Article
Gastroenterology & Hepatology
Juan F. Burgueno, Julia Fritsch, Eddy E. Gonzalez, Kevin S. Landau, Ana M. Santander, Irina Fernandez, Hajar Hazime, Julie M. Davies, Rebeca Santaolalla, Matthew C. Phillips, Sophia Diaz, Rishu Dheer, Nivis Brito, Judith Pignac-Kobinger, Ester Fernandez, Gregory E. Conner, Maria T. Abreu
Summary: Chronic colonic inflammation can lead to dysplasia and cancer. Activation of TLR4 is associated with up-regulation of DUOX2 and NOX1, leading to increased epithelial production of H2O2, promoting colorectal tumor formation.
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cell Biology
Ahmed Kouki, Wafa Ferjani, Pham My-Chan Dang, Neziha Ghanem-Boughanmi, Abdelaziz Souli, Mossadok Ben-Attia, Jamel El-Benna
Summary: This study demonstrates the preventive effect of apocynin on acetic acid-induced ulcerative colitis in rats. Apocynin reduces pro-oxidant markers, preserves colonic cytoarchitecture, and decreases systemic inflammatory markers. These findings suggest that apocynin could be a promising therapeutic option for the prevention of ulcerative colitis.
Article
Medicine, Research & Experimental
Chunlan Huang, Zehua Huang, Ling Ding, Yang Fu, Junjie Fan, Qixiang Mei, Lihong Lou, Jingjing Wang, Nuoming Yin, Yingying Lu, Sanwei Guo, Yue Zeng
Summary: This study compared the efficacy and safety of fecal microbiota transplantation (FMT) with glucocorticoids as induction therapy in ulcerative colitis (UC). The results showed that FMT was as effective as glucocorticoids in inducing remission in active mild to moderate UC, with fewer adverse events. Changes in certain cytokines in the serum might be related to the efficacy of FMT therapy in UC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Renato Simoes Gaspar, Plinio M. Ferreira, Joanne L. Mitchell, Giordano Pula, Jonathan M. Gibbins
Summary: The study shows that PDEVs contain Nox-1 and can induce platelet activation through Nox1-mediated superoxide generation. Inhibition of Nox-1 eliminates PDEV-mediated platelet activation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hassan Dakik, Maya El Dor, Joan Leclerc, Farah Kouzi, Ali Nehme, Margaux Deynoux, Christelle Debeissat, Georges Khamis, Elfi Ducrocq, Aida Ibrik, Marie-Jose Stasia, Houssam Raad, Hamid Reza Rezvani, Fabrice Gouilleux, Kazem Zibara, Olivier Herault, Frederic Mazurier
Summary: The study found that NOX2 is widely expressed in AML blasts, especially in certain types of cells, but less expressed in stem cells and relapsed AML. Endogenous NOX activity could not be detected without stimulation. Although CYBB knockdown affected NOX2 activity, it did not impact the proliferation and differentiation of THP-1 and HL-60 cells.
Article
Food Science & Technology
Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Doris D'Souza, Hari B. Krishnan, Vermont P. Dia
Summary: This study assessed the in vivo anti-inflammatory properties of Lunasin protease inhibitor concentrate (LPIC). In vitro tests showed that LPIC induced the production of nitric oxide and maintained cytokine levels. In vivo experiments demonstrated that LPIC significantly attenuated tissue damage in ulcerative colitis.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Review
Chemistry, Medicinal
Jose Israel Rodrigues Jr, Joice Kelly Gomes de Vasconcelos, Lylian Ellen Militao dos Santos Xavier, Amanda da Silva Gomes, Juliana Celia de Farias Santos, Samara Bomfim Gomes Campos, Amylly Sanuelly da Paz Martins, Marilia Oliveira Fonseca Goulart, Fabiana Andrea Moura
Summary: The objective of this study was to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review and meta-analysis were conducted, and it was found that antioxidant capacity and lipid peroxidation levels were not significantly modulated, while superoxide dismutase levels showed significant modulation. However, there is still limited research on oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment. The results highlight the potential of antioxidant supplementation in IBD management and emphasize the need for further investigations into its effects on oxidative stress biomarkers and cytokines.
