Article
Pharmacology & Pharmacy
Walter Schmitt, Hauke Ruehs, Rolf Burghaus, Christian Diedrich, Sulav Duwal, Thomas Eissing, Dirk Garmann, Michaela Meyer, Bart Ploeger, Joerg Lippert
Summary: The study demonstrates that NT-proBNP can serve as a surrogate for clinical outcomes in HF trials, with a well-described relationship between NT-proBNP concentration and clinical events using an E-max model. Quantitative analysis provided insights into potential risks and risks associated with clinical events. Model-based predictions solely based on NT-proBNP measurements match final trial results, and early NT-proBNP measurements enable shorter yet reliable HF trials.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Kieran F. Docherty, Mark C. Petrie, James L. Januzzi, Christian Mueller, Lisa Andreson, Biykem Bozkurt, Javed Butler, Ovidiu Chioncel, John G. F. Cleland, Ruxandra Christodorescu, Stefano Del Prato, Finn Gustafsson, Carolyn S. P. Lam, Brenda Moura, Rodica Pop-Busui, Petar Seferovic, Maurizio Volterrani, Muthiah Vaduganathan, Marco Metra, Giuseppe Rosano
Summary: Diagnosing heart failure is often difficult due to non-specific symptoms. This document explores the use of NT-proBNP as a biomarker for diagnosing heart failure in different clinical scenarios. Validated cut-points are provided for ruling in or ruling out acute and de novo heart failure. The concept of 'heart stress' is introduced, and a simple acronym FIND-HF is proposed for early diagnosis of heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Chin-Shern Lau, Ya Li Liang, Soon Kieng Phua, Gillian Murtagh, Imo E. Hoefer, Ron H. Stokwielder, Milica Kosevich, Jennifer Yen, Jaganathan Sickan, Christos Varounis, Tar-Choon Aw
Summary: This study evaluated the performance of the Abbott NT-proBNP assay compared to the Roche NT-proBNP immunoassay at two sites. Precision, linearity, and sensitivity studies were conducted, and a regression analysis was performed. The results showed excellent agreement between the two assays, with slight bias in the Roche assay. The age groups recommended for acute heart failure diagnosis by ESC/AHA were also applicable to the Abbott assay.
Article
Cardiac & Cardiovascular Systems
Jr James L. Januzzi, Faiez Zannad, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Stuart J. Pocock, Joao Pedro Ferreira, Naveed Sattar, Subodh Verma, Ola Vedin, Janet Schnee, Tomoko Iwata, Dan Cotton, Milton Packer
Summary: This study found that empagliflozin treatment reduced the risk of heart failure or renal events regardless of baseline NT-proBNP concentration in patients with heart failure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biology
Aidonis Rammos, Aris Bechlioulis, Petros Kalogeras, Chris J. Watson, Pietro Salvo, Tommaso Lomonaco, Olga Kardakari, Evanthia E. Tripoliti, Yorgos Goletsis, Dimitris I. Fotiadis, Christos S. Katsouras, Lampros K. Michalis, Katerina K. Naka
Summary: This study found that saliva NT-proBNP correlates with serum values in patients with acute decompensated HF, but cannot differentiate between HF and other causes of dyspnea.
