Article
Genetics & Heredity
Gun Woo Byeon, Elif Sarinay Cenik, Lihua Jiang, Hua Tang, Rhiju Das, Maria Barna
Summary: Extremely conserved 5' UTRs play a crucial role in gene expression and translation regulation by possessing cis-regulatory elements that promote cell-type-specific translation control. The new icM(2) method allows mapping of RNA structures within cells, revealing the mechanism by which conserved 5' UTRs encode multiple alternative structures.
Article
Microbiology
Hong Liu, Jun Zhang, Yuzhen Niu, Guodong Liang
Summary: The study systematically analyzed the UTRs of different JEV genotypes, identifying specific structures and elements unique to JEV, such as sequence motifs and repetitive elements. By comparing with other mosquito-borne Flaviviruses, the research revealed the distinct characteristics of JEV UTRs.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Deepti Maisnam, Arcy Billoria, V. S. V. Prasad, Musturi Venkataramana
Summary: Dengue virus infections are prevalent in India, particularly in Hyderabad city, where recent strains with genetic mutations have been identified. These mutations, particularly in the 3' UTR region, have been found to cause severe dengue even though they cannot replicate. The study highlights the importance of dengue virus 3' UTRs in the emergence of outbreaks and severe cases.
Article
Virology
Nicole Wildi, Torsten Seuberlich
Summary: Astroviruses are small nonenveloped single-stranded RNA viruses that cause gastrointestinal disease in various species. However, little is known about the role of the 5' and 3' untranslated regions (UTRs) in the viral replication of HAstV-1. This study showed that UTR deletions significantly affected viral protein expression and infectious virus particle production, indicating the essentiality of UTRs in the life cycle of HAstV-1 and providing opportunities for further research.
Review
Biochemistry & Molecular Biology
Tingyu Peng, Fayu Yang, Fan Yang, Weijun Cao, Haixue Zheng, Zixiang Zhu
Summary: The genomic arrangement of most picornavirus of the Picornaviridae family shares a similar monocistronic genomic pattern and a defining organizational feature, which includes evolutionarily conserved and highly-structured RNA elements in the untranslated regions (UTRs). However, the functional characterization and biological significance of UTRs, especially the 5' UTR, are still not fully understood due to the diversity and complexity of RNA structure and limitations of molecular biology techniques. This review summarizes the current knowledge of the 5' UTR of picornavirus, focusing on its structural characterization and biological function of RNA secondary and tertiary structures. Understanding the role of the 5' UTR of picornavirus provides insights into viral replication cycle and pathogenic mechanisms.
Article
Biotechnology & Applied Microbiology
Lisa Tietze, Antonia Mangold, Maria W. Hoff, Rahmi Lale
Summary: This study reports on the identification and cross-characterization of artificial promoters and 5' untranslated regions (artificial regulatory sequence, ARES) that lead to the production of fluorescent proteins with a wide range of expression levels in both V. natriegens and E. coli. The DNA sequence and motif analysis of the ARESs using various algorithms are also reported. This expands the pool of characterized genetic DNA parts that can be used for different biotechnological applications using V. natriegens as a host microorganism.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Virology
Alexander G. Litov, Egor V. Okhezin, Ivan S. Kholodilov, Oxana A. Belova, Galina G. Karganova
Summary: This study obtained complete untranslated regions (UTRs) of four strains of ALSV and eight strains of YGTV, and analyzed these sequences and JVG sequences from GenBank. It found highly conserved regions within viral UTRs, and bioinformatics predictions suggested that the UTRs of YGTV, ALSV, and JMTV could form similar RNA structures, which have a stable stem-loop with one (5 'UTR) or two (3 'UTR) AAGU tetraloops on the end of a hairpin.
Article
Polymer Science
Zishuo Wu, Yuqi Xiong, Chengyan Li, Hong Cheng, Yahui Li, Wei Chen
Summary: The crystallization-driven gelation kinetics of semidilute poly(vinyl alcohol) (PVA) aqueous solution at 20 degrees C was investigated using various time-resolved time-domain NMR techniques. The relationship between PVA crystallinity index and normalized proton double-quantum intensity was used to confirm the crystallization-driven gelation of PVA. The three-phase structure, including crystalline, interphase, and mobile amorphous domains, was further elucidated using a combination of MSE-FID and PFG-NMR.
Article
Polymer Science
Zishuo Wu, Yuqi Xiong, Chengyan Li, Hong Cheng, Yahui Li, Wei Chen
Summary: The crystallization-driven gelation kinetics of semidilute poly(vinyl alcohol) (PVA) aqueous solution was investigated using NMR techniques. The study confirmed the presence of crystallization-driven gelation in PVA and characterized the three-phase structure and key parameters of the gel.
Article
Biochemistry & Molecular Biology
Akihiro Ezoe, Satoshi Iuchi, Tetsuya Sakurai, Yukie Aso, Hiroki Tokunaga, Anh Thu Vu, Yoshinori Utsumi, Satoshi Takahashi, Maho Tanaka, Junko Ishida, Manabu Ishitani, Motoaki Seki
Summary: The complete sequencing of a cassava full-length cDNA library facilitates the annotation of unique transcript structures and alternative splicing events by avoiding cassava-specific issues affecting annotations, including extensive heterozygosity.
