Review
Urology & Nephrology
Mary Zare, Maria J. G. T. Vehreschild, Florian Wagenlehner
Summary: This review discusses the optimal management of recurrent urinary tract infections (UTIs) in women. Women are particularly susceptible to rUTI due to female anatomy, as well as behavioral, genetic, and urological factors. Various non-antibiotic strategies, prophylactic approaches, and emerging experimental treatments like faecal microbiota transfer (FMT) and bacteriophages show promising effects in interrupting the cycle of rUTI. Further clinical research is needed to explore the potential of these novel treatment options for bacterial infections, especially UTIs.
Review
Immunology
Jonathan Josephs-Spaulding, Thoger Jensen Krogh, Hannah Clara Rettig, Mark Lyng, Mariam Chkonia, Silvio Waschina, Simon Graspeuntner, Jan Rupp, Jakob Moller-Jensen, Christoph Kaleta
Summary: This article discusses the ecological interactions of human urogenital microbial communities, the mechanism of imbalance between microbial ecology and host physiology. A greater understanding of environmental mechanisms and microbial ecology is needed for the treatment and management of UTIs. The use of next generation and systems level methods is recommended to elucidate the systemic consequences of rUTIs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Urology & Nephrology
Jennifer T. Anger, Brooke R. Bixler, Rebecca S. Holmes, Una J. Lee, Yahir Santiago-Lastra, Shelley S. Selph
Summary: The purpose of this study is to update the 2019 guideline on recurrent uncomplicated urinary tract infections in women by the American Urological Association. The study utilized a systematic review and literature review to gather new evidence and make revisions to the guideline. The updates primarily focused on recent publications related to antibiotic prophylaxis, non-antibiotic prophylaxis, and estrogen therapy.
JOURNAL OF UROLOGY
(2022)
Article
Immunology
Michael W. Dunne, Steven Aronin, Anita F. Das, Karthik Akinapelli, Michael T. Zelasky, Sailaja Puttagunta, Helen W. Boucher
Summary: This study demonstrates that sulopenem is an effective alternative for the treatment of urinary tract infections, with superiority in infections caused by resistant pathogens.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Sky Wei Chee Koh, Tracy Si Min Ng, Victor Weng Keong Loh, Jun Cong Goh, Si Hui Low, Wei Zhi Tan, Hung Chew Wong, Pradeep Durai, Louisa Jin Sun, Doris Young, Paul Anantharajah Tambyah
Summary: This study aimed to investigate the treatment failure variation among different antibiotics for uncomplicated urinary tract infections (UTIs) with different resistance rates in Singapore. The study also aimed to identify gaps for improvement in diagnosis, investigations, and management.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Review
Infectious Diseases
Richard R. Watkins, Dipendra Thapaliya, Tracy L. Lemonovich, Robert A. Bonomo
Summary: The ongoing spread of antimicrobial resistance has led to difficulties in treating uncomplicated UTIs and urogenital gonorrhoea. Gepotidacin is a novel oral antibiotic that shows promising results in Phase II clinical trials for these infections. It inhibits bacterial DNA replication by blocking two essential topoisomerase enzymes and has the potential to maintain long-term effectiveness against resistance.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Medicine, General & Internal
Oghenekome Gbinigie, Julie Allen, Nicola Williams, Michael Moore, Alastair D. Hay, Carl Heneghan, Anne-Marie Boylan, Christopher C. Butler
Summary: This study aimed to assess the feasibility of a randomized trial testing the effectiveness of cranberry extract in reducing antibiotic use for women with symptoms of acute, uncomplicated UTI. The study found that it was feasible to conduct such a trial in general practice, with high recruitment rates and participant compliance.
