Article
Biotechnology & Applied Microbiology
Zhinan Lin, Yuqi Huang, Sihan Liu, Qiwen Huang, Biliang Zhang, Tianpeng Wang, Ziding Zhang, Xiaowei Zhu, Chenghong Liao, Qian Han
Summary: In this study, a gene coexpression network was constructed to explore the ontogeny of Ae. aegypti. Six gene modules and their intramodular hub genes associated with various developmental processes were identified. These findings provide valuable insights into potential molecular targets for disease control.
Review
Medicine, Research & Experimental
Jose Tuells, Andres F. Henao-Martinez, Carlos Franco-Paredes
Summary: Despite the availability of a vaccine, yellow fever remains a significant preventable disease in endemic regions. Yellow fever is a viral hemorrhagic fever that has had a major impact on human societies. Throughout history, it has caused epidemics and played a role in shaping modern societies. Efforts of scientists have led to the discovery of the virus and the development of a vaccine. In the present day, it is important to enhance immunization activities, ensure fair distribution of vaccines, immunize at-risk populations during outbreaks, and promote vaccination among international travelers.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Sharath Chandra Gaddelapati, Najla M. Albishi, Ramesh Kumar Dhandapani, Subba Reddy Palli
Summary: This study identified 10 genes coding for HDACs in the yellow fever mosquito and determined their role in larval development using RNA interference. The findings suggest that HDAC3 plays a crucial role in larval development and knockdown of HDAC3 leads to larval death and affects midgut size.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Krithika Venkataraman, Nadav Shai, Priyanka Lakhiani, Sarah Zylka, Jieqing Zhao, Margaret Herre, Joshua Zeng, Lauren A. Neal, Henrik Molina, Li Zhao, Leslie B. Vosshall
Summary: Female Aedes aegypti mosquitoes face climate challenges due to rising global temperatures, causing suboptimal conditions for egg-laying. In the laboratory, under drought-like conditions, these mosquitoes retain mature eggs until suitable conditions for laying eggs arise. The genes tweedledee and tweedledum are found to play a crucial role in this extended egg retention.
Article
Public, Environmental & Occupational Health
Chao-Ying Pan, Lie Cheng, Wei-Liang Liu, Matthew P. Su, Hui-Pin Ho, Che-Hun Liao, Jui-Hun Chang, Yu-Chieh Yang, Cheng-Chun Hsu, Joh-Jong Huang, Chun-Hong Chen
Summary: The study compared Aedes mosquito catch rates between passive gravitraps and active fan-traps in six urban areas of Kaohsiung City in 2019. Fan-traps consistently showed higher capture rates compared to gravitraps, with values more closely aligned with reported dengue fever cases and weekly fluctuations in temperature and rainfall. This supports the use of fan-traps for Aedes mosquito surveillance and control within broader vector management strategies, potentially aiding in early identification and prevention of disease outbreaks.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Andre B. B. Wilke, Chalmers Vasquez, Augusto Carvajal, Maday Moreno, William D. Petrie, John C. Beier
Summary: This study found that important mosquito vector species were present in great numbers in all of the 12 maritime ports of entry surveyed. The relative abundance of Culex quinquefasciatus and Aedes aegypti was substantially higher in the commercial freight cargo ship ports than in the marinas. These results indicate that the port area in the Miami River is especially suitable for the proliferation of vector mosquitoes.
Article
Ecology
Jonas Frankel-Bricker, Laurie K. Frankel
Summary: Laboratory studies have shown that the food source ingested by the yellow fever mosquito significantly impacts the host-associated microbiota, but differences in laboratory conditions may lead to differential microbiomes across independent environments.
Article
Multidisciplinary Sciences
Shiheng Liu, Xian Xia, Eric Calvo, Z. Hong Zhou
Summary: Female mosquitoes transmit mosquito-borne human pathogens that cause approximately 1,000,000 deaths/year by injecting saliva into vertebrate hosts during blood feeding. Salivary gland surface protein 1 (SGS1), a highly conserved protein secreted by female mosquitoes, plays a crucial role in pathogen transmission. By determining the native structure of SGS1, this study reveals its Tc toxin-like Rhs/YD shell, multiple receptor domains, and transformative potential of its C-terminal helices. Understanding the mechanism of SGS1 could provide insights into sporozoite/arbovirus invasion into salivary glands and manipulation of the host's immune response.