Article
Medical Laboratory Technology
Ling Li, Alexander G. Semenov, Evgeniya E. Feygina, Chenchen Yang, Nan Wang, Chao Chen, Xinghai Hu, Xiaoqin Ni, Zhenlu Zhang
Summary: The study compared the diagnostic accuracy of two NT-proBNP assays and found that the clinical value of total NT-proBNP for HF diagnosis was similar to the non-glycosylated subfraction of NT-proBNP. The lower percentage of non-glycosylated NT-proBNP to total NT-proBNP in non-HF patients suggests that total NT-proBNP might be more sensitive in individuals without current or prior symptoms of HF.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Emergency Medicine
Cecilie Budolfsen, Anders Sjorslev Schmidt, Kasper Glerup Lauridsen, Camilla Bang Hoeks, Farhad Waziri, Christian Bo Poulsen, Dung Nguyen Riis, Hans Rickers, Bo Lofgren
Summary: This study aims to identify the optimal NT-proBNP cut-off value for ruling out heart failure among atrial fibrillation patients. The results showed that NT-proBNP can be used to rule out heart failure in atrial fibrillation patients, but with low specificity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Se-Eun Kim, Dong-Hyuk Cho, Jang Young Kim, Seok-Min Kang, Myeong-Chan Cho, Hae-Young Lee, Dong-Ju Choi, Eun-Seok Jeon, Byung-Su Yoo
Summary: NT-proBNP levels are an important prognostic factor for both de novo heart failure (DNHF) and acute decompensated chronic heart failure (ADHF), with patients with ADHF consistently having higher risks compared to those with DNHF at the same NT-proBNP level for 1-year all-cause mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michele Senni, Jose Lopez-Sendon, Alain Cohen-Solal, Piotr Ponikowski, Richard Nkulikiyinka, Cecilia Freitas, Vanja Miodrag Vlajnic, Lothar Roessig, Burkert Pieske
Summary: The treatment response to vericiguat in heart failure patients is influenced by baseline NT-proBNP levels, with patients with higher NT-proBNP values potentially not benefiting from the treatment.
Article
Chemistry, Analytical
Qian Luo, Xiaomin Qian, Xiaona Mi, Yifeng Tu
Summary: A new type of immunosensor based on a gold nanoparticles/aminozeolitic imidazolate framework-67 nanocomposite was developed for the detection of NT-proBNP, a biomarker for heart failure. The immunosensor showed excellent response and sensitivity, with a broad linear range and low detection limit. It also demonstrated good specificity, stability, and reproducibility, making it suitable for detecting NT-proBNP in real blood samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Paul W. Armstrong, Yinggan Zheng, Richard W. Troughton, Lars H. Lund, Jian Zhang, Carolyn S. P. Lam, Cynthia M. Westerhout, Robert O. Blaustein, Javed Butler, Adrian F. Hernandez, Lothar Roessig, Christopher M. O'Connor, Adrian A. Voors, Justin A. Ezekowitz
Summary: This study assessed the effect of vericiguat on changes in NT-proBNP levels and its relationship with clinical outcomes. The results showed that vericiguat treatment led to a significant decline in NT-proBNP levels, which was associated with a relative improvement in the primary outcome of cardiovascular death or heart failure hospitalization.
JACC-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Juan Caro-Codon, Juan R. Rey, Antonio Buno, Angel M. Iniesta, Sandra O. Rosillo, Sergio Castrejon-Castrejon, Laura Rodriguez-Sotelo, Luis A. Martinez, Irene Marco, Carlos Merino, Lorena Martin-Polo, Jose M. Garcia-Veas, Marcel Martinez-Cossiani, Luis Gonzalez-Valle, Alicia Herrero, Esteban Lopez-de-Sa, Jose L. Merino
Summary: Research has shown that NT-proBNP levels are frequently elevated in COVID-19 patients and are strongly associated with prognosis.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Oncology
Yu An, Qingsong Wang, Hong Wang, Na Zhang, Fengming Zhang
Summary: This study found that sFRP5, RBP-4, and NT-proBNP were closely correlated with CHF, and played important roles in the diagnosis and prognosis of CHF.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Rafael de la Espriella, Antoni Bayes-Genis, Pau Llacer, Patricia Palau, Gema Minana, Enrique Santas, Mauricio Pellicer, Miguel Gonzalez, Jose Luis Gorriz, Vicent Bodi, Juan Sanchis, Julio Nunez
Summary: This study evaluated the impact of glomerular filtration rate (eGFR) on the predictive value of NT-proBNP and CA125 in patients with AHF. The results showed that CA125 outperformed NT-proBNP in predicting 1-year mortality in patients with severely reduced eGFR, while their predictive abilities were similar in other eGFR categories.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Kwaku D. Tawiah, Caroline E. Franks, Jessica Tang, Avihu Gazit, Dennis J. Dietzen, Christopher W. Farnsworth
Summary: This study investigated the concordance and correlation between BNP and NT-proBNP in pediatric patients. The results showed a positive correlation and moderate concordance between BNP and NT-proBNP. Age group and cardiac pathology had some impact on the concordance.
