Review
Immunology
Yanzhi Jiang, Jianxin Lin, Haiyun Zheng, Ping Zhu
Summary: This review examines the role of purinergic signaling in ischemia-reperfusion injury and rejection after heart transplantation, as well as its clinical applications and prospects.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Corrado De Marco, Thierry Charron, Guy Rousseau
Summary: Adenosine has the potential benefits in the treatment of acute myocardial infarction by inhibiting the pathophysiological processes leading to reperfusion injury. However, the heterogenous evidence regarding its effects has resulted in limited uptake in clinical practice. Therefore, studying the dose, route, timing, and site of administration of adenosine is crucial for its efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Nathaniel R. Smilowitz, Olga Toleva, Alaide Chieffo, Divaka Perera, Colin Berry
Summary: Coronary microvascular disease (CMD) can lead to myocardial ischemia in various clinical scenarios. Routine testing for CMD is supported in patients with ischemia and nonobstructive coronary artery disease. Invasive testing using Doppler or thermodilution measures can determine coronary flow reserve and microvascular resistance. Comprehensive testing can improve symptoms, quality of life, and patient satisfaction by establishing a diagnosis and guiding targeted medical therapy and lifestyle changes. CMD testing may also be useful in other cardiovascular conditions such as acute myocardial infarction, angina after coronary revascularization, heart failure with preserved ejection fraction, Takotsubo syndrome, and after heart transplantation. Educating healthcare providers about CMD is crucial for improving patient-centered outcomes in ischemic heart disease.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Biochemistry & Molecular Biology
Peng Wang, Rifeng Gao, Tingting Wu, Jinyan Zhang, Xiaolei Sun, Fan Fan, Cong Wang, Sanli Qian, Bingyu Li, Yunzeng Zou, Yuqing Huo, John Fassett, Yingjie Chen, Junbo Ge, Aijun Sun
Summary: This study demonstrates that cardiomyocyte ADK deletion improves myocardial I/R injury through epigenetic upregulation of IGF-1 expression.
Review
Pharmacology & Pharmacy
P. Boknik, J. Eskandar, B. Hofmann, N. Zimmermann, J. Neumann, U. Gergs
Summary: This review provides an overview of the localization and role of cardiac A(2A)-adenosine receptors, as well as their potential involvement in relevant cardiac pathologies. The review also discusses the cardiac utility of A(2A)-AR as therapeutic targets and identifies gaps in knowledge for future research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiechun Zhu, Samantha Ligi, Guangdong Yang
Summary: This review summarized the role of hydrogen sulfide (H2S) in the origin of life and its metabolism in organisms, examined the relationship between H2S and oxygen, emphasizing the oxygen-dependent manner of H2S signaling in physiological and pathological processes.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Pharmacology & Pharmacy
Abigail R. Bland, Fergus M. Payne, John C. Ashton, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: During cardiac reperfusion after myocardial infarction, the heart faces ischaemia reperfusion injury (IRI) which leads to myocardial dysfunction and cell death. Research has identified potential targeted therapies focusing on mitochondria, such as opening of the mitochondrial permeability transition pore, activation of mitoK(ATP) channels, and inhibition of GSK3 beta phosphorylation, to reduce the severity of myocardial IRI. Additionally, statins have shown direct cardioprotective effects on specific mitochondrial components, indicating their potential as a preconditioning agent.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medical Laboratory Technology
Wenyu Li, Pengfei Xu, Lingqi Kong, Shuo Feng, Nan Shen, Hongmei Huang, Wuxuan Wang, Xiang Xu, Xinyue Wang, Guoping Wang, Yan Zhang, Wen Sun, Wei Hu, Xinfeng Liu
Summary: This study investigated the role of endothelial Elabela (ELA) in post-ischemic cerebral angiogenesis. The research found that treatment with ELA-32 could mitigate brain injury, enhance restoration of cerebral blood flow, and promote the formation of functional vessels after cerebral ischemia/reperfusion (I/R) injury. Furthermore, it was demonstrated that ELA-32 could enhance the proliferation, migration, and tube formation abilities of brain endothelial cells under oxygen-glucose deprivation/reoxygenation (OGD/R) conditions. Mechanistically, ELA was found to bind to Apelin receptor (APJ) and activate the YAP/TAZ signaling pathway. Silencing APJ or pharmacological blockade of YAP abolished the pro-angiogenesis effects of ELA-32. Overall, these findings highlight the potential therapeutic strategy of the ELA-APJ axis in ischemic stroke.
TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Rickard P. F. Lindblom, Thomas Tovedal, Bo Norlin, Lars Hillered, Elisabet Englund, Stefan Thelin
Summary: The study investigated the effects of prolonged normothermic global cerebral ischemia with controlled brain reperfusion in young adult pigs. It found that adding a customized buffer solution during isolated mechanical brain reperfusion improved outcomes, resulting in lower intracranial pressure, decreased intraparenchymal glycerol, and less signs of excitotoxicity and ischemia, despite similar degrees of injury on histology.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Immunology
Vittoria Lopez, H. J. Maximilian Schuh, Salahuddin Mirza, Victoria J. Vaassen, Michael S. Schmidt, Katharina Sylvester, Riham M. Idris, Christian Renn, Laura Schaekel, Julie Pelletier, Jean Sevigny, Annamaria Naggi, Bjoern Scheffler, Sang-Yong Lee, Gerd Bendas, Christa E. Mueller
Summary: The study discovered that heparin and its derivatives are potent and selective allosteric inhibitors of the poorly investigated ectonucleotidase NPP1. The inhibition of NPP1 by heparins may contribute to their anti-cancer effects and could lead to improved therapeutics for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Plinio Bezerra Palacio, Aline Maria Brito Lucas, Joana Varlla de Lacerda Alexandre, Pedro Lourenzo Oliveira Cunha, Yuana Ivia Ponte Viana, Amanda Cabral Albuquerque, Anna Lidia Nunes Varela, Heberty Tarso Facundo
Summary: The study reveals competitive binding of glibenclamide and diazoxide at mitoSUR, with the cyclohexylurea portion of glibenclamide being essential for mitoKATP inhibition. IMP-A does not inhibit diazoxide-induced cardioprotection, but glibenclamide effectively inhibits it. This research provides valuable insights into the pharmacological and biochemical aspects of mitoKATP activation and cardioprotection, potentially leading to new therapeutic strategies for ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Saveria Femmino, Fabrizio D'Ascenzo, Francesco Ravera, Stefano Comita, Filippo Angelini, Andrea Caccioppo, Luca Franchin, Alberto Grosso, Cecilia Thairi, Emilio Venturelli, Claudia Cavallari, Claudia Penna, Gaetano Maria De Ferrari, Giovanni Camussi, Pasquale Pagliaro, Maria Felice Brizzi
Summary: In this study, it was found that extracellular vesicles (EVs) recovered from ACS patients after PCI were not cardio-protective, regardless of whether they underwent remote ischemic pre-conditioning or not.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Fabrizio D'Ascenzo, Saveria Femmino, Francesco Ravera, Filippo Angelini, Andrea Caccioppo, Luca Franchin, Alberto Grosso, Stefano Comita, Claudia Cavallari, Claudia Penna, Gaetano Maria De Ferrari, Giovanni Camussi, Pasquale Pagliaro, Maria Felice Brizzi
Summary: The study investigated the role of extracellular vesicles (EV) in cardiac damage and recovery upon Ischemia Reperfusion Injury (IRI) and Remote Ischemic PreConditioning (RIPC). Patient-derived EV were analyzed, showing that EV-naive provided cardio-protection against IRI in vitro and in rat hearts, while EV-RIPC did not. In vitro assays were shown to accurately predict EV effectiveness in vivo.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Arun Surendran, Negar Atefi, Hannah Zhang, Michel Aliani, Amir Ravandi
Summary: Metabolomics as an emerging platform technology offers new insights into the pathomechanisms of complex diseases like cardiovascular diseases, and holds immense potential for biomarker discovery and understanding disease progression. In the context of ACS, metabolomics studies have identified metabolomic signatures associated with disease progression, providing valuable mechanistic insights and potential biomarkers.
