Article
Endocrinology & Metabolism
Samuel Rosin, Kai Xia, M. Andrea Azcarate-Peril, Alexander L. Carlson, Cathi B. Propper, Amanda L. Thompson, Karen Grewen, Rebecca C. Knickmeyer
Summary: The study shows that gut microbial composition may influence HPA axis reactivity in early human development, suggesting potential for future clinical interventions targeting gut microbes to promote the development of stress-response systems.
PSYCHONEUROENDOCRINOLOGY
(2021)
Review
Behavioral Sciences
Hannah Klusmann, Noemi Luecking, Sinha Engel, Meike Katharina Blecker, Christine Knaevelsrud, Sarah Schumacher
Summary: Sex disparities in the biological response to acute stressors were investigated in this systematic review and meta-analysis, with a focus on the influence of ovarian hormones on HPA axis functioning. The study found higher cortisol reactivity in the luteal phase compared to the follicular phase, suggesting a difference in HPA axis reactivity between menstrual cycle phases. However, more high-quality primary studies are needed to further explore this association. This review was not funded and was pre-registered in PROSPERO.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Endocrinology & Metabolism
Pauline S. Effenberger, Tabea S. Send, Maria Gilles, Josef Frank, Stephan Bongard, Robert Kumsta, Stephanie H. Witt, Marcella Rietschel, Michael Deuschle, Fabian Streit, Isabell A. C. Wolf
Summary: There is no strong association between urbanicity and behavior problems or HPA axis regulation in preschool age, and urinary cortisol and salivary cortisol response after stress exposure are not identified as mediators of this relationship.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Psychology, Developmental
Cong Cao, Jolien Rijlaarsdam
Summary: This study examines the moderation effect of multilocus HPA-axis related genetic variants on the association between parenting and adolescent internalizing and externalizing symptoms. Results suggest that these genetic variants interact with both maternal and paternal parenting in the association with internalizing symptoms, but not externalizing symptoms. Adolescents with high genetic variants exhibit more internalizing symptoms with low quality parenting, and less internalizing symptoms with high quality parenting.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Behavioral Sciences
Lili Qing, Changqing Gao, Aicen Ji, Xin Lu, Li Zhou, Shengjie Nie
Summary: Aggressive behavior may have adaptive value in certain environmental conditions, but when extreme or improper, it can pose a serious threat to human and social well-being. The NR3C2 gene, involved in regulating the stress-related HPA axis, has been found to be associated with aggressive behavior through DNA methylation, suggesting it could be a potential biomarker for aggressive behavior.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biology
Ayeisha Milligan Armstrong, Tenielle Porter, Hazel Quek, Anthony White, John Haynes, Connie Jackaman, Victor Villemagne, Kylie Munyard, Simon M. Laws, Giuseppe Verdile, David Groth
Summary: Chronic psychosocial stress is recognized as a risk factor for sporadic Alzheimer's disease. Factors such as dysregulation of the HPA axis and elevated levels of cortisol may contribute to the disease process. Individual differences in sensitivities to glucocorticoid and stress responses could also impact an individual's risk of developing AD.
BIOLOGICAL REVIEWS
(2021)
Article
Medicine, Legal
Linlin Liu, Jiajue Li, Lili Qing, Ming Yan, Gen Xiong, Xinqing Lian, Liping Hu, Shengjie Nie
Summary: Aggressive behavior poses a serious threat to personal safety and property. Research indicates the crucial role of the HPA axis in aggressive behavior, and significant correlation between DNA methylation of the NR3C1 gene and aggressive behavior has been found.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2021)
Article
Oncology
Eric Trepo, Stefano Caruso, Jie Yang, Sandrine Imbeaud, Gabrielle Couchy, Quentin Bayard, Eric Letouze, Nathalie Ganne-Carrie, Christophe Moreno, Abderrahim Oussalah, Cyrille Feray, Jean Frederic Blanc, Bruno Clement, Patrick Hillon, Jerome Boursier, Valerie Paradis, Julien Calderaro, Viviane Gnemmi, Jean-Charles Nault, Jean-Louis Gueant, Jacques Deviere, Isabelle Archambeaud, Carole Vitellius, Bruno Turlin, Jean-Pierre Bronowicki, Thierry Gustot, Angela Sutton, Marianne Ziol, Pierre Nahon, Jessica Zucman-Rossi
Summary: This study identified genetic variants associated with alcohol-related hepatocellular carcinoma through a genome-wide association analysis. The researchers found that WNT3A-WNT9A is a susceptibility locus for alcohol-related hepatocellular carcinoma and discovered several other genetic variants associated with the risk of liver cancer.
