Article
Medicine, General & Internal
Rataya Tanomrat, Chonnapat Naktubtim, Parichaya Aimvijarn, Prasit Suwannalert
Summary: This study aimed to evaluate the improvement effect of quercetin in combination with NAC in human CRC cell progression, migration, and invasion. The results revealed that the combination treatment was most effective in decreasing cellular oxidants, increasing glutathione levels, suppressing cancer cell migration and invasion, and inhibiting the expression of iNOS, ICAM-1, and MMP-2 proteins. Bioinformatic analysis further confirmed the association of these proteins with poor prognosis in CRC.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Cell Biology
Ye Feng, Ying Xu, Yongjian Gao, Yiying Chen, Xuefeng Wang, Zhi Chen
Summary: SOX2OT is an up-regulated oncogene in CRC, promoting cell proliferation, migration, and invasion. It acts as a competing endogenous RNA to upregulate SOX5 by sponging miR-194-5p, thus affecting tumorgenesis of CRC.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Xiaosong Wang, Xiaojun Yu, Haoran Xu, Kang Wei, Shanxi Wang, Yingguang Wang, Junfei Han
Summary: In this study, the researchers found that extracellular vesicles (EVs) transfer a long non-coding RNA (lncRNA) called HOTAIR, which regulates resistance to the chemotherapy drug temozolomide (TMZ) in glioblastoma (GBM). Through in vitro and in vivo experiments, it was demonstrated that HOTAIR promotes tumor growth, increases invasiveness, and enhances resistance to TMZ. In GBM cells, HOTAIR competitively binds to miR-526b-3p, weakening its ability to bind to EVA1 and consequently increasing EVA1 expression. Furthermore, HOTAIR carried by serum-EVs suppresses miR-526b-3p-mediated inhibition of EVA1, promoting tumor growth and TMZ resistance in vivo.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Yi Jer Tan, Yeuan Ting Lee, Ricardo L. Mancera, Chern Ein Oon
Summary: The study revealed the cytotoxic mechanisms of BZD9L1, showing its regulation of multiple cancer pathways, inducing oxidative stress and regulating apoptosis-related proteins, ultimately leading to cell apoptosis through the p53 pathway.
Article
Multidisciplinary Sciences
Maan T. Khayat, Mohamed A. Zarka, Dalia Farag A. El-Telbany, Ali M. El-Halawany, Hussam Ibrahim Kutbi, Walid F. Elkhatib, Ayman M. Noreddin, Ahdab N. Khayyat, Rania Farag A. El-Telbany, Sherif F. Hammad, Ashraf B. Abdel-Naim, Ebtesam M. Alolayan, Majid Mohammad Al-Sawahli
Summary: This study compared the antiproliferative, pro-apoptotic, and oxidative stress potentials of RSV-ZN NPs and free RSV in human colorectal carcinoma HCT-116 cells. The results showed that ZN-RSV NPs exhibited stronger inhibitory effects on HCT-116 cells, as well as enhanced cellular uptake and oxidative stress induction.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Sian Chen, Chenbin Chen, Yuanbo Hu, Gendi Song, Xian Shen
Summary: Pancreatic cancer is a type of malignant tumor with poor prognosis, and the molecular mechanisms behind its development are not fully understood. In addition to key signaling pathways, noncoding RNAs like circRNAs have been found to be involved in pancreatic cancer progression. Compounds that regulate circRNA expression could potentially be beneficial in treating pancreatic cancer.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Le Du, Ning Liu, Jianfeng Jin, Meng Cao, Yuantian Sun, Xinzheng Gao, Banzhan Ruan, Shangfeng Yang, Dongsheng Ge, Yingzhuan Ye, Yinxi Zhou, Erfei Chen, Jin Yang
Summary: Colorectal cancer is a highly prevalent and deadly tumor. This study investigated the role of zinc finger protein 3 (ZNF3) in colorectal cancer and found that ZNF3 is highly expressed in colorectal cancer tissue and cells, particularly in older patients. Overexpression of ZNF3 promotes cell migration, while knockdown of ZNF3 suppresses cell proliferation, migration, and invasion and induces cell cycle arrest. ZNF3 appears to regulate the expression of TWIST and MMP1, which are involved in epithelial-mesenchymal transition, and their overexpression exacerbates cell proliferation and affects cell functions.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Oncology
Sang-Soo Park, Yea Seong Ryu, Dong-In Koh, Seung-Woo Hong, Jai-Hee Moon, Jae-Sik Shin, Mi Jin Kim, Do Yeon Kim, Jun Ki Hong, Eun Ho Kim, Hong-Rae Jeong, Yoon Sun Park, Joseph Kim, Dong Min Kim, Hyeseon Yun, Joo-Yeon Shin, Dong-Hoon Jin
Summary: SVCT2 E264K mutation plays a critical role in proliferation in colorectal cancer (CRC), with its overexpression increasing cell growth and knockdown reducing cell proliferation while promoting apoptosis. The findings suggest that SVCT2 E264K could be a promising novel therapeutic target in CRC.
Article
Biotechnology & Applied Microbiology
Qi-Qi Zhan, Qian-Yu Liu, Xin Yang, Yu-Hui Ge, Lei Xu, Guan-Yi Ding, Shang Guo, Bing Zhu, Wei-Guo Xu
Summary: The silencing of neuropilin-2 (NRP-2) was found to significantly inhibit the proliferation, migration, and invasion abilities of colorectal cancer HT-29 cells.