NATURE COMMUNICATIONS
(2023)
Article
Entomology
Murat Turan
Summary: This study identified and characterized HSP proteins in the Aedes aegypti genome for the first time, revealing 80 potential HSP genes. Phylogenetic analysis showed distinct relationships within each HSP group, with conserved genetic structures and motifs. Expression analysis revealed high expression of certain HSP20 and HSP70 genes, with sex-dependent expression differences observed, particularly in HSP20 genes.
JOURNAL OF INSECT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Jamie M. Caldwell, A. Desiree LaBeaud, Eric F. Lambin, Anna M. Stewart-Ibarra, Bryson A. Ndenga, Francis M. Mutuku, Amy R. Krystosik, Efrain Beltran Ayala, Assaf Anyamba, Mercy J. Borbor-Cordova, Richard Damoah, Elysse N. Grossi-Soyster, Froilan Heras Heras, Harun N. Ngugi, Sadie J. Ryan, Melisa M. Shah, Rachel Sippy, Erin A. Mordecai
Summary: Climate has complex effects on population dynamics and vector-borne diseases, with seemingly opposing effects in different contexts. Models incorporating laboratory-measured physiological traits of mosquitoes can predict outbreak characteristics in diverse settings, yet with variable accuracy. The effects of climate on disease dynamics are highly dependent on specific contexts, such as population demographics and environmental factors.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Zhilei Zhao, Jessica L. Zung, Annika Hinze, Alexis L. Kriete, Azwad Iqbal, Meg A. Younger, Benjamin J. Matthews, Dorit Merhof, Stephan Thiberge, Rickard Ignell, Martin Strauch, Carolyn S. McBride
Summary: The globally invasive mosquito Aedes aegypti has a strong preference for biting humans over animals, and the researchers have discovered that it is able to distinguish between human and animal odour. The study found that a specific glomerulus in the mosquito's antennal lobe is strongly activated by human odour but weakly or not at all responsive to animal odour. This glomerulus is tuned to certain components present in human odour, which are consistently enriched in human skin lipids. The research suggests that animal brains may simplify complex odour stimuli into simple neural codes, and this knowledge can be used to develop more effective mosquito-control strategies.
Article
Ecology
Carla Rodriguez Gonzalez, Claudio Guzman, Veronica Andreo
Summary: Surveillance is crucial for controlling and preventing mosquito-borne diseases, but current sampling methods often lack a systematic approach. This study improves mosquito surveillance in Cordoba, Argentina by using a spatial sampling scheme to optimize ovitrap collections in complex urban areas.
ECOLOGICAL INFORMATICS
(2023)
Article
Biology
Jun Isoe, Carter J. Simington, Max E. Oscherwitz, Alyssa J. Peterson, Alberto A. Rascon, Brooke B. Massani, Roger L. Miesfeld, Michael A. Riehle
Summary: This study identified several essential proteins for eggshell formation in Aedes aegypti and characterized their roles through molecular and biochemical approaches. These proteins, along with additional secreted eggshell enzymes, provide potential targets for future mosquito control strategies. Further research is needed to fully understand the mechanisms by which these proteins regulate eggshell formation and melanization.
Article
Entomology
Nia Keyes-Scott, Aryan Lajevardi, Kyle R. Swade, Mark R. Brown, Jean-Paul Paluzzi, Kevin J. Vogel
Summary: Mosquito reproduction is regulated by hormones acting through membrane-bound receptor proteins. Two receptor proteins, AeCNMaR-1a and AeCNMaR-1b, in Aedes aegypti were identified as orthologs of the fruit fly CNMa receptor. The receptors have different expression patterns and respond to a hormone at different concentrations. Injecting the hormone into mated female mosquitoes resulted in reduced egg-laying.
Article
Biodiversity Conservation
Jose G. Juarez, Luis F. Chaves, Selene M. Garcia-Luna, Estelle Martin, Ismael Badillo-Vargas, Matthew C. Medeiros, Gabriel L. Hamer
Summary: The Autocidal Gravid Ovitrap (AGO) intervention for Aedes aegypti control showed variable efficacy depending on coverage rates, with high coverage leading to significant female population suppression. Areas with low AGO coverage did not show significant reduction in female population. This study highlights the importance of achieving target coverage rates for effective vector control.
JOURNAL OF APPLIED ECOLOGY
(2021)