CLINICAL BIOCHEMISTRY
(2022)
Article
Rehabilitation
Vicki L. Johnson, Lindsay Apps, Michelle Hadjiconstantinou, Marian E. Carey, Elizabeth Kreit, Ricky Mullis, Jonathan Mant, Melanie J. Davies
Summary: This study aimed to develop a structured self-management programme to address the unmet long-term needs of stroke survivors. The programme was developed through a systematic process based on evidence and theory, and involved three phases.
DISABILITY AND REHABILITATION
(2023)
Review
Cardiac & Cardiovascular Systems
Faye Forsyth, Sandra Mulrennan, Jenni Burt, Peter Hartley, Isla Kuhn, Helen Lin, Jonathan Mant, Sapphire Tan, Roy Zhang, Christi Deaton
Summary: This study aims to determine the dietary interventions tested in heart failure with preserved ejection fraction (HFpEF), assess the method of modulation and outcomes employed, and summarize the evidence for any benefit. The study identified 25 clinical investigations, with only 40% conducted exclusively in HFpEF. Most studies used highly tailored prescribed diets or dietary supplementation, while dietary pattern interventions were less common. The study highlights the challenges of pooling heterogeneous studies and the importance of better reporting and standardized definitions and measurements.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Faye Forsyth, Thomas Blakeman, Jenni Burt, Carolyn A. Chew-Graham, Muhammad Hossain, Jonathan Mant, John Sharpley, Emma Sowden, Christi Deaton
Summary: This study investigates the impact of heart failure with preserved ejection fraction (HFpEF) on patients' lives within the context of limited clinical services. The findings suggest that HFpEF patients face a heavy workload and multiple threats, while lacking recognition of their illness. These factors contribute to negative physical, social, and psychological outcomes, as well as a perception of loss of control.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Review
Cardiac & Cardiovascular Systems
Faye Forsyth, Sandra Mulrennan, Jenni Burt, Peter Hartley, Isla Kuhn, Helen Lin, Jonathan Mant, Sapphire Tan, Roy Zhang, Christi Deaton
Summary: This study aimed to determine the effectiveness of dietary interventions in HFpEF. The analysis of randomized or controlled studies revealed that caloric restriction and carbohydrate restriction led to significant improvements in blood pressure, while protein supplementation improved blood pressure and body weight. However, due to study heterogeneity and overall quality of the evidence, it is difficult to make firm recommendations.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Letter
Public, Environmental & Occupational Health
Zhirong Yang, Sengwee Toh, Jonathan Mant
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tove Hygrell, Fredrik Viberg, Erik Dahlberg, Peter H. Charlton, Katrin Kemp Gudmundsdottir, Jonathan Mant, Josef Lindman Hornlund, Emma Svennberg
Summary: The study aimed to observe the accuracy of an artificial intelligence-based network in predicting paroxysmal atrial fibrillation from a normal sinus rhythm single-lead ECG. The algorithm performed well in predicting paroxysmal AF in a wide age range, but had lower performance in age-homogeneous groups.
