Article
Clinical Neurology
Ping-Huei Tseng, Chi-Chao Chao, Ya-Yin Cheng, Chieh-Chang Chen, Ping-Hao Yang, Wei-Kang Yang, Shao-Wei Wu, Yen-Wen Wu, Mei-Fang Cheng, Wei-Shiung Yang, Ming-Shiang Wu, Sung-Tsang Hsieh
Summary: This study quantitatively examined the gastric mucosal innervation density (MID) and its relationship with gastroparesis symptoms and gastric emptying in patients with diabetes. The study found that the gastric MID in patients with diabetes was significantly lower compared to healthy controls, and this reduction was correlated with gastroparesis symptoms and glycemic control. The study also showed prolonged gastric emptying in patients with diabetes. These findings provide important pathology and functional biomarkers for diabetic gastroparesis and shed light on the underlying pathophysiology.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Pathology
Siyuan Xu, Shaochan Liang, Ying Pei, Rui Wang, Yao Zhang, Yifei Xu, Bin Huang, Haiwen Li, Juanjuan Li, Bo Tan, Hongying Cao, Shaoju Guo
Summary: This study suggests that dysfunction of TRPV1 channels may contribute to the impaired gastric relaxation in diabetic gastroparesis (DGP) induced by high-fat diet.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Clinical Neurology
Le Yu Naing, Prateek Mathur, Garvit Chhabra, Abigail Stocker, Thomas L. Abell
Summary: Gastroparesis syndromes (GpS) are a group of gastrointestinal neuromuscular disorders that present with characteristic symptoms. This review examines GpS as a manifestation of neurologic disorders of GI NMD, and highlights its association with systemic abnormalities, autoimmune antibodies, and autonomic and enteric dysfunction. The article also discusses the management of GpS and its impact on diagnosis and treatment.
SEMINARS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michal Zalecki, Adrianna Plywacz, Hanna Antushevich, Amelia Franke-Radowiecka
Summary: Research shows that gastric ulcers in pigs lead to a decrease in CART expression and a significant reduction in the percentage of CART-immunofluorescent neuronal fibers. This indicates a unique CART-dependent response of the stomach to ulcer disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yanjuan Wang, Yan Wang, Boqian Zhu, Ying Zhu, Ya Jiang, Wenjie Xiong, Lin Lin, Yaoyao Gong
Summary: Our study revealed that MALAT1 was upregulated in gastric tissues of DGP model mice, adjacent healthy tissues of diabetic patients with DGP symptoms, and HGSMCs cultured under HG conditions. MALAT1 knockdown in vitro affected the viability, proliferation, migration, and promoted phenotypic switch of HGSMCs under HG conditions. MALAT1 sponged miR-449a to regulate DLL1 expression in HGSMCs, affecting proliferation, migration, phenotypic switch, and carbachol-induced Ca2+ transient signals under HG conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Sport Sciences
Dominik Pesta, Jule Heieis, Olga Hand, Petra Frings-Meuthen, Katrin Marcus, Christoph S. Clemen, Ben Levine, Hesham Sadek, Fabian Hoffmann, Ulrich Limper, Jens Jordan, Wolfram Sies, Jens Tank, Jochen Zange, Joern Rittweger
Summary: This study aims to assess changes in muscle volume after exposure to low oxygen levels. The results indicate that low oxygen levels can lead to muscle loss in athletes, especially in proximal muscles. This has important implications for the training and performance of mountaineers.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Engineering, Biomedical
Sandya Subramanian, David C. Kunkel, Linda Nguyen, Todd P. Coleman
Summary: This study aimed to identify biomarkers for autonomic and gastric myoelectric activities that differentiate patients with gastroparesis, diabetics without gastroparesis, and healthy controls. By analyzing 24-hour recordings of electrocardiogram (ECG) and electrogastrogram (EGG) data, the researchers extracted information related to autonomic functions and gastric myoelectric activities. The identified differentiators showed potential in automatically classifying the distinct groups and suggested varying etiologies for different phenotypes.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Xiaojing Quan, Jie Zhang, Yanli Liu, Ceng Sun, Hesheng Luo, Jinhai Wang
