Article
Agriculture, Dairy & Animal Science
Chen Yuan, Penghao Zhang, Yuxin Jin, Abid Ullah Shah, En Zhang, Qian Yang
Summary: This study compared the morphological and immunological differences in the small intestine of neonatal and weaned piglets, revealing that the small intestine of weaned piglets had better structure and immune components compared to neonatal piglets, which could help prevent intestinal infectious diseases.
Article
Agriculture, Dairy & Animal Science
K. S. Hare, K. M. Wood, Y. Mustapha, K. C. Swanson, M. A. Steele
Summary: The study aimed to examine the effect of varying colostral insulin concentrations on small intestinal development and metabolism in neonatal Holstein bulls. Insulin supplementation at different levels was used to maintain equivalent macronutrient intake among treatments. Blood metabolites and insulin concentration were measured at different time points after colostrum feeding. Insulin supplementation affected glucose clearance rate, glucose absorption rate, and nonesterified fatty acid clearance rate. It also had an impact on small intestinal histomorphological development, carbohydrase activity, and gastrointestinal tissue mass. Overall, changes in colostrum insulin concentrations rapidly influenced gastrointestinal growth and carbohydrase activity, resulting in minor changes in postprandial metabolite availability and clearance.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Morteza H. Ghaffari, Hassan Sadri, Julia Steinhoff-Wagner, Harald M. Hammon, Helga Sauerwein
Summary: The study suggests that feeding colostrum may improve immune responsiveness and epithelial barrier function in neonatal calves, as evidenced by the higher mRNA abundance of certain TLR genes and CLDN1 in most intestinal sections of the colostrum-fed calves.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Gastroenterology & Hepatology
Shunji Fujimori, Ryohei Hamakubo, Aitoshi Hoshimoto, Takayoshi Nishimoto, Jun Omori, Naohiko Akimoto, Shu Tanaka, Atsushi Tatsuguchi, Katsuhiko Iwakiri
Summary: The frequency of primary small intestinal adenocarcinoma is low, and it mainly occurs in the proximal small intestine. Dietary factors and the influence of intestinal content may contribute to its carcinogenesis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Yaqi Li, Cheng-Hsin Wei, J. Kalina Hodges, Michael H. Green, A. Catharine Ross
Summary: The study investigated the unique effect of retinoic acid (RA) on intestinal vitamin A (VA) kinetics by administering an RA dose before VA supplementation. The results showed that RA pretreatment could stimulate the influx of supplemental VA into the intestine, leading to increased VA accumulation in neonatal rats' intestines.
Review
Pediatrics
Vicente Rey Y. Formoso, Ricardo Barreto Mota, Henrique Soares
Summary: The hemostatic system undergoes different developmental changes in neonates, leading to differences in the coagulation system compared to other age groups. However, a balance is maintained for physiological hemostasis. Understanding developmental hemostasis is crucial for the care of newborns and children.
WORLD JOURNAL OF PEDIATRICS
(2022)
Article
Developmental Biology
Anne M. Bara, Lei Chen, Celina Ma, Julie Underwood, Rebecca S. Moreci, Kaelyn Sumigray, Tongyu Sun, Yarui Diao, Michael Verzi, Terry Lechler
Summary: This study identifies MAFB and c-MAF as markers of terminally differentiated intestinal enterocytes and reveals their regulation by HNF4 alpha and HNF4 gamma. Loss of Maf factors leads to neonatal-specific failure to thrive and loss of macromolecular nutrient uptake. The researchers also demonstrate major transcriptional changes in metabolic pathways and an increase in peroxisome number in response to loss of Maf proteins. Additionally, loss of BLIMP1 shows similar changes in gene expression and defects in macromolecular uptake.
Article
Agriculture, Dairy & Animal Science
Pawel Konieczka, Elzbieta Zelechowska, Wieslaw Przybylski, Danuta Jaworska, Piotr Salek, Misza Kinsner, Jan Jankowski
Summary: This study investigated the effects of the Arginine/Lysine (Arg/Lys) ratio in low- and high-methionine diets on the sarcoplasmic protein profile of turkey breast muscles under optimal or challenge conditions. The results showed that the Arg content affected meat color, and glycolytic enzymes were the most abundant in the sarcoplasmic protein profile. In addition, the study found a relationship between C. perfringens infection and the intake of Arg and Met.
