Article
Engineering, Biomedical
Aylin Acun, Ruben Oganesyan, Korkut Uygun, Heidi Yeh, Martin L. Yarmush, Basak E. Uygun
Summary: The extracellular matrix of the liver changes with age, affecting cell function, and donor age should be considered an important factor for bioengineering liver substitutes.
Article
Multidisciplinary Sciences
Tomohiro Shirai, Dan Takase, Junkichi Yokoyama, Kuniyuki Nakanishi, Chisaki Uehara, Naoko Saito, Aya Kato-Namba, Keiichi Yoshikawa
Summary: This study investigates the constituents and functions of olfactory mucus, finding that it contains high concentrations of solutes and molecules related to odorant metabolism. The study also reveals the age-dependent decrease in the amount of olfactory mucus and its impact on the sensitivity of odorant detection by receptors. These findings provide insights into the molecular processes of olfactory mucus and propose a potential cause of olfactory decline.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Matthew T. Rich, Samantha J. Worobey, Sharvari Mankame, Zhiping P. Pang, Sarah E. Swinford-Jackson, R. Christopher Pierce
Summary: Cocaine exposure in male rats affects fear-associated behaviors in their offspring, with enhanced freezing behavior in female progeny and enhanced expression of cue-conditioned fear during extinction in male progeny. The absence of long-term potentiation (LTP) in the basolateral amygdala (BLA) suggests synaptic plasticity deficits in male offspring of cocaine-exposed sires.
Article
Cell Biology
Sinem Erisken, George Nune, Hyokwon Chung, Joon Won Kang, Sookyong Koh
Summary: This study compared seizure-induced changes in gene expression in mature and immature rats and correlated them with epilepsy patients, revealing that inflammatory gene expression is more sustained and stronger in mature rats after seizures. The findings indicate that persistent changes in inflammatory gene expression may lead to epileptogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Robin J. G. Hartman, Michal Mokry, Gerard Pasterkamp, Hester M. den Ruijter
Summary: A study using RNA-sequencing data of over 700 individuals across 24 tissues found that nearly one-third of gene co-expression in different tissues is influenced by sex, leading to sex-biased diseases and responses to drugs. This suggests that differences in gene co-expression driven by sex affect biological gene networks and warrant attention in medical research and treatment.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Farman Ullah, Hina Gul, Kaleem Tariq, Nicolas Desneux, Xiwu Gao, Dunlun Song
Summary: The study found that the melon aphid developed resistance to acetamiprid, resulting in reduced fitness including adult longevity and fecundity. The Ace-R strain also showed shorter pre-adult and pre-oviposition periods, along with changes in gene expression associated with reproduction and development.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Iddo Paldor, Nimrod Madrer, Shani Vaknine Treidel, Dana Shulman, David S. Greenberg, Hermona Soreq
Summary: In this study, the expression levels of tRFs in cerebrospinal fluid (CSF) and blood were found to be distinct, with CSF showing higher levels of long tRFs. The CSF tRF profiles were also found to be significantly influenced by age, sex, and Parkinson's disease (PD), suggesting their potential as biomarkers for cerebral differences and neurological disorders. Furthermore, specific sets of tRFs in CSF and blood could differentiate PD patients from healthy controls. These findings highlight the importance of incorporating tRFs into future studies of CNS-related diseases.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Anna Allue-Guardia, Andreu Garcia-Vilanova, Angelica M. Olmo-Fontanez, Jay Peters, Diego J. Maselli, Yufeng Wang, Joanne Turner, Larry S. Schlesinger, Jordi B. Torrelles
Summary: This study reveals that Mycobacterium tuberculosis (M.tb) alters the expression of its cell envelope genes upon contact with alveolar lining fluid (ALF). The dysfunctional ALF of elderly individuals, characterized by impaired innate soluble responses and high oxidative stress, may play an important role in determining infection outcome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Zhiqiang Wang, Chunxiao Zhang, Charles David Warden, Zheng Liu, Yate-Ching Yuan, Chao Guo, Charles Wang, Jinhui Wang, Xiwei Wu, Richard Ermel, Steven L. Vonderfecht, Xiuli Wang, Christine Brown, Stephen Forman, Yaling Yang, M. James You, WenYong Chen
Summary: SIRT1 plays an unexpected role in promoting aging of HSCs and age-dependent MPAL. Knockout of Sirt1 improves the function of aging HSCs and suppresses the development of MPAL.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Shimpei Kawamoto, Ken Uemura, Nozomi Hori, Lena Takayasu, Yusuke Konishi, Kazutaka Katoh, Tomonori Matsumoto, Masae Suzuki, Yusuke Sakai, Tatsuyuki Matsudaira, Takahiro Adachi, Naoko Ohtani, Daron M. Standley, Wataru Suda, Shinji Fukuda, Eiji Hara
Summary: The mechanisms and control methods of ageing have been extensively studied. It has been discovered that the accumulation of senescent cells and the change in gut microbiota composition are two important factors in ageing. However, the relationship between these two phenomena during ageing is not well understood. In this study, researchers found that commensal bacteria gradually induce cellular senescence in gut germinal centre B cells, leading to reduced production and diversity of immunoglobulin A antibodies and changes in gut microbiota composition in aged mice. These findings reveal the existence of IgA-mediated crosstalk between gut microbiota and cellular senescence, providing insights into the mechanism of gut microbiota changes with age and potential strategies for control.