Article
Biochemistry & Molecular Biology
Javier Ib, Lalla Hasna Zinelabidine, Rafael Torres-Perez, Jerome Grimplet, Elisa Baroja, Sergio Ibanez, Pablo Carbonell-Bejerano, Jose Miguel Martinez-Zapater, Javier Ibanez, Javier Tello
Summary: The study revealed that grape yield components are determined by complex polygenic factors, with certain SNPs showing additive effects on the phenotype. This suggests that superior grape cultivars with optimized fruit production can potentially be generated by pyramiding advantageous alleles from different genetic loci.
Article
Clinical Neurology
Xing-xing Chen, Luo-piao Xu, Chen-chen Zeng, Xing-yan Zhang, Fang-biao Tao, Ying Sun
Summary: The study found that adolescents who experienced prolonged separation from both parents are at heightened risk of pain when carrying more risk alleles related to HPA-axis stress reactivity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Jacob M. Maskal, Luiz F. Brito, Alan W. Duttlinger, Kouassi R. Kpodo, Betty R. McConn, Christopher J. Byrd, Brian T. Richert, Jeremy N. Marchant, Donald C. Lay, Shelbi D. Perry, Matthew C. Lucy, Tim J. Safranski, Jay S. Johnson
Summary: The study found that in utero heat stress can affect the postnatal hormone system responses of pigs, specifically related to the hypothalamic-pituitary-adrenal axis involved in corticotropin releasing hormone signaling. Additionally, age was shown to influence this response.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Weining Li, Zhaojun Wang, Shenghao Luo, Jianliang Wu, Lei Zhou, Jianfeng Liu
Summary: This study investigates the genetic architecture of feed efficiency (FE) and related traits in pig breeds. It identifies genetic relationships between FE and growth traits, and identifies SNPs and candidate genes associated with FE and FE-related traits. The study also identifies pathways involved in digestive and metabolic processes that are significantly associated with FE and FE-related traits. The results provide valuable information for the genomic selection of FE and FE-related traits in pigs.
Article
Plant Sciences
Jinyang Liu, Yun Lin, Jingbin Chen, Qiang Yan, Chenchen Xue, Ranran Wu, Xin Chen, Xingxing Yuan
Summary: In this study, a large number of genetic resources and extensive genomic data were used to systematically investigate the quantitative trait nucleotides (QTNs) and QTN-by-environment interactions (QEIs) for seed length, width, and weight in mungbean. Genes and candidate genes associated with these traits were identified, providing a reliable approach and solid foundation for identifying seed size-related genes and further molecular biology research.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Marius Nistor, Martin Schmidt, Carsten Klingner, Caroline Klingner, Matthias Schwab, Sabine Juliane Bischoff, Georg Matziolis, Guadalupe Leticia Rodriguez-Gonzalez, Rene Schiffner
Summary: The study demonstrated that prenatal dexamethasone injection may impact HPAA, reducing renal glucose release during hypoglycaemia while maintaining renal function parameters unchanged and significantly increasing urinary sodium excretion. Specimens with elevated HPAA may undergo long-term adaptations to maintain glucose homeostasis, but the decrease in renal net glucose release warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Hongyuan Zhu, Luming Wu, Tingwei Su, Lei Jiang, Weiwei Zhou, Yiran Jiang, Cui Zhang, Xu Zhong, Weiqing Wang
Summary: This study investigated the association between radiological characteristics of benign adrenocortical tumors and the hypothalamus-pituitary-adrenal (HPA) axis in 494 patients. It was found that patients with mild autonomous cortisol secretion (MACS) had larger tumor diameter, thinner contralateral adrenal gland, and lower plasma ACTH and serum DHEAS levels compared to those with non-functional adrenocortical tumors (NFAT). ACTH was shown to mediate the effects of MACS on DHEAS and contralateral adrenal gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Adewunmi O. Omotoso, Henry Reyer, Michael Oster, Steffen Maak, Siriluck Ponsuksili, Klaus Wimmers
Summary: Phosphorus inclusion in broiler diets needs to be tailored to their physiological demands at different developmental stages. A timed nutritional conditioning strategy, such as P depletion, may enhance mineral homeostasis mechanisms and reduce dietary P supply. This study investigated the effects of dietary P depletion on broiler chickens at different developmental stages, revealing marked responses early on, but indications of compensatory mechanisms later. Endocrine control mediated by calcitriol, intestinal P uptake, and mineral mobilization from bones were identified as potential mechanisms for maintaining mineral homeostasis. Precise timing, duration, and extent of P depletion should be considered for optimized nutrient utilization in broiler husbandry.