Review
Chemistry, Multidisciplinary
Ludivine Delon, Rachel J. Gibson, Clive A. Prestidge, Benjamin Thierry
Summary: Micro- and nano-scale particulate formulations can improve the oral bioavailability of biologics and drugs with low solubility and/or low intestinal permeability. Understanding absorption pathways and the role of intestinal cells is crucial for enhancing oral bioavailability.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Mei Lan Chen, Xiangsheng Huang, Hongtao Wang, Courtney Hegner, Yujin Liu, Jinsai Shang, Amber Eliason, Huitian Diao, HaJeung Park, Blake Frey, Guohui Wang, Sarah A. Mosure, Laura A. Solt, Douglas J. Kojetin, Alex Rodriguez-Palacios, Deborah A. Schady, Casey T. Weaver, Matthew E. Pipkin, David D. Moore, Mark S. Sundrud
Summary: The study identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells, protecting the small intestine from bile acid toxicity and inflammation. Activation of CAR in T-eff cells infiltrating the small intestine induced large-scale transcriptional reprogramming and promoted the expression of the anti-inflammatory cytokine IL-10.
Article
Biology
Judith M. Lionarons, Govert Hoogland, Rutger J. Slegers, Hellen Steinbusch, Sandra M. H. Claessen, Johan S. H. Vles
Summary: Dp71 protein is expressed highest in the distal intestine in neonatal and adult rats, with a regional difference observed at the protein level but not at the mRNA level. Dp co-localizes with aSMA and HuC/HuD in the muscularis propria, suggesting a potential role in GI comorbidities treatment.
Article
Anatomy & Morphology
Clarisse Maria Barbosa Fonseca, Ingrid dos Santos Farias, Joao Victor Silva Araujo, Rita de Cassia Viana, Andrezza Braga Soares da Silva, Maria Michele Araujo de Sousa Cavalcante, Airton Mendes Conde
Summary: The objective of this study was to examine the morphology and histological features of the small and large intestines of the six-banded armadillo (E. sexcinctus). The results showed that the small intestine has three parts and the typical four layers of tubular organs, while the large intestine has similar histological subdivisions as the small intestine but with some specializations.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Review
Nutrition & Dietetics
Andreanna Burman, Izumi Kaji
Summary: The small intestine plays a major role in nutrient sensing, with taste receptors responding to specific ligands like carbohydrates, fats, and proteins. Activation of nutrient sensors helps in processing incoming nutrients and defects can lead to metabolic disorders. Recent studies focus on mechanisms related to intestinal nutrient sensors and their roles in disease.
Article
Multidisciplinary Sciences
Orli Snir, Hanan Alwaseem, Soren Heissel, Anurag Sharma, Stephany Valdes-Rodriguez, Thomas S. Carroll, Caroline S. Jiang, Jacopo Razzauti, Daniel J. C. Kronauer
Summary: This study reveals the crucial role of ant pupae secretion in eliciting parental care and providing nutrition for early larvae. The secretion, analogous to mammalian milk, is essential for pupal survival and has implications for the evolution of ant eusociality.
Article
Agriculture, Dairy & Animal Science
P. Langendijk, M. Fleuren, K. Venrooy, K. Ernst, G. Page
Summary: To evaluate the importance of natural variation in colostrum intake for piglet gastrointestinal and reproductive development, two female piglets with low (average 226 g) and high (average 401 g) colostrum intake were selected from each of 27 litters. Measurements were taken on the ileum, colon, cervix, and uterus tissues, and tissue samples were analyzed histologically. Piglets with high colostrum intake showed greater overall development, with increased weight and size of various organs and more advanced histological architecture in the uterus and cervix.