Review
Health Care Sciences & Services
Katharina Piontek, Theresa Donhauser, Gesina Kann, Marie Fechtner, Christian Apfelbacher, Michaela Gabes
Summary: This study conducted a systematic review of the quality of existing patient-reported outcome measures (PROMs) for women with uncomplicated urinary tract infections (UTIs) using the COSMIN methodology, and provided recommendations for future research. The Acute Cystitis Symptom Score (ACSS) and the Urinary Tract Infection-Symptom and Impairment Questionnaire (UTI-SIQ-8) were found to be suitable for further use, while other PROMs require further validation.
QUALITY OF LIFE RESEARCH
(2023)
Article
Infectious Diseases
Luciano Garofalo, Claudia Nakama, Douglas Hanes, Heather Zwickey
Summary: Urobiome dysbiosis is a common problem in women with uncomplicated urinary tract infection. Traditional antibiotics are not effective in addressing this issue, so new treatment approaches are needed. A whole-person, multi-modal approach may be more effective in reducing recurrent UTI.
Review
Microbiology
Nicole E. Scangarella-Oman, Mohammad Hossain, Jennifer L. Hoover, Caroline R. Perry, Courtney Tiffany, Aline Barth, Etienne F. Dumont
Summary: This article reviews data for Gepotidacin from nonclinical studies, including in vitro activity, in vivo animal efficacy, and pharmacokinetic/pharmacodynamic models. The selected dose for phase III clinical evaluation of Gepotidacin in the treatment of uUTIs is a 1,500-mg oral dose twice daily for 5 days.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Claire Beecher, Sinead Duane, Akke Vellinga, Andrew W. W. Murphy, Martin Cormican, Andrew Smyth, Patricia Healy, Michael Moore, Paul Little, Carmel Geoghegan, Declan Devane
Summary: This study aimed to develop a Core Outcome Set (COS) for interventions for the treatment of uncomplicated Urinary Tract Infections (UTIs). Through a systematic review, Delphi survey, and consensus meeting, a core set of six outcomes were identified for measuring and reporting in randomized trials and systematic reviews of interventions treating uncomplicated UTIs in adults.
Article
Infectious Diseases
Tommaso Cai, Umberto Anceschi, Irene Tamanini, Serena Migno, Michele Rizzo, Giovanni Liguori, Alejandro Garcia-Larrosa, Alessandro Palmieri, Paolo Verze, Vincenzo Mirone, Truls E. Bjerklund Johansen
Summary: This study conducted a systematic review and meta-analysis to compare the effectiveness and safety profile of a medical device containing xyloglucan, hibiscus, and propolis with a comparator in the treatment of uncomplicated cystitis in women. The results showed that the medical device was more effective in achieving clinical or microbiological resolution without causing clinically significant adverse effects.
Review
Infectious Diseases
Yveline Ansaldi, Begona Martinez de Tejada Weber
Summary: Urinary tract infections (UTIs) during pregnancy can have significant consequences for both the mother and the baby. Treating asymptomatic bacteriuria (ASB) can reduce the risk of low birth weight and preterm birth. Further research is needed to understand the complications of ASB and to explore preventive measures.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Dominique Esmee Werter, Brenda M. Kazemier, Elisabeth van Leeuwen, Maurits C. F. J. de Rotte, Sacha D. Kuil, Eva Pajkrt, Caroline Schneeberger
Summary: This study aims to evaluate and compare the diagnostic accuracy of urine dipstick analysis and urine sediment in pregnant women with urinary tract infections. Additionally, it will compare these tests to a predefined 'true urinary tract infection' in order to distinguish between an infection and asymptomatic bacteriuria.
Review
Infectious Diseases
Stefan Cox, Kelly Lo-A-Foe, Minke van Hoof, Geert-Jan Dinant, Guy Oudhuis, Paul Savelkoul, Jochen Cals, Eefje de Bont
Summary: Urinary tract infections (UTIs) are a common reason for women to visit a general practitioner, but there is often a discrepancy between prescribed antibiotics and established guidelines. Researchers have conducted interventions to improve GPs' prescribing behavior, and found that these interventions have some positive effects on antibiotic prescriptions for UTIs.
