Article
Medicine, Research & Experimental
Zhixiong Liu, Minbiao Yan, Wanying Lei, Rencai Jiang, Wenxiu Dai, Jialin Chen, Chaomeng Wang, Li Li, Mei Wu, Ximing Nian, Daopeng Li, Di Sun, Xiaoqi Lv, Chaoying Wang, Changchuan Xie, Luming Yao, Caiming Wu, Jin Hu, Naian Xiao, Wei Mo, Zhanxiang Wang, Liang Zhang
Summary: This study found that the COPII component Sec13 is essential for oligodendrocyte (OL) maturation and myelin repair. Deletion of Sec13 in OLs prevented OPC differentiation and inhibited remyelination after demyelinating injury, while improving protein trafficking or ectopic expression of COPII components accelerated myelination. Loss of Sec13 altered the secretome of OLs and inhibited the secretion of pleiotrophin, which plays a role in promoting OL differentiation and myelin repair.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Xiang Tao, Can Chen, Yingxiang Chen, Luoying Zhang, Jiong Hu, Hongjun Yu, Minglu Liang, Qin Fu, Kai Huang
Summary: This study reveals that beta(2)-adrenergic receptor (beta(2)AR) plays a critical role in liver regeneration by interacting with c-met and activating ERK signaling, leading to increased hepatocyte proliferation.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Maria Giovanna De Leo, Philipp Berger, Andreas Mayer
Summary: Autophagosome formation requires specific proteins and phosphoinositides, with WIPI1 playing a crucial role in endosomal trafficking. WIPI1 is involved in the formation and fission of tubulo-vesicular transport carriers, supporting the transport of cargo proteins towards various organelles. The inactivation of WIPI1 leads to a significant enlargement of endosomes and accumulation of long tubules, impacting both autophagy and protein exit from endosomes.
Article
Dermatology
Yuri Ahn, Eun Jung Lee, Enzhi Luo, Junjeong Choi, Ji Young Kim, Suho Kim, Se-Hwa Kim, Yu Jeong Bae, Sujin Park, Jinu Lee, Sang Ho Oh
Summary: Particulate matter (PM) is known to be associated with cardiovascular and respiratory diseases. This study found that PM exposure can increase melanin production and the IRE1a pathway is involved in PM-induced melanogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seung-Ho Park, Sung-Jin Yoon, Song Choi, Jaeeun Jung, Jun-Young Park, Young-Ho Park, Jinho Seo, Jungwoon Lee, Moo-Seung Lee, Seon-Jin Lee, Mi-Young Son, Young-Lai Cho, Jang-Seong Kim, Hyo Jin Lee, Jinyoung Jeong, Dae-Soo Kim, Young-Jun Park
Summary: The study reveals that exposure to particulate matter pollutants can induce immune cells to secrete HBEGF, leading to a more invasive state in cancer cells. This finding helps uncover the mechanism by which PM promotes cancer metastasis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Mengyuan Liu, Heming Li, Huijing Zhang, Huan Zhou, Taiwei Jiao, Mingliang Feng, Fangjian Na, Mingjun Sun, Mingfang Zhao, Lei Xue, Lu Xu
Summary: By analyzing high-throughput sequencing datasets, this study identified RBMS1 as a potential promoter gene for gastric cancer metastasis, which activates the JAK2/STAT3 signaling pathway and IL-6 transcriptional activation, promoting cell migration and invasion.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Mohammad Abu-Odeh, Yuan Zhang, Shannon M. Reilly, Nima Ebadat, Omer Keinan, Joseph M. Valentine, Maziar Hafezi-Bakhtiari, Hadeel Ashayer, Lana Mamoun, Xin Zhou, Jin Zhang, Ruth T. Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M. Evans, Steven A. Kliewer, David J. Mangelsdorf, Alan R. Saltiel
Summary: The study reveals that FGF21 in adipocytes serves as a cell-autonomous autocrine regulator of adipose tissue function. Adipose-specific deletion of the FGF21 co-receptor beta-Klotho renders mice unresponsive to beta-adrenergic stimulation, while liver-specific ablation of FGF21 does not affect mice's response to beta-adrenergic browning of adipose tissue.