Review
Biochemistry & Molecular Biology
Nutmethee Kruepunga, Theodorus B. M. Hakvoort, Jill P. J. M. Hikspoors, S. Eleonore Kohler, Wouter H. Lamers
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Article
Multidisciplinary Sciences
C. C. de Theije, A. M. W. J. Schols, W. H. Lamers, D. Neumann, S. E. Kohler, R. C. J. Langen
Review
Cell Biology
Jill P. J. M. Hikspoors, Nutmethee Kruepunga, Greet M. C. Mommen, Jean-Marie P. W. U. Peeters, Cindy J. M. Hulsman, S. Eleonore Kohler, Wouter H. Lamers
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Thomas J. M. Verlinden, Paul van Dijk, Andreas Herrler, Corrie de Gier-de Vries, Wouter H. Lamers, S. Eleonore Kohler
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Thomas J. M. Verlinden, Paul van Dijk, Jill Hikspoors, Andreas Herrler, Wouter H. Lamers, S. Eleonore Kohler
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Anatomy & Morphology
Nutmethee Kruepunga, Jill P. J. M. Hikspoors, Hayelom K. Mekonen, Greet M. C. Mommen, Krai Meemon, Wattana Weerachatyanukul, Somluk Asuvapongpatana, S. Eleonore Kohler, Wouter H. Lamers
JOURNAL OF ANATOMY
(2018)
Article
Anatomy & Morphology
Nutmethee Kruepunga, Jill P. J. M. Hikspoors, Cindy J. M. Hulsman, Greet M. C. Mommen, S. Eleonore Kohler, Wouter H. Lamers
JOURNAL OF ANATOMY
(2020)
Article
Anatomy & Morphology
Nutmethee Kruepunga, Jill P. J. M. Hikspoors, Cindy J. M. Hulsman, Greet M. C. Mommen, S. Eleonore Kohler, Wouter H. Lamers
JOURNAL OF ANATOMY
(2020)
Article
Anatomy & Morphology
Nutmethee Kruepunga, Jill P. J. M. Hikspoors, Cindy J. M. Huelsman, Greet M. C. Mommen, S. Eleonore Koehler, Wouter H. Lamers
Summary: The development of sympathetic trunks in human embryos was visualized using 3D-reconstruction software, revealing a change in position from lateral to dorsolateral as a criterion to distinguish primary and secondary trunks. The differential growth accounted for the regional differences in position of the sympathetic trunks as they transitioned from para-aortic to prevertebral or paravertebral positions during development.
JOURNAL OF ANATOMY
(2021)
Article
Oncology
Rom Keshet, Joo Sang Lee, Lital Adler, Muhammed Iraqi, Yarden Ariav, Lisha Qiu Jin Lim, Shaul Lerner, Shiran Rabinovich, Roni Oren, Rotem Katzir, Hila Weiss Tishler, Noa Stettner, Omer Goldman, Hadas Landesman, Sivan Galai, Yael Kuperman, Yuri Kuznetsov, Alexander Brandis, Tevi Mehlman, Sergey Malitsky, Maxim Itkin, S. Eleonore Koehler, Yongmei Zhao, Keyur Talsania, Tsai-wei Shen, Nir Peled, Igor Ulitsky, Angel Porgador, Eytan Ruppin, Ayelet Erez
Article
Physiology
Ramesh Chennupati, Merlijn J. Meens, Ben J. Janssen, Paul van Dijk, Theodorus B. M. Hakvoort, Wouter H. Lamers, Jo G. R. De Mey, S. Eleonore Koehler
PHYSIOLOGICAL REPORTS
(2018)
Article
Respiratory System
Roy H. E. Cloots, Matthew E. Poynter, Els Terwindt, Wouter H. Lamers, S. Eleonore Kohler
RESPIRATORY RESEARCH
(2018)
Article
Endocrinology & Metabolism
Chiel C. de Theije, Annemie M. W. J. Schols, Wouter H. Lamers, Judith J. M. Ceelen, Rick H. van Gorp, J. J. Rob Hermans, S. Elonore Kohler, Ramon C. J. Langen
Article
Biochemistry & Molecular Biology
Sonia C. Garcia Caraballo, Tine M. Comhair, Cornelis H. C. Dejong, Wouter H. Lamers, S. Eleonore Koehler
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2017)
Article
Nutrition & Dietetics
Tine M. Comhair, Sonia C. Garcia Caraballo, Cornelis H. C. Dejong, Wouter H. Lamers, S. Eleonore Koehler
CLINICAL NUTRITION
(2017)