Article
Nutrition & Dietetics
Jin-Su Oh, Sang-Jun Lee, Se-Young Choung
Summary: The study found that Lithospermum erythrorhizon can alleviate clinical symptoms of atopic dermatitis in mice by modulating immune balance and restoring skin barrier function.
Article
Biochemistry & Molecular Biology
Hyun Jung Park, Sung Won Lee, Luc Van Kaer, Myeong Sup Lee, Seokmann Hong
Summary: Interleukin-7 (IL-7) is important in maintaining the balance of CD4(+) and CD8(+) T cells. However, its role in allergic disorders, such as atopic dermatitis (AD), has not been well understood. By studying IL-7-deficient AD-prone mice, it was found that IL-7 deficiency worsened AD development, indicating that IL-7 could be a potential therapeutic target for treating AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Hyun-Kyung Song, Sun Haeng Park, Hye Jin Kim, Seol Jang, Taesoo Kim
Summary: Alpinia officinarum water extract shows therapeutic effects against atopic dermatitis by alleviating skin lesions, suppressing inflammatory mediators, and inhibiting major signaling molecules.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yoshie Umehara, Juan Valentin Trujillo-Paez, Hainan Yue, Ge Peng, Hai Le Thanh Nguyen, Ko Okumura, Hideoki Ogawa, Francois Niyonsaba
Summary: Calcitriol has a positive therapeutic effect on atopic dermatitis by repairing the skin barrier and improving inflammatory symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Hyeong Rok Yun, Sang Woo Ahn, Bomin Seol, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han, Kyung Soo Ko, Byoung Doo Rhee, Jung Eun Seol, Hyoung Kyu Kim
Summary: The study demonstrated the anti-inflammatory effects of Echinochrome A (Ech A) extracted from sea urchins in alleviating atopic dermatitis (AD) like skin lesions in an NC/Nga mouse model. Ech A treatment improved clinical symptoms of AD, reduced water loss, enhanced stratum corneum hydration, and suppressed inflammatory response and cytokine expression in skin lesions.
Article
Pharmacology & Pharmacy
Ju Hyun Lee, Linsha Dong, Hyeon Min Noh, Sung-Gu Park, Seung-Hyung Kim, Eun Heui Jo, Dong-Sung Lee, Min Cheol Park
Summary: The increase of atopic dermatitis has led to higher socio-economic cost and raised a need for alternative medicine. This study evaluated the inhibitory effects of Donkey Hide Gelatin (DHG) water extract on atopic dermatitis and investigated its underlying mechanisms. The results showed that DHG reduced skin symptoms, immune cell numbers, allergic reactions, and levels of neutrophils and eosinophils. In addition, DHG inhibited pro-inflammatory cytokines and chemokines in keratinocytes, and suppressed NF-kappa B and MAPK signaling pathway activation. DHG may be a potential therapeutic agent or supplement for atopic dermatitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jin-Su Oh, Geum-Su Seong, Yong-Deok Kim, Se-Young Choung
Summary: The prevalence of atopic dermatitis (AD) is rapidly increasing worldwide. A study found that deacetylasperulosidic acid (DAA) has anti-atopic activity and can alleviate symptoms of AD by reducing pruritus, modulating immune imbalance, and restoring skin barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Chandra K. K. Singh, Charlotte A. A. Mintie, Mary A. A. Ndiaye, Gagan Chhabra, Sushmita Roy, Ruth Sullivan, B. Jack Longley, Stefan M. M. Schieke, Nihal Ahmad
Summary: In this study, dietary grape powder was found to alleviate AD-like symptoms in mice. It reduced skin lesions, decreased inflammation markers, and modulated various cytokines/chemokines. These findings suggest that grape powder may be a promising approach for AD management.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kanako Nakayama, Hiroe Tetsu, Taku Nishijo, Takuo Yuki, Masaaki Miyazawa
