Article
Microbiology
Connie F. Canete-Gibas, James Mele, Hoja P. Patterson, Carmita J. Sanders, Dora Ferrer, Victor Garcia, Hongxin Fan, Marjorie David, Nathan P. Wiederhold
Summary: Dermatophytes are common pathogens causing skin, hair, and nail infections in humans. A study evaluated the antifungal susceptibility profiles and species identification of dermatophytes received from North America, revealing relatively common terbinafine resistance and the presence of Trichophyton indotineae in multiple areas. Continued surveillance is necessary.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fritz Ka-Ho Ho, Albert Bolhuis, M. Begona Delgado-Charro
Summary: The study tested the use of polymeric films sprayed on the skin for the prevention and treatment of dermatophytosis, showing that the films can both prevent and treat fungal infections, and are generally acceptable for use by healthy volunteers.
Article
Chemistry, Applied
Eduardo Valarezo, Paola Flores-Maza, Luis Cartuche, Santiago Ojeda-Riascos, Jorge Ramirez
Summary: This study analyzed the chemical composition and biological activity of essential oil from Piper ecuadorense, revealing its strong antimicrobial and antioxidant properties.
NATURAL PRODUCT RESEARCH
(2021)
Article
Immunology
Zhen Su, Weiwei Deng, Shuting Zhan, Meirong Li, Songchao Yin, Jian Chen
Summary: In this study, a mouse-human fusion TLR2 was constructed and compared to human TLR2. It was found that the fusion TLR2 activated different downstream signal pathways in response to T. rubrum and M. canis infections, leading to different inflammatory responses. This suggests that the interspecific difference of TLR2 ectodomain may contribute to the differential inflammatory manifestations between humans and mice infected by these two dermatophytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Anita Ciesielska, Anna Kawa, Katarzyna Kanarek, Adrian Sobon, Rafal Szewczyk
Summary: This study compared the intracellular metabolite content in T. rubrum and M. canis during keratin degradation, revealing key compounds associated with interactions of these fungi with the host tissue. The metabolomic results were supported by qPCR gene expression analysis, suggesting that metabolomic analysis could aid in understanding the pathogenesis of dermatophytes.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Muhammad Abdullah Akram, Barkat Ali Khan, Muhammad Khalid Khan, Ali Alqahtani, Sultan M. Alshahrani, Khaled M. Hosny
Summary: The study successfully developed a polymeric emulgel of eugenol and linalool for the treatment of Trichophyton rubrum infections. The emulgel showed good physical properties and demonstrated significant effects in treating the infections both in vitro and in vivo, making it a promising topical treatment option.
Article
Dermatology
Remya Rajamohanan, Renu Raj, Janaki Chellam, Madhu Rengasamy
Summary: This study investigated the epidemiology, clinical types, and factors associated with chronicity in patients with chronic dermatophytosis. The findings showed that extensive area of involvement, atopy, diabetes, and long-term use of systemic corticosteroids were associated with chronicity in these patients. Additionally, the most common etiological agent of chronic dermatophytosis in this study was Trichophyton mentagrophytes.
INDIAN JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemical Research Methods
Jessica Houang, Catriona Halliday, Sharon Chen, Chun-Hoong Ho, Alina Bekmukhametova, Antonio Lauto
Summary: The study demonstrated that photodynamic therapy using Rose Bengal can act against a broader spectrum of fungal pathogens, potentially expanding its clinical antifungal applications.
JOURNAL OF BIOPHOTONICS
(2021)
Review
Infectious Diseases
Huilin Su, Weiwei Jiang, Paul E. Verweij, Li Li, Junhao Zhu, Jiande Han, Min Zhu, Shuwen Deng
Summary: The emergence of resistance in Trichophyton rubrum to azoles and terbinafine has led to the need for the development of new antifungal drugs. In this study, the in vitro antifungal activity of 3 echinocandins against clinical isolates of T. rubrum was evaluated. The results showed that micafungin and anidulafungin exhibited greater potency than caspofungin, suggesting that echinocandins could be potential treatment options for managing recalcitrant dermatophytoses resulting from resistance.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Diletta Mazzantini, Francesco Celandroni, Marco Calvigioni, Antonella Lupetti, Emilia Ghelardi
Summary: The emergence/evolution of resistance against tavaborole in Trichophyton rubrum was analyzed in vitro, showing different frequency and levels of resistance under varying concentrations and exposure durations. Mutants isolated had similar increases in drug resistance, but no cross-resistance to other antifungals was observed.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Wenting Hu, Xiujiao Xia, Yangyang Ma, Ai-E Xu
Summary: This is a case report on a rare fungal infection of the scalp, which is often overlooked in clinic due to its atypical clinical symptoms or being accompanied with scalp ringworm. After fungal culture and identification, the patient was diagnosed with annular erythema with scales around the ear canal orifice and was cured after 3 weeks of topical use of clotrimazole cream.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Mycology
Zixiang Si, Juan Bai, Linwei Wei, Honglei Zhao, Songting Wang, Bin Liu, Jingjing Xu, Hong Fang, Zongxin Ling, Jianjun Qiao
Summary: This study analyzed the clinical features, pathogenic agents, and skin microbiome changes of tinea scrotum. The results showed that tinea scrotum is often accompanied by superficial fungal infections of other skin sites, with tinea cruris being the most common condition. The most frequently identified pathogen for tinea scrotum was Trichophyton rubrum, and the skin microbiome exhibited changes with increased Trichophyton and decreased Malassezia abundance.
