Article
Orthopedics
Chun-Ru Lin, Sung Huang Laurent Tsai, Ko-Yen Huang, Po-An Tsai, Hsuan Chou, Shu-Hao Chang
Summary: Collagen peptides have been shown to provide significant pain relief for patients with knee osteoarthritis compared to placebo, with no significant difference in adverse events. Further well-designed randomized controlled trials are needed to confirm these findings.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Nutrition & Dietetics
Akifumi Toguchi, Naoto Noguchi, Toshihiro Kanno, Akira Yamada
Summary: This study found that oral consumption of MSM improved knee joint pain and overall health conditions in healthy participants, based on a randomized, double-blind, placebo-controlled trial.
Article
Rehabilitation
Bugra Ince, Altinay Goksel Karatepe, Seniz Akcay, Taciser Kaya
Summary: This study aimed to investigate the effects of balance and proprioception exercises in patients with knee osteoarthritis. The results showed that balance and proprioception exercises may have positive effects on dynamic balance and pain. However, further studies are needed to examine the effects on physical function and quality of life.
CLINICAL REHABILITATION
(2023)
Article
Orthopedics
Pawan Kumar Gupta, Sunil Maheshwari, Joe Joseph Cherian, Vijay Goni, Arun Kumar Sharma, Sujith Kumar Tripathy, Keerthi Talari, Vivek Pandey, Parag Kantilal Sancheti, Saurabh Singh, Nikhil N. Verma, Uday Kumar
Summary: This study aimed to assess the potential of allogenic mesenchymal stromal cells (MSCs) to improve functional parameters and induce cartilage regeneration in patients with osteoarthritis. The results showed that MSCs significantly improved pain, stiffness, and physical function, and cartilage quality did not worsen after 12 months of treatment.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Medicine, General & Internal
Sangah Youn, Ji Hye Choi, Chulmin Kim, Seon-Mee Kim, Whan Seok Choi
Summary: The study showed that the combination therapy of diacerein and celecoxib is effective and safe in relieving symptoms of osteoarthritis, especially in improving stiffness and physical function early on.
Article
Chemistry, Medicinal
Jestin V. Thomas, Thozhuthum Parambil Smina, Aman Khanna, Ajaikumar B. Kunnumakkara, Balu Maliakel, Ratheesh Mohanan, Illathu Madhavamenon Krishnakumar
Summary: A 6-week trial showed that low-dose curcumagalactomannosides (CGM) had superior effects in alleviating pain and symptoms of OA subjects compared to a high-dose chondroitin sulphate and glucosamine combination. Further studies are needed to confirm the long-term efficacy of CGM in OA management.
PHYTOTHERAPY RESEARCH
(2021)
Article
Medicine, General & Internal
Sang Ha Woo, Hyun-Jong Lee, Yu-kyeong Park, Jihoon Han, Jae Soo Kim, Jung Hee Lee, Chung A. Park, Seong-Hun Choi, Woo Dong Lee, Chang Sop Yang, Min Ji Kim, Chang-Hyun Han
Summary: This pilot study suggests that thread embedding acupuncture (TEA) is a safe and effective procedure for relieving pain in patients with knee osteoarthritis (KOA). The results of this study provide basic data and indicate the feasibility of large-scale clinical studies to evaluate the efficacy and safety of TEA for KOA.
Article
Rheumatology
Mazlum Serdar Akaltun, Ozlem Altindag, Neytullah Turan, Savas Gursoy, Ali Gur
Summary: The study demonstrated the effectiveness of high intensity laser therapy combined with exercise therapy for pain, functionality, and cartilage measurement in knee osteoarthritis patients. Both treatment groups showed significant improvements at the end of treatment.
CLINICAL RHEUMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
NamHoon Kim, Si-Yeon Kim, Sang-Woo Kim, Jung Min Lee, Sung-Kyu Kim, Mi-Houn Park, Ki-Hwan Kim, Minseok Oh, Chang-Gue Son, In Chul Jung, Eun-Jung Lee
Summary: This study aimed to evaluate the clinical efficacy and safety of PE extracts on semi-healthy people with mild knee joint pain. The results showed that PE intake for eight weeks was more effective than placebo in reducing knee joint pain and improving knee joint function. It was concluded that PE extracts were effective and safe for relieving knee joint pain and improving knee joint function.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Rehabilitation
Patricia Pereira Alfredo, Jan Magnus Bjordal, Rodrigo Alvaro Brandao Lopes-Martins, Mark Johnson, Washington Steagall Junior, Amelia Pasqual Marques, Raquel Aparecida Casarotto
Summary: This study investigated the effect of prolonged low-level laser therapy combined with exercise on pain and disability in patients with knee osteoarthritis. The results showed that the isolated application of low-level laser therapy in the initial 3 weeks and combined with exercises in the final 8 weeks reduced pain, disability, and medication intake over a 6-month period.
CLINICAL REHABILITATION
(2022)
Article
Medicine, General & Internal
Jeong Ku Ha, Jin Seong Kim, Joo Young Kim, Jong Bok Yun, Yun Young Kim, Kyu Sung Chung
Summary: The study demonstrates that GCWB106 is effective and safe in reducing pain and improving knee function in patients with osteoarthritis of the knee joint.
Article
Medicine, General & Internal
Yookyung Jang, Lee Gyeong Je, Sunhee Lee, Donghyun Na, Hyekyung Shin, Jong Bum Choi, Jae Chul Koh
Summary: This study compared the clinical effectiveness of radiofrequency diathermy and therapeutic ultrasound in individuals with knee osteoarthritis. The results showed that both treatments were equally effective in reducing pain and improving functional capacity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Plant Sciences
Jinlong Zhao, Weiyi Yang, Guihong Liang, Minghui Luo, Jianke Pan, Jun Liu, Lingfeng Zeng
Summary: The Jinwu Gutong capsule showed good clinical efficacy and safety in treating knee osteoarthritis, and could significantly improve the treatment efficacy when combined with NSAIDs, hyaluronic acid, or glucosamine.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Orthopedics
Kun Yang, Yuwu Ding, Haichen Xu, Minghui Lai, Xueping Xu, Xiaoming Yu, Qian Deng, Liming Jiang
Summary: This study aims to evaluate the effectiveness and safety of combined intra-articular injection of platelet-rich plasma (IAI-PRP) and Tai Chi (TC) for the treatment of knee osteoarthritis (KOA). The study will involve a placebo-controlled, assessor-blinded randomized trial with a 12-week intervention period and a 1-year follow-up. The primary outcome measures will include the efficacy, acceptability, and safety of the interventions, while secondary outcome measures will include physical function, walking function, inflammatory factor levels, quality of life, and MRI findings. This study will provide high-quality evidence for the integrated approach of IAI-PRP and TC in treating KOA.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Huazheng Qu, Shui Sun
Summary: The meta-analysis showed that treatment with MSCs significantly reduced pain and improved function in patients with knee osteoarthritis in long-term follow-ups. However, more high-quality, large-scale randomized controlled trials are needed to further confirm these findings.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)