Summary: Allergic contact dermatitis (ACD) and atopic dermatitis (AD) are common inflammatory diseases. This study investigated the commonality of findings across haptens and mechanisms focused on dendritic cells (DCs) in AD. The results revealed that attenuated contact hypersensitivity (CHS) responses in AD may be hapten-independent and the tolerogenic phenotype of hapten-bearing DCs can contribute to reduced T-cell proliferation and CHS responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Seokwoo Lee, Na Yeon Lim, Min Soo Kang, Yunho Jeong, Jin-Ok Ahn, Jung Hoon Choi, Jin-Young Chung
Summary: This study evaluated the expression of IL-31 receptor alpha (IL-31RA) and TRPV1 in the skin of Nc/Nga mice, which were induced to develop atopic dermatitis (AD) by administering trinitrochlorobenzene (TNCB). The results showed significant differences in skin lesion scores between different groups, and immunohistochemistry analysis highlighted overexpression of IL-31RA and TRPV1 in the nerve fibers of the TNCB 8-weeks-treated group. This confirms that long-term application of TNCB can induce chronic atopic-like dermatitis and result in overexpression of IL-31RA and TRPV1 in peripheral nerve fibers in this AD model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Qi Qi Pang, Byeong Wook Noh, Hye Sook Park, Young Sil Kim, Ji-Hyun Kim, Eun Ju Cho
Summary: Membrane-free stem cell extract (MFSCE) derived from adipose tissue has demonstrated anti-inflammatory activity. This study used a mouse model to investigate the effects of MFSCE on atopic dermatitis (AD)-like skin inflammation. Results showed that topical application of MFSCE significantly improved clinical symptoms and reduced serum immunoglobulin E and inflammatory cytokine levels. MFSCE treatment also inhibited epidermal thickness, mast cell infiltration, and expression of inflammatory mediators. The findings suggest that MFSCE may be a potential natural product for AD treatment.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Medicinal
Tae-Hee Kim, Seong-Yeong Heo, Gun-Woo Oh, Won Sun Park, Il-Whan Choi, Zhong-Ji Qian, Won-Kyo Jung
Summary: The study showed that low molecular weight peptides extracted from abalone viscera can suppress allergic responses and alleviate atopic dermatitis, suggesting that this peptide may be a potential candidate for treating AD.
Article
Pharmacology & Pharmacy
Tsugunobu Andoh, Yoko Yoshihisa, Mati Ur Rehman, Yoshiaki Tabuchi, Tadamichi Shimizu
Summary: The study found that berberine has a certain ameliorative effect on the AD-like symptoms in mice, acting by inhibiting the expression of inflammatory factors and the recruitment of inflammatory cells.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Katsuhiko Matsui, Midori Nakamura, Noriko Obana
Summary: The study demonstrated that topical application of josamycin ointment significantly suppressed the increase in skin severity score in NC/Nga mice with AD-like skin lesions. This was associated with decreases in S. aureus count on the skin, reduction in scratching behavior, and downregulation of IL-31 mRNA expression in the lesions. The results suggest that controlling S. aureus colonization with josamycin could be beneficial for managing AD symptoms.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Sung Won Lee, Hyun Jung Park, Jungmin Jeon, Yun Hoo Park, Tae-Cheol Kim, Sung Ho Jeon, Rho Hyun Seong, Luc Van Kaer, Seokmann Hong
Summary: The overexpression of SRG3 has been shown to accelerate the development of AD in mice, leading to increased clinical severity and immune cell infiltration in skin lesions. This enhanced pathogenesis is linked to the expansion of IL-4-producing cells and suppression of Treg cells, suggesting that modulation of SRG3 function may be a potential therapeutic option for controlling AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Dae Yun Seo, Jun-Won Heo, Mi-Hyun No, Su-Zi Yoo, Jeong Rim Ko, Dong-Ho Park, Ju-Hee Kang, Chang-Ju Kim, Su-Jeen Jung, Jin Han, Hyo-Bum Kwak
