Editorial Material
Neurosciences
Richard S. Finkel, Kenneth H. Fischbeck
Summary: Gene replacement therapies have made significant progress in the treatment of spinal muscular atrophy, but there are concerns about the potential toxic overexpression of SMN protein in diseased mice.
NATURE NEUROSCIENCE
(2021)
Editorial Material
Cell Biology
Mark W. Pataky, K. Sreekumaran Nair
Summary: Moderate aerobic exercise is beneficial for health, but excessive and high-intensity aerobic exercise may have negative effects on mitochondrial function and glucose tolerance.
Review
Endocrinology & Metabolism
Frances M. Ashcroft, Matthew Lloyd, Elizabeth A. Haythorne
Summary: Type 2 diabetes is a global health problem characterized by inadequate insulin secretion and chronic high blood sugar. While it was initially believed that drugs stimulating glucokinase would enhance insulin secretion, recent studies have shown that it is the hyperactivation of glucose metabolism, not glucose itself, that leads to the progressive decline in beta-cell function. This perspective discusses the potential exacerbation of this decline by glucokinase activators and counterintuitively proposes that glucokinase inhibitors might be a better therapeutic strategy for preserving beta-cell function in Type 2 diabetes.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Editorial Material
Biochemistry & Molecular Biology
Lea P. Wilhelm, Ian G. Ganley
Summary: Three new studies demonstrate that the disease-associated FBXL4 protein plays a crucial role in regulating constitutive mitophagy by controlling the stability of mitophagy receptors BNIP3 and NIX.
Article
Psychology, Multidisciplinary
Claudia Vogrincic-Haselbacher, Joachim I. Krueger, Brigitta Lurger, Isabelle Dinslaken, Julian Anslinger, Florian Caks, Arnd Florack, Hilmar Brohmer, Ursula Athenstaedt
Summary: When making online purchases, consumers are faced with a wealth of information, with varying degrees of willingness and ability to process it. Research shows that successful search strategies involve focused selection and processing of a moderate amount of information. Consumers can be categorized into three groups based on their information processing strategies, which also impact decision quality.
FRONTIERS IN PSYCHOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
John A. Hawley, David J. Bishop
Summary: Exercise training can have positive effects on mitochondrial function and metabolic health outcomes, but there may be a limit to the amount of high-intensity training that the body can tolerate before disruptions occur.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Review
Immunology
Christo Tsilifis, Mary A. Slatter, Andrew R. Gennery
Summary: Primary immune regulatory disorders (PIRDs) are a group of inborn errors of immunity caused by defects in the regulatory mechanism of the immune response. They can lead to various diseases such as infections, autoimmunity, autoinflammation, malignancy, and allergy. Recognition and treatment of PIRDs remain challenging due to their diverse phenotype and limited data on natural history and treatment. International collaboration is needed to better understand PIRDs and develop effective therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Anthony J. Michael
Summary: Researchers identified yeast high-affinity spermidine transporter, elucidated the translational mechanism driven by mRNA uORF/eIF5a for sensing spermidine levels, and demonstrated that excess spermidine competitively inhibits eIF5a function, leading to reduced spermidine uptake.
Article
Obstetrics & Gynecology
Robert John Norman
Summary: Intracytoplasmic sperm injection (ICSI) was initially introduced for male infertility but is now widely used in assisted reproduction techniques. The indications for ICSI use need to be re-evaluated to ensure appropriate application in infertility management.
FERTILITY AND STERILITY
(2022)
Article
Cell Biology
Chen Han, May Barakat, Luisa A. DiPietro
Summary: Angiogenesis, the growth of new blood vessels, is crucial for wound repair. The restoration of normal oxygen levels is essential for proper tissue healing. However, excessive angiogenesis can lead to abnormal blood vessels. Fine-tuning capillary regrowth in wounds has significant therapeutic potential in treating poorly healing wounds.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Kevin J. Downes, Jennifer L. Goldman
Summary: Antimicrobials are a common cause of drug toxicity, and understanding the relationship between systemic antimicrobial exposure and toxicity is necessary for healthcare providers to prevent undesired drug effects. Different categories are used to classify the relationship between exposure and toxicity of antimicrobial agents, which can help minimize observed toxicities and integrate effective therapeutic drug monitoring strategies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Business, Finance
Douglas (DJ) Fairhurst, Daniel T. Greene
Summary: This study examines the relationship between corporate social responsibility (CSR) and firm value using the takeover market as an empirical setting. The findings suggest that firms with either very high or very low CSR scores are more likely to experience takeovers with lower wealth gains, while firms with moderate CSR policies tend to have higher firm value.
JOURNAL OF CORPORATE FINANCE
(2022)
Article
Biochemistry & Molecular Biology
John E. Cronan
Summary: FadR is a transcription factor in E. coli that regulates fatty acid metabolism in response to environmental fatty acids. It represses fatty acid degradation genes and activates fatty acid synthesis genes. Overproduction of FadR increases fatty acid yields but may have negative effects on cell physiology.
MOLECULAR MICROBIOLOGY
(2021)
Article
Economics
Elisa Operti, Amit Kumar
Summary: This paper offers a multilevel understanding of the impact of brokerage on regional innovation, proposing a typology of regional networks based on the extent of connections among inventors within a region and with inventors in other regions. The study shows that configurations balancing high internal brokerage and low external boundary-spanning lead to higher innovation performance.
Article
Plant Sciences
Christopher J. Lortie, Mario Zuliani, Nargol Ghazian, Stephanie Haas, Jenna Braun, Malory Owen, Florencia Miguel, Merav Seifan, Alessandro Filazzola, Jacob Lucero
Summary: The study explored the complex interactions between local plant species richness and shrub facilitation intensity to maintain biodiversity in arid ecosystems. It was found that increasing local plant species richness shifted the interaction with shrubs from positive to negative, indicating that higher richness does not always enhance functions that maintain diversity in plant communities.
JOURNAL OF ECOLOGY
(2021)