Evolutionary profiling reveals the heterogeneous origins of classes of human disease genes: implications for modeling disease genetics in animals

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Functional and evolutionary implications of gene orthology

(2013) Toni Gabaldón et al.   NATURE REVIEWS GENETICS

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genome of the Ctenophore Mnemiopsis leidyi and Its Implications for Cell Type Evolution

(2013) J. F. Ryan et al.   SCIENCE

How old is my gene?

(2013) John A. Capra et al.   TRENDS IN GENETICS

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

(2013) Konstantinos K. Tsilidis et al.   PLOS BIOLOGY

Regulation of cnidarian–dinoflagellate mutualisms: Evidence that activation of a host TGFβ innate immune pathway promotes tolerance of the symbiont

(2012) Olivier Detournay et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Comparative description of ten transcriptomes of newly sequenced invertebrates and efficiency estimation of genomic sampling in non-model taxa

(2012) Ana Riesgo et al.   Frontiers in Zoology

Hydractinia, a pioneering model for stem cell biology and reprogramming somatic cells to pluripotency

(2012) Günter Plickert et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Establishing a model organism: A report from the first annual Nematostella meeting

(2011) Adam M. Reitzel et al.   BIOESSAYS

On the Origins of Mendelian Disease Genes in Man: The Impact of Gene Duplication

(2011) J. E. Dickerson et al.   MOLECULAR BIOLOGY AND EVOLUTION

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

(2011) U. B. Pandey et al.   PHARMACOLOGICAL REVIEWS

Evolution of the TGF-β Signaling Pathway and Its Potential Role in the Ctenophore, Mnemiopsis leidyi

(2011) Kevin Pang et al.   PLoS One

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

(2011) A. Rongvaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa

(2010) Tomislav Domazet-Lošo et al.   BMC BIOLOGY

Adult zebrafish as a model organism for behavioural genetics

(2010) William Norton et al.   BMC NEUROSCIENCE

Comparative genomic and phylogenetic analysis of vitellogenin and other large lipid transfer proteins in metazoans

(2010) Alexander Hayward et al.   FEBS LETTERS

Of Mice and Humans: Are They the Same?--Implications in Cancer Translational Research

(2010) M. de Jong et al.   JOURNAL OF NUCLEAR MEDICINE

The Amphimedon queenslandica genome and the evolution of animal complexity

(2010) Mansi Srivastava et al.   NATURE

The benefits and limitations of animal models for translational research in neurodegenerative diseases

(2010) Mathias Jucker   NATURE MEDICINE

"Control" laboratory rodents are metabolically morbid: Why it matters

(2010) B. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Profound human/mouse differences in alpha-dystrobrevin isoforms: a novel syntrophin-binding site and promoter missing in mouse and rat

(2009) Sabrina V Böhm et al.   BMC BIOLOGY

Exploring the Differences in Evolutionary Rates between Monogenic and Polygenic Disease Genes in Human

(2009) S. Podder et al.   MOLECULAR BIOLOGY AND EVOLUTION

The universal distribution of evolutionary rates of genes and distinct characteristics of eukaryotic genes of different apparent ages

(2009) Y. I. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessing the root of bilaterian animals with scalable phylogenomic methods

(2009) A. Hejnol et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis

(2009) Crystal Y. Chen et al.   PLoS Pathogens

Ctenophores

(2008) Kevin Pang et al.   CURRENT BIOLOGY

Failure is an option: learning from unsuccessful proof-of-concept trials

(2008) Stefan Schäfer et al.   DRUG DISCOVERY TODAY

EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates

(2008) A. J. Vilella et al.   GENOME RESEARCH

An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases

(2008) T. Domazet-Loso et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Trichoplax genome and the nature of placozoans

(2008) Mansi Srivastava et al.   NATURE

Broad phylogenomic sampling improves resolution of the animal tree of life

(2008) Casey W. Dunn et al.   NATURE

Targeting the murine serotonin transporter: insights into human neurobiology

(2008) Dennis L. Murphy et al.   NATURE REVIEWS NEUROSCIENCE

Insights Into Parturition Biology From Genetically Altered Mice

(2008) Christine K Ratajczak et al.   PEDIATRIC RESEARCH

The Ediacaran emergence of bilaterians: congruence between the genetic and the geological fossil records

(2008) K. J Peterson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Network properties of genes harboring inherited disease mutations

(2008) I. Feldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The evolution of plasma cholesterol: Direct utility or a “spandrel” of hepatic lipid metabolism?

(2008) Patrick J. Babin et al.   PROGRESS IN LIPID RESEARCH

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY