Article
Agronomy
Maria Gonceariuc, Mircea Valentin Muntean, Violeta Butnaras, Marcel Matei Duda, Anna Benea, Tamara Jelezneac, Zinaida Vornicu, Ludmila Cotelea, Pantelimon Botnarenco
Summary: This study comparatively analyzed two subspecies of Origanum vulgare in climatic conditions with higher temperatures, focusing on essential oil production and polyphenol content. The research identified varieties with higher essential oil content but lower polyphenol content, as well as vice versa. The selection of two promising cultivars was based on these findings.
Article
Chemistry, Applied
Yun Zhao, Yun-Hai Yang, Min Ye, Kai-Bo Wang, Li-Ming Fan, Fa-Wu Su
Summary: The chemical composition of Origanum vulgare essential oil was characterized, and its antifungal activity against Botrytis cinerea was determined. Major components like thymol and carvacrol showed strong inhibition on the mycelial growth and spore germination of B. cinerea. The essential oil, thymol, and carvacrol demonstrated effective suppression of gray mold in cherry tomatoes, indicating their potential as eco-friendly botanical fungicides.
Article
Biochemistry & Molecular Biology
Huawei Yu, Panpan Zhang, Hongbing Liu, Xiaojuan Sun, Jichao Liang, Lijuan Sun, Yong Chen
Summary: The study demonstrated the strong hypoglycemic effect of Origanum vulgare leaf extract, which inhibited alpha-glucosidase activity, promoted glucose uptake, inhibited glycosylation, and relieved oxidative stress. Mechanistic analysis showed that the extract decreased the promoter activity and the mRNA and protein expression of PEPCK and SREBP-1c, while also inhibiting the expression of CPY2E1 and enhancing the expression of GLUT2. HPLC-ESI-QTOF-MS analysis identified the main phenolic compounds in the herb, supporting its traditional use as an antidiabetic herbal medicine or dietary supplement.
Article
Biochemistry & Molecular Biology
Yuanpeng Hao, Xiaoqi Guo, Rui Yang, Yihao Yan, Meiyu Sun, Hui Li, Hongtong Bai, Hongxia Cui, Jingyi Li, Lei Shi
Summary: The study identified high carvacrol content with tissue-dependence in Origanum vulgare 'Hot and Spicy', shedding light on the biosynthesis of carvacrol and providing important candidate genes for metabolic engineering and breeding of Origanum cultivars.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Farnaz Bahrami, Ahmed H. Mekkawy, Samina Badar, David L. Morris, Mohammad H. Pourgholami
Summary: Epithelial ovarian cancer is the leading cause of gynaecological malignancy-related deaths in women. Research has shown that MPL has potential as an anticancer drug by effectively suppressing growth and proliferation of ovarian cancer cells through inhibition of the mTOR/p70S6K pathway. Further studies are needed to explore the full potential of MPL in cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Timea Claudia Ghitea, Amina El-Kharoubi, Mariana Ganea, Erika Bimbo-Szuhai, Tiberiu Sebastian Nemeth, Gabriela Ciavoi, Monica Foghis, Luciana Dobjanschi, Annamaria Pallag, Otilia Micle
Summary: The study found that Origanum vulgare L. essential oil has antibacterial effects and can reduce minor infections in MS patients. Improvement in phase angle can be used as an indicator of health and cellular function.
Article
Environmental Sciences
Arshi Choudhry, Atul Sharma, Sharf Ilahi Siddiqui, Irshad Ahamad, Md Sajid, Tabrez Alam Khan, Saif Ali Chaudhry
Summary: The study aimed to fabricate a sustainable and cost-effective material for comprehensive water filtration. An economic, phytogenic, and multifunctional nanocomposite material, MnFe2O4/OV, was prepared using a one-pot synthetic technique. The synthesized material exhibited excellent photocatalytic performance and adsorption capabilities for organic dyes, as well as inhibition of bacterial growth. Various characterization techniques were used to analyze the nanocomposite. The results showed that MnFe2O4/OV can serve as an affordable and sustainable material for water purification.
ENVIRONMENTAL RESEARCH
(2023)
Article
Plant Sciences
Asta Klimiene, Ramutis Klimas, Hanna Shutava, Liuda Razmuviene
Summary: This study aimed to investigate the relationship between the chemical properties of soil and the concentration of bioactive compounds in Origanum vulgare L. plants. The results showed significant correlations between soil pH, humus, total nitrogen, phosphorus, potassium, calcium, magnesium, sodium and the phenolic, flavonoid, and extractive content in the plants, providing useful insights for commercial cultivation of O. vulgare.
Article
Microbiology
Fouzia Idir, Sybren Van Ginneken, Guglielmo A. Coppola, Daniel Grenier, Hans P. Steenackers, Farida Bendali
Summary: Dental caries and periodontal diseases pose challenges to oral health, and traditional medicinal plants may offer potential bioactive compounds to address these issues. Screening of nine Algerian medicinal plants revealed that ethanolic extracts exhibited broad-spectrum antimicrobial and anti-biofilm properties, making them a promising source for controlling oral biofilms. The ethanolic extract of O. vulgare showed the most promising effects, inhibiting biofilm formation, reducing bacterial adherence, and suppressing virulence-associated genes. Thymol was identified as an important active compound in the extract, highlighting the potential of the whole extract over purified compounds. Further research into the bioactive compounds of O. vulgare could lead to novel products for combating dental caries.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Infectious Diseases
Larisa Bora, Stefana Avram, Ioana Zinuca Pavel, Delia Muntean, Sergio Liga, Valentina Buda, Daniela Gurgus, Corina Danciu
Summary: Origanum vulgare L. essential oil (OvEo) has gained attention in dermatology due to its cosmeceutical potential and pharmacological activities. It has been extensively studied for its antimicrobial and anti-inflammatory activities, showing potential in wound healing and treatment of skin disorders. Modern formulations, such as microemulsions and nanoemulsions, have also been developed for topical application.
Article
Chemistry, Applied
Narjes Roshandel-hesari, Majid Mokaber-Esfahani, Akram Taleghani, Reza Akbari
Summary: Edible coatings made from chitosan, casein, and oregano essential oil were developed to delay the spoilage process of cherry tomatoes. The results showed that the addition of oregano essential oil improved the flexibility, barrier properties, as well as antimicrobial and antioxidant properties of the coatings.
Article
Agricultural Engineering
Roya Emrahi, Mohammad Reza Morshedloo, Hosein Ahmadi, Abdollah Javanmard, Filippo Maggi
Summary: This study compared the effects of water deficit stress on biochemical traits and essential oil profiles of two carvacrol-rich subspecies of Oregano. The results showed that subsp. hirtum had higher dry weight, essential oil, and carvacrol content, with a positive correlation between dry weight and EO content.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Multidisciplinary Sciences
Emel Karaca Oner, Meryem Yesil
Summary: Altitude significantly affects the essential oil content, yield, and composition of O. majorana. This study collected plant samples from different altitudes and found that the highest essential oil percentage (6.50%) was obtained at 766 m altitude. The GC-MS analyses showed that low altitude positively affected some essential oil components, such as linalool. Different altitudes also led to variations in the levels of other essential oil constituents.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Naser A. ElSawy, Osama F. Mosa
Summary: The study results demonstrate that Origanum vulgare has a significant effect in preventing urolithiasis, through various mechanisms affecting the deposition of renal calcium oxalate crystals.
Article
Plant Sciences
Lumen Chao, Yongsig Kim, Sarah J. Gilmour, Michael F. Thomashow
Summary: This study reveals that the gene induction activity of CAMTA3 is modulated by temperature independently from the C-terminal calmodulin-binding domains. The CG-1 domain of CAMTA3 confers temperature dependence to the transcriptional activation domain (TAD) for inducing gene expression.
Article
Chemistry, Applied
Naveed Muhammad, Shafiq Ur Rahman, Hilal Uddin, Omer Shehzad, Muhammad Ismail, Niaz Ali, Aslam Khan, Muhammad Shahid, Abid Ullah, Shujaat Ahmad, Haya Hussain, Ikram ul Haq, Sara Vitalini, Marcello Iriti
Summary: Trillium govanianum has a significant antidiarrheal effect, reducing stool number and weight while increasing stool latency time. It also inhibits contractions in the intestine and acts as a calcium channel blocker, showing promise for medicinal use in treating diarrhea and gut spasms.
NATURAL PRODUCT RESEARCH
(2022)
Article
Environmental Sciences
Zackary Alghamdy, Ashwaq Alshahrani, Ismail Memon, Aslam Khan, Muhammad Anwar Khan, Yazeed Alrayan, Fulwah Alfawzan, Syed Faisal Zaidi
Summary: In light of the COVID-19 outbreak, this study explores the impact of the pandemic on the mental health of pre-professional health sciences students. Findings reveal that a majority of students are experiencing depression and anxiety, with females and those with separated parents being more susceptible to severe symptoms. Proper action should be taken to address this issue.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Asaad Khalid, Mohnad Abdalla, Maria Saeed, Muhammad Nabeel Ghayur, Surya Kant Kalauni, Mohammed Albratty, Hassan A. Alhazmi, Mohammed Ahmed Mesaik, Anwarul Hassan Gilani, Zaheer Ul-Haq
Summary: The study reveals that Sarcorucinine-D, a pregnane type steroidal alkaloid, is a potential lead molecule for the treatment of Alzheimer's disease due to its properties as a noncompetitive acetylcholinesterase inhibitor and a calcium channel blocker.
Article
Biotechnology & Applied Microbiology
Muhammad Nabeel Ghayur, Mohnad Abdalla, Asaad Khalid, Saeed Ahmad, Anwarul Hassan Gilani
Summary: This study found that Fenugreek extract did not have any stimulant or relaxant activity on isolated GI smooth muscles, and its constituent diosgenin could inhibit the activity of acetylcholinesterase. This suggests that Fenugreek extract may enhance memory.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Saara Ahmad, Saad Bilal Ahmed, Asra Khan, Muhammad Wasim, Saiqa Tabassum, Saida Haider, Fatima Ahmed, Zehra Batool, Saima Khaliq, Hamna Rafiq, Prashant Tikmani, Anwar-ul-Hassan Gilani
Summary: This review explores the role of natural alternatives in the treatment of Alzheimer's disease (AD). The analysis shows that herbal remedies, especially when combined with FDA-approved drugs, have positive effects on AD and are more effective than allopathic treatment alone.
METABOLIC BRAIN DISEASE
(2023)
Article
Nutrition & Dietetics
Nisar Fatima, Fareeha Anwar, Uzma Saleem, Aslam Khan, Bashir Ahmad, Irum Shahzadi, Hammad Ahmad, Tariq Ismail
Summary: The methanolic extract of Brugmansia aurea has potential antidiabetic activity, increasing insulin sensitivity and reducing insulin resistance in diabetic rats. It also lowers blood glucose levels and improves glucose tolerance.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Razia Hanif, Muhammad Imran Khan, Asadullah Madni, Muhammad Furqan Akhtar, Muhammad Farhan Sohail, Ammara Saleem, Mubashar Rehman, Sufyan Junaid Usmani, Aslam Khan, Athar Masood
Summary: The study aimed to enhance the oral bioavailability of the poorly water-soluble drug tacrolimus by developing niosomes using polyoxyethylene lauryl ether (Brij-35) and poloxamer 407 surfactants. The niosomes were prepared using a thin film hydration technique and evaluated using various techniques including FTIR, ultra-centrifugation, DLS experiments, SEM microscopy, and DSC technique. The results showed that the newly developed niosomes can improve the dissolution profile of tacrolimus and can be considered as potential oral carriers.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Immunology
Yasmin Bangash, Ammara Saleem, Muhammad Furqan Akhtar, Fareeha Anwar, Bushra Akhtar, Ali Sharif, Muhammad Imran Khan, Aslam Khan
Summary: This study found that PTN can alleviate the symptoms of atopic dermatitis by reducing inflammation, oxidative damage, and inflammatory cytokine expression in the skin of diseased animals. Therefore, PTN may be an effective drug for treating atopic dermatitis and other inflammatory skin disorders.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Amna Tahir, Muhammad Furqan Akhtar, Ammara Saleem, Muhammad Naveed, Basiru Olaitan Ajiboye, Fareeha Anwar, Aslam Khan
Summary: PCCR is a traditional herbal medicine used for treating muscular swelling, inflammation, pain, and fever. This study confirmed the anti-inflammatory, analgesic, and neuroprotective effects of PCCR in arthritic rats. PCCR exhibited antioxidant and anti-inflammatory activities, improved oxidative stress, and reduced inflammatory markers in rats with arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Plant Sciences
