Article
Engineering, Biomedical
Chenghua Liang, Xiangyang Bai, Cuiling Qi, Qingxue Sun, Xiaoyan Han, Tianyun Lan, Haibo Zhang, Xiaoming Zheng, Rongpu Liang, Ju Jiao, Zongheng Zheng, Jiafeng Fang, Purun Lei, Yan Wang, Diana Moeckel, Josbert M. Metselaar, Gert Storm, Wim E. Hennink, Fabian Kiessling, Hongbo Wei, Twan Lammers, Yang Shi, Bo Wei
Summary: Electron-stabilized polymeric micelles loaded with docetaxel showed high efficiency in enhancing chemotherapy responses in advanced-stage GI cancer mouse models, achieving complete cures and tumor regression in both CDX and PDX models. Moreover, the micellar docetaxel modulated the tumor immune microenvironment and was well-tolerated toxicologically, indicating significant potential for the treatment of advanced-stage GI cancers.
Article
Chemistry, Multidisciplinary
Zhengqing Guo, Hui He, Yi Zhang, Jiaming Rao, Tao Yang, Ting Li, Lu Wang, Mengke Shi, Mengya Wang, Shihong Qiu, Xue Song, Hengte Ke, Huabing Chen
Summary: This study demonstrates the use of self-assembled micellar nanoarchitecture for potent phototherapy against triple-negative breast cancer, showing efficient suppression against primary, metastatic, and recurrent TNBC through tunable photoconversion and cytoplasmic translocation.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Zixu Liu, Yang Liu, Huan Liu, Ruiqing Lv, Boyuan Liu, Linxuan Zhao, Tian Yin, Yu Zhang, Haibing He, Jingxin Gou, Xing Tang, Li Yang, Song Gao
Summary: This article presents a method to enhance the delivery of docetaxel (DTX) using carboxymethylcellulose (CMC)-conjugated polymeric prodrug micelles. The micelles exhibited improved drug loading, stability, and sustained release behavior, leading to reduced systemic toxicity and enhanced anti-tumor efficacy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Min Lu, Xu Huang, Xiaohui Cai, Jiajia Sun, Xuemeng Liu, Lingyan Weng, Li Zhu, Qianqian Luo, Zhongping Chen
Summary: This study reports the development of hypoxia-responsive stereocomplex micelles as a reliable drug delivery system to treat breast cancer metastasis. These micelles exhibit high structural stability, improved drug loading, and sensitive response to the hypoxic tumor environment, reversing hypoxia-induced drug resistance and cell migration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Agriculture, Dairy & Animal Science
Stephen Hsien-Chi Yuan, Shih-Chieh Chang, Yenlin Huang, Hao-Ping Liu
Summary: Canine malignant mammary tumors (MMTs) in intact female dogs often have high incidence of metastasis and recurrence. The overexpression of AGR2 in MMT tissues and elevated levels of AGR2 in serum are significantly associated with disease progression and poor survival outcomes, indicating a potential prognostic value for MMT dogs.
Article
Engineering, Biomedical
Dawei Ni, Beibei Guo, Zhangyan Zhong, Yu Chen, Guang Yang, Jiangtao Yang, Zhiyuan Zhong, Fenghua Meng
Summary: This paper studies the influence of disulfide crosslinking on actively targeted nanomedicines for tumor therapy and finds that micellar docetaxel with a high disulfide content is advantageous in terms of stability, tumor uptake, and therapeutic efficacy.
ACTA BIOMATERIALIA
(2023)
Article
Polymer Science
Nicole Lecot, Belen Davila, Carina Sanchez, Marcelo Fernandez, Mercedes Gonzalez, Pablo Cabral, Hugo Cerecetto, Romina Glisoni
Summary: 2-Amino-7-fluorophenazine 5,10-dioxide (FNZ) is a poorly soluble bioreducible prodrug with potential anticancer activity. In this study, amphiphilic polymeric micelles were used to improve the solubility and bioavailability of FNZ. The encapsulated FNZ showed increased solubility and exhibited stability and spherical morphology. In vitro and in vivo studies demonstrated the non-toxicity and significant tumor weight reduction of the encapsulated FNZ.