Article
Cardiac & Cardiovascular Systems
Rutger G. T. Feenstra, Coen K. M. Boerhout, Janneke Woudstra, Caitlin E. M. Vink, Marianne E. Wittekoek, Guus A. de Waard, Yolande Appelman, Etto C. Eringa, Koen M. J. Marques, Robbert J. de Winter, Marcel A. M. Beijk, Tim P. van de Hoef, Jan J. Piek
Summary: This study evaluated the diagnostic value of additional endothelial function testing in diagnosing vasomotor dysfunction in patients with INOCA. The results showed that endothelial dysfunction was prevalent in the vast majority of patients with INOCA with inducible CAS and/or impaired adenosine-mediated vasodilation.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Anesthesiology
Keisuke Yoshida, Tsuyoshi Isosu, Yoshie Noji, Hideaki Ebana, Jun Honda, Norie Sanbe, Shinju Obara, Masahiro Murakawa
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2020)
Article
Anesthesiology
Tomoko Ogawa, Shinju Obara, Mitsue Akino, Chie Hanayama, Hidemi Ishido, Masahiro Murakawa
JOURNAL OF ANESTHESIA
(2020)
Letter
Anesthesiology
Hideaki Ebana, Masahiro Murakawa, Yoshie Noji, Keisuke Yoshida, Jun Honda, Norie Sanbe, Tsuyoshi Isosu, Shinju Obara
MINERVA ANESTESIOLOGICA
(2020)
Article
Anesthesiology
Keisuke Yoshida, Shiori Tanaka, Kazuhiro Watanabe, Shinju Obara, Masahiro Murakawa
JOURNAL OF ANESTHESIA
(2020)
Article
Biotechnology & Applied Microbiology
Keisuke Yoshida, Yukihiro Ikegami, Shinju Obara, Keiko Sato, Masahiro Murakawa
Article
Pharmacology & Pharmacy
Yuzo Iseki, Yuko Ono, Chihiro Hibi, Shoko Tanaka, Shunya Takeshita, Yuko Maejima, Junko Kurokawa, Masahiro Murakawa, Kenju Shimomura, Kazuho Sakamoto
Summary: By activating the IKCa channel, DCEBIO can increase the diameter of skeletal muscle cells, leading to muscle hypertrophy, possibly through the mitoROS/Akt/mTOR pathway. DCEBIO can also attenuate the effects of endotoxin on muscle cell diameter, indicating its potential application in muscle development and muscle wasting diseases.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Issei Morimoto, Yoshimasa Koyama, Masahiro Murakawa
Summary: The study demonstrated that blood pressure fluctuations induced by ketamine were associated with the amygdala, with an average latency of approximately 193.5 seconds, peak reached at an average of 180.2 seconds, duration around 706.7 seconds, and mean fluctuation of 17.1 mmHg.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Anesthesiology
Keisuke Yoshida, Masahiro Murakawa, Atsuyuki Hosono
Summary: The present study investigated whether several commonly used anesthetics affect the expression of dopamine D-2 and acetylcholine M-1 receptors in the rat brain. The results suggest that the doses of each anesthetic used in this study are unlikely to cause postsynaptic changes in dopamine D-2 and acetylcholine M-1 receptors.
JOURNAL OF ANESTHESIA
(2022)
Article
Anesthesiology
Rieko Oishi, Kiwamu Nakamura, Yoko Yahagi, Kazutaka Ohashi, Yukiko Takano, Rie Harada, Shinju Obara, Satoki Inoue, Keiji Kanemitsu, Masahiro Murakawa
Summary: A study conducted in operating rooms of a university-affiliated tertiary care hospital in Japan revealed that computer mice had the highest bacterial isolation rate, followed by the outside of cuff pressure gauges and cuff pressure gauge storage drawers. Most identified bacteria belonged to the Bacillus species, indicating a potential pathogen contamination risk from medical equipment.
JA CLINICAL REPORTS
(2021)
Article
Anesthesiology
Shinju Obara, Rieko Oishi, Yuko Nakano, Yoshie Noji, Hideaki Ebana, Tsuyoshi Isosu, Shin Kurosawa, Masahiro Murakawa
Summary: The study showed that the incidence of AHPSi decreased with the use of the updated version of the SedLine(R) algorithm. Lower TP values and the use of the old algorithm had a significant effect on increasing PSi values.
MINERVA ANESTESIOLOGICA
(2021)
Article
Medicine, General & Internal
Keisuke Yoshida, Shiori Tanaka, Yuki Sato, Kazuhiro Watanabe, Kenichi Muramatsu, Masahiro Murakawa
JOURNAL OF MEDICAL CASE REPORTS
(2020)
Letter
Anesthesiology
Shinju Obara, Yoshie Noji, Takayuki Hasegawa, Chie Hanayama, Rieko Oishi, Masahiro Murakawa
JA CLINICAL REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Yuko Nakano, Daisuke Kobayashi, Masao Miyake, Ryoko Kanno, Masahiro Murakawa, Akihiro Hazama
BIORESEARCH OPEN ACCESS
(2019)
Letter
Anesthesiology
Hironao Matsuda, Chiaki Nemoto, Takumi Sekine, Katsuhiko Sato, Youichi Tanaka, Masahiro Murakawa
JA CLINICAL REPORTS
(2019)
Correction
Anesthesiology
Shinju Obara, Koh Kakinouchi, Jun Honda, Yoshie Noji, Chie Hanayama, Masahiro Murakawa
JA CLINICAL REPORTS
(2019)