Review
Food Science & Technology
Marta Justyna Koziel, Maksymilian Ziaja, Agnieszka Wanda Piastowska-Ciesielska
Summary: The intestinal barrier acts as the main defense against substances entering the body, ensuring balance in the organism; Mycotoxins, toxic fungi metabolites, may disrupt homeostasis by affecting the intestinal barrier; Claudins, proteins involved in tight junction formation between epithelial cells, play a significant role in responding to mycotoxin-induced cytotoxicity.
Review
Microbiology
Hong-Zhong Gou, Yu-Lin Zhang, Long-Fei Ren, Zhen-Jiao Li, Lei Zhang
Summary: The intestinal barrier prevents harmful substances from penetrating the intestinal wall, while intestinal probiotics are beneficial to the host and can restore the intestinal barrier.
FRONTIERS IN MICROBIOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Mengdie Chen, Yuyu Liu, Shanbai Xiong, Moucheng Wu, Bin Li, Zheng Ruan, Xiaobo Hu
Summary: This study investigated the effect of dietary L-tryptophan on the regulation of tight junctions in LPS-induced intestinal barrier injury in a Caco-2 cell monolayer model.
Article
Food Science & Technology
Laura Benvenuti, Vanessa D'Antongiovanni, Carolina Pellegrini, Matteo Fornai, Nunzia Bernardini, Chiara Ippolito, Cristina Segnani, Clelia Di Salvo, Rocchina Colucci, Alma Martelli, Lorenzo Flori, Vincenzo Calderone, Gianfranca Carta, Emilia Ghelardi, Marco Calvigioni, Adelaide Panattoni, Raffaella Coppolecchia, Achille Arini, Luca Antonioli
Summary: This study aimed to evaluate the effects of alterations in intestinal microbiota and its metabolites on intestinal epithelial barrier integrity and enteric inflammation in obesity, and to assess the therapeutic potential of probiotic Enterococcus faecium (SF68). The results showed that SF68 treatment reduced body weight gain, decreased inflammation markers, and improved intestinal barrier integrity and functionality in obese mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Engineering, Biomedical
Elisa Boehm, Linda Droessler, Salah Amasheh
Summary: CBD, as a component of Cannabis-based biomaterials, has a strengthening effect on the cellular barrier under inflammatory conditions and mitigates the disruption of paracellular permeability and sealing proteins. These findings demonstrate the potential of CBD in therapeutic approaches against inflammatory pathogenesis.
MATERIALS TODAY BIO
(2023)
Article
Physiology
Kristina Sundell, Gerd Marit Berge, Bente Ruyter, Henrik Sundh
Summary: Due to limited access to marine raw materials, Atlantic salmon feeds have low levels of omega-3 fatty acids, which may affect the growth and intestinal function of salmon.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Linda Droessler, Valeria Cornelius, Alexander G. Markov, Salah Amasheh
Summary: The study demonstrates the detrimental effects of TNFα on non-transformed intestinal epithelial cells, leading to barrier dysfunction. This is achieved through modulation of tight junction proteins and TNF receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Andre Barany, Milagrosa Oliva, Silvia Filipa Gregorio, Gonzalo Martinez-Rodriguez, Juan Miguel Mancera, Juan Fuentes
Summary: This study investigated the physiological effects of Aflatoxin B1 (AFB1) on the gastrointestinal system of seabream through in vitro and in vivo experiments, as well as molecular analysis. Results showed dose-related effects on ion transport, changes in Na+/K+-ATPase and H+-ATPase activities, and alterations in intestinal barrier proteins expression. These findings suggest that AFB1 may be the underlying cause of growth impairment in fish reported previously.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qing-yu Cui, Xiao-ying Tian, Xi Liang, Zhe Zhang, Rui Wang, Yu Zhou, Hua-xi Yi, Pi-min Gong, Kai Lin, Tong-jie Liu, Lan-wei Zhang
Summary: This study aimed to identify probiotics with the potential to alleviate inflammatory bowel disease and elucidate their mechanism of action. Two strains of Bifidobacterium bifidum, FL-276.1 and FL-228.1, were found to be the most effective in improving body weight loss, colon shortening, and intestinal barrier disruption in mice. It was further discovered that these strains activated the aryl hydrocarbon receptor (AhR) in the intestine, potentially contributing to their anti-inflammatory properties.
Review
Nutrition & Dietetics
Raphaela Staltner, Katharina Burger, Anja Baumann, Ina Bergheim
Summary: Studies suggest that high dietary fructose intake may interfere with human health, leading to health disturbances such as hypertension, diabetes type 2, and non-alcoholic fatty liver disease. The metabolism of fructose can impact intestinal homeostasis and barrier function, altering the composition of intestinal microbiota and causing changes in tight junction proteins in the small intestine. These alterations may result in the translocation of harmful substances and the induction of signaling cascades in the liver and other tissues.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Medicine, General & Internal
Nuria Perez-Diaz-del-Campo, Gabriele Castelnuovo, Davide Giuseppe Ribaldone, Gian Paolo Caviglia
Summary: The study of intestinal permeability is of growing interest due to its relevance in various diseases. There is a need for non-invasive biomarkers or tools to accurately detect changes in intestinal barrier integrity.
Review
Immunology
Susana Lechuga, Manuel B. B. Braga-Neto, Nayden G. G. Naydenov, Florian Rieder, Andrei I. I. Ivanov
Summary: Disruption of the intestinal epithelial barrier is a common feature in mucosal inflammation, which leads to an inflammatory response. Previous studies on the breakdown of the gut barrier have mainly utilized colon cancer cell lines, which do not fully represent normal human intestinal epithelial cells. The development of human intestinal organoids provides a more physiologically-relevant platform to study the regulation and dysfunction of the intestinal barrier. This review discusses the use of human intestinal organoids to understand gut barrier disruption during mucosal inflammation, comparing them to conventional cell lines and identifying unique research questions that can be addressed using organoid platforms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ningjing Lei, Yanru Cheng, Jiajia Wan, Rosel Blasig, Anqi Li, Yueyue Bai, Reiner F. Haseloff, Ingolf E. Blasig, Linyu Zhu, Zhihai Qin
Summary: The role of claudin-3 in tumor-induced lymphangiogenesis was investigated. It was found that overexpression of claudin-3 inhibits lymphatic endothelial cell migration, leading to restricted lymphangiogenesis.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Bruna Cristina dos Santos Cruz, Luis Fernando de Sousa Moraes, Leticia De Nadai Marcon, Kelly Aparecida Dias, Leonardo Borges Murad, Mariaurea Matias Sarandy, Lisiane Lopes da Conceicao, Reggiani Vilela Goncalves, Celia Lucia de Luces Fortes Ferreira, Maria do Carmo Gouveia Peluzio
Summary: The study evaluated the effects of probiotic VSL#3 and a synbiotic product on oxidative stress modulation and intestinal permeability in an experimental model of colorectal carcinogenesis. Both the probiotic and synbiotic showed antioxidant activity, reducing markers of oxidative stress and protecting the mucosa from damage. Additionally, they reduced intestinal permeability, demonstrating potential for use as food supplements or ingredients for food products.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Cell Biology
Daniel Maucher, Birte Schmidt, Julia Schumann
Summary: Dysfunction of the endothelial barrier is central in inflammatory processes like sepsis and atherosclerosis. In this study, cytokine-induced weakening of the endothelial barrier was associated with changes in the transcriptome and upregulation of miR-29a-3p, miR-29b-3p, and miR-155-5p, which target central adhesion proteins' mRNAs. This suggests a posttranscriptional mechanism regulated by inflammatory cytokines.