Summary: This study investigated the role of hydrogen sulfide (H2S) in the colonic hypomotility of mice with streptozotocin (STZ)-induced diabetes. It was found that diabetic mice showed decreased stool output, impaired colonic contractility, and increased endogenous generation of H2S. H2S overproduction with subsequent suppression of muscle contraction may contribute to the pathogenesis of colonic hypomotility in diabetes mellitus.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Cell Biology
Hailing Yao, Huiying Shi, Chen Jiang, Mengke Fan, Yurui Zhang, Wei Qian, Rong Lin
Summary: The study revealed that L-Fucose could promote neurogenesis and gliogenesis derived from ENPCs by inhibiting the SMAD2 signaling, facilitating ENS regeneration and gastrointestinal motility recovery in type 1 diabetic mice.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Gastroenterology & Hepatology
Elisabeth K. Steinsvik, Dag A. Sangnes, Eirik Softeland, Martin Biermann, Jorg Assmus, Georg Dimcevski, Odd Helge Gilja, Trygve Hausken
Summary: The study showed that patients with diabetic gastroparesis have motility disturbances in the proximal stomach and antral distension. Ultrasound examination of the stomach provides valuable information about gastric motility in these patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Leticia Camargo Tavares, Tenghao Zheng, Madeline Kwicklis, Emily Mitchell, Anita Pandit, Suraj Pullapantula, Cheryl Bernard, Maris Teder-Laving, Francine Z. Marques, Tonu Esko, Braden Kuo, Robert J. Shulman, Bruno P. Chumpitazi, Kenneth L. Koch, Irene Sarosiek, Thomas L. Abell, Richard W. Mccallum, Henry P. Parkman, Pankaj J. Pasricha, Frank A. Hamilton, James Tonascia, Matthew Zawistowski, Gianrico Farrugia, Madhusudan Grover, Mauro D'Amato
Summary: This study conducted a genome-wide association study (GWAS) on gastroparesis (GP), identifying candidate genes and pathways related to immune and sensory-motor dysregulation. Larger studies are needed to validate and expand these findings.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Oncology
Paul Girot, Nicolas Chapelle, Laetitia Aymeric, Anne Bessard, Alice Prigent, Yann Touchefeu, Christine Varon, Michel Neunlist, Emilie Duchalais, Tamara Matysiak-Budnik
Summary: Gastric cancer is a leading cause of cancer-related deaths globally. This study investigated the adhesion of gastric cancer cells to enteric neurons, and found that enteric neurons are a privileged site for gastric cancer cell adhesion, especially in diffuse-type gastric cancer. The adhesion was partially mediated by N-Cadherin, and blocking N-Cadherin significantly decreased the adhesion ability. These findings suggest a potential role of enteric neurons in the dissemination of gastric cancer cells.
Article
Developmental Biology
Pierre Sicard, Amandine Falco, Sandrine Faure, Jerome Thireau, Stephanie E. Lindsey, Norbert Chauvet, Pascal de Santa Barbara
Summary: This study utilized non-invasive high-resolution echography and speckle tracking analysis to observe and quantify gastrointestinal motility in chick embryos. The researchers found that gastrointestinal contractions begin early in development but only become synchronized at the end of the fetal period. The enteric nervous system plays a role in initiating synchronized contractions, and alterations in smooth muscle fiber organization can impair gastrointestinal function.
Article
Agriculture, Dairy & Animal Science
Liliana Rytel, Ignacy Gonkowski, Waldemar Grzegorzewski, Joanna Wojtkiewicz
Summary: The enteric nervous system (ENS) located in the gastrointestinal tract regulates stomach and intestine functions. Nitric oxide (NO) synthesized by enteric neurons is involved in intestinal regulation. Inflammation leads to an increase in nitrergic nerve structures, suggesting NO's involvement in pathological processes in the bowel.
Article
Biochemistry & Molecular Biology
Silvia Cerantola, Valentina Caputi, Gabriella Contarini, Maddalena Mereu, Antonella Bertazzo, Annalisa Bosi, Davide Banfi, Dante Mantini, Cristina Giaroni, Maria Cecilia Giron
Summary: This study evaluated the impact of DAT genetic reduction on the integrity of the enteric nervous system in mice, finding that reduced DAT activity led to increased dopamine-mediated effects, decreased cholinergic response, and altered neurochemical coding and architecture of the small intestine myenteric plexus.