Sana Saleem, Fareeha Anwar, Aslam Khan, Uzma Saleem, Muhammad Furqan Akhtar, Irum Shahzadi, Tariq Ismail
Summary: This study aimed to detect any hazardous effects of B. aurea on animals and find out its LD50. The results revealed no mortality and morbidity in both acute oral and sub-acute toxicity studies. However, oxidative stress markers were significantly increased in the treatment groups, and animals showed decreased food and water intake in the acute oral toxicity study. A slight difference in renal function tests was observed, but no significant change in histopathology was found in selected organs. This study concluded that B. aurea can be safely used for pharmacological purposes.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Oncology
Amna Roheel, Aslam Khan, Fareeha Anwar, Zunaira Akbar, Muhammad Furqan Akhtar, Mohammad Imran Khan, Mohammad Farhan Sohail, Rizwan Ahmad
Summary: This review examines the likelihood of variation in incidence, prevalence, and risk factors for breast cancer by geographic region, food, and cultural practices. The systematic review analyzes epidemiological and risk factor reports from different world regions, finding that demographic, genetic, and lifestyle risk factors vary among countries.
FRONTIERS IN ONCOLOGY
(2023)
Article
Environmental Sciences
Sadaf Yasmeen, Aslam Khan, Fareeha Anwar, Muhammad Furqan Akhtar, Sidra Yasmeen, Shafeeq Ali Shah
Summary: This study aimed to examine the antifibrotic effect of direct-acting antiviral drugs Sofosbuvir and Velpatasvir in a rat model of carbon tetrachloride-induced fibrosis. The results showed that Sofosbuvir and Velpatasvir, alone or in combination, significantly inhibited fibrosis and mediated this effect by reducing the levels of TNF-a/NF-& kappa;B and the IL-6 signaling pathway. Therefore, Sofosbuvir and Velpatasvir may have antifibrotic effects independent of their antiviral activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Urology & Nephrology
Aslam Khan, Anwar H. Gilani
Summary: The crude extract of Trachyspermum ammi seeds (Ta.Cr) has shown antiurolithic activity through diuretic effects, inhibition of calcium oxalate crystal aggregation, antioxidant effects, renal epithelial cell protection, and antispasmodic effects. This suggests that Ta.Cr has therapeutic potential in urolithiasis.
Article
Medicine, General & Internal
Syed Faisal Zaidi, Abdullah Alzahrani, Zackary Alghamdy, Dheyya Alnajar, Nawaf Alsubhi, Aslam Khan, Mohamed E. Ahmed
Summary: This study investigated the awareness, self-use, perceptions, beliefs, and attitudes towards complementary and alternative medicine (CAM) in the general public of Jeddah, Saudi Arabia. The majority of the population was aware of various CAM modalities and considered prayers and spirituality to be the most effective. Information about CAM was mainly obtained from friends and relatives, while lack of knowledge and lack of trained professionals were perceived as barriers to CAM implementation. Gender, educational level, and relationship to the medical field were found to be associated with awareness and self-use of CAM modalities.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Integrative & Complementary Medicine
Syed Faisal Zaidi, Sheikh Abdul Saeed, Muhammad Anwar Khan, Aslam Khan, Yaqoub Hazazi, Mohammed Otayn, Mohammed Rabah, Muhammad Daniyal
Summary: This study evaluated the knowledge, attitudes, and practices regarding herbal medicines among the general population in Saudi Arabia. The results showed that the use of herbal medicines is common in Jeddah, with a significant association between female gender and usage. Despite the belief that herbal medicines are safe and do not require consultation, there is a need to increase awareness and establish strategies to evaluate their safety and efficacy.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
