期刊
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 13, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1472-6882-13-78
关键词
Cytotoxic; Antimicrobial; Edible plants; Cameroon
资金
- Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)
- Centre for International Co-operation in Science (CICS)
- Indian Institute of Integrative Medicine, Jammu, India
Background: In Cameroon, the use of edible plants is an integral part of dietary behavior. However, evidence of the antimicrobial as well as the cytotoxic effects of many of them has not been investigated. In the present study, aqueous and methanol extracts from barks, seeds, leaves and roots of three Cameroonian edible plants namely Garcina lucida, Fagara heitzii and Hymenocardia lyrata were evaluated for their cytotoxic and antimicrobial activities. Methods: Antibacterial and antifungal activities were assessed by the broth micro-dilution method meanwhile the cytotoxicity was performed using sulphorhodamine B assay (SRB) against the human leukemia THP-1, the alveolar epithelial A549, prostate cancer PC-3, breast adenocarcinoma MCF-7 and cervical cancer HeLa cell lines. Results: The minimum inhibitory concentration (MIC) values of the seven tested extracts ranged from 62.5 mu g/ml to 1000 mu g/ml. The methanol (MeOH) extract from the roots of H. lyrata showed the highest antibacterial activity against Gram-positive bacteria S. aureus and S. epidermitis. The best antifungal activity was obtained with the MeOH extract from the leaves of G. lucida against C. tropicalis (MIC value of 62.5 mu g/ml). The in vitro antiproliferative activity revealed that, extract from the bark of F. heitzii and extract from H. lyrata roots had significant cytotoxic activity on THP-1 (IC50 8.4 mu g/ml) and PC-3 (IC50 9.5 mu g/ml) respectively. Conclusion: Our findings suggest that Cameroonian spices herein studied could be potentially useful for the development of therapeutic agents against bacterial infections as well as for prostate and leukemia cancer.
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