Article
Multidisciplinary Sciences
Joelle S. Suarez, Flavia Novelli, Keisuke Goto, Michiko Ehara, Mika Steele, Jin-Hee Kim, Alicia A. Zolondick, Jiaming Xue, Ronghui Xu, Mai Saito, Sandra Pastorino, Michael Minaai, Yasutaka Takanishi, Mitsuru Emi, Ian Pagano, Andrew Wakeham, Thorsten Berger, Harvey I. Pass, Giovanni Gaudino, Tak W. Mak, Michele Carbone, Haining Yang
Summary: Asbestos is found to be the main cause of malignant mesothelioma, and HMGB1 plays a crucial role in its development. HMGB1 is mainly released by mesothelial cells during the early stages of inflammation after asbestos exposure, leading to an inflammatory response and atypical mesothelial hyperplasia. Knocking out HMGB1 in mesothelial cells significantly reduces the inflammatory response and the incidence of mesothelioma.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Pinar cakilkaya, Rikke Raagaard Sorensen, Henrik Jessen Jurgensen, Oliver Krigslund, Henrik Gardsvoll, Christoffer F. Nielsen, Eric Santoni-Rugiu, Niels Behrendt, Lars H. Engelholm
Summary: The study found significant upregulation of uPARAP in malignant mesothelioma, independent of asbestos exposure and chemotherapy. Internalization of anti-uPARAP monoclonal antibody led to specific eradication of MM cells with antibody-drug conjugate at sub-nanomolar concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Maria J. Disselhorst, Yoni Lubeck, Vincent van der Noort, Josine Quispel-Janssen, Iris M. Seignette, Joyce Sanders, Dennis Peters, Erik Hooijberg, Paul Baas
Summary: This study examined immune cell subgroups in tumor biopsies of MPM patients treated with ICI. The results showed that a higher cell density of CD4+, CD8+, FoxP3+, and PD-1+ cells was correlated with treatment response.
Article
Medicine, Research & Experimental
Rosanna Mezzapelle, Francesco De Marchis, Chiara Passera, Manuela Leo, Francesca Brambilla, Federica Colombo, Maura Casalgrandi, Alessandro Preti, Samuel Zambrano, Patrizia Castellani, Riccardo Ertassi, Marco Silingardi, Francesca Caprioglio, Veronica Basso, Renzo Boldorini, Angelo Carretta, Francesca Sanvito, Ottavio Rena, Anna Rubartelli, Lina Sabatino, Anna Mondino, Massimo P. Crippa, Vittorio Colantuoni, Marco E. Bianchi
Summary: Enhancing antitumor immunity is a powerful strategy in cancer treatment, involving the release of DAMPs and interfering with the CD47 signal to induce T-cell immune responses. Additionally, CXCR4 activation can also flag tumor cells for immune recognition.
EMBO MOLECULAR MEDICINE
(2021)
Article
Oncology
Faith Chang, Synat Keam, Tracy Seymour Hoang, Jenette Creaney, Suki Gill, Anna K. Nowak, Martin Ebert, Alistair M. Cook
Summary: This study characterizes the dose- and time-dependent changes in immune marker expression of commonly studied mesothelioma cell lines following radiation, providing insights for future studies on optimal dosing and scheduling of combined radiotherapy and immune checkpoint inhibition for mesothelioma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Licun Wu, Mikihiro Kohno, Junichi Murakami, Amin Zia, Jonathan Allen, Hana Yun, Meilin Chan, Cristina Baciu, Mingyao Liu, Veronique Serre-Beinier, Michele De Palma, Emanuela Felley-Bosco, Jonathan Yeung, Trevor J. Pugh, Marc de Perrot
Summary: Defining the origin of tumor-associated macrophages (TAM) is crucial for developing targeted therapies for mesothelioma. Two distinct macrophage populations, small peritoneal/pleural macrophages (SPM) and large peritoneal/pleural macrophages (LPM), were identified in mice. SPM, which mainly consisted of M2-like TAM, rapidly increased in the tumor microenvironment and contributed to tumor development. On the other hand, LPM activated the IFN-gamma response and played a crucial role in the immune response, as confirmed by their depletion leading to loss of antitumoral memory immunity. The gene signature of SPM was observed in the pleural effusion and tumor of untreated mesothelioma patients, suggesting potential therapeutic targets.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Samuel G. Armato, Anna K. Nowak, Roslyn J. Francis, Sharyn Katz, Manizha Kholmatov, Kevin G. Blyth, Eyjolfur Gudmundsson, Andrew C. Kidd, Ritu R. Gill
Summary: Imaging of mesothelioma plays a crucial role in various aspects of patient management, and researchers are developing advanced techniques to extract more information from medical images and utilize it for sophisticated tasks.