Article
Gastroenterology & Hepatology
Caroline Voskens, Diane Stoica, Marita Rosenberg, Francesco Vitali, Sebastian Zundler, Marion Ganslmayer, Heike Knott, Manuel Wiesinger, Jutta Wunder, Mirko Kummer, Britta Siegmund, Elisabeth Schnoy, Timo Rath, Arndt Hartmann, Holger Hackstein, Beatrice Schuler-Thurner, Carola Berking, Gerold Schuler, Raja Atreya, Markus F. Neurath
Summary: This study reports a successful case of adoptive transfer of ex vivo expanded Tregs in a patient with refractory UC, showing positive responses. These findings suggest that adoptive Treg therapy might be effective in refractory UC.
Article
Biochemistry & Molecular Biology
Eloisa A. Vilas-Boas, Christopher Carlein, Lisa Nalbach, Davidson C. Almeida, Emmanuel Ampofo, Angelo R. Carpinelli, Leticia P. Roma, Fernanda Ortis
Summary: In the development of type 1 diabetes, proinflammatory cytokines released by immune cells lead to increased reactive oxygen species production in beta-cells. NOX2 may be a potential target for therapies against early beta-cell dysfunction.
Article
Cell Biology
Faezeh Niazi Shahraki, Saeideh Momtaz, Maryam Baeeri, Danial Khayatan, Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Ali Reza Abdollahi, Ahmad Reza Dehpour, Amir Hossein Abdolghaffari
Summary: This study evaluated the anti-inflammatory effects of Licofelone in a rat model of acetic acid-induced colitis. The results showed that Licofelone attenuated colitis, increased superoxide dismutase activity, and significantly reduced colonic levels of inflammatory factors. Additionally, the concurrent use of nitric oxide synthase inhibitors with Licofelone reversed the observed positive effects, demonstrating the role of nitric oxide in the pathogenesis of inflammatory bowel disease and the mechanism of action of Licofelone in colitis healing.
Article
Biochemistry & Molecular Biology
Renato Simoes Gaspar, Tanya Sage, Gemma Little, Neline Kriek, Giordano Pula, Jonathan M. Gibbins
Summary: This study demonstrates that PDI and Nox-1 cooperate to control platelet function and are associated with cardiometabolic risk factors.
Article
Biochemistry & Molecular Biology
Yosef Fichman, Sara Zandalinas, Scott Peck, Sheng Luan, Ron Mittler
Summary: The leucine-rich-repeat receptor-like kinase HPCA1 plays a key role in mediating and coordinating systemic cell-to-cell reactive oxygen species and calcium signals required for plant acclimation to stress.
Article
Physiology
Caspar Schiffers, Lennart K. A. Lundblad, Milena Hristova, Aida Habibovic, Christopher M. Dustin, Nirav Daphtary, Minara Aliyeva, David J. Seward, Yvonne M. W. Janssen-Heininger, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet
Summary: Aging is associated with a decline in innate airway injury responses to external nonmicrobial triggers, primarily due to downregulation of DUOX1 and its redox-dependent signaling pathways. However, the impact of DUOX1 deficiency on age-related airspace enlargement and decline in lung function varies between different C57BL6 substrains, possibly related to metabolic alterations due to differences in NNT function.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Marija Podolski, Lidija Pozgaj, Ivan Faraho, Adriana Petrinic Grba, Daniela Belamaric, Andrea Paravic Radicevic, Martina Bosnar, Marija Crncevic Urek, Aleksandar Cubranic, Sanda Mustapic, Brankica Mijandrusic-Sincic, Marko Banic, Vesna Erakovic Haber
Summary: In this study, fresh biopsies were collected from ulcerative colitis (UC) patients to investigate cytokine production in ex vivo culture conditions. The correlation between cytokine production and disease severity scores was analyzed. The results showed increased levels of various cytokines in UC patients compared to controls. The cytokine levels correlated better with Mayo Endoscopic Subscore and Mayo score than with the more complex Ulcerative Colitis Endoscopic Index of Severity (UCEIS).
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)