NATURE CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Maroun Bou Sleiman, Suheeta Roy, Arwen W. Gao, Marie C. Sadler, Giacomo V. G. von Alvensleben, Hao Li, Saunak Sen, David E. Harrison, James F. Nelson, Randy Strong, Richard A. Miller, Zoltan Kutalik, Robert W. Williams, Johan Auwerx
Summary: This study provides insights into the determinants of health, disease, and aging by examining DNA variants that affect life span. The researchers identified sex-specific genetic effects on life span and gene expression, and validated several genes as conserved longevity genes. The findings underscore the importance of early access to nutrients and early growth for longevity.
Article
Biochemistry & Molecular Biology
Francesca Biagioni, Ottavio Croci, Silvia Sberna, Elisa Donato, Arianna Sabo, Andrea Bisso, Laura Curti, Arianna Chiesa, Stefano Campaner
Summary: YAP functions as a master regulator of liver function by reshaping the enhancer landscape to control transcription of genes related to metabolism, proliferation, and inflammation. It antagonizes HNF4a, modulates immune infiltrate, and alters the vascular architecture of the liver to subvert lineage specification programs.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Christopher A. Wolff, Miguel A. Gutierrez-Monreal, Lingsong Meng, Xiping Zhang, Lauren G. Douma, Hannah M. Costello, Collin M. Douglas, Elnaz Ebrahimi, Ann Pham, Aline C. Oliveira, Chunhua Fu, Amy Nguyen, Bryan R. Alava, Stuart J. Hesketh, Andrew R. Morris, Mehari M. Endale, G. Ryan Crislip, Kit-yan Cheng, Elizabeth A. Schroder, Brian P. Delisle, Andrew J. Bryant, Michelle L. Gumz, Zhiguang Huo, Andrew C. Liu, Karyn A. Esser
Summary: Cellular circadian clocks regulate daily transcriptional program and are important for maintaining homeostasis and resilience. Age-related changes in circadian functions have been observed. This study characterized age-dependent changes in the circadian transcriptome in multiple tissues, revealing tissue-specific alterations in clock output and decreased number of rhythmically expressed genes (REGs) with aging. Analysis of differentially expressed genes (DEGs) at different times of day identified distinct gene expression patterns, with increased variability in aged tissues. This study expands our understanding of aging and highlights the impact of aging on circadian clock function and temporal gene expression changes.
Article
Multidisciplinary Sciences
Rui Meng, Junxian Song, Lina Guan, Qian Li, Cuige Shi, Dongmei Su, Xu Ma
Summary: This study used MethylRAD sequencing to investigate changes in methylation levels in the fetal heart genome in a rat model of hyperglycemia. The results showed that methylation was enriched in intergenic regions and genes related to abnormal CCGG/CCNGG methylation in the upstream region may play dominant roles in heart malformations. Further research on these genes may provide potential molecular targets or diagnostic biomarkers for heart diseases under hyperglycemia.