Article
Cell Biology
Kuan-Yuan Chen, Chien-Hua Tseng, Po-Hao Feng, Wei-Lun Sun, Shu-Chuan Ho, Cheng-Wei Lin, Nguyen Van Hiep, Ching-Shan Luo, Yen-Han Tseng, Tzu-Tao Chen, Wen-Te Liu, Kang-Yun Lee, Sheng-Ming Wu
Summary: Chronic exposure of human lung epithelial cells to 3-NBA leads to malignant transformation, in which the EREG signaling pathway plays a pivotal mediating role.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Immunology
Min Chao, Nan Liu, Zhichuan Sun, Yongli Jiang, Tongtong Jiang, Meng Xv, Lintao Jia, Yanyang Tu, Liang Wang
Summary: Sox9, an upregulated transcription factor in clinical gliomas associated with poor prognosis, promotes migration and invasion of glioma cells and in vivo tumor development. It functions downstream of the TGF-beta pathway, where TGF-beta signaling prevents proteasomal degradation of Sox9 protein in glioma cells. These findings provide new insights into the interaction between TGF-beta signaling and oncogenic transcription factors, with implications for targeted therapy and prognostic assessment of gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhou Xu, Xingruo Zeng, Mingchang Li, Jianming Liao, Qianxue Chen
Summary: The study demonstrated that downregulation of PRDX3 by miR-383 induced cell apoptosis and mitochondrial ROS production in U87 cells, thereby promoting oxidative stress-induced autophagy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Neurosciences
Zeyu Wu, Peng Lun, Tao Ji, Jiaojiao Niu, Xiuyan Sun, Xia Liu, Jian Xu
Summary: This study demonstrates that SNHG25 is upregulated in glioma cells and tissues, and its knockdown inhibits glioma cell proliferation and tumor growth. SNHG25 positively regulates MAPK signaling through sponging miR-579-5p and activating MAP2K2. Therefore, SNHG25 may serve as a potential target and biomarker for glioma.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Moshit Lindzen, Soma Ghosh, Ashish Noronha, Diana Drago, Nishanth Belugali Nataraj, Orith Leitner, Silvia Carvalho, Einav Zmora, Stav Sapoznik, Keren Bahar Shany, Keren Levanon, Dan Aderka, Belinda Sanchez Ramirez, Maik Dahlhoff, Iain McNeish, Yosef Yarden
Summary: Research suggests that AREG is overexpressed in abdominal fluids of ovarian cancer patients, and its immune modulation is associated with animal survival. The generation of a new antibody to target AREG has extended the survival time of mice.
Article
Oncology
Qi Lin, Zhen Chen, Zhao-Li Shen, Fei Xue, Jia-Jun Qin, Xi-Peng Kang, Zhong-Rong Chen, Zhong -Yuan Xia, Liang Gao, Xian-Zhen Chen
Summary: TRAF3IP3 is associated with poor prognosis in glioma patients and promotes tumor growth, migration, and invasion by activating the ERK signaling pathway. These findings suggest that TRAF3IP3 could serve as a potential biomarker for glioma prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dong Hoon Shin, Sun Ha Kim, Minyoung Choi, Young-Ki Bae, Chungyong Han, Beom K. Choi, Sang Soo Kim, Ji-Youn Han
Summary: The study demonstrates that KRAS mutation can increase the cleavage of NRG1 from the S-N fusion protein, enhancing various signaling pathways. The coexistence of KRAS mutant and S-N fusion in lung tumors makes them more vulnerable to MEK1/2 and ADAM17 inhibitors.
Article
Oncology
Xu Chen, Chao Liu, Zhenyu Zhang, Meng Wang, Shewei Guo, Tianhao Li, Hongwei Sun, Peng Zhang
Summary: This study investigated the clinical significance, biological behavior, and molecular mechanism of ZNF655 in glioma. The results showed that ZNF655 promoted glioma progression by binding to the promoter of AURKA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ghmkin Hassan, Toshiaki Ohara, Said M. Afify, Kazuki Kumon, Maram H. Zahra, Xiaoying Fu, Mohamad Al Kadi, Akimasa Seno, David S. Salomon, Masaharu Seno
Summary: This study found that normal stem cells can be converted into cancer stem cells in the cancer-inducing microenvironment. The converted cells exhibited tumorigenicity and self-renewal characteristics and their drug responses and metastatic abilities varied depending on the microenvironment of cancer cells. Transcriptome analysis showed upregulation of pathways related to aggressiveness and energy production in the converted cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yanning Xu, Said M. Afify, Juan Du, Bingbing Liu, Ghmkin Hassan, Qing Wang, Hanbo Li, Yixin Liu, Xiaoying Fu, Zhengmao Zhu, Ling Chen, Masaharu Seno
Summary: This study established a model of cancer stem cells (CSCs) derived from mouse induced pluripotent stem cells (miPSCs) and found that the activation of PI3K-Akt and EGFR signaling pathways played significant roles in the process. The inhibitors targeting these pathways showed significant anti-tumor effects in vitro and in vivo, with PI3K-gamma inhibitor Eganelisib demonstrating better therapeutic efficacy and fewer side effects.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ghmkin Hassan, Maram H. Zahra, Akimasa Seno, Masaharu Seno
Summary: This study reveals the importance of the ErbB2/ErbB3 signaling pathway in CSC generation induced by the conditioned medium from pancreatic ductal adenocarcinoma cells. Inhibition of ErbB2 or ErbB3 prevents CSC proliferation and stemness, while also inhibiting tube formation ability and overactivating the MAPK pathway.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Said M. Afify, Ghmkin Hassan, Akimasa Seno, Masaharu Seno
