Article
Biochemistry & Molecular Biology
Lucas M. N. Silva, Wilza W. M. Franca, Victor H. B. Santos, Renan A. F. Souza, Adriana M. Silva, Emily G. M. Diniz, Thierry W. A. Aguiar, Joao V. R. Rocha, Mary A. A. Souza, Wheverton R. C. Nascimento, Reginaldo G. Lima Neto, Iranildo J. Cruz Filho, Eulalia C. P. A. Ximenes, Hallysson D. A. Araujo, Andre L. Aires, Monica C. P. A. Albuquerque
Summary: This study evaluated the schistosomicidal potential of Plumbagin (PLUM) against Schistosoma mansoni and its pharmacokinetic parameters. The results showed that PLUM significantly reduced the worm and egg load, as well as demonstrated good pharmacokinetic profiles in silico.
Article
Infectious Diseases
Julien Kincaid-Smith, Alan Tracey, Ronaldo de Carvalho Augusto, Ingo Bulla, Nancy Holroyd, Anne Rognon, Olivier Rey, Cristian Chaparro, Ana Oleaga, Santiago Mas-Coma, Jean-Francois Allienne, Christoph Grunau, Matthew Berriman, Jerome Boissier, Eve Toulza
Summary: The article describes the occurrence of schistosomiasis and the genetic admixture of hybrid schistosomes, as well as their compatibility with snail vectors. The results indicate that the hybrid is strongly introgressed genetically, with ancient hybridization events and subsequent backcrosses with the human-specific species. The study also highlights the discrepancy between egg morphology and genetic composition of schistosomes, emphasizing the importance of genetic testing for accurate hybrid identification.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Parasitology
Debora Veronica Sarmento Pereira da Silva, Pedro Henrique do Bomfim Nascimento, Joao Victor Ritinto da Rocha, Diego Santa Clara Marques, Fabio Andre Brayner, Luiz Carlos Alves, Hallysson Douglas Andrade de Araujo, Iranildo Jose da Cruz Filho, Monica Camelo Pessoa de Azevedo Albuquerque, Maria do Carmo Alves de Lima, Andre de Lima Aires
Summary: The aim of this study was to conduct in vitro biological assays and pharmacokinetic parameter determination of thiazole compounds against adult worms of Schistosoma mansoni. Thiazole compounds showed moderate to low cytotoxicity against mammalian cells and were not hemolytic. PBT2 and PBT5 exhibited the highest activity against the parasites, causing 100% mortality after 3 hours of incubation at a concentration of 200μM. Ultrastructural analysis revealed that PBT2 and PBT5 induced changes in the integument, including exposure of muscles, formation of blisters, abnormal morphology, and destruction of tubercles and spicules. Thus, PBT2 and PBT5 are promising antiparasitic agents against S. mansoni.
Article
Infectious Diseases
Julien Kincaid-Smith, Eglantine Mathieu-Begne, Cristian Chaparro, Marta Reguera-Gomez, Stephen Mulero, Jean-Francois Allienne, Eve Toulza, Jerome Boissier
Summary: The study found that mate choice is not a reproductive isolating factor between Schistosoma haematobium and S. bovis, and there are few pre-zygotic barriers limiting interbreeding between these two species, except for spatial isolation by the final vertebrate host.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Serhat Sirekbasan, Tugba Gurkok Tan
Summary: By analyzing the RNA datasets of S. mansoni and S. haematobium, common lncRNAs were identified, suggesting potential similar functions, especially in sexual development. These results provide important clues for further studies on interactions between human hosts and parasites, as well as the infection mechanisms of Schistosoma parasites.
JOURNAL OF TROPICAL MEDICINE
(2021)
Article
Evolutionary Biology
Maria Stitz, Cristian Chaparro, Zhigang Lu, V. Janett Olzog, Christina E. Weinberg, Jochen Blom, Alexander Goesmann, Christoph Grunau, Christoph G. Grevelding
Summary: The study focuses on satellite-DNA elements of the blood fluke Schistosoma mansoni, revealing new insights into the classification and transcription of W-elements in different stages, sexes, pairings, gonads, and strains. Additionally, structural analyses suggest a potential role as a source of noncoding RNA-like hammerhead ribozymes. The variable occurrence of W-element families in different schistosome species indicates potential genetic factors influencing the variability and evolution of the Schistosomatidae family.
GENOME BIOLOGY AND EVOLUTION
(2021)
Article
Parasitology
Lenka Ulrychova, Pavel Ostasov, Marta Chanova, Michael Mares, Martin Horn, Jan Dvorak
Summary: The study identified and characterized the spatial gene expression patterns of a group of S1 family Schistosoma mansoni serine proteases in adult worms using a highly sensitive fluorescence in situ RNA hybridization (FISH) assay. The results showed distinct expression patterns of SmSPs in various tissues, providing insights into their roles in parasite processes. This sensitive method allowed visualization of low-abundantly expressed genes that cannot be detected by standard techniques, suggesting potential applications for other trematodes.
