Article
Cell Biology
Cara L. Green, Michaela E. Trautman, Krittisak Chaiyakul, Raghav Jain, Yasmine H. Alam, Reji Babygirija, Heidi H. Pak, Michelle M. Sonsalla, Mariah F. Calubag, Chung-Yang Yeh, Anneliese Bleicher, Grace Novak, Teresa T. Liu, Sarah Newman, Will A. Ricke, Kristina A. Matkowskyj, Irene M. Ong, Cholsoon Jang, Judith Simcox, Dudley W. Lamming
Summary: Restriction of dietary isoleucine (IleR) improves metabolic health, promotes leanness and glycemic control in mice, and extends lifespan.
Article
Multidisciplinary Sciences
Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko, Miho Suzuki, Naoki Kobayashi, Yukiko Okazaki, Miwa Tamura-Nakano, Tomoki Chiba, Domenico Accili, C. Ronald Kahn, Tetsuo Noda, Hiroshi Asahara, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki
Summary: This study reveals that suppression of Akt activity in skeletal muscle of mammals associated with insulin resistance and aging could accelerate sarcopenia and reduce lifespan.
NATURE COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Sara Montserrat-Vazquez, Noelle J. Ali, Francesca Matteini, Javier Lozano, Tu Zhaowei, Eva Mejia-Ramirez, Gina Marka, Angelika Vollmer, Karin Soller, Mehmet Sacma, Vadim Sakk, Loris Mularoni, Jan Philipp Mallm, Mireya Plass, Yi Zheng, Hartmut Geiger, M. Carolina Florian
Summary: This study demonstrates that a short systemic treatment to decrease the activity of small RhoGTPase Cdc42 can improve the regenerative capacity of aged stem cells. Transplanting these rejuvenated stem cells can extend the healthspan and lifespan of aged mice, showing a broad systemic effect.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ross S. Firestone, Mu Feng, Indranil Basu, Karina Peregrina, Leonard H. Augenlicht, Vern L. Schramm
Summary: The use of MTDIA in a mouse model of Familial Adenomatous Polyposis demonstrated its efficacy in inhibiting tumor growth by increasing cellular MTA levels and inhibiting PRMT5-mediated methylations. This suggests potential for MTDIA as a therapeutic for delaying the onset and progression of colorectal cancers in FAP patients.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Victor Tkachev, Ashley Vanderbeck, Eric Perkey, Scott N. Furlan, Connor McGuckin, Daniela Gomez Atria, Ulrike Gerdemann, Xianliang Rui, Jennifer Lane, Daniel J. Hunt, Hengqi Zheng, Lucrezia Colonna, Michelle Hoffman, Alison Yu, Riley Outen, Samantha Kelly, Anneka Allman, Ute Koch, Freddy Radtke, Burkhard Ludewig, Brandon Burbach, Yoji Shimizu, Angela Panoskaltsis-Mortari, Guoying Chen, Stephen M. Carpenter, Olivier Harari, Frank Kuhnert, Gavin Thurston, Bruce R. Blazar, Leslie S. Kean, Ivan Maillard
Summary: This study demonstrates that blockade of DLL4-Notch signaling improves posttransplant survival and reduces gastrointestinal graft-versus-host disease (GVHD) in a nonhuman primate model similar to human allo-HCT. Notch inhibition affects the expression of α4β7 integrin differently in conventional T cells and regulatory T cells, and fibroblastic reticular cells in secondary lymphoid organs are identified as the critical cellular source of Delta-like Notch ligands. These findings suggest a conserved and targetable role of DLL4-Notch signaling in intestinal GVHD.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Behavioral Sciences
E. J. Tehovnik, E. Froudarakis, F. Scala, S. M. Smirnakis, S. S. Patel, A. S. Tolias
Summary: In this study, a comparative evaluation of the visual systems of mice and macaque monkeys was conducted, discussing differences and similarities in various aspects of visual processing. Insights into how the neocortex mediates conscious vision in these species were provided, emphasizing the need for a comparative analysis of how the brain generates visuomotor responses in these two species.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biology
Kai R. Caspar, Fabian Pallasdies, Larissa Mader, Heitor Sartorelli, Sabine Begall
Summary: The evolution of human handedness has been debated extensively. By investigating non-human primates, the researchers found that human right-handedness is unique among anthropoids. Species-level direction of manual lateralization is consistent among non-human primates. The strength of hand preference shows variability and is influenced by both ecology and phylogeny. Human lateralization patterns do not align with trends found in other anthropoids, suggesting unique selective pressures.