Article
Geriatrics & Gerontology
Francesca Di Cesare, Claudio Luchinat, Leonardo Tenori, Edoardo Saccenti
Summary: This study investigated the variations in concentrations, correlations, and ratios of 202 free circulating blood metabolites and lipids with age. The results showed that certain metabolites and lipids were associated with age in a sex-dependent manner, with linoleic acid, alpha-linoleic acid, and carnitine being associated with age in women, and monoacylglycerols and lysophosphatidylcholines being associated with age in men. Furthermore, correlations among phosphatidylcholines tended to have a positive trend with age in women, while correlations among monoacylglycerols and lysophosphatidylcholines tended to have a negative trend with age in men. The ratios between molecular features also showed age-dependent changes, with the decanoyl-l-carnitine/lysophosphatidylcholine ratio decreasing with age in women, and the l-carnitine/phosphatidylcholine and l-acetylcarnitine/phosphatidylcholine ratios increasing with age in men.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Oncology
Yanira Gonzalez, Kaytee L. Pokrzywinski, Elliot T. Rosen, Steven Mog, Baikuntha Aryal, Leena M. Chehab, Vikrant Vijay, Carrie L. Moland, Varsha G. Desai, Jennifer S. Dickey, V. Ashutosh Rao
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2015)
Article
Endocrinology & Metabolism
Joshua C. Kwekel, Vikrant Vijay, Varsha G. Desai, Carrie L. Moland, James C. Fuscoe
BIOLOGY OF SEX DIFFERENCES
(2015)
Article
Toxicology
Laura K. Schnackenberg, Lisa Pence, Vikrant Vijay, Carrie L. Moland, Nysia George, Zhijun Cao, Li-Rong Yu, James C. Fuscoe, Richard D. Beger, Varsha G. Desai
JOURNAL OF APPLIED TOXICOLOGY
(2016)
Article
Pharmacology & Pharmacy
Vikrant Vijay, Carrie L. Moland, Tao Han, James C. Fuscoe, Taewon Lee, Eugene H. Herman, G. Ronald Jenkins, Sherry M. Lewis, Connie A. Cummings, Yuan Gao, Zhijun Cao, Li-Rong Yu, Varsha G. Desai
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2016)
Article
Pharmacology & Pharmacy
G. Ronald Jenkins, Taewon Lee, Carrie L. Moland, Vikrant Vijay, Eugene H. Herman, Sherry M. Lewis, Kelly J. Davis, Levan Muskhelishvili, Susan Kerr, James C. Fuscoe, Varsha G. Desai
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2016)
Article
Endocrinology & Metabolism
Joshua C. Kwekel, Vikrant Vijay, Tao Han, Carrie L. Moland, Varsha G. Desai, James C. Fuscoe
BIOLOGY OF SEX DIFFERENCES
(2017)
Article
Multidisciplinary Sciences
Vikrant Vijay, Tao Han, Carrie L. Moland, Joshua C. Kwekel, James C. Fuscoe, Varsha G. Desai
Article
Pharmacology & Pharmacy
Varsha G. Desai, Eugene H. Herman, Carrie L. Moland, William S. Branham, Sherry M. Lewis, Kelly J. Davis, Nysia I. George, Taewon Lee, Susan Kerr, James C. Fuscoe
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2013)
Article
Pharmacology & Pharmacy
Varsha G. Desai, Joshua C. Kwekel, Vikrant Vijay, Carrie L. Moland, Eugene H. Herman, Taewon Lee, Tao Han, Sherry M. Lewis, Kelly J. Davis, Levan Muskhelishvili, Susan Kerr, James C. Fuscoe
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2014)
Article
Multidisciplinary Sciences
Ravi K. Sajja, Mohammad A. Kaisar, Vikrant Vijay, Varsha G. Desai, Shikha Prasad, Luca Cucullo
SCIENTIFIC REPORTS
(2018)
Article
Reproductive Biology
Noriko Nakamura, Vikrant Vijay, Varsha G. Desai, Deborah K. Hansen, Tao Han, Ching-Wei Chang, Yu-Chuan Chen, Wafa Harrouk, Barry McIntyre, Paul M. Foster, James C. Fuscoe, Amy L. Inselman
REPRODUCTIVE TOXICOLOGY
(2018)
Article
Pharmacology & Pharmacy
Varsha G. Desai, Taewon Lee, Carrie L. Moland, Vikrant Vijay, Tao Han, Sherry M. Lewis, Eugene H. Herman, James C. Fuscoe
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Article
Toxicology
Varsha G. Desai, Vikrant Vijay, Tao Han, Carrie L. Moland, Bounleut Phanavanh, Taewon Lee, Kelly J. Davis, Levan Muskhelishvili, Kimo C. Stine, James C. Fuscoe
Summary: Research suggests that low doses of doxorubicin may lead to cardiotoxicity and subsequent cardiomyopathy. Experiments on mice showed that higher cumulative doses of DOX were associated with decreased cardiac function and increased cardiomyocyte apoptosis.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Toxicology
Varsha G. Desai, Vikrant Vijay, Taewon Lee, Tao Han, Carrie L. Moland, Bounleut Phanavanh, Eugene H. Herman, Kimo Stine, James C. Fuscoe
Summary: The study identified miR-34a-5p as a potential circulating biomarker for early-onset cardiotoxicity caused by DOX, with its expression altered before the onset of myocardial injury and correlated with cardiac expression. Administration of a cardioprotective drug attenuated miR-34a-5p expression in both plasma and heart, suggesting its potential as an early biomarker. Higher expression of miR-34a-5p in plasma and heart also indicated its potential as an early biomarker of delayed-onset cardiotoxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Toxicology
Varsha G. Desai, Ana Azevedo-Pouly, Vikrant Vijay, Bounleut Phanavanh, Carrie L. Moland, Tao Han, Javier Revollo, Baikuntha Aryal, V. Ashutosh Rao, James C. Fuscoe
Summary: The present study found sexual dimorphism in cardiotoxicity induced by DOX, with more differentially expressed genes in males than females. The apelin-APJ pathway may play a critical role in sex-related differential DOX-induced cardiotoxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2023)