mitochondrial aging processes, increasing cellular lifespan. These oscillations delay the commitment to aging caused by loss of chromatin silencing or heme depletion. Our study establishes a connection between gene network architecture and cellular longevity, potentially enabling the rational design of gene circuits to slow aging.
Article
Biotechnology & Applied Microbiology
Cristobal A. Onetto, Anthony R. Borneman, Simon A. Schmidt
Summary: Interactions between non-Saccharomyces yeast species and Saccharomyces cerevisiae can impact fermentation performance, with strain selection playing a key role in optimizing fermentation outcomes when using non-Saccharomyces species.
FERMENTATION-BASEL
(2021)
Article
Agriculture, Dairy & Animal Science
Rafael E. Martinez, Jessica L. Leatherwood, Carolyn E. Arnold, Kati G. Glass, Kelly W. Walter, Hannah C. Valigura, Sharon A. Norton, Sarah H. White-Springer
Summary: The study suggests that dietary intervention with Saccharomyces cerevisiae fermentation product may help control intra-articular inflammation in young horses and potentially influence cartilage turnover.
JOURNAL OF ANIMAL SCIENCE
(2021)
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Biotechnology & Applied Microbiology
Maria Cecilia Della Vedova, Jose Oscar Bonilla, Maria Daniela Paez, Eduardo Alberto Callegari, Raill Andres Gil, Liliana Beatriz Villegas
Summary: To understand how organisms cope with copper and chromium stress, researchers used Saccharomyces cerevisiae as a model. They analyzed the microelemental composition and surface mapping of microbial biomass using Scanning Electron Microscopy coupled to X-Ray Dispersive Energy Spectrometry (SEM-EDS) in the presence and absence of 30 μg mL-1 Cu(II) and Cr(VI) after 72 hours of incubation. They also conducted a shotgun proteomic analysis to examine the differential protein expression at the intracellular and extracellular level in the presence of the metals. The results showed that the microorganism responds to stress by adjusting protein expression and microelemental composition variation.
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2023)
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Microbiology
Rupali Gupta, Gautam Anand, Lorena Pizarro, Dana Laor, Neta Kovetz, Noa Sela, Tal Yehuda, Ehud Gazit, Maya Bar
Summary: Cytokinin is an important plant growth and developmental hormone that not only plays a role in plant growth and development, but also directly inhibits the growth and virulence of fungal phytopathogens. This demonstrates a conserved role for cytokinins in yeast and fungal biology, suggesting that pathogen-host interactions may cause molecular adaptations in fundamental processes in eukaryotic biology.
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Multidisciplinary Sciences
Lea Marie, Lorraine S. Symington
Summary: This study reveals the recombination mechanism of repeated sequences under replication stress and proposes a model for generating chromosome rearrangements.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Vanessa Simoes, Blanche K. Cizubu, Lana Harley, Ye Zhou, Joshua Pajak, Nathan A. Snyder, Jonathan Bouvette, Mario J. Borgnia, Gaurav Arya, Alberto Bartesaghi, Gustavo M. Silva
Summary: Protein ubiquitination is an important process that regulates protein synthesis, function, and fate. The E2 Rad6 associates and modifies ribosomes during stress, and its activity is redox regulated. This study provides insights into the role and regulation of E2 enzymes in the ubiquitination pathway and reveals the physiological role of Rad6 in translation, antioxidant defense, and stress adaptation.
Review
Cell Biology
Jee Whu Lee, Eugene Boon Beng Ong
Summary: Cellular senescence, triggered by nucleic acid damage and genetic alterations, is one of the pathways leading to aging. Telomere erosion and ribosomal DNA instability can also result in cellular senescence. Lessons from budding yeast provide insights into the molecular mechanisms linking telomere length homeostasis and ribosomal DNA stability to cellular senescence and longevity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peyman P. Aryanpur, Telsa M. Mittelmeier, Timothy A. Bolger
Summary: The research on Ded1 in different models demonstrates its role in regulating translation under cellular stress conditions and affecting stress granule formation, while the ded1-Delta CT mutant shows inhibitory effects on these phenotypes. Furthermore, the involvement of Ded1 during oxidative stress suggests its role in stress recovery processes.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hyejin Kim, Jihyeon Park, Hyunwoo Kim, Naho Ko, Jumi Park, Eunhong Jang, So Young Yoon, Joyce Anne R. Diaz, Changwook Lee, Youngsoo Jun
Summary: Vac8 is a yeast vacuolar protein that mediates various cellular processes by changing its binding partners, but the mechanism by which Vac8 regulates these processes is poorly understood.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
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Biotechnology & Applied Microbiology
Marjan Barazandeh, Divya Kriti, Corey Nislow, Guri Giaever
Summary: Chemogenomic profiling is a powerful method for studying the cellular response to small molecules. This study analyzed two large yeast chemogenomic datasets and found robust chemogenomic response signatures, providing further support for their biological relevance.