Article
Surgery
Carmen S. S. Latenstein, Sarah Z. Wennmacker, Aafke H. van Dijk, Joost P. H. Drenth, Gert P. Westert, Cornelis J. H. M. van Laarhoven, Marja A. Boermeester, Philip R. de Reuver, Marcel G. W. Dijkgraaf
Summary: A restrictive strategy for cholecystectomy in patients with gallstones and abdominal pain significantly reduces the rate of surgery and surgical costs, resulting in savings from a societal perspective. However, it may lead to fewer pain-free patients.
Review
Health Care Sciences & Services
Joris L. J. M. Muskens, Rudolf Bertijn Kool, Simone A. van Dulmen, Gert P. Westert
Summary: The overuse of diagnostic testing is prevalent across healthcare settings, with significant differences in the prevalence of overuse for similar diagnostic tests. Preoperative testing and imaging for non-specific low back pain are the most frequently identified low-value diagnostic tests. Uniform definitions and assessments are needed to better understand the extent of overuse in diagnostic testing.
BMJ QUALITY & SAFETY
(2022)
Article
Health Care Sciences & Services
Yvette Emond, Andre Wolff, Gerrit Bloo, Johan Damen, Gert Westert, Hub Wollersheim, Hiske Calsbeek
Summary: The implementation of the IMPROVE program faced challenges in varying levels of involvement between hospitals, particularly in aspects such as study design, hospital and department selection process, and program scope. The process analysis revealed the importance of a less complex implementation program, a more flexible study design, and increased commitment from hospital management and surgeons to improve implementation outcomes.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Anesthesiology
Yvette E. J. J. M. Emond, Hiske Calsbeek, Yvonne A. S. Peters, Gerrit J. A. Bloo, Steven Teerenstra, Gert P. Westert, Johan Damen, Hub C. Wollersheim, Andre P. Wolff
Summary: This study evaluated the effectiveness of the IMPROVE programme in improving guideline adherence and patient safety. The programme had mixed implementation effects, with positive associations found between guideline adherence and patient safety in certain areas, except for timely administration of antibiotics.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Primary Health Care
Joris L. J. M. Muskens, Simone A. van Dulmen, Tjerk Wiersma, Jako S. Burgers, Karin Hek, Gert P. Westert, Rudolf B. Kool
Summary: Low-value pharmaceutical care exists among Dutch GPs, with significant variation in inappropriate prescribing between different types of pharmaceutical care - and GP practices.
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Review
Health Care Sciences & Services
Stefan L. Auener, Toine E. P. Remers, Simone A. van Dulmen, Gert P. Westert, Rudolf B. Kool, Patrick P. T. Jeurissen
Summary: Most studies indicate that telemonitoring has no significant effects on healthcare utilization measures, except for an increase in nonemergency outpatient department visits. The consequences of telemonitoring on nonemergency outpatient visits should be given more attention by regulators, payers, and providers. This review highlights the high clinical and methodological heterogeneity of telemonitoring programs, which should be considered in future meta-analyses aiming to identify the effective components of telemonitoring programs.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Health Care Sciences & Services
Yvonne A. C. Bekker, Ankie F. Suntjens, Y. Engels, H. Schers, Gert P. Westert, A. Stef Groenewoud
Summary: This study investigated the documentation of Advance Care Planning (ACP) for patients with cancer, organ failure, and multimorbidity in Dutch general practice. The results showed that documentation of ACP items by general practitioners (GPs) was limited, especially in patients with multimorbidity or organ failure. More attention and documentation of ACP in daily practice are recommended to address the needs of all people living with advanced conditions.