Article
Microbiology
Karen Marie Thyssen Astvad, Rasmus Kroger Hare, Karin Meinike Jorgensen, Ditte Marie Lindhardt Saunte, Philip Kjettinge Thomsen, Maiken Cavling Arendrup
Summary: Terbinafine resistance in Trichophyton species is increasing in Denmark, with a high prevalence of non-wildtype isolates and known/novel SQLE mutations. T. rubrum is the most common species, but T. mentagrophytes/interdigitale SC isolates also contribute to resistance. Population-based studies and susceptibility testing are important for understanding and addressing this emerging problem.
Article
Biochemistry & Molecular Biology
Basem M. M. Abdallah, Peramaiyan Rajendran, Enas M. M. Ali
Summary: In this study, green synthesized silver nanoparticles (AS-AgNPs) using Achillea santolina extract were found to have anti-dermatophytic potential against Trichophyton rubrum. AS-AgNPs inhibited the growth of T. rubrum, suppressed conidial germination and hyphal growth, and caused structural and membrane damage. Moreover, AS-AgNPs reduced cell wall integrity and inflammatory response. Overall, AS-AgNPs represent a novel green topical therapy for T. rubrum dermatophytosis.
Article
Microbiology
Leonardo Martins-Santana, Monise Fazolin Petrucelli, Pablo R. Sanches, Nilce M. Martinez-Rossi, Antonio Rossi
Summary: The study reveals the importance of alternative splicing in generating isoforms of virulence factors in Trichophyton rubrum, a common causative agent of dermatophytosis. The transcription factor StuA plays a crucial role in coordinating the expression of peptidase genes through alternative splicing in the presence of keratin. These findings shed light on the physiological adaptations of fungal cells and the regulation of virulence traits in dermatophyte infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zi-Jun Wang, Ping Zhong, Kaijie Ma, Ji-Seon Seo, Fengwei Yang, Zihua Hu, Freddy Zhang, Lin Lin, Jie Wang, Tao Liu, Emmanuel Matas, Paul Greengard, Zhen Yan
MOLECULAR PSYCHIATRY
(2020)
Correction
Biochemistry & Molecular Biology
Zi-Jun Wang, Ping Zhong, Kaijie Ma, Ji-Seon Seo, Fengwei Yang, Zihua Hu, Freddy Zhang, Lin Lin, Jie Wang, Tao Liu, Emmanuel Matas, Paul Greengard, Zhen Yan
MOLECULAR PSYCHIATRY
(2020)
Article
Multidisciplinary Sciences
Yixuan Zhou, Ingmar Niels Bastian, Mark D. Long, Michelle Dow, Weihua Li, Tao Liu, Rachael Katie Ngu, Laura Antonucci, Jian Yu Huang, Qui T. Phung, Xi-He Zhao, Sourav Banerjee, Xue-Jia Lin, Hongxia Wang, Brian Dang, Sylvia Choi, Daniel Karin, Hua Su, Mark H. Ellisman, Christina Jamieson, Marcus Bosenberg, Zhang Cheng, Johannes Haybaeck, Lukas Kenner, Kathleen M. Fisch, Richard Bourgon, Genevive Hernandez, Jennie R. Lill, Song Liu, Hannah Carter, Ira Mellman, Michael Karin, Shabnam Shalapour
Summary: The study found that lysine acetyl transferases p300/CREB binding protein (CBP) control MHC-I antigen processing and presentation (AgPP) in human cancers, and that chemotherapeutic drugs like oxaliplatin and mitoxantrone can enhance tumor sensitivity to PD-(L)1 inhibitors by up-regulating MHC-I AgPP.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Fuguo Wu, Jonathan E. Bard, Julien Kann, Donald Yergeau, Darshan Sapkota, Yichen Ge, Zihua Hu, Jie Wang, Tao Liu, Xiuqian Mu
Summary: The study explores the roles of transcription factors Atoh7, Pou4f2, and Isl1 in retinal development using bulk RNA-seq and single-cell RNA-seq, revealing the emergence of the RGC lineage in the absence of Atoh7 and the defined competence of RPCs for different retinal fates in the transitional state.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Evan Tarbell, Kaiyu Jiang, Teresa R. Hennon, Lucy Holmes, Sonja Williams, Yao Fu, Patrick M. Gaffney, Tao Liu, James N. Jarvis
Summary: Juvenile idiopathic arthritis (JIA) is a common chronic disease in children, with unclear understanding of the underlying biology and therapeutic mechanisms. This study used a multi-omics approach to identify genetic influences on transcriptional abnormalities in CD4+T cells of children with active JIA. Results showed alterations in CD4+T cell chromatin, while normal 3D chromatin architecture was largely preserved, demonstrating the utility of multi-omics approaches in autoimmune disease research.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Adaobi Amobi-McCloud, Ravikumar Muthuswamy, Sebastiano Battaglia, Han Yu, Tao Liu, Jianmin Wang, Vasanta Putluri, Prashant K. Singh, Feng Qian, Ruea-Yea Huang, Nagireddy Putluri, Takemasa Tsuji, Amit A. Lugade, Song Liu, Kunle Odunsi