PARASITES & VECTORS
(2021)
Article
Microbiology
Mostafa Y. Morad, Heba El-Sayed, Ahmed A. Elhenawy, Shereen M. Korany, Abeer S. Aloufi, Amina M. Ibrahim
Summary: The myco-synthesized nano-selenium (SeNPs) showed significant molluscicidal, miracidicidal, and cercaricidal properties against Biomphlaria alexandrina snails and Schistosoma mansoni, making it a potential non-toxic route for reducing the spread of schistosomiasis. Furthermore, the SeNPs exhibited antioxidant properties and caused DNA damage.
Article
Plant Sciences
Peipei Hong, Mei Wang, Liting Zhi, Hongwei Chen, Kefeng Liu, Hongli Wang
Summary: The branching system of higher plants plays a crucial role in plant morphogenesis, influencing crop yield and ornamental value. The study investigates the molecular mechanisms underlying branching in Salvia splendens using suppressive subtractive hybridization (SSH) technology. Differentially expressed genes related to plant hormone synthesis and signal transduction were identified, revealing their involvement in the branching process. Additionally, a gene called phytoene synthase (PSY), which is a precursor of a new plant hormone group called strigolactones, was found to play a key role in lateral branch development.
PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biology
Hiroshi Harada, Hirofumi Matsumoto, Shin-ichi Nakatsuka, Akira Kurose
Summary: Lymphoepithelial carcinoma (LEC) is a rare independent disease in salivary glands, showing characteristic histology of nesting growth of tumor cells with unclear differentiation. A case report revealed a patient with LEC in the parotid gland, with immunohistochemistry suggesting a possible link to human papillomavirus (HPV) infection, and the patient showed no signs of recurrence or metastasis 18 months post-operation.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Article
Fisheries
Cybele Prigot-Maurice, Sophie Beltran-Bech, Christine Braquart-Varnier
Summary: Growing evidence shows that invertebrates exhibit adaptive-like immune abilities known as immune priming, which can be enhanced by beneficial symbionts to protect the host against pathogens. This symbiotic immune priming plays a crucial role in the tripartite interaction of hosts/symbionts/pathogens, leading to improved tolerance or resistance against different types of microbes. The coexistence of protective symbionts and immune priming mechanisms inside hosts may offer insights into the diversity of pathogenic immune priming in invertebrate populations and species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cyril Hammoud, Stephen Mulero, Bert Van Bocxlaer, Jerome Boissier, Dirk Verschuren, Christian Albrecht, Tine Huyse
Summary: The new workflow developed in this study utilizes high-throughput amplicon sequencing to simultaneously genotype snail hosts and their infecting trematode parasites. After stringent quality control, the workflow can identify snails and trematodes with high sensitivity, successfully detecting co-infections and providing new possibilities for studying parasite-parasite interactions.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Environmental Sciences
Delphine Destoumieux-Garzon, Franziska Matthies-Wiesler, Nicolas Bierne, Aurelie Binot, Jerome Boissier, Anais Devouge, Jeanne Garric, Kim Gruetzmacher, Christoph Grunau, Jean-Francois Guegan, Sylvie Hurtrez-Bousses, Anke Huss, Serge Morand, Clare Palmer, Denis Sarigiannis, Roel Vermeulen, Robert Barouki
Summary: The implementation of One Health/EcoHealth/Planetary Health approaches is crucial for addressing the interconnected global crises of pandemics, climate change, and biodiversity loss. Research priorities include understanding the social ecology of infectious diseases, their evolution, factors influencing susceptibility to infections, and human and ecological factors driving disease emergence. Nature-based solutions, ethical considerations, and transformative changes are essential to safeguarding the environment and human health in the face of global environmental change.
ENVIRONMENT INTERNATIONAL
(2022)
Editorial Material
Parasitology
Yohann Le Govic, Jerome Boissier, Nicolas Papon
Summary: Scientists have discovered that the beta-alanyl-tryptamine dipeptide (BATT) emitted by male schistosomes is the key factor inducing sexual maturation and egg-laying in females.
TRENDS IN PARASITOLOGY
(2022)
Article
Zoology
Cybele Prigot-Maurice, Charlotte Depeux, Helene Paulhac, Christine Braquart-Varnier, Sophie Beltran-Bech
Summary: This study investigated the reproductive cost and senescence patterns of immune priming against S. enterica in A. vulgare. The results showed that immune priming did not significantly impact reproductive abilities, senescence patterns, and haemocyte parameters of female A. vulgare, but had an indirect effect through body weight.
Article
Infectious Diseases
Felicite Flore Djuikwo Teukeng, Manon Blin, Nicolas Bech, Marta Reguera Gomez, Rima Zein-Eddine, Alain Michel Kouam Simo, Jean-Francois Allienne, Louis Albert Tchuem-Tchuente, Jerome Boissier
Summary: This study investigated the presence of hybrids between Schistosoma haematobium and S. bovis in Cameroonian humans, as well as the genetic diversity and structure of S. haematobium populations. The results showed that hybrids accounted for 11.3% of the miracidia, and their presence correlated with increased genetic diversity in the parasite. Hybridization was found to be a major process shaping the genetic diversity of S. haematobium.