Article
Cell Biology
Michelle Meyer, Bronwyn M. Gunn, Delphine C. Malherbe, Karthik Gangavarapu, Asuka Yoshida, Colette Pietzsch, Natalia A. Kuzmina, Erica Ollmann Saphire, Peter L. Collins, James E. Jr Jr Crowe, James J. Zhu, Marc A. Suchard, Douglas L. Brining, Chad E. Mire, Robert W. Cross, Joan B. Geisbert, Siba K. Samal, Kristian G. Andersen, Galit Alter, Thomas W. Geisbert, Alexander Bukreyev
Summary: Research showed that different vaccines have varying degrees of protection against the Ebola virus, with each vaccine generating distinct antibody responses. The functional qualities of the antibody response, particularly Fc-mediated effects and GP specificity, rather than simply the magnitude of the response, appear to be central to vaccine-induced protection against EBOV.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
Anqi Qiu, Han Zhang, Brian K. Kennedy, Annie Lee
Summary: Evidence from neuroimaging and genetic studies suggests that brain aging mirrors development, but it is unclear whether mechanisms connecting brain development and aging can delay or reverse aging. This study identified genes associated with cortical volumes across the lifespan, mainly in astrocytes, with up-regulation during development and down-regulation during aging. These genes are involved in fundamental astrocytic functions and signaling pathways related to aging.
Article
Biology
Francisco J. Luongo, Lu Liu, Chun Lum Andy Ho, Janis K. Hesse, Joseph B. Wekselblatt, Frank Lanfranchi, Daniel Huber, Doris Y. Tsao
Summary: The rodent visual system has been of interest due to its experimental tractability, but it remains unclear how mice represent the visual world. This study investigates if mice exhibit behavioral and neural signatures of figure-ground segmentation, a key step in visual representation. The results show that mice have limited ability to segment figure from ground using opponent motion cue, unlike primates.
Article
Geriatrics & Gerontology
Helen Overhoff, Yiu Hong Ko, Daniel Feuerriegel, Gereon R. Fink, Jutta Stahl, Peter H. Weiss, Stefan Bode, Eva Niessen
Summary: The study found that metacognitive accuracy decreases with age, especially in cases of low confidence errors, while adaptive adjustment of behavior remains intact. Pe amplitudes following errors varied by confidence rating but did not mirror the reduction in metacognitive accuracy.
NEUROBIOLOGY OF AGING
(2021)
Article
Cell Biology
Mihai Bogdan Preda, Carmen Alexandra Neculachi, Ioana Madalina Fenyo, Ana-Maria Vacaru, Mihai Alin Publik, Maya Simionescu, Alexandrina Burlacu
Summary: The study found that transplanted MSC had limited migration capacity and were short-lived, disappearing almost completely within a week of transplantation regardless of the administration route. The transplanted MSC activated hypoxia signaling pathways, followed by apoptosis and subsequent engulfment by macrophages.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jiaze Tang, Anji Ju, Boya Li, Shaosen Zhang, Yuanchao Gong, Boyuan Ma, Yi Jiang, Hongyi Liu, Yan Fu, Yongzhang Luo
Summary: The injection of exogenous recombinant mouse serum albumin (rMSA) reduced protein damages in mice, improving their healthspan and lifespan significantly. The young and undamaged rMSA used in the study showed better results than endogenous serum albumin, leading to potential further improvements in healthspan and lifespan.
Article
Biochemistry & Molecular Biology
Kart Matlik, Daniel R. Garton, Ana R. Montano-Rodriguez, Soophie Olfat, Feride Eren, Laoise Casserly, Anastasios Damdimopoulos, Anne Panhelainen, L. Lauriina Porokuokka, Jaakko J. Kopra, Giorgio Turconi, Nadine Schweizer, Erika Bereczki, Fredrik Piehl, Goran Engberg, Simon Cervenka, T. Petteri Piepponen, Fu-Ping Zhang, Petra Sipila, Johan Jakobsson, Carl M. Sellgren, Sophie Erhardt, Jaan-Olle Andressoo
Summary: This study found that increased striatal dopamine signaling in a subgroup of schizophrenia patients may be related to the increase of GDNF. A possible mediator of GDNF-driven dopaminergic abnormalities is A(2A)R. By inhibiting A(2A)R with a drug, striatal and cortical dopamine levels can be partially normalized. These results provide potential therapeutic targets for the treatment of schizophrenia.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Michela Milani, Cesare Canepari, Tongyao Liu, Mauro Biffi, Fabio Russo, Tiziana Plati, Rosalia Curto, Susannah Patarroyo-White, Douglas Drager, Ilaria Visigalli, Chiara Brombin, Paola Albertini, Antonia Follenzi, Eduard Ayuso, Christian Mueller, Andrea Annoni, Luigi Naldini, Alessio Cantore
Summary: Liver gene therapy using lentiviral vectors that integrate into the host cell genome has shown efficient liver gene transfer in mice, dogs, and non-human primates. In this study, we compared engineered coagulation factor VIII transgenes and found that codon-usage optimization and inclusion of an unstructured XTEN peptide significantly increased factor VIII expression in mice and non-human primates. Stable and long-term normal or above-normal factor VIII activity was achieved in hemophilia A mouse models. This research opens up new possibilities for treating hemophilia A using lentiviral gene therapy.
NATURE COMMUNICATIONS
(2022)