Review
Obstetrics & Gynecology
Jingjing Gu, Dandan Chen, Zhiqiang Li, Yongliang Yang, Zhaoming Ma, Guanhong Huang
Summary: This meta-analysis investigated the relationship between the CD44(+)/CD24(-) phenotype and various pathological characteristics and survival rates of breast cancer patients. The results showed that the CD44(+)/CD24(-) phenotype was not associated with tumor size, lymph node metastasis, and distant metastasis, but it was negatively correlated with postoperative DFS and OS.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Review
Oncology
Mahdi Abdoli Shadbad, Negar Hosseinkhani, Zahra Asadzadeh, Afshin Derakhshani, Noora Karim Ahangar, Nima Hemmat, Parisa Lotfinejad, Oronzo Brunetti, Nicola Silvestris, Behzad Baradaran
Summary: CD44 and CD44(+)CD24(-/low) phenotype are associated with poor prognosis in TNBC patients, and these cancer stem cell markers are linked to advanced tumor stage, size, grade, metastasis, and lymphatic involvement in TNBC patients. Additionally, chemoradiotherapy-treated TNBC patients show an upregulation of CD44(+)CD24(-/low) phenotype, which inversely correlates with androgen receptor (AR) and leads to inferior prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Weiyan Hou, Lingwei Kong, Zhiping Hou, Hairu Ji
Summary: This study found that CD44 is highly expressed in gastric cancer cells and is associated with immune infiltration, serving as an independent prognostic factor.
BMC MEDICAL GENOMICS
(2022)
Article
Biology
Xinbo Qiao, Yixiao Zhang, Lisha Sun, Qingtian Ma, Jie Yang, Liping Ai, Jinqi Xue, Guanglei Chen, Hao Zhang, Ce Ji, Xi Gu, Haixin Lei, Yongliang Yang, Caigang Liu
Summary: The study found that a higher frequency of CD44(-)/CD24(-) breast cancer cells was associated with delayed breast cancer metastasis, and that RHBDL2 may play a role in breast cancer metastasis and CSC formation.
Article
Biochemistry & Molecular Biology
Ruizhi Geng, Niklas Harland, Ivonne A. Montes-Mojarro, Falko Fend, Wilhelm K. Aicher, Arnulf Stenzl, Bastian Amend
Summary: In this study, it was found through experiments that the expression of CD24 in bladder cancer cell organoids may serve as an indicator for the prolonged proliferation potential of the cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jing Li Huang, Masanori Oshi, Itaru Endo, Kazuaki Takabe
Summary: Clinically, patients with high CD24 expression in colorectal cancer tumors have better disease-specific and overall survival rates, and tumors with high CD133, CD24, and CD44 expression are associated with increased EGFR, KRAS, and Ki67 expression. Moreover, CD133-high/CD24-low tumors show potential for predicting worse prognosis in colorectal cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Jian-xian Lin, Changhwan Yoon, Ping Li, Qian Yu, Sheng-liang Qiu, Chao-hui Zheng, Sam S. Yoon, Chang-Ming Huang
Summary: The study demonstrated that high CD44 and high p-MEK expression are independent negative prognostic factors for gastric adenocarcinoma patients. Targeting the RTK-RAS pathway may improve the prognosis of these patients by inhibiting metastasis and reversing chemotherapy resistance.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Shanglin Wang, Rong Fan, Huayu Gao, Xiaoli Ma, Yufei Wu, Yuanxin Xing, Yunshan Wang, Yanfei Jia
Summary: The overphosphorylation of signal transduction and transcriptional activator 5A (STAT5A) is associated with tumor invasion and poor prognosis in gastric cancer (GC). STAT5A promotes GC cell proliferation by upregulating CD44 expression and directly binds to the CD44 promoter to promote its transcription. The STAT5A/CD44 pathway plays a critical role in GC progression, showing potential clinical applications for improving GC treatment.
Review
Biochemistry & Molecular Biology
Malak Hassn Mesrati, Saiful Effendi Syafruddin, M. Aiman Mohtar, Amir Syahir
Summary: CD44, a non-kinase cell surface transmembrane glycoprotein, is widely implicated as a cancer stem cell marker in multiple cancers. Cells overexpressing CD44 possess CSC traits and resistance to therapy. The CD44 gene undergoes alternative splicing, resulting in different isoforms that interact with various ligands and drive cancer-associated signaling pathways. However, the association between CD44 expression levels and clinicopathological features is contradictory, although high CD44 expression significantly contributes to tumorigenic mechanisms.
Review
Multidisciplinary Sciences
Agus Rizal Ardy Hariandy Hamid, Yasmina Zahra Syadza, Oliver Emmanuel Yausep, Roberto Bagaskara Indy Christanto, Bayu Hernawan Rahmat Muharia, Chaidir Arif Mochtar
Summary: Bladder cancer is associated with high recurrence rates and metastasis. Cancer stem cells (CSCs) contribute to these processes and may serve as prognostic markers for bladder cancer. This study reviewed 12 clinical studies and identified multiple CSC markers that are implicated in the recurrence and metastasis of bladder cancer. The detection of these markers offers a promising approach to determine the prognosis of bladder cancer.
Article
Biochemistry & Molecular Biology
Natalia Izycka, Marcin Rucinski, Malgorzata Andrzejewska, Sebastian Szubert, Ewa Nowak-Markwitz, Karolina Sterzynska
Summary: Recurrent disease and treatment-associated chemoresistance are major contributors to poor clinical outcomes in ovarian cancer patients. This study investigated the expression of CSC-associated markers ALDH1A, CD44, and CD133 to predict patient prognosis. ALDH1A1-positive patients had significantly shorter overall survival (OS) and progression-free survival (PFS). Multivariate analysis revealed that ALDH1A1 expression, FIGO stage III-IV, and residual disease were associated with shorter OS. Targeting ALDH1A1-positive cancer cells may be a promising therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Lornella Seeneevassen, Pierre Dubus, Caroline Gronnier, Christine Varon
Summary: The Hippo signalling pathway is important and complex in physiology, and its dysregulation can lead to cancer. In gastric carcinogenesis, the Hippo pathway and its effectors, YAP and TAZ, play a vital role. This review discusses the dysregulation of the Hippo pathway in gastric cancer and the strategies used to target it.
Article
Oncology
Sarah Courtois, Maria Haykal, Clement Bodineau, Elodie Sifre, Lamia Azzi-Martin, Armelle Menard, Francis Megraud, Philippe Lehours, Raul V. Duran, Christine Varon, Emilie Bessede
Summary: The infection of Helicobacter pylori can induce autophagy, which in turn affects the formation of gastric cancer stem cells. Inhibiting autophagy may be a potential therapeutic target for gastric cancer.
Review
Medicine, General & Internal
Lisbeth Escudero Mendez, Mirra Srinivasan, Ranim K. Hamouda, Baba Ambedkar, Hadia Arzoun, Isra Sahib, Jack Fondeur, Lubna Mohammed
Summary: Triple-negative breast cancer (TNBC) is a heterogeneous tumor with complex molecular characteristics and aggressive behavior. It does not express estrogen receptor, progesterone receptor, or HER2 gene, and is often high grade with distinct histological types. TNBC has a correlation with breast stem cell markers CD44+/CD24- and high levels of ALDH, which are associated with poor prognosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Cell & Tissue Engineering
Angel A. Gomez-Gallegos, Lizbeth Ramirez-Vidal, Jared Becerril-Rico, Elizabeth Perez-Islas, Zuly J. Hernandez-Peralta, Mariel E. Toledo-Guzman, Alejandro Garcia-Carranca, Elizabeth Langley, Angelica Hernandez-Guerrero, Fernando Lopez-Casillas, Roberto Herrera-Goepfert, Luis F. Onate-Ocana, Elizabeth Ortiz-Sanchez
Summary: By conducting multiparametric flow cytometry analysis, we identified an extended phenotype for gastric cancer stem cells (GCSCs) that can provide better identification and development of therapeutic targets. CD24+CD44+CD54+EpCAM+ cells were present in all treatment-naive patients with gastric cancer and their percentage was correlated with TNM staging and metastatic potential.
STEM CELL RESEARCH & THERAPY
(2023)