Article
Biochemistry & Molecular Biology
Weiye Liang, Jia Zuo, Mingkai Liu, Yuling Su, Baoyin Guo, Jiangtao Hou, Qi Xing, Yinglong Peng, Lian Fang, Yihui Cao, Jiajie Shan, Ruixia Sun, Jie Zhao, Jian Wang
Summary: VASN is upregulated in CRC and correlates with tumor progression. Overexpression of VASN promotes CRC cell progression, while knockdown of VASN inhibits CRC progression. VASN interacts with YAP/TAZ and PI3K/AKT pathways, and may serve as a novel biomarker for CRC.
Article
Pathology
Ding-Ping Sun, Chia-Chun Wu, Chia-Lin Chou, Li-Chin Cheng, Wen-Ching Wang, Shiau-Shiuan Lin, Shih-Ting Hung, Yu-Feng Tian, Chia-Lang Fang, Kai-Yuan Lin
Summary: The study investigates the correlation between NCAPG and CRC prognosis, as well as its function in CRC cells. The overexpression of NCAPG is positively correlated with clinicopathologic characteristics and negatively correlated with disease-free survival and overall survival. Knockdown of NCAPG inhibits the proliferation, migration, and invasion of CRC cells, and interferes with G2/M-G1 transition in the cell cycle, leading to inhibited cell proliferation. NCAPG may serve as a candidate biomarker for CRC prognosis and a potential therapeutic target for CRC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Jiaqiang Deng, Huani Wang, Yutong Liang, Lili Zhao, Yan Li, Yan Yan, Hong Zhao, Xiao Zhang, Fangdong Zou
Summary: miR-15a-5p is highly expressed in CRC tissues and promotes the proliferation, migration, and invasion of CRC cells by targeting SIRT4 and modulating STAT3/TWIST1 and PETN/AKT signaling. Inhibition of the miR-15a-5p/SIRT4 axis enhances chemosensitivity of drug-resistant cells.
CELLULAR SIGNALLING
(2023)
Article
Cell Biology
Yang Bai, Ling Li, Zhiyong Zhang
Summary: This study found that Linc00883 plays a promoting role in the proliferation, invasion, and migration of colorectal cancer cells, and this function is achieved through regulating the miR-577/FKBP14 axis.
Article
Oncology
Yandong Huang, Qinyang Bai, Zhanlong Wang, Hongbo Yu, Yanru Li, Hao Lu, Huimin Kang, Xuewei Shi, Kai Feng
Summary: This study revealed that circ_0052184 promotes the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis, providing an explanation for the malignant progression of colorectal cancer at the molecular level.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Anthropology
Huanjiu Xi, Zhao Chen, Wenhui Li, Youfeng Wen, Hailong Zhang, Yanjie Xiao, Suwei Liu, Linguo Pei, Meizhi Zhang, Po Lv, Fu Ren, Keqiang Huang, Liping Ye, Chunshan Li, Liguang Zhao
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2016)
Letter
Biology
Zheng LianBin, Li YongLan, Xi HuanJiu, Yu KeLi, Lu ShunHua, Shi Rui, Wen YouFeng, Bao JingPing, Zhang XingHua, Li YuLing, Ren Fu, Xu GuoChang
SCIENCE CHINA-LIFE SCIENCES
(2015)
Article
Endocrinology & Metabolism
Xuwei Hou, Wei Wu, Bo Yin, Xuefeng Liu, Fu Ren
Article
Medicine, Research & Experimental
Shuang Pan, Liwen An, Xin Meng, Liming Li, Fu Ren, Yifu Guan
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2017)
Article
Oncology
Da-Hua Liu, Min An, Bai-Li Bao, Fu Ren, Pu Xia
INTERNATIONAL JOURNAL OF ONCOLOGY
(2018)
Article
Oncology
Ning Li, Dong Mao, Yansha Cao, Hua Li, Fu Ren, Keyan Li
INTERNATIONAL JOURNAL OF ONCOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Guannan Wang, Li Jin, Yukuan Dong, Lu Niu, Yaxue Liu, Fu Ren, Xingguang Su
NEW JOURNAL OF CHEMISTRY
(2014)
Article
Endocrinology & Metabolism
Xiaoxu Zhang, Miao Guo, Jing Yang, Yuxiao Zheng, Yanjie Xiao, Wei Liu, Fu Ren
ENDOCRINE PATHOLOGY
(2019)
Article
Genetics & Heredity
Wei Wu, Guiying Zhai, Zejun Xu, Bo Hou, Dahua Liu, Tianyi Liu, Wei Liu, Fu Ren
Article
Oncology
Shuang Pan, Fu Ren, Lei Li, Dahua Liu, Yao Li, Aimei Wang, Weihong Li, Yongyan Dong, Wenjuan Guo
EXPERIMENTAL CELL RESEARCH
(2020)
Article
Medicine, Research & Experimental
Shuang Pan, Wei Wu, Fu Ren, Lei Li, Yao Li, Weihong Li, Aimei Wang, Dahua Liu, Yongyan Dong
Article
Medicine, Research & Experimental
Xingyuan Liu, Xuefeng Liu, Jingyuan Li, Fu Ren
MEDICAL SCIENCE MONITOR
(2019)
Article
Oncology
Jing Gao, Jia-Yi Zhang, Yu-Hong Li, Fu Ren
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2015)
Article
Cell Biology
Shuang Tian, Da-Hua Liu, Dan Wang, Fu Ren, Pu Xia
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)