PLANT MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Gregoire Quinet, Pierre Genin, Oznur Ozturk, Naima Belgareh-Touze, Lilas Courtot, Renaud Legouis, Robert Weil, Mickael M. Cohen, Manuel S. Rodriguez
Summary: The regulation of autophagy pathway and the development of LC3-traps, which can capture target proteins from various sources, have been studied. The LC3-traps have potential applications in monitoring selective autophagy events.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Maria Bibi, Naveeda Akhter Qureshi, Abdul Sadiq, Umar Farooq, Abbas Hassan, Nargis Shaheen, Irfa Asghar, Duaa Umer, Azmat Ullah, Farhan A. Khan, Muhammad Salman, Ahtaram Bibi, Umer Rashid
Summary: Efforts to find efficient therapeutic drug targets for leishmaniasis have focused on DHFR. This study aimed to design and synthesize selective antifolates targeting L. major, with compound 59 showing potent inhibition of the parasite. Selectivity for LmDHFR over human DHFR was demonstrated, with compounds 56 and 58 showing the highest selectivity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Ruijie Yang, Yuanfang Guo, Ruikui Wang, Xiaohan Zhao, Yunhong Wang
Summary: Adversarial attack is a hot topic in machine learning and deep learning, and this study presents a method that applies region constraint to reduce unnecessary adversarial perturbations and increase attack success rate, with experimental results proving its superiority.
2022 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS (ISCAS 22)
(2022)
Article
Biotechnology & Applied Microbiology
Kuei-Han Lin, Ben-Yang Liao, Hao-Wei Chang, Shiao-Wei Huang, Ting-Yan Chang, Cheng-Yu Yang, Yu-Bin Wang, Yu-Teh Kirk Lin, Yu-Wei Wu, Sen-Lin Tang, Hon-Tsen Yu
Article
Multidisciplinary Sciences
Ben-Yang Liao, Meng-Pin Weng
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Biochemistry & Molecular Biology
Chia-Hsin Hsu, Austin W. T. Chiang, Ming-Jing Hwang, Ben-Yang Liao
MOLECULAR BIOLOGY AND EVOLUTION
(2016)
Article
Cell Biology
Ben-Yang Liao, Meng-Pin Weng
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2016)
Article
Biochemistry & Molecular Biology
Andrew Ying-Fei Chang, Ben-Yang Liao
Article
Gastroenterology & Hepatology
Wei-Kai Wu, Chieh-Chang Chen, Po-Yu Liu, Suraphan Panyod, Ben-Yang Liao, Pei-Chen Chen, Hsien-Li Kao, Han-Chun Kuo, Ching-Hua Kuo, Tina H. T. Chiu, Rou-An Chen, Hsiao-Li Chuang, Yen-Te Huang, Hsin-Bai Zou, Cheng-Chih Hsu, Ting-Yan Chang, Chin-Lon Lin, Chi-Tang Ho, Hon-Tsen Yu, Lee-Yan Sheen, Ming-Shiang Wu
Article
Multidisciplinary Sciences
Yu-Ting Lai, Carol K. L. Yeung, Kevin E. Omland, Er-Li Pang, Yu Hao, Ben-Yang Liao, Hui-Fen Cao, Bo-Wen Zhang, Chia-Fen Yeh, Chih-Ming Hung, Hsin-Yi Hung, Ming-Yu Yang, Wei Liang, Yu-Cheng Hsu, Cheng-Te Yao, Lu Dong, Kui Lin, Shou-Hsien Li
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Agriculture, Dairy & Animal Science
Tze-Ho Chen, Gwo-Chin Ma, Wen-Hsiang Lin, Dong-Jay Lee, Sheng-Hai Wu, Ben-Yang Liao, Ming Chen, Liang-Kong Lin
Article
Biochemistry & Molecular Biology
Andrew Ying-Fei Chang, Ben-Yang Liao
MOLECULAR BIOLOGY AND EVOLUTION
(2020)
Article
Evolutionary Biology
Min R. Lu, Cheng-Kuo Lai, Ben-Yang Liao, Isheng Jason Tsai
GENOME BIOLOGY AND EVOLUTION
(2020)
Article
Microbiology
Wei-Kai Wu, Suraphan Panyod, Po-Yu Liu, Chieh-Chang Chen, Hsien-Li Kao, Hsiao-Li Chuang, Ying-Hsien Chen, Hsin-Bai Zou, Han-Chun Kuo, Ching-Hua Kuo, Ben-Yang Liao, Tina H. T. Chiu, Ching-Hu Chung, Angela Yu-Chen Lin, Yi-Chia Lee, Sen-Lin Tang, Jin-Town Wang, Yu-Wei Wu, Cheng-Chih Hsu, Lee-Yan Sheen, Alexander N. Orekhov, Ming-Shiang Wu
Editorial Material
Ecology
Ben-Yang Liao
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Chia-Yin Chiang, Yung-Hao Ching, Ting-Yan Chang, Liang-Shuan Hu, Yee Siang Yong, Pei Ying Keak, Ivana Mustika, Ming-Der Lin, Ben-Yang Liao
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
D. Suresh, Y. Ching, M. Lin, B. Liao
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Biochemical Research Methods
Meng-Pin Weng, Ben-Yang Liao