Article
Immunology
Masaya Yokoyama, Motoko Y. Kimura, Toshihiro Ito, Koji Hayashizaki, Yukihiro Endo, Yangsong Wang, Ryoji Yagi, Tomoo Nakagawa, Naoya Kato, Hisahiro Matsubara, Toshinori Nakayama
Summary: This study found that Myl9/12 were highly expressed in patients with inflammatory bowel disease and mice with DSS-induced colitis. Administration of anti-Myl9/12 Ab alleviated inflammation and prolonged survival, indicating Myl9/12 may be a new therapeutic target for patients with IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhimin Ye, Ximiao Yang, Boxiong Deng, Zhenlin Liao, Xiang Fang, Jie Wang
Summary: This study investigated the preventative effects and underlying mechanism of water kefir microbiota on inflammatory bowel disease (IBD). The results showed that water kefir microbiota effectively improved disease severity in a colitis mouse model induced by dextran sodium sulfate (DSS), including decreased body weight and colon length, increased spleen index and DAI score, and colonic tissue damage. Water kefir microbiota also restored the abnormal expression of tight junction proteins and pro-inflammatory and anti-inflammatory cytokines, and inactivated the TLR4-MyD88-NF-κB pathway induced by DSS. Additionally, water kefir microbiota improved the composition and metabolism of intestinal microbiota.
Article
Cell Biology
Caigui Xiang, Moting Liu, Qiukai Lu, Chen Fan, Huimin Lu, Chunlan Feng, Xiaoqian Yang, Heng Li, Wei Tang
Summary: CA was shown to significantly alleviate mucosal inflammation in a murine model of ulcerative colitis, possibly through interfering with the activation of macrophages, providing a potential alternative therapeutic option for UC.
CELLULAR IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Alexa N. Sasson, Ashwin N. Ananthakrishnan, Maitreyi Raman
Summary: The global incidence of inflammatory bowel diseases (IBDs) has increased significantly in the past few decades, with genetic and environmental factors playing a role in the pathogenesis. Diet is a potentially modifiable environmental risk factor for IBD, as it can promote intestinal inflammation through various mechanisms such as dysregulating the immune system and altering intestinal permeability. Dietary changes may be integrated into therapeutic strategies for IBD treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Wang Shujun, Zhang Huijie, Bai Xia, Wang Hongjian
Summary: Cerebral venous sinus thrombosis is a rare complication of inflammatory bowel disease, and early diagnosis along with prompt treatment is crucial for better prognosis. Anemia, low albumin, and elevated d-dimer are independent predictors of CVST in IBD patients.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Bikash Thapa, Seongwon Pak, Dohyeon Chung, Hye Kyoung Shin, Seong Ho Lee, Keunwook Lee
Summary: This study evaluated the immunomodulatory potential of a TLR inhibitor peptide in an animal model of ulcerative colitis. The peptide suppressed the production of pro-inflammatory cytokines in macrophages and ameliorated colitis symptoms in mice. It also enhanced the differentiation of monocyte-driven macrophages into regulatory macrophages and suppressed the activation of Th17 cells. Therefore, the TLR inhibitor peptide shows promise as a novel therapeutic candidate for the treatment of inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Maryam Ranjbar Bushehri, Nahid Babaei, Hadi Esmaeili Gouvarchin Ghaleh, Gholamreza Khamisipour, Gholamreza Farnoosh
Summary: This study investigates the anti-inflammatory effects of peiminine on ulcerative colitis. The results demonstrate that peiminine treatment can alleviate inflammatory manifestations, reduce intestinal tissue damage, and affect gene expression. Peiminine holds potential as a therapeutic adjunct for the management of ulcerative colitis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Immunology
Ning Xu, Xuelian Bai, Xiaoling Cao, Wenjing Yue, Weiwei Jiang, Zhenhai Yu
Summary: The study revealed significant alterations in the diversity and composition of fecal microbiota in patients with ulcerative colitis compared to healthy individuals. The dysbiosis of gut microbiota and its correlation with TLR expression levels may play crucial roles in the pathogenesis and progression of ulcerative colitis.
MICROBIAL PATHOGENESIS
(2021)
Article
Nutrition & Dietetics
Ammar Hassanzadeh Keshteli, Rosica Valcheva, Cheryl Nickurak, Heekuk Park, Rupasri Mandal, Kendall van Diepen, Karen I. Kroeker, Sander Veldhuyzen van Zanten, Brendan Halloran, David S. Wishart, Karen L. Madsen, Levinus A. Dieleman
Summary: The study reveals that dietary modifications, including increased intake of anti-inflammatory foods and decreased intake of pro-inflammatory foods, are associated with metabolic and microbial changes in ulcerative colitis patients in clinical remission, effectively preventing subclinical inflammation.
Article
Gastroenterology & Hepatology
Zhen-Huan Yang, Fang Liu, Xiao-Ran Zhu, Fei-Ya Suo, Zi-jun Jia, Shu-Kun Yao
Summary: The gut microbiota, fecal bile acids, and inflammatory cytokines are closely related in ulcerative colitis patients. Changes in the gut microbiota and fecal bile acid profiles may play a role in regulating inflammatory responses through bile acid receptors TGR5 and VDR.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Immunology
Maarit Eskuri, Niko Kemi, Olli Helminen, Heikki Huhta, Joonas H. Kauppila
Summary: The study found that high nuclear expression of TLR3 is associated with poorer 5-year survival in gastric cancer patients, while TLR7, TLR8, and TLR9 are not.