Article
Chemistry, Analytical
Mohd. Rahil Hasan, Pradakshina Sharma, Shifa Shaikh, Saumitra Singh, Roberto Pilloton, Jagriti Narang
Summary: We have developed a paper-based experimental platform for analyzing dengue virus, which incorporates screen-printing technology and black carbon conductive ink. The platform utilizes both two-electrode and three-electrode systems, with an LOD of 0.1 μg/mL for detecting the virus. The three-electrode system exhibits a significantly higher current range and amplification compared to the two-electrode system, making it a viable option for sensitive detection of dengue virus and other diseases.
Article
Nutrition & Dietetics
Maruf Hasan, Michael Oster, Henry Reyer, Klaus Wimmers, Dagmar-Christiane Fischer
Summary: Vitamin D-3 (Vit D-3) and 25(OH)D-3 are used as dietary sources of active vitamin D in pig husbandry, and while their primary effects are on the intestine, kidney, and bone, they also have wide-ranging effects on peripheral tissues. The use of Vit D-3 and 25(OH)D-3 in pig nutrition has been shown to have different outcomes in terms of reproductive capacities, growth performance, immunity, and bone development.
BRITISH JOURNAL OF NUTRITION
(2023)
Correction
Nutrition & Dietetics
Maruf Hasan, Michael Oster, Henry Reyer, Klaus Wimmers, Dagmar-Christiane Fischer
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Zoology
Nicole Maffezzini, Simon P. Turner, J. Elizabeth Bolhuis, Gareth Arnott, Irene Camerlink
Summary: This study investigated third-party interference and found that interferers derive benefits from winning a fight and the patterns of intervention depend on familiarity. Dyadic fights last longer than triadic fights and interferers engage in non-agonistic social behaviours afterwards.
FRONTIERS IN ZOOLOGY
(2023)
Meeting Abstract
Agriculture, Dairy & Animal Science
Julia A. Calderon Diaz, Suzanne Desire, Craig Lewis, Rainer Roehe, Simon Turner Turner
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Hanne Honerlagen, Henry Reyer, Ibrahim Abou-Soliman, Dierck Segelke, Siriluck Ponsuksili, Nares Trakooljul, Norbert Reinsch, Bjoern Kuhla, Klaus Wimmers
Summary: Improving the nitrogen-utilization efficiency (NUE) of dairy cows through breeding selection has benefits in terms of nutrition, environment, and economics. The individual milk urea concentration (MU) of cows has been proposed as an indicator trait for NUE. This study aimed to identify different microbial genera in the rumen of Holstein cows with divergent genomic breeding values for MU (GBVMU). The identified microbial genera were further investigated for their correlations with MU and other NUE-associated traits, providing insight into genetically determined N-utilization in Holstein cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Cell Biology
Julia Brenmoehl, Elli Brosig, Nares Trakooljul, Christina Walz, Daniela Ohde, Antonia Noce, Michael Walz, Martina Langhammer, Stefan Petkov, Monika Roentgen, Steffen Maak, Christina E. E. Galuska, Beate Fuchs, Bjoern Kuhla, Siriluck Ponsuksili, Klaus Wimmers, Andreas Hoeflich
Summary: This study investigated the contribution of non-mitochondrial and mitochondrial metabolic pathways in contracting muscles during repeated training. The results showed that marathon mice displayed increased glucose and fatty acid oxidation, reduced lactate dehydrogenase activity, and inhibited lactate formation compared to trained control mice. This suggests that marathon mice have enhanced metabolic flexibility towards lipid catabolism regulated by lactate dehydrogenase.