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Lakkyong Hwang, Il-Gyu Ko, Jun-Jang Jin, Sang-Hoon Kim, Chang-Ju Kim, Jae-Joon Hwang, Cheon Woong Choi, Bok Soon Chang
Summary: This study demonstrated the protective effect of PDRN in PM10-induced injury in human bronchial-derived cells, reducing cytotoxicity, inflammation, and apoptosis by influencing cAMP activation and PKA, CREB phosphorylation. These effects were attributed to the enhancement of adenosine A2AR in PM10-exposed bronchial cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biology
Mi-Hyun No, Youngju Choi, Jinkyung Cho, Jun-Won Heo, Eun-Jeong Cho, Dong-Ho Park, Ju-Hee Kang, Chang-Ju Kim, Dae Yun Seo, Jin Han, Hyo-Bum Kwak
Article
Immunology
Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Chang-Ju Kim, Kyu Yeoun Won, Yong Gil Na, Khae Hawn Kim, Su Jin Kim
Summary: The study investigated the effect of polydeoxyribonucleotide (PDRN) on a cyclophosphamide-induced interstitial cystitis (IC) animal model in rats. Results showed that PDRN treatment alleviated voiding dysfunction, bladder edema, and histological damage caused by cyclophosphamide-induced IC. PDRN treatment also suppressed secretion of pro-inflammatory cytokines and expressions of apoptotic factors, suggesting its potential as an effective therapeutic agent for IC.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Chang-Ju Kim, Jung Won Jeon, Jun-Young Chung, Jin Hee Han
Summary: The study demonstrated that PDRN treatment can improve short-term memory impairment induced by cerebral ischemia by suppressing the production of pro-inflammatory cytokines and inactivation of MAPK signaling factors. This suggests that PDRN may be developed as the primary treatment for cerebral ischemia.
Editorial Material
Rehabilitation
Chang-Ju Kim
JOURNAL OF EXERCISE REHABILITATION
(2021)
Article
Physiology
Sang-Seo Park, Hye-Sang Park, Chang-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Kim
Summary: Exercising in a 40-Hz light flicker environment was found to be more effective than exercise or 40-Hz light flicker alone. This synergistic effect may prevent cognitive dysfunction by inhibiting the Aβ, tau pathway, and neuroinflammation, and enhancing neuroplasticity and mitochondrial functions in the hippocampus during the early stages of Alzheimer's disease.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Editorial Material
Rehabilitation
Chang-Ju Kim
JOURNAL OF EXERCISE REHABILITATION
(2022)
Editorial Material
Rehabilitation
Chang-Ju Kim
JOURNAL OF EXERCISE REHABILITATION
(2022)
Article
Rehabilitation
Chang-Ju Kim
JOURNAL OF EXERCISE REHABILITATION
(2022)
Editorial Material
Rehabilitation
Yong-Seok Jee
JOURNAL OF EXERCISE REHABILITATION
(2022)
Article
Rehabilitation
Young-A Cho, Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Jung Won Jeon, Myoung Joo Yang, Chang-Ju Kim
Summary: The study shows that PDRN has the potential to be used as a therapeutic agent for alcoholic liver injury by inhibiting inflammation and apoptosis through the PI3K/Akt signaling pathway, improving liver function.
JOURNAL OF EXERCISE REHABILITATION
(2022)
Editorial Material
Rehabilitation
Chang-Ju Kim
JOURNAL OF EXERCISE REHABILITATION
(2020)
Article
Medicine, General & Internal
Sihwa Park, Sunhee Park, Sukyung Min, Chang-Ju Kim, Yong-Seok Jee
MEDICINA-LITHUANIA
(2020)
Article
Urology & Nephrology
Ji-Youn Kim, Eun-Surk Yi, Hyunju Lee, Jun-Su Kim, Yong-Seok Jee, Sung Eun Kim, Chang-Ju Kim, Il-Gyu Ko
INTERNATIONAL NEUROUROLOGY JOURNAL
(2020)