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Nutrition & Dietetics
Arno R. Bourgonje, Laura A. Bolte, Lianne L. C. Vranckx, Lieke M. Spekhorst, Ranko Gacesa, Shixian Hu, Hendrik M. van Dullemen, Marijn C. Visschedijk, Eleonora A. M. Festen, Janneke N. Samsom, Gerard Dijkstra, Rinse K. Weersma, Marjo J. E. Campmans-Kuijpers
Summary: This study aimed to investigate the association between dietary patterns and circulating inflammatory proteins in patients with inflammatory bowel disease (IBD). The results showed that a high-sugar diet was inversely associated with fibroblast growth factor-19 (FGF-19), while a Mediterranean-style diet was associated with higher FGF-19 levels. A diet characterized by high alcohol and coffee intake was positively associated with CCL11 levels and lower levels of IL-12B.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Carlos A. Guzman-Martin, Yaneli Juarez-Vicuna, Aaron Dominguez-Lopez, Javier Gonzalez-Ramirez, Luis M. Amezcua-Guerra, Laura A. Martinez-Martinez, Fausto Sanchez-Munoz
Summary: This study is the first to report that lncRNAs FGD5-AS1, OIP5-AS1, and GAS5 are promising candidates that play a role in APS monocytes and are differently expressed between patients and controls.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jose J. Leija-Martinez, Carlos A. Guzman-Martin, Javier Gonzalez-Ramirez, Abraham Giacoman-Martinez, Blanca E. Del-Rio-Navarro, Rodrigo Romero-Nava, Santiago Villafana, Jose Luis Flores-Saenz, Fausto Sanchez-Munoz, Fengyang Huang
Summary: Asthma is a heterogeneous condition with different endotypes and phenotypes, characterized by common clinical manifestations. Long noncoding RNAs (lncRNAs) are involved in various biological functions and could potentially act as biomarkers in allergic-asthma and obesity-related asthma. This study compared the expression levels of certain lncRNAs in different groups of adolescents and found differential expression and discriminative value of these lncRNAs between the groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Ingrid Rivera-Iniguez, Karina Gonzalez-Becerra, Omar Ramos-Lopez, Yolanda E. E. Perez-Beltran, Marian S. S. Chaguen-Hernandez, Erika Martinez-Lopez, Edgar J. J. Mendivil
Summary: This systematic review aims to identify genetic variants associated with lipid abnormalities for use in nutrigenetic interventions to prevent and treat dyslipidemia effectively.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jose de Jesus Rodriguez-Romero, Alejandro Arce-Reynoso, Claudia G. Parra-Torres, Victor M. Zamora-Gasga, Edgar J. Mendivil, Sonia G. Sayago-Ayerdi
Summary: Through this study, it was found that Hibiscus sabdariffa has great potential to be used as an ingredient in products with natural-based ingredients. The content of bioactive compounds in Hibiscus beverages was characterized and their bioaccessibility was evaluated. Results showed significant differences in the content of bioactive compounds before and after in vitro intestinal digestion, indicating that digestion significantly affects the profile of bioactive compounds in the beverage.
Article
Immunology
Carlos A. Barrera-Ochoa, Gabriela Fonseca-Camarillo, Maria Elisa Vega-Memije, Janette Furuzawa-Carballeda, Karen Uriarte-Ruiz, Dheni Aide Fernandez-Camargo, Jesus K. Yamamoto-Furusho
Summary: This study is the first to report the expression of TOB/BTG family genes and proteins in skin tissues from patients with plaque psoriasis. The mRNA levels and protein expression of TOB/BTG family were significantly decreased in psoriatic skin tissue compared to non-inflammatory control skin tissue. The expression of TOB1/2, BTG1,2, and BTG4/CD16 double-positive cells was found to be higher in normal control skin tissues and much lower in patients with plaque psoriasis, especially in moderate-severe patients.
IMMUNOLOGIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jose L. Sanchez-Gloria, Constanza E. Martinez-Olivares, Leonardo Del Valle-Mondragon, Fernando Cortes-Camacho, Oscar R. Zambrano-Vasquez, Rogelio Hernandez-Pando, Fausto Sanchez-Munoz, Laura G. Sanchez-Lozada, Horacio Osorio-Alonso
Summary: In this study, we evaluated the effects of allicin on vascular remodeling, endothelial function, and oxidative stress in experimental pulmonary arterial hypertension (PAH). Allicin administration improved body weight, survival rate, and prevented wall thickness and right ventricle hypertrophy. Allicin also maintained normal levels of angiotensin II and its receptors, increased nitric oxide and other beneficial molecules, and prevented oxidative stress and hypoxia response. These effects of allicin contribute to preventing endothelial dysfunction, remodeling of the pulmonary arteries, and heart failure in PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Sophie Vieujean, James O. Lindsay, Ferdinando D'Amico, Vineet Ahuja, Mark S. Silverberg, Ajit Sood, Jesus K. Yamamoto-Furusho, Masakazu Nagahori, Mamoru Watanabe, Ioannis E. Koutroubakis, Kalliopi Foteinogiannopoulou, Irit Avni Biron, Alissa Walsh, An Outtier, Rie Louise Moller Nordestgaard, Maria T. Abreu, Marla Dubinsky, Corey Siegel, Edouard Louis, Iris Dotan, Walter Reinisch, Silvio Danese, David T. Rubin, Laurent Peyrin-Biroulet
Summary: This study analyzes the reasons for non-enrollment of IBD patients in RCTs and finds that patients are lost at each step, with eligibility criteria, the risk of placebo assignment, and insufficient disease activity being the main barriers.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Nutrition & Dietetics
Ximena Flores-Balderas, Mario Pena-Pena, Karla M. Rada, Yamnia Q. Alvarez-Alvarez, Carlos A. Guzman-Martin, Jose L. Sanchez-Gloria, Fengyang Huang, Dayanara Ruiz-Ojeda, Sofia Moran-Ramos, Rashidi Springall, Fausto Sanchez-Munoz
Summary: The human skin is protected by both intrinsic and extrinsic factors. Intrinsic factors such as aging and genetics contribute to weakened skin, while extrinsic factors like UV radiation and poor diet also impact skin health. Plant-based diets are gaining popularity as a complementary therapy for skin health.
Article
Multidisciplinary Sciences
Abraham Said Arellano Buendia, Juan Gabriel Juarez Rojas, Fernando Garcia-Arroyo, Omar Emiliano Aparicio Trejo, Fausto Sanchez-Munoz, Raul Arguello-Garcia, Laura Gabriela Sanchez-Lozada, Rafael Bojalil, Horacio Osorio-Alonso
Summary: This study found that allicin has antioxidant and anti-inflammatory effects on metabolic syndrome, reducing systemic and renal inflammation as well as oxidative stress. These findings suggest that allicin may be a therapeutic option for kidney injury caused by metabolic syndrome risk factors.
Article
Microbiology
Luis M. Amezcua-Guerra, Carlos A. Guzman-Martin, Isela Montufar-Robles, Rashidi Springall, Adrian Hernandez-Diazcouder, Rosa Elda Barbosa-Cobos, Fausto Sanchez-Munoz, Julian Ramirez-Bello
Summary: This study investigated the impact of the CD147 gene rs8259T>A single nucleotide variant on individuals with COVID-19 in Mexico. The results suggest that the CD147 rs8259T>A variant is significantly associated with susceptibility to COVID-19, acting as a risk factor.
Article
Biochemistry & Molecular Biology
Brianda Amezcua-Guerra, Luis M. Amezcua-Castillo, Jazmin A. Guerra-Lopez, Kietsee A. Diaz-Dominguez, Jose L. Sanchez-Gloria, Andres Cruz-Melendez, Adrian Hernandez-Diazcouder, Yaneli Juarez-Vicuna, Fausto Sanchez-Munoz, Fengyang Huang, Claudia Tavera-Alonso, Malinalli Brianza-Padilla, Elvira Varela-Lopez, Daniel Sierra-Lara, Alexandra Arias-Mendoza, Gabriela Fonseca-Camarillo, Ricardo Marquez-Velasco, Hector Gonzalez-Pacheco, Rashidi Springall, Luis M. Amezcua-Guerra
Summary: This study suggests that miR-133b and miR-126 may serve as potential diagnostic biomarkers for distinguishing patients with ST-segment elevation myocardial infarction (STEMI) from those presenting with nonischemic chest discomfort. However, microRNAs have no associations with inflammatory markers or cardiovascular risk scores, nor do they have associations with the occurrence of major adverse cardiovascular events.
Review
Biochemistry & Molecular Biology
Karla Aidee Aguayo-Ceron, Fausto Sanchez-Munoz, Rocio Alejandra Gutierrez-Rojas, Lourdes Nallely Acevedo-Villavicencio, Aurora Vanessa Flores-Zarate, Fengyang Huang, Abraham Giacoman-Martinez, Santiago Villafana, Rodrigo Romero-Nava
Summary: Glycine is a non-essential amino acid that has various functions and effects. It binds to specific receptors and transporters in different types of cells throughout the body to exert its effects. Studies have shown that glycine has anti-inflammatory effects, such as reducing pro-inflammatory cytokines and free fatty acid levels, improving insulin response, and mediating other changes. However, the exact mechanism through which glycine acts is still unclear. This review emphasizes the importance of glycine in modulating the expression of nuclear factor kappa B (NF-κB) in various cells to exert its anti-inflammatory effects, and highlights the significance of dietary glycine supplementation in preventing the development of chronic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Rafael Barreto-Zuniga, Braulio Martinez-Benitez, Jesus K. Yamamoto-Furusho
Summary: This study identified increased expression of IL-39 in patients with inflammatory bowel disease, suggesting its potential role in regulating inflammation.
IMMUNOLOGIC RESEARCH
(2023)