INFECTIOUS DISEASES OF POVERTY
(2022)
Article
Cell Biology
Nelia Luviano, David Duval, Wannaporn Ittiprasert, Jean-Francois Allienne, Genevieve Tavernier, Cristian Chaparro, Celine Cosseau, Christoph Grunau
Summary: Snail-borne parasitic diseases pose a significant challenge to human and animal health, and controlling the intermediate snail host has proven effective. This study demonstrates that methylome engineering can be used to modify the methylation level of a target gene in a freshwater snail.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microbiology
Amos Mathias Onyekwere, Olivier Rey, Jean-Francois Allienne, Monday Chukwu Nwanchor, Moses Alo, Clementina Uwa, Jerome Boissier
Summary: This study provides insight into hybridization and population genetic structure of S. haematobium in Nigeria, revealing the common occurrence of hybrids in the country.
Review
Environmental Sciences
Raquel Sanchez-Marques, Santiago Mas-Coma, Joaquin Salas-Coronas, Jerome Boissier, Maria Dolores Bargues
Summary: This study aims to examine the impact of the COVID-19 pandemic on schistosomiasis research, identify the most productive countries and journals, and analyze the association between total publications and socio-economic and demographic factors. The findings suggest that while there was no direct impact on schistosomiasis research, resources have been redirected to COVID-19 research, affecting the activities for the eradication of schistosomiasis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Microbiology
Manon Fallet, Caroline Montagnani, Bruno Petton, Luc Dantan, Julien de Lorgeril, Sebastien Comarmond, Cristian Chaparro, Eve Toulza, Simon Boitard, Jean-Michel Escoubas, Agnes Vergnes, Jacqueline Le Grand, Ingo Bulla, Yannick Gueguen, Jeremie Vidal-Dupiol, Christoph Grunau, Guillaume Mitta, Celine Cosseau
Summary: This study found that early microbial exposure in Pacific oysters can significantly improve their survival rate against a pathogen causing mortality syndrome. The protection provided by microbial exposure is inheritable across generations and is associated with changes in epigenetic marks and immune gene expression. This discovery suggests that microbial exposure may be an important strategy for protecting oyster aquaculture from infectious diseases.
Article
Parasitology
Manon Blin, Bruno Senghor, Jerome Boissier, Stephen Mulero, Olivier Rey, Julien Portela
Summary: This study aimed to develop a simple molecular method using LAMP to detect environmental DNA of Bulinus truncatus, the vector of Schistosoma haematobium. The results showed that this new method can effectively detect the environmental DNA of Bulinus truncatus and even detect a fourth of positive samples that were not detectable by other methods.
PARASITES & VECTORS
(2023)
Article
Infectious Diseases
Antoine Huguenin, Julien Kincaid-Smith, Jerome Depaquit, Jerome Boissier, Hubert Ferte
Summary: MALDI-TOF mass spectrometry was found to be effective in identifying cercariae of Schistosoma, enabling the detection of hybrids and specific species identification. This technique provides a reliable and efficient tool for the high-throughput identification of schistosomiasis cercariae in both human and non-human hosts, and has important implications for field surveys.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Infectious Diseases
Marta Reguera-Gomez, Maria Adela Valero, Patricio Artigas, Alejandra De Elias-Escribano, Maria Cecilia Fantozzi, Maria Pilar Luzon-Garcia, Joaquin Salas-Coronas, Jerome Boissier, Santiago Mas-Coma, Maria Dolores Bargues
Summary: This study examines the morphological variations of Schistosoma haematobium eggs from migrants in Spain, finding differences based on the geographical origin of the parasite.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
A. M. Onyekwere, O. Rey, M. C. Nwanchor, M. Alo, E. K. Angora, J. F. Allienne, J. Boissier
Summary: Urogenital schistosomiasis remains a public health problem in rural areas of Nigeria, especially among school-age children. Factors such as frequent contact with freshwater bodies (rivers/steams), bathing/swimming, fishing, primary education of fathers, and age are significantly associated with S. haematobium infection.
PARASITE EPIDEMIOLOGY AND CONTROL
(2022)
Article
Parasitology
Etienne K. Angora, Alexane Vangraefschepe, Jean-Francois Allienne, Herve Menan, Jean T. Coulibaly, Aboulaye Meite, Giovanna Raso, Mirko S. Winkler, William Yavo, Andre O. Toure, Eliezer K. N'Goran, Jakob Zinsstag, Jurg Utzinger, Oliver Balmer, Jerome Boissier
Summary: This study investigated the population genetics and genetic structure of Schistosoma haematobium in different parts of Cote d'Ivoire, as well as the frequency of S. haematobium x S. bovis hybrids in school-aged children. The results showed significant differences in genetic diversity between different sites and clustering of parasite genotypes within individual children.