BMC PALLIATIVE CARE
(2022)
Review
Health Care Sciences & Services
Erik Wackers, Niek Stadhouders, Anthony Heil, Gert Westert, Simone van Dulmen, Patrick Jeurissen
Summary: This study aims to identify and summarize hospital strategies that improve quality while reducing costs, as well as determining factors that influence implementation. The results show that hospitals use different management strategies to achieve their goals, with predominantly positive effects on quality and costs. Factors influencing implementation include strategy, leadership, engagement, finances, data and IT, projects, support, skill development, culture, and communication. However, barriers such as lack of physician engagement, insufficient financial support, and poor data collection exist.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2022)
Article
Health Care Sciences & Services
Gijs Petrus Gerardus Lemmers, Jasper Daniel Bier, Wim van Lankveld, Gerard Pieter Westert, Jacobus Bart Staal, Philip Jan van der Wees
Summary: The study aims to understand the considerations of Dutch physiotherapists regarding adherence to the national physiotherapy guideline for the treatment of low back pain. The results indicate that physiotherapists feel the guideline should provide more information on psychosocial factors and treatment options. They also face challenges in addressing patient expectations conflicting with guideline recommendations. To improve adherence, the guideline should offer more guidance on addressing psychosocial factors, and physiotherapists should receive training in communication skills. A more extensive implementation process is also needed.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2022)
Article
Cardiac & Cardiovascular Systems
Stefan L. L. Auener, Patrick P. T. Jeurissen, Dirk J. A. Lok, Huug J. J. van Duijn, Petra E. J. van Pol, Gert P. P. Westert, Simone A. A. van Dulmen
Summary: The aim of this study was to gain insight into how stakeholders have experienced the development and use of regional transmural agreements (RTAs) for chronic heart failure (CHF) and explore which factors affected this.
NETHERLANDS HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Danielle Kroon, Simone A. van Dulmen, Gert P. Westert, Patrick P. T. Jeurissen, Rudolf B. Kool
Summary: The study aims to increase understanding of the scaling of de-implementation strategies by identifying and developing a determinant framework. Through an integrative review and focus group discussions, the SPREAD framework was developed, which includes determinants from four domains: scaling plan, external context, de-implementation strategy, and adopters.
Article
Health Care Sciences & Services
Stefan L. Auener, Simone A. van Dulmen, Femke Atsma, Onno van der Galien, Louise Bellersen, Roland van Kimmenade, Gert P. Westert, Patrick P. T. Jeurissen
Summary: The adoption of telemonitoring for heart failure in hospitals in the Netherlands is limited and varies greatly among institutions. Male patients and those with a history of hospital treatment for heart failure are more likely to use telemonitoring, while older patients, female patients, and those without a history of hospital treatment for heart failure are less likely to use telemonitoring. The findings highlight the need to understand the underlying mechanisms behind these associations in order to better tailor telemonitoring interventions for different patient groups.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Gerrit Bloo, Hiske Calsbeek, Gert Westert, Wim Dekkers, George Akkersdijk, Robbert Jan van Krugten, Andre P. Wolff, Hub Wollersheim
Summary: By interviewing 17 patients, we found that the behavior of nurses and physicians, as well as the performance of the team, influenced patients' safety experience during the perioperative period. Positive behavior built trust while negative behavior made patients feel unsafe. Seeking support from nurses, physicians, and family contributed to a safe care experience.
JOURNAL OF PATIENT SAFETY AND RISK MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Eva W. Verkerk, Simone A. van Dulmen, Gert P. Westert, Lotty Hooft, Pauline Heus, Rudolf B. Kool
Summary: Reducing the overuse of low-value care improves the quality and safety of healthcare. This study examined eight projects aimed at reducing low-value care, identifying successful strategies, barriers, and practical recommendations.
Article
Social Sciences, Biomedical
Wieteke van Dijk, Marjan J. Meinders, Marit A. C. Tanke, Eva W. Verkerk, Gert P. Westert, Patrick P. T. Jeurissen
Summary: Patients and clinicians share the problem definition of sciatica but differ in preferred course of action after diagnosis. Medicalization in practice is often an uncertain and contested process.
SOCIAL THEORY & HEALTH
(2022)