Summary: The study reveals the connection between IDO1 and AHR pathways with PD-1 expression and T cell infiltration in ovarian cancer, by affecting the tumor microenvironment through regulating tryptophan metabolic pathways. These findings facilitate the design of strategies to enhance anti-tumor immunity in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Haowen Zhang, Li Song, Xiaotao Wang, Haoyu Cheng, Chenfei Wang, Clifford A. Meyer, Tao Liu, Ming Tang, Srinivas Aluru, Feng Yue, X. Shirley Liu, Heng Li
Summary: Chromap is an efficient computational method designed to align and preprocess high throughput sequencing data from chromatin profiling techniques, significantly reducing runtime. As sequencing depth in chromatin studies increases, Chromap proves to be over 10 times faster than traditional workflows, as well as 10x Genomics' CellRanger v2.0.0 pipeline, while maintaining alignment accuracy comparable to BWA-MEM and Bowtie2.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Masayuki Hagiwara, Atsushi Fushimi, Atrayee Bhattacharya, Nami Yamashita, Yoshihiro Morimoto, Mototsugu Oya, Henry G. Withers, Qiang Hu, Tao Liu, Song Liu, Kwok K. Wong, Mark D. Long, Donald Kufe
Summary: The oncogenic MUC1-C protein plays a crucial role in driving the dedifferentiation of castrate resistant prostate cancer cells. It activates the type II interferon-gamma (IFN-gamma) pathway and induces chromatin remodeling, leading to the suppression of immune response and promotion of cancer stem cell state.
Article
Biochemistry & Molecular Biology
Yichen Ge, Xushen Chen, Nan Nan, Jonathan Bard, Fuguo Wu, Donald Yergeau, Tao Liu, Jie Wang, Xiuqian Mu
Summary: This study investigates the epigenetic landscape changes during retinal cell differentiation using single-cell ATAC sequencing (scATAC-seq) and identifies enhancers, enriched motifs, and potential interacting transcription factors associated with cell state/type-specific gene expression. Using CUT&Tag, the study also identifies enhancers directly bound by four key transcription factors and reveals the sequential and combinatorial interactions of these factors with the epigenetic landscape to control gene expression along retinal cell lineages. The results provide insights into the collaborative and competitive regulation of distinct retinal cell types from multipotent retinal progenitor cells (RPCs) by transcription factors.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Tao Liu, Jiaojiao Zhou, Yanmin Chen, Jia Fang, Song Liu, Costa Frangou, Hai Wang, Jianmin Zhang
Summary: The protein TAZ plays a crucial role in the Hippo signaling pathway and its activation leads to binding to enhancer and non-coding regions, as well as chromatin structural alterations. This study provides important insights into the mechanism by which TAZ regulates gene expression and its potential role in breast cancer therapy.
Article
Biology
Atrayee Bhattacharya, Atsushi Fushimi, Keyi Wang, Nami Yamashita, Yoshihiro Morimoto, Satoshi Ishikawa, Tatsuaki Daimon, Tao Liu, Song Liu, Mark D. Long, Donald Kufe
Summary: Chronic inflammation plays a crucial role in promoting cancer progression through epigenetic reprogramming. In this study, we demonstrate that the MUC1-C protein, activated by the NF-kappa B pathway, regulates H3K4 methylation levels and the expression of COMPASS SET1A/SETD1A and WDR5 genes. Furthermore, MUC1-C, along with other proteins, is involved in the expression of key regulators of pluripotency network and stemness.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Ophthalmology
Xiuqian Mu, Yichen Ge, Fuguo Wu, Jonathan Bard, Julien Kann, Donald Yergeau, Darshan Sapkota, Zihua Hu, Jie Wang, Tao Liu
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Article
Biotechnology & Applied Microbiology
Chenfei Wang, Dongqing Sun, Xin Huang, Changxin Wan, Ziyi Li, Ya Han, Qian Qin, Jingyu Fan, Xintao Qiu, Yingtian Xie, Clifford A. Meyer, Myles Brown, Ming Tang, Henry Long, Tao Liu, X. Shirley Liu
Meeting Abstract
Rheumatology
Kaiyu Jiang, Yungki Park, Tao Liu, Marc Sudman, Susan Thompson, James Jarvis
ARTHRITIS & RHEUMATOLOGY
(2020)
Meeting Abstract
Rheumatology
Kaiyu Jiang, Tao Liu, Ryan Tewhey, James Jarvis
ARTHRITIS & RHEUMATOLOGY
(2020)