Summary: The growth of cancer tissue is driven by a small group of cells called cancer stem cells, which have the potential to self-renew, differentiate, and form tumors. Chronic diseases like obesity and diabetes may establish an environment that promotes the transformation of undifferentiated cells into cancer stem cells and the development of malignant tumors. Chronic inflammation is believed to play a key role in this process.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Sadia Monzur, Ghmkin Hassan, Said M. Afify, Kazuki Kumon, Hager Mansour, Hend M. Nawara, Mona Sheta, Hagar A. Abu Quora, Maram H. Zahra, Yanning Xu, Xiaoyin Fu, Akimasa Seno, Per Wikstrom, Ferenc L. M. Szekeres, Masaharu Seno
Summary: This study found that DPI may be a suitable drug candidate targeting mitochondrial respiration in cancer stem cells. Additionally, 3D culture assays are more efficient in screening anti-cancer stem cell drug candidates and better mimic the tumor microenvironment compared to traditional 2D culture assays.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Article
Biochemistry & Molecular Biology
Said M. Afify, Ghmkin Hassan, Hend M. Nawara, Maram H. Zahra, Yanning Xu, Md Jahangir Alam, Koichi Saitoh, Hager Mansour, Hagar A. Abu Quora, Mona Sheta, Sadia Monzur, Juan Du, Sue Young Oh, Akimasa Seno, David S. Salomon, Masaharu Seno
Summary: This article describes the optimization of a T7 expression system for the purification and refolding of Cripto-1 protein from inclusion bodies. The study found that a functional soluble form of Cripto-1 can be obtained under specific conditions, and this protein has inhibitory effects on cancer stem cells and promotes cell differentiation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Margaux Sala, Nathalie Allain, Melanie Moreau, Arnaud Jabouille, Elodie Henriet, Aya Abou-Hammoud, Arnaud Uguen, Sylvaine Di-Tommaso, Cyril Dourthe, Anne-Aurelie Raymond, Jean-William Dupuy, Emilie Gerard, Nathalie Dugot-Senant, Benoit Rousseau, Jean-Phillipe Merlio, Anne Pham-Ledart, Beatrice Vergier, Sophie Tartare-Deckert, Violaine Moreau, Frederic Saltel
Summary: Combined therapy with anti-BRAF plus anti-MEK is the first-line treatment for metastatic melanomas. However, tumor cell resistance is a major issue. This study shows that DDR2 inhibition can reduce AXL expression and stress fiber formation in resistant melanoma cells. Furthermore, DDR2 inhibition can control cell and tumor proliferation through the MAP kinase pathway.
Article
Biochemistry & Molecular Biology
Sandra Dubes, Anais Soula, Sebastien Benquet, Beatrice Tessier, Christel Poujol, Alexandre Favereaux, Olivier Thoumine, Mathieu Letellier
Summary: This study reveals the molecular mechanism of synapse-specific homeostatic plasticity. The synaptic tagging mechanism, driven by synaptopodin, regulates the enhancement of synaptic strength in a synapse-specific manner. This finding shifts the understanding of homeostatic plasticity towards the idea that the ability for changes depends on the functional and biochemical state of individual synapses.
Article
Multidisciplinary Sciences
Hideki Minematsu, Said M. Afify, Yuki Sugihara, Ghmkin Hassan, Maram H. Zahra, Akimasa Seno, Masaki Adachi, Masaharu Seno
Summary: In this study, the factors responsible for induction of Cancer Stem Cells (CSCs) were investigated. The results suggest that chronic stimulation of stem cells with prostaglandin E2 (PGE2) enhances the PI3K/Akt axis, which may be responsible for cancer initiation. The study provides new insights into the growth mechanisms of CSCs and the induction of cancer.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Ling Chen, Yanxia Liu, Yanning Xu, Said M. Afify, Ang Gao, Juan Du, Bingbing Liu, Xiaoying Fu, Yixin Liu, Ting Yan, Zhengmao Zhu, Masaharu Seno
Summary: In this study, it was discovered that the up-regulation of Dsg2 expression during the conversion of miPSCs into CSCs activates the Wnt/beta-catenin signaling pathway, implying a potential mechanism for the transformation of stem cells into a malignant phenotype.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Ghmkin Hassan, Said M. Afify, Maram H. Zahra, Hend M. Nawara, Kazuki Kumon, Yoshiaki Iwasaki, David S. Salomon, Akimasa Seno, Masaharu Seno
Summary: Researchers have successfully converted human induced pluripotent stem cells into cancer stem cells by culturing them in a medium mimicking the microenvironment of tumor initiation. The converted cells exhibited characteristics of cancer stem cells and could be used to establish personalized cancer models for studying tumor initiation and screening personalized therapies.
Meeting Abstract
Oncology
Hiroko Ishii, Maram Zahra, Ghmkin Hassan, Masaharu Seno
Meeting Abstract
Oncology
Monzur Sadia, Ghmkin Hassan, Said M. Affify, Hager Mansour, Mona Sheta, Kazuki Kumon, Maram H. Zahra, Akimasa Seno, Masaharu Seno
Meeting Abstract
Oncology
Akimasa Seno, Maram Zahra, Masaharu Seno
Meeting Abstract
Oncology
Hassan Ghmkin, Said M. Afify, Maram H. Zahara, David S. Salomon, Akimasa Seno, Masaharu Seno