Review
Genetics & Heredity
Julia J. Wattacheril, Srilakshmi Raj, David A. Knowles, John M. Greally
Summary: It is believed that environmental influences can affect gene expression by altering epigenetic regulators of transcription. These epigenetic changes can be maintained long term and through cell division, resulting in a prolonged effect of the exposure. The evidence supporting this model comes from the observation of changes in molecular regulators of transcription following exposures. However, this model may be oversimplistic, and further research is needed to fully understand the complex associations between environmental exposures and phenotypes.
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Biochemistry & Molecular Biology
Julia Becker-Kettern, Nicole Paczia, Jean-Francois Conrotte, Daniel P. Kay, Cedric Guignard, Paul P. Jung, Carole L. Linster
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
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Genetics & Heredity
Paul P. Jung, Anastasie Sigwalt, Shinsuke Ohnuki, Jacky de Montigny, Yoshikazu Ohya, Joseph Schacherer
G3-GENES GENOMES GENETICS
(2016)
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Biotechnology & Applied Microbiology
Gotthard Kunze, Claude Gaillardin, Malgorzata Czernicka, Pascal Durrens, Tiphaine Martin, Erik Boeer, Toni Gabaldon, Jose A. Cruz, Emmanuel Talla, Christian Marck, Andre Goffeau, Valerie Barbe, Philippe Baret, Keith Baronian, Sebastian Beier, Claudine Bleykasten, Ruediger Bode, Serge Casaregola, Laurence Despons, Cecile Fairhead, Martin Giersberg, Przemyslaw Piotr Gierski, Urs Haehnel, Anja Hartmann, Dagmara Jankowska, Claire Jubin, Paul Jung, Ingrid Lafontaine, Veronique Leh-Louis, Marc Lemaire, Marina Marcet-Houben, Martin Mascher, Guillaume Morel, Guy-Franck Richard, Jan Riechen, Christine Sacerdot, Anasua Sarkar, Guilhem Savel, Joseph Schacherer, David J. Sherman, Nils Stein, Marie-Laure Straub, Agnes Thierry, Anke Trautwein-Schult, Benoit Vacherie, Eric Westhof, Sebastian Worch, Bernard Dujon, Jean-Luc Souciet, Patrick Wincker, Uwe Scholz, Cecile Neuveglise
BIOTECHNOLOGY FOR BIOFUELS
(2014)
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Genetics & Heredity
Paul P. Jung, Anne Friedrich, Jean-Luc Souciet, Veronique Louis, Serge Potier, Jacky de Montigny, Joseph Schacherer
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Biotechnology & Applied Microbiology
Paul P. Jung, Joseph Schacherer, Jean-Luc Souciet, Serge Potier, Patrick Wincker, Jacky de Montigny
FEMS YEAST RESEARCH
(2009)
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Biotechnology & Applied Microbiology
Claudine Bleykasten-Grosshans, Paul P. Jung, Emilie S. Fritsch, Serge Potier, Jacky de Montigny, Jean-Luc Souciet
FEMS YEAST RESEARCH
(2011)
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Biochemistry & Molecular Biology
Anne Friedrich, Paul Jung, Cyrielle Reisser, Gilles Fischer, Joseph Schacherer
MOLECULAR BIOLOGY AND EVOLUTION
(2015)
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Multidisciplinary Sciences
Paul P. Jung, Nils Christian, Daniel P. Kay, Alexander Skupin, Carole L. Linster
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Genetics & Heredity
Paul P. Jung, Anne Friedrich, Cyrielle Reisser, Jing Hou, Joseph Schacherer
G3-GENES GENOMES GENETICS
(2012)
Article
Genetics & Heredity
Veronique Leh Louis, Laurence Despons, Anne Friedrich, Tiphaine Martin, Pascal Durrens, Serge Casaregola, Cecile Neuveglise, Cecile Fairhead, Christian Marck, Jose A. Cruz, Marie-Laure Straub, Valerie Kugler, Christine Sacerdot, Zlatyo Uzunov, Agnes Thierry, Stephanie Weiss, Claudine Bleykasten, Jacky De Montigny, Noemie Jacques, Paul Jung, Marc Lemaire, Sandrine Mallet, Guillaume Morel, Guy-Franck Richard, Anasua Sarkar, Guilhem Savel, Joseph Schacherer, Marie-Line Seret, Emmanuel Talla, Gaelle Samson, Claire Jubin, Julie Poulain, Benoit Vacherie, Valerie Barbe, Eric Pelletier, David J. Sherman, Eric Westhof, Jean Weissenbach, Philippe V. Baret, Patrick Wincker, Claude Gaillardin, Bernard Dujon, Jean-Luc Souciet
G3-GENES GENOMES GENETICS
(2012)
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Geriatrics & Gerontology
Paul P. Jung, Zhi Zhang, Nicole Paczia, Christian Jaeger, Tomasz Ignac, Patrick May, Carole L. Linster
NPJ AGING AND MECHANISMS OF DISEASE
(2018)
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Biotechnology & Applied Microbiology
Anastasie Sigwalt, Claudia Caradec, Christian Brion, Jing Hou, Jacky de Montigny, Paul Jung, Gilles Fischer, Bertrand Llorente, Anne Friedrich, Joseph Schacherer
FEMS YEAST RESEARCH
(2016)