Article
Multidisciplinary Sciences
Masayuki Watanabe, Tomohito Higashi, Kana Ozeki, Atsuko Y. Higashi, Kotaro Sugimoto, Hayato Mine, Hironori Takagi, Yuki Ozaki, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Yutaka Shio, Hiroyuki Suzuki, Hideki Chiba
Summary: This study identified claudin-15 as a potential positive marker for malignant pleural mesotheliomas, with high expression levels in 83% of MPM tissue samples. The specificity of CLDN15 was comparable to other markers in lung adenocarcinoma sections. CLDN15 showed low expression in non-mesothelial tumors, suggesting its potential clinical utility for MPM diagnosis.
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Koki Nakashima, Yasuhiro Sakai, Hitomi Hoshino, Yukihiro Umeda, Hiroto Kawashima, Yoshitaka Sekido, Tamotsu Ishizuka, Motohiro Kobayashi
Summary: In this study, a monoclonal antibody named S1 was found to have a high positivity rate in immunostaining of malignant pleural mesothelioma (MPM). Additionally, a unique glycan structure was identified in MPM cells. Therefore, the S1 glycoepitope could potentially serve as a new diagnostic marker for MPM.
Article
Oncology
Filiz Bogar, Guntulu Ak, Selma Metintas, Adnan Ayhanci, Muzaffer Metintas
Summary: This study longitudinally investigated the levels of biomarkers in malignant pleural mesothelioma (MPM) patients before and after chemotherapy and at the time of relapse. The results showed that changes in biomarker levels were associated with treatment response, suggesting the potential usefulness of biomarkers in monitoring treatment response.
Article
Oncology
Dmitry V. Sverchinsky, Bashar A. Alhasan, Marina A. Mikeladze, Vladimir F. Lazarev, Liubov S. Kuznetcova, Alisa V. Morshneva, Alina D. Nikotina, Amr Ziewanah, Lidia V. Koludarova, Tatiana Y. Starkova, Boris A. Margulis, Irina V. Guzhova
Summary: Cancer recurrence is regulated by factors such as heat shock protein 70 (Hsp70) signaling. The abundance of Hsp70-HMGB1 complex in the extracellular matrix may serve as a novel marker of cancer relapse state, and targeting this complex could be a promising treatment for cancers with a high risk of recurrence.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Francesca Napoli, Angela Listi, Vanessa Zambelli, Gianluca Witel, Paolo Bironzo, Mauro Papotti, Marco Volante, Giorgio Scagliotti, Luisella Righi
Summary: The tumor immune microenvironment plays a crucial role in the growth and progression of malignant pleural mesothelioma. Understanding the pathological characteristics of this microenvironment can lead to the discovery of new biomarkers and the development of advanced therapeutic strategies for this aggressive disease.
Article
Genetics & Heredity
Clement Meiller, Francois Montagne, Theo Z. Hirsch, Stefano Caruso, Julien de Wolf, Quentin Bayard, Jean-Baptiste Assie, Lea Meunier, Yuna Blum, Lisa Quetel, Laure Gibault, Ecaterina Pintilie, Cecile Badoual, Sarah Humez, Francoise Galateau-Salle, Marie-Christine Copin, Eric Letouze, Arnaud Scherpereel, Jessica Zucman-Rossi, Francoise Le Pimpec-Barthes, Marie-Claude Jaurand, Didier Jean
Summary: This study investigated intra-tumor heterogeneity in malignant pleural mesothelioma (MPM) using the largest series to date and multi-omics profiling of a substantial series of multi-site tumor samples. The results revealed patient-dependent spatial heterogeneity at genetic, transcriptomic, and epigenetic levels, as well as changes in the immune landscape of the tumor microenvironment, supporting the need for multi-sampling for precision medicine.
Review
Oncology
Francesca Cersosimo, Marcella Barbarino, Silvia Lonardi, William Vermi, Antonio Giordano, Cristiana Bellan, Emanuele Giurisato
Summary: Interaction among tumor cells, immune cells, stromal cells, and the extracellular matrix in the tumor microenvironment is crucial for supporting pro-tumor mechanisms such as drug resistance and metastases. Understanding the crosstalk between tumor and non-tumor cells is important for designing more effective anti-cancer therapeutic strategies. Studies have shown that the cellular and soluble components of the tumor microenvironment play a key role in cancer initiation and progression.
Article
Oncology
Zhenying Guo, Li Shen, Ningning Li, Xiaoxiao Wu, Canming Wang, Zheng Gu, Zhongjian Chen, Junping Liu, Weimin Mao, Yuchen Han
Summary: This study used bioinformatics to identify key genes in malignant mesothelioma, finding that Aurora-A could be an optimal diagnostic biomarker and a potential prognostic marker. Additionally, seven genes were identified as potential prognostic markers for MM.
FRONTIERS IN ONCOLOGY
(2021)