Article
Cardiac & Cardiovascular Systems
Ewa A. Jankowska, Peter P. Liu, Martin R. Cowie, Max Groenhart, Kelly D. Cobey, Jonathan Howlett, Michel Komajda, Lars H. Lund, Jose Antonio Magana Serrano, Ricardo Mourilhe-Rocha, Giuseppe M. C. Rosano, Clara Saldarriaga, Pedro V. Schwartzmann, Faiez Zannad, Jian Zhang, Yuhui Zhang, Andrew J. S. Coats
Summary: As part of the REWOLUTION HF programme, two international surveys were conducted to assess the educational needs of healthcare professionals (HCPs) and patients' perspectives on the care of heart failure (HF). The surveys revealed that most HCPs prioritize rapid initiation of guideline-mandated medications and discuss treatment goals with patients. There was good agreement between HCPs and patients on key treatment goals, although HCPs placed greater emphasis on reducing hospitalizations. Patients expressed a desire for more information about HF and its consequences, prognosis, and treatments.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Philip Moons, Tone M. Norekval, Elena Arbelo, Britt Borregaard, Barbara Casadei, Bernard Cosyns, Martin R. Cowie, Donna Fitzsimons, Alan G. Fraser, Tiny Jaarsma, Paulus Kirchhof, Josepa Mauri, Richard Mindham, Julie Sanders, Francois Schiele, Aleksandra Torbica, Ann Dorthe Zwisler
Summary: Patient-reported outcomes (PROs) play a crucial role in understanding patients' perspectives on their health and medical conditions. Their use can lead to improvements in healthcare quality and informed clinical decisions. This article provides an overview of PROs for cardiovascular populations, including disease-specific and domain-specific measures, as well as international standards and guidelines for their selection. Collaboration and evaluation of PROs are needed to guide decision-making in regulatory contexts and to monitor care quality and resource allocation. New sources, such as wearable devices and electronic health records, offer opportunities for collecting PROs.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Amr Abdin, Stefan D. Anker, Martin R. Cowie, Gerasimos S. Filippatos, Piotr Ponikowski, Luigi Tavazzi, Jakob Schoepe, Stefan Wagenpfeil, Michel Komajda, Michael Boehm
Summary: This study evaluated the associations between baseline resting heart rate and systolic blood pressure with outcomes and treatment patterns in heart failure patients. The results showed that high resting heart rate and low systolic blood pressure were associated with worse cardiovascular outcomes, but were not the only reasons for suboptimal treatment in patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Vasileios Kouranos, Rajdeep S. Khattar, Joseph Okafor, Raheel Ahmed, Alessia Azzu, John Arun Baksi, Kshama Wechalekar, Martin R. Cowie, Athol Umfrey Wells, Thomas F. Luscher, Rakesh Sharma
Summary: This study describes the baseline characteristics of a sizable and deeply phenotyped contemporary cohort of cardiac sarcoidosis (CS) patients and investigates the predictors of poor outcomes. The study found that CS is associated with significant morbidity and mortality, particularly in those with cardiac involvement as the first manifestation. Serum brain natriuretic peptide levels, left ventricular ejection fraction, and myocardial inflammation were identified as independent predictors of outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Health Care Sciences & Services
Sarah Hoare, Gwilym P. A. Thomas, Alison Powell, Natalie Armstrong, Jonathan Mant, Jenni Burt
Summary: While many individuals feel obligated to participate in screening programs for early treatment of detectable conditions, why some people choose not to participate receives less attention. In a study examining nonparticipation in a national research trial of atrial fibrillation screening, participants who declined the invitation expressed doubts about the necessity and utility of the screening at their age. The study concluded that nonparticipation was based on the consideration of perceived necessity, legitimacy, and utility of the screening.
HEALTH EXPECTATIONS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Liesl Zuhlke, Jennifer Franke, Martin R. Cowie
Article
Medicine, Research & Experimental
David de Gonzalo-Calvo, Pablo Martinez-Camblor, Thalia Belmonte, Ferran Barbe, Kevin Duarte, Martin R. Cowie, Christiane E. Angermann, Andrea Korte, Isabelle Riedel, Josephine Labus, Wolfgang Koenig, Faiez Zannad, Thomas Thum, Christian Baer
Summary: This study found that the combination of clinical information, circulating miRNAs, and decision tree learning allows the identification of specific risk subphenotypes in patients with HFrEF and CSA.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Thomas Woodcock, Dionne Matthew, Raffaele Palladino, Mable Nakubulwa, Trish Winn, Hugh Bethell, Stephen Hiles, Susan Moggan, Jackie Dowell, Paul Sullivan, Derek Bell, Martin R. Cowie
Summary: This study evaluates the impact of a care bundle intervention on improving care for patients with acute heart failure. The intervention includes testing NT-proBNP, transthoracic Doppler echocardiography, and specialist evaluation. The study finds that this intervention is associated with reduced emergency readmissions and improved in-hospital mortality for acute heart failure patients.
BMJ QUALITY & SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Martin R. Cowie, Praveen Thokala, Zenichi Ihara, Philip B. Adamson, Christiane Angermann
Summary: Based on the most recent data, this paper updates the cost-effectiveness analysis of CardioMEMS compared to usual care for patients with persistent New York Heart Association class III symptoms and at least one heart failure hospitalization within 12 months. The results suggest that CardioMEMS is likely to be cost-effective in the United Kingdom.