期刊
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 12, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1472-6882-12-104
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资金
- Universiti Sains Malaysia (USM)
- USM [1001/PFARMASI/81144]
- King Saud University on drug targeting and treatment of cancer using nanoparticles
Background: Xanthones are a group of oxygen-containing heterocyclic compounds with remarkable pharmacological effects such as anti-cancer, antioxidant, anti-inflammatory, and antimicrobial activities. Methods: A xanthones extract (81% a-mangostin and 16%.-mangostin), was prepared by crystallization of a toluene extract of G. mangostana fruit rinds and was analyzed by LC-MS. Anti-colon cancer effect was investigated on HCT 116 human colorectal carcinoma cells including cytotoxicity, apoptosis, anti-tumorigenicity, and effect on cell signalling pathways. The in vivo anti-colon cancer activity was also investigated on subcutaneous tumors established in nude mice. Results: The extract showed potent cytotoxicity (median inhibitory concentration 6.5 +/- 1.0 mu g/ml), due to induction of the mitochondrial pathway of apoptosis. Three key steps in tumor metastasis including the cell migration, cell invasion and clonogenicity, were also inhibited. The extract and a-mangostin up-regulate the MAPK/ERK, c-Myc/Max, and p53 cell signalling pathways. The xanthones extract, when fed to nude mice, caused significant growth inhibition of the subcutaneous tumor of HCT 116 colorectal carcinoma cells. Conclusions: Our data suggest new mechanisms of action of a-mangostin and the G. mangostana xanthones, and suggest the xanthones extract of as a potential anti-colon cancer candidate.
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