Article
Agriculture, Dairy & Animal Science
Babatope E. Akinyemi, Faical Akaichi, Janice M. Siegford, Simon P. Turner
Summary: This study analyzes the perceptions of precision livestock farming (PLF) technology held by stakeholders in the US swine industry using the Q-methodology approach. By following up with stakeholders interviewed 6 months earlier, the study found three distinct viewpoints: PLF improves farm management, animal welfare, and labor conditions; PLF does not solve industry problems; PLF has limitations and could lead to data ownership conflicts. Stakeholders with in-depth knowledge of PLF were optimistic about its potential, while those with basic understanding were skeptical. However, all stakeholders agreed on the importance of training and adoption of PLF. The study's results hold promise for informed decision-making about PLF implementation in the US swine industry.
Article
Endocrinology & Metabolism
A. Foury, N. Mach, A. Ruet, L. Lansade, M. -p. Moisan
Summary: The improvement of horse welfare through housing conditions has raised concerns about the detrimental effects of individual housing on horse health and behavior. In this study, blood transcriptome analysis was performed on sport horses housed individually to identify the molecular pathways associated with behavioral changes and welfare impairment. Aggressiveness towards humans was found to be the most correlated behavioral indicator with blood gene expression, mainly related to systemic inflammation. Stereotypies were also correlated with blood gene expression when combined with fecal microbiota analysis. Further studies are needed to understand the biological correlates of unresponsiveness to the environment and alert postures.
COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Bjarne Nielsen, Lizette Vestergaard Horndrup, Simon P. Turner, Ole Fredslund Christensen, Hanne Marie Nielsen, Birgitte Ask
Summary: In this study, it was found that selection of purebred parents for social breeding values (SBV) for growth rate resulted in calmer crossbred pigs in the weighing crate and fewer ear lesions. However, no effect of SBV was observed on tail biting behavior.
GENETICS SELECTION EVOLUTION
(2023)
Article
Agriculture, Dairy & Animal Science
Babatope E. Akinyemi, Belinda Vigors, Simon P. Turner, Faical Akaichi, Madonna Benjamin, Anna K. Johnson, Monique D. Pairis-Garcia, Dale W. Rozeboom, Juan P. Steibel, David P. Thompson, Cassey Zangaro, Janice M. Siegford
Summary: Precision livestock farming (PLF) technology development has been rapid, but adoption on farms has been slow. Understanding stakeholders' views, applications, limitations, and concerns regarding PLF technology is crucial for understanding adoption factors. Through online interviews, 12 influential stakeholders' views and experiences were investigated. Two distinct stakeholder groups were identified, the PLF enthusiasts and the PLF cautious. The majority of participants were familiar with and experienced in using PLF technologies in the swine industry. PLF technology was perceived to improve decision-making, care for animals, labor efficiency, and resource-use efficiency. Poor internet connectivity and the need to prioritize daily farm tasks were identified as key obstacles to implementation. Stakeholders' concerns included data privacy and the impact of PLF technology on human-animal relationships and farmers' duty of care. Stakeholders prioritized camera systems for monitoring pig health and welfare and ensuring individual pig identification in future PLF development.
FRONTIERS IN ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Suzanne Desire, Julia A. Calderon Diaz, Craig R. G. Lewis, Rainer Roehe, Simon P. Turner
Summary: This study estimated the genetic parameters of human-directed behavior and intraspecific social aggression in growing pigs and found that these traits are heritable and potentially useful for genetic selection. Additionally, there were genetic associations between aggression and fear/boldness indicators. Selecting against extreme shyness and boldness could result in easier to handle pigs during routine farm procedures.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Amanda B. B. Alvarenga, Hinayah R. R. Oliveira, Simon P. P. Turner, Andre Garcia, Kelli J. J. Retallick, Stephen P. P. Miller, Luiz F. F. Brito
Summary: This study evaluates the temperament and genomic background of North American Angus cows and finds that their temperament can be improved through learning and behavioral plasticity. The heritability of temperament increases with age, and the candidate genes are mainly associated with hormones, cognitive development, and behavioral changes.
GENETICS SELECTION EVOLUTION
(2023)
Review
Biochemistry & Molecular Biology
Fabio Sarais, Alvaro Perdomo-Sabogal, Klaus Wimmers, Siriluck Ponsuksili
Summary: This review focuses on the latest discoveries of tsRNAs, with special attention to molecules initially thought to be associated with tiRNAs. The paper outlines their biological functions, provides a collection of useful databases, and discusses future research perspectives and applications in livestock basic and applied research.