Article
Pharmacology & Pharmacy
Leilei Guo, Xiaokang Qin, Liting Xue, Janine Y. Y. Yang, Yumei Zhang, Shunwei Zhu, Gang Ye, Renhong Tang, WenQing Yang
Summary: The study investigated the anti-tumor effects of HT001 as monotherapy or in combination with anti-angiogenic agents, demonstrating potent anti-tumor activity in multiple solid tumor models or malignant ascites models.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yumei Zhang, Shunli Wang, Xiaofan Duan, Xiaoxiao Xu, Yuan Gao, Jiuli Zhou, Xiaolin Xu, Jin Li
Summary: This study developed an alternative, less toxic, and more effective docetaxel (DTX) formulation by preparing methoxy-poly(ethylene glycol)-block-poly(D,L-lactide) (mPEG-PDLLA) micelles loaded with DTX. Compared to traditional DTX, this new formulation showed improved pharmacokinetics and efficacy against ovarian cancer with peritoneal metastasis. The results suggest that DTX-mPEG-PDLLA has the potential to be used in the clinical treatment of peritoneal metastatic cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Nilesh Rarokar, Roshani Agrawal, Sakshi Yadav, Pramod Khedekar, C. Ravikumar, Darshan Telange, Shailendra Gurav
Summary: Targeting cancer cells can be achieved by surface functionalizing nanocarriers like polymeric micelles using block copolymers with conjugation moiety, increasing targeting ability and inhibiting drug efflux by inhibiting P-gp. This study develops FA-linked Pluronic (R) F68 (FA-PF68) micelles for DTX delivery to treat cancer progression associated with FR. The FA-PF68-DTX micelles demonstrate increased particle size, better physical stability, and higher entrapment efficiency. They also show sustained release of DTX and higher efficiency against MDA-MB-231 cells with lower toxicity on liver, kidney, and lung cells.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Kaitlyn E. Simpson, Christina A. Staikos, Katrina L. Watson, Roger A. Moorehead
Summary: This study investigates the role of MXRA8 in breast cancer and demonstrates that MXRA8 plays a significant role in the progression and metastasis of triple-negative breast cancer (TNBC). The loss of MXRA8 reduces cell proliferation and delays tumor development and metastatic dissemination. Additionally, MXRA8 is found to be expressed at higher levels in aggressive subtypes of breast cancer. These findings highlight the potential importance of MXRA8 in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ilaria Biancacci, Federica De Lorenzi, Benjamin Theek, Xiangyang Bai, Jan-Niklas May, Lorena Consolino, Maike Baues, Diana Moeckel, Felix Gremse, Saskia von Stillfried, Asmaa El Shafei, Karina Benderski, Armin Azadkhah Shalmani, Alec Wang, Jeffrey Momoh, Quim Pena, Eva Miriam Buhl, Johannes Buyel, Wim Hennink, Fabian Kiessling, Josbert Metselaar, Yang Shi, Twan Lammers
Summary: Cancer nanomedicines rely on the EPR effect for efficient target site accumulation. This study longitudinally studied the dynamics of the EPR effect during nanotherapy and found that the extent of nanomedicine tumor accumulation is predictive for therapy outcome. It also showed that the interindividual heterogeneity in EPR-based tumor accumulation significantly increases during treatment, especially for more efficient double-dose nanotaxane therapy. These findings highlight the importance of the EPR effect in nanomedicine treatment.
Article
Multidisciplinary Sciences
David Buechel, Nami Sugiyama, Natalia Rubinstein, Meera Saxena, Ravi K. R. Kalathur, Fabiana Luond, Vida Vafaizadeh, Tomas Valenta, George Hausmann, Claudio Cantu, Konrad Basler, Gerhard Christofori
Summary: The transcriptional activity of beta-catenin plays a crucial role in the malignant progression of breast cancer, affecting tumor growth, invasion, and metastasis formation. This contrasts its adhesion function, highlighting the importance of Wnt/beta-catenin-dependent transcription in cancer progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Sabna Kotta, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Anroop B. Nair, Y. T. Kamal
Summary: Polymeric micelles (PMs) have shown significant progress in drug delivery applications due to their robust core-shell structure and ability to solubilize hydrophobic drugs. This review presents the recent advances and understandings of PMs, including preparation methods, applications, and tumor-targeted delivery.
Article
Chemistry, Multidisciplinary
Wencheng Yan, Beibei Guo, Zhe Wang, Jiangtao Yang, Zhiyuan Zhong, Fenghua Meng
Summary: cRGD-MDTX exhibits low liver accumulation, high tumor uptake, and deep tumor penetration, leading to potent suppression of different solid tumors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Meeting Abstract
Chemistry, Multidisciplinary
Wei Huang, Feifei Yang, Yunfei Li, Shan Liu, Qiming Wang, Mingji Jin, Zhonggao Gao
JOURNAL OF CONTROLLED RELEASE
(2015)
Article
Nanoscience & Nanotechnology
Yunfei Li, Brock Humphries, Zhishan Wang, Shuyao Lang, Xuefei Huang, Hua Xiao, Yiguo Jiang, Chengfeng Yang
ACS APPLIED MATERIALS & INTERFACES
(2016)
Review
Chemistry, Multidisciplinary
Yunfei Li, Brock Humphries, Chengfeng Yang, Zhishan Wang
Article
Engineering, Biomedical
Feifei Yang, Wei Huang, Yunfei Li, Shan Liu, Mingji Jin, Yuli Wang, Lihua Jia, Zhonggao Gao
Review
Pharmacology & Pharmacy
Lei Yang, Liming Gong, Ping Wang, Xinghui Zhao, Feng Zhao, Zhijie Zhang, Yunfei Li, Wei Huang
Summary: mRNA technology utilizes messenger RNA transcribed from DNA as a template to treat diseases. Lipid nanoparticles (LNPs) show potential in clinical translation as non-viral delivery tools and are particularly important for delivering nucleic acids into cells in current mRNA regimens. The latest research progress of LNPs is mainly focused on the treatment of other diseases such as oncological, cardiovascular, and infectious diseases.
Article
Pharmacology & Pharmacy
Yingpeng Li, Liang Liu, Hongtao Shang, Xuchen Feng, Ni Fan, Jingyu Wang, Yuqi Wu, Yatong Chen, Xinhong Chu, Min Zhong, Yujiao Sun, Hui Fu, Wei Huang, Yunfei Li
Summary: This study reports a chitosan-based hyaluronic acid nanoparticle that self-assembles and effectively treats triple-negative breast cancer in vivo. The nanoparticle targets tumor cells and improves the bioavailability of the drug, offering a new strategy for